6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound

A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability

(2017) Chiara Fulci et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition

(2016) Camilla Palumbo et al.   Journal of Translational Medicine

Medicine Nobel for research on how cells 'eat themselves'

(2016) Richard Van Noorden et al.   NATURE

A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib

(2015) Grazia Graziani et al.   BIOCHEMICAL PHARMACOLOGY

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Synthesis and structure–activity relationship of new cytotoxic agents targeting human glutathione-S-transferases

(2015) Dante Rotili et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

(2015) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics

(2015) Prashanta Kumar Panda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A novel orally active water-soluble Inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts

(2015) Anastasia De Luca et al.   Oncotarget

The FAD-dependent glycerol-3-phosphate dehydrogenase of Giardia duodenalis: an unconventional enzyme that interacts with the g14-3-3 and it is a target of the antitumoral compound NBDHEX

(2015) Marco Lalle et al.   Frontiers in Microbiology

Targeting Glutathione-S Transferase Enzymes in Musculoskeletal Sarcomas: A Promising Therapeutic Strategy

(2015) Michela Pasello et al.   Analytical Cellular Pathology

Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells

(2014) Subhasree Basu et al.   Autophagy

Cytoprotective and regulatory functions of glutathione S-transferases in cancer cell proliferation and cell death

(2014) Simendra Singh   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The fine-tuning of TRAF2–GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex

(2014) A De Luca et al.   Cell Death & Disease

Targeting Glutathione S-transferase M4 in Ewing sarcoma

(2014) Rupeng Zhuo et al.   Frontiers in Pediatrics

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

(2013) Xinbing Sui et al.   CANCER LETTERS

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Glutathione Transferases as Targets for Cancer Therapy

(2012) Paolo Ruzza et al.   Anti-Cancer Agents in Medicinal Chemistry

Glutathione-S-Transferases As Determinants of Cell Survival and Death

(2012) Kenneth D. Tew et al.   ANTIOXIDANTS & REDOX SIGNALING

New Insights into the Mechanism of JNK1 Inhibition by Glutathione Transferase P1-1

(2012) Anastasia De Luca et al.   BIOCHEMISTRY

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Abstract 2970: Cyclooxygenase-2 mediates significant changes in the extracellular matrix in triple negative breast cancer

(2012) Ioannis A. Stasinopoulos et al.   CANCER RESEARCH

Glutathione S-transferase P1-1 as a target for mesothelioma treatment

(2012) Anastasia De Luca et al.   CANCER SCIENCE

Regulation and Function of Autophagy during Cell Survival and Cell Death

(2012) G. Das et al.   Cold Spring Harbor Perspectives in Biology

Nutritional Stress and Arginine Auxotrophy Confer High Sensitivity to Chloroquine Toxicity in Mesothelioma Cells

(2011) Sonia Battisti et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma

(2011) Lucio Tentori et al.   EUROPEAN JOURNAL OF CANCER

Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines

(2011) Andrea Sau et al.   Molecular BioSystems

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Glutathione transferases and development of new principles to overcome drug resistance

(2010) Andrea Sau et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Evidence for the interplay between JNK and p53-DRAM signaling pathways in the regulation of autophagy

(2010) Séverine Lorin et al.   Autophagy

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells

(2009) Alessandro Ascione et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Structural Basis for the Binding of the Anticancer Compound 6-(7-Nitro-2,1,3-Benzoxadiazol-4-Ylthio)Hexanol to Human Glutathione S-Transferases

(2009) L. Federici et al.   CANCER RESEARCH

In vitro and in vivo efficacy of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on human melanoma

(2009) Francesca Pellizzari Tregno et al.   EUROPEAN JOURNAL OF CANCER

Overcoming Glutathione S-Transferase P1-Related Cisplatin Resistance in Osteosarcoma

(2008) M. Pasello et al.   CANCER RESEARCH

6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer

(2008) G. Filomeni et al.   MOLECULAR CANCER THERAPEUTICS