Glutathione S-Transferases in Cancer

The mercapturic acid pathway

(2020) Patrick E. Hanna et al.   CRITICAL REVIEWS IN TOXICOLOGY

Vimentin S‐glutathionylation at Cys328 inhibits filament elongation and induces severing of mature filaments in vitro

(2020) Magdalena Kaus‐Drobek et al.   FEBS Journal

Management of glioblastoma: State of the art and future directions

(2020) Aaron C. Tan et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways

(2020) Rahul R. Singh et al.   Cancers

Glutathione transferase Omega 1‐1 (GSTO1‐1) modulates Akt and MEK1/2 signaling in human neuroblastoma cell SH‐SY5Y

(2019) Chonticha Saisawang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Glutathione Transferase P1-1 an Enzyme Useful in Biomedicine and as Biomarker in Clinical Practice and in Environmental Pollution

(2019) Alessio Bocedi et al.   Nutrients

Transcriptional Activation of Gstp1 by MEK/ERK Signaling Confers Chemo-Resistance to Cisplatin in Lung Cancer Stem Cells

(2019) Jingyuan Li et al.   Frontiers in Oncology

Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking

(2019) Anna Kruyer et al.   PLoS One

Presenting symptoms of cancer and stage at diagnosis: evidence from a cross-sectional, population-based study

(2019) Minjoung Monica Koo et al.   LANCET ONCOLOGY

Peroxiredoxin 6 Is a Key Antioxidant Enzyme in Modulating the Link between Glycemic and Lipogenic Metabolism

(2019) Roberto Arriga et al.   Oxidative Medicine and Cellular Longevity

Glutathionylation: a regulatory role of glutathione in physiological processes

(2018) Kristina Dominko et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

The multifaceted role of glutathione S-transferases in cancer

(2018) Anupam Chatterjee et al.   CANCER LETTERS

Borderline resectable pancreatic cancer. Challenges and controversies

(2018) Luis Sabater et al.   CANCER TREATMENT REVIEWS

Development of an Efficient Dual-Action GST-Inhibiting Anticancer Platinum(IV) Prodrug

(2018) Keefe Guang Zhi Lee et al.   ChemMedChem

Synthesis and molecular modeling of new benzimidazoles as glutathione S-transferase inhibitors and anticancer agents

(2018) Somaia S Abd El-Karim et al.   Future Medicinal Chemistry

miR-133b reverses cisplatin resistance by targeting GSTP1 in cisplatin-resistant lung cancer cells

(2018) Chen Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Piperlongumine and p53-reactivator APR-246 selectively induce cell death in HNSCC by targeting GSTP1

(2018) Wei Hang et al.   ONCOGENE

GSTM3 and GSTP1: novel players driving tumor progression in cervical cancer

(2018) Alberto Checa-Rojas et al.   Oncotarget

Reactive Oxygen and Nitrogen Species–Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy

(2018) Nurbubu T. Moldogazieva et al.   CANCER RESEARCH

Glutathione S-transferase Pi 1 is a valuable predictor for cancer drug resistance in esophageal squamous cell carcinoma

(2018) Shinpei Ogino et al.   CANCER SCIENCE

A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells

(2018) Yuko Shishido et al.   CHEMBIOCHEM

Glutathione S-Transferases and Cytochrome P450 enzyme expression in patients with Intracranial Tumors: Preliminary Report of 55 Patients

(2018) Cahit Kural et al.   MEDICAL PRINCIPLES AND PRACTICE

Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease

(2017) Yannis Gerakis et al.   FEBS Journal

Mutations in TGM6 induce the unfolded protein response in SCA35

(2017) Debasmita Tripathy et al.   HUMAN MOLECULAR GENETICS

CLDN6 promotes chemoresistance through GSTP1 in human breast cancer

(2017) Minlan Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Current and future therapies for advanced pancreatic cancer

(2017) Rohan Gupta et al.   JOURNAL OF SURGICAL ONCOLOGY

MDG-1 inhibits H2O2-induced apoptosis and inflammation in human umbilical vein endothelial cells

(2017) Luo-Cheng Li et al.   Molecular Medicine Reports

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

ER stress and the unfolded protein response in neurodegeneration

(2017) Claudio Hetz et al.   Nature Reviews Neurology

Piperlongumine potentiates the effects of gemcitabine in in vitro and in vivo human pancreatic cancer models

(2017) Jiyan Mohammad et al.   Oncotarget

The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis

(2017) Anastasia De Luca et al.   Oncotarget

The molecular mechanisms of chemoresistance in cancers

(2017) Hua-Chuan Zheng   Oncotarget

Redox signaling during hypoxia in mammalian cells

(2017) Kimberly A. Smith et al.   Redox Biology

MicroRNA-130b targets PTEN to mediate drug resistance and proliferation of breast cancer cells via the PI3K/Akt signaling pathway

(2017) Yuan Miao et al.   Scientific Reports

Structural and Biochemical Analyses Reveal the Mechanism of GlutathioneS-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine

(2016) Wayne Harshbarger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer metabolism at a glance

(2016) Alexei Vazquez et al.   JOURNAL OF CELL SCIENCE

A tyrosine-reactive irreversible inhibitor for glutathione S-transferase Pi (GSTP1)

(2016) L. A. Crawford et al.   Molecular BioSystems

Cancer stem cells and chemoresistance: The smartest survives the raid

(2016) Jihe Zhao   PHARMACOLOGY & THERAPEUTICS

Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells

(2016) Genki Tanaka et al.   Cancer Medicine

Cytosolic thiol switches regulating basic cellular functions: GAPDH as an information hub?

(2015) Thomas Hildebrandt et al.   BIOLOGICAL CHEMISTRY

Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression

(2015) Zhaoyong Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs

(2015) Sonja Kaisarevic et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Chemotherapy is getting ‘smarter’

(2015) Thomas Mehrling   Future Oncology

Continuous exposure of non-small cell lung cancer cells with wild-type EGFR to an inhibitor of EGFR tyrosine kinase induces chemoresistance by activating STAT3

(2015) JIE TANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione

(2015) Grazia Luisi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Survivorship in Non–Small Cell Lung Cancer: Challenges Faced and Steps Forward

(2015) Namrata Vijayvergia et al.   Journal of the National Comprehensive Cancer Network

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

A novel orally active water-soluble Inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts

(2015) Anastasia De Luca et al.   Oncotarget

Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis

(2015) Zhipeng Wang et al.   Scientific Reports

Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer

(2015) Jong-Lyel Roh et al.   Oncotarget

Sensitization of mesothelioma cells to platinum-based chemotherapy by GSTπ knockdown

(2014) Jianli Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Soy Intake and Breast Cancer Risk: An Evaluation Based on a Systematic Review of Epidemiologic Evidence Among the Japanese Population

(2014) Chisato Nagata et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins

(2014) HongBin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The fine-tuning of TRAF2–GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex

(2014) A De Luca et al.   Cell Death & Disease

Protein kinase C pharmacology: refining the toolbox

(2013) Alyssa X. Wu-zhang et al.   BIOCHEMICAL JOURNAL

FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1

(2013) Yaman Musdal et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The association between chemosensitivity and Pgp, GST-π and Topo II expression in gastric cancer

(2013) Ming Geng et al.   Diagnostic Pathology

A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects

(2013) Ki-Hyun Kim et al.   ENVIRONMENT INTERNATIONAL

Causes and Consequences of CysteineS-Glutathionylation

(2013) Christina L. Grek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic significance of several biomarkers in epithelial ovarian cancer: a meta-analysis of published studies

(2013) Linjuan Xu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite

(2013) R. E. Moellering et al.   SCIENCE

Novel control of cardiac myofilament response to calcium by S-glutathionylation at specific sites of myosin binding protein C

(2013) Bindiya G. Patel et al.   Frontiers in Physiology

Oxidative stress and cancer: An overview

(2012) Venus Sosa et al.   AGEING RESEARCH REVIEWS

Redox Environment, Free Radical, and Oxidative DNA Damage

(2012) Sarah J. Storr et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

PHASE II DRUG METABOLIZING ENZYMES

(2012) Petra Jancova et al.   BIOMEDICAL PAPERS-OLOMOUC

The synthesis of ethacrynic acid thiazole derivatives as glutathione S-transferase pi inhibitors

(2012) Ting Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

S-Glutathionylated Serine Proteinase Inhibitors as Plasma Biomarkers in Assessing Response to Redox-Modulating Drugs

(2012) C. L. Grek et al.   CANCER RESEARCH

Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation

(2012) Y. Manevich et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways

(2012) JINGJIE LI et al.   ONCOLOGY REPORTS

Genetic Polymorphisms of GSTM1, GSTT1, and GSTP1 with Prostate Cancer Risk: A Meta-Analysis of 57 Studies

(2012) Mancheng Gong et al.   PLoS One

Human cytosolic glutathione transferases: structure, function, and drug discovery

(2012) Baojian Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Protein Glutathionylation in the Regulation of Peroxiredoxins: A Family of Thiol-Specific Peroxidases That Function As Antioxidants, Molecular Chaperones, and Signal Modulators

(2011) Ho Zoon Chae et al.   ANTIOXIDANTS & REDOX SIGNALING

Prostate Cancer Chemoprevention Study: An investigative randomized control study using purified isoflavones in men with rising prostate-specific antigen

(2011) Naoto Miyanaga et al.   CANCER SCIENCE

Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesions

(2011) Fernando Benavides et al.   CELL CYCLE

Regulatory functions of glutathioneS-transferase P1-1 unrelated to detoxification

(2011) Kenneth D. Tew et al.   DRUG METABOLISM REVIEWS

Glutathione transferases: a structural perspective

(2011) Aaron Oakley   DRUG METABOLISM REVIEWS

Biomarkers for hazard identification in humans

(2011) Helmut Bartsch et al.   Environmental Health

The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma

(2011) Lucio Tentori et al.   EUROPEAN JOURNAL OF CANCER

The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer

(2011) Kenneth D. Tew et al.   FREE RADICAL BIOLOGY AND MEDICINE

Signal Transduction by Mitochondrial Oxidants

(2011) Toren Finkel   JOURNAL OF BIOLOGICAL CHEMISTRY

Amitriptyline may have a supportive role in cancer treatment by inhibiting glutathione S-transferase pi (GST-π) and alpha (GST-α)

(2011) Gulnihal Kulaksiz-Erkmen et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Potent and Selective Inhibitors of GlutathioneS-Transferase Omega 1 That Impair Cancer Drug Resistance

(2011) Katsunori Tsuboi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of protein glutathionylation on neuronal cytoskeleton: a potential link to neurodegeneration

(2011) B. Carletti et al.   NEUROSCIENCE

Secondary oxidation of cyclic 1,N2-propano and 1,N2-etheno-2′-deoxyguanosine DNA adducts. Consequences in oxidative stress biomarker development

(2010) Stéphane Barbati et al.   CHEMOSPHERE

GSTM1, GSTT1, GSTP1, GSTA1 and colorectal cancer risk: A comprehensive meta-analysis

(2010) Konstantinos P. Economopoulos et al.   EUROPEAN JOURNAL OF CANCER

Cys-141 glutathionylation of human p53: Studies using specific polyclonal antibodies in cancer samples and cell lines

(2010) Mohd. A. Yusuf et al.   FREE RADICAL BIOLOGY AND MEDICINE

Establishment and characterization of multi-drug resistant, prostate carcinoma-initiating stem-like cells from human prostate cancer cell lines 22RV1

(2010) Te Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

(2010) Chun-An Chen et al.   NATURE

Glutathione Transferases Are Structural and Functional Outliers in the Thioredoxin Fold

(2009) Holly J. Atkinson et al.   BIOCHEMISTRY

Structural Basis for the Binding of the Anticancer Compound 6-(7-Nitro-2,1,3-Benzoxadiazol-4-Ylthio)Hexanol to Human Glutathione S-Transferases

(2009) L. Federici et al.   CANCER RESEARCH

Nitrosative Stress-Induced S-Glutathionylation of Protein Disulfide Isomerase Leads to Activation of the Unfolded Protein Response

(2009) D. M. Townsend et al.   CANCER RESEARCH

Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib

(2009) Henk J. Broxterman et al.   DRUG RESISTANCE UPDATES

Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra(R), TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome

(2009) Azra Raza et al.   Journal of Hematology & Oncology

Inhibition of heme oxygenase-1 with an epidermal growth factor receptor inhibitor and cisplatin decreases proliferation of lung cancer A549 cells

(2009) Hideyo Kuroda et al.   LUNG CANCER

Role of nuclear glutathione as a key regulator of cell proliferation

(2009) Federico V. Pallardó et al.   MOLECULAR ASPECTS OF MEDICINE

Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes

(2009) Daniel A Bachovchin et al.   NATURE BIOTECHNOLOGY

Inhibition of caspase-3 activity and activation by protein glutathionylation

(2008) Zhishan Huang et al.   BIOCHEMICAL PHARMACOLOGY

Cancer Stem Cells Contribute to Cisplatin Resistance in Brca1/p53-Mediated Mouse Mammary Tumors

(2008) N. Shafee et al.   CANCER RESEARCH

S-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling

(2008) Yi Xie et al.   ENDOCRINOLOGY

Novel Role for GlutathioneS-Transferase π

(2008) Danyelle M. Townsend et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Environmental toxicity, redox signaling and lung inflammation: The role of glutathione

(2008) Saibal K. Biswas et al.   MOLECULAR ASPECTS OF MEDICINE

Glutathione in liver diseases and hepatotoxicity

(2008) Liyun Yuan et al.   MOLECULAR ASPECTS OF MEDICINE