Monocarbonyl Curcumin Analogues as Potent Inhibitors against Human Glutathione Transferase P1-1

Comparative structural analysis of the human and Schistosoma glutathione transferase dimer interface using selective binding of bromosulfophthalein

(2022) Akeel Valli et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Insight into Inhibitory Mechanism of PDE4D by Dietary Polyphenols Using Molecular Dynamics Simulations and Free Energy Calculations

(2021) Veronika Furlan et al.   Biomolecules

Curcumin Derivatives as Potential Mosquito Larvicidal Agents against Two Mosquito Vectors, Culex pipiens and Aedes albopictus

(2021) Dimitris Matiadis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity

(2021) Dimitris Matiadis et al.   Biomedicines

CANDOCK: Chemical Atomic Network-Based Hierarchical Flexible Docking Algorithm Using Generalized Statistical Potentials

(2020) Jonathan Fine et al.   Journal of Chemical Information and Modeling

Drug-metabolizing enzymes: role in drug resistance in cancer

(2020) G. Kaur et al.   Clinical & Translational Oncology

Curcumin effect on cancer cells' multidrug resistance: An update

(2020) Saeedeh Keyvani‐Ghamsari et al.   PHYTOTHERAPY RESEARCH

From cyclohexanone to photosensitive polyesters: Synthetic pathway, basic characterization, and photo-/halochromic properties

(2020) Mihaela Homocianu et al.   JOURNAL OF MOLECULAR LIQUIDS

Acidochromic Behavior of Dibenzylidene Cyclohexanone-Based Bischalcone: Experimental and Theoretical Study

(2020) Md Mizanur Rahman Badal et al.   ACS Omega

Aflatoxin B1–Formamidopyrimidine DNA Adducts: Relationships between Structures, Free Energies, and Melting Temperatures

(2019) Martin Klvana et al.   MOLECULES

A Review of Curcumin and Its Derivatives as Anticancer Agents

(2019) Mhd Tomeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin analogues and derivatives with anti-proliferative and anti-inflammatory activity: Structural characteristics and molecular targets

(2019) Eirini Chainoglou et al.   Expert Opinion on Drug Discovery

Functional, Structural and Biochemical Features of Plant Serinyl-Glutathione Transferases

(2019) Elodie Sylvestre-Gonon et al.   Frontiers in Plant Science

Design, synthesis, and evaluation of a water soluble C5-monoketone type curcumin analogue as a potent amyloid β aggregation inhibitor

(2019) Mayumi Hotsumi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Glutathione Transferase P1-1 an Enzyme Useful in Biomedicine and as Biomarker in Clinical Practice and in Environmental Pollution

(2019) Alessio Bocedi et al.   Nutrients

Therapeutic effects of turmeric in several diseases: An overview

(2019) Eleonora Hay et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Uncovering the Role of Key Active-Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalyzed by Wild-Type and Variants of Triosephosphate Isomerase

(2019) Yashraj S. Kulkarni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors

(2019) Dorota Krasowska et al.   MOLECULES

Curcumin Derivatives Verify the Essentiality of ROS Upregulation in Tumor Suppression

(2019) Ikuko Nakamae et al.   MOLECULES

Curcumin and Cancer

(2019) Giordano et al.   Nutrients

Curcumin analogue 1,5-bis(4-hydroxy-3-((4-methylpiperazin-1-yl)methyl)phenyl)penta-1,4-dien-3-one mediates growth arrest and apoptosis by targeting the PI3K/AKT/mTOR and PKC-theta signaling pathways in human breast carcinoma cells

(2018) Gamal Badr et al.   BIOORGANIC CHEMISTRY

6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound

(2018) Huan-huan Sha et al.   BIOSCIENCE REPORTS

Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth

(2018) Yonika Arum Larasati et al.   Scientific Reports

Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

(2018) Nerino Allocati et al.   Oncogenesis

Targeting glutathione S-transferase P and its interactome with selenium compounds in cancer therapy

(2018) D. Bartolini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione Transferases: Potential Targets to Overcome Chemoresistance in Solid Tumors

(2018) Marija Pljesa-Ercegovac et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The therapeutic potential of curcumin: A review of clinical trials

(2018) Bahare Salehi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploring the Stability of Ligand Binding Modes to Proteins by Molecular Dynamics Simulations: A Cross-docking Study

(2017) Kai Liu et al.   Journal of Chemical Information and Modeling

A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability

(2017) Chiara Fulci et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Enzyme Architecture: Modeling the Operation of a Hydrophobic Clamp in Catalysis by Triosephosphate Isomerase

(2017) Yashraj S. Kulkarni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and synthesis of 2-substituted-5-(4-trifluoromethylphenyl-sulphonamido)benzoxazole derivatives as human GST P1-1 inhibitors

(2017) Tugba Ertan-Bolelli et al.   Artificial Cells Nanomedicine and Biotechnology

Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling

(2016) Jian Sha et al.   BIOMEDICINE & PHARMACOTHERAPY

Glutathione analogues as substrates or inhibitors that discriminate between allozymes of the MDR-involved human glutathione transferase P1-1

(2016) Aikaterini Zompra et al.   BIOPOLYMERS

Anticancer Activity of Curcumin and Its Analogues: Preclinical and Clinical Studies

(2016) Alessandro Allegra et al.   CANCER INVESTIGATION

Glutathione-Associated Enzymes In Anticancer Drug Resistance

(2016) K. D. Tew   CANCER RESEARCH

Palladium(II) and platinum(II) complexes of derivatives of 2-(4′-aminophenyl)benzothiazole as potential anticancer agents

(2016) Barbara Mavroidi et al.   INORGANICA CHIMICA ACTA

Structural and Biochemical Analyses Reveal the Mechanism of GlutathioneS-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine

(2016) Wayne Harshbarger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin and Health

(2016) Mario Pulido-Moran et al.   MOLECULES

Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells

(2015) Xiuhua Zhang et al.   BMC CANCER

Isoenzyme- and Allozyme-Specific Inhibitors: 2,2′-Dihydroxybenzophenones and Their Carbonyl N-Analogues that Discriminate between Human Glutathione Transferase A1-1 and P1-1 Allozymes

(2015) Foteini M. Pouliou et al.   Chemical Biology & Drug Design

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

PLIP: fully automated protein–ligand interaction profiler

(2015) Sebastian Salentin et al.   NUCLEIC ACIDS RESEARCH

Curcumin mediates reversion of HGF-induced epithelial-mesenchymal transition via inhibition of c-Met expression in DU145 cells

(2015) HUI-JUN HU et al.   Oncology Letters

Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

(2014) L Sawers et al.   BRITISH JOURNAL OF CANCER

Synthesis of novel curcumin analogues for inhibition of 11β-hydroxysteroid dehydrogenase type 1 with anti-diabetic properties

(2014) Xiaohuan Yuan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

ff14ipq: A Self-Consistent Force Field for Condensed-Phase Simulations of Proteins

(2014) David S. Cerutti et al.   Journal of Chemical Theory and Computation

Eliminating the Heart from the Curcumin Molecule: Monocarbonyl Curcumin Mimics (MACs)

(2014) Dinesh Shetty et al.   MOLECULES

Synthesis, docking, and in vitro studies of some substituted bischalcones on acid and alkaline phosphatases

(2013) Mamta Singh et al.   MEDICINAL CHEMISTRY RESEARCH

The Interaction of the Chemotherapeutic Drug Chlorambucil with Human Glutathione Transferase A1-1: Kinetic and Structural Analysis

(2013) Michael Karpusas et al.   PLoS One

Role of Phase II Drug Metabolizing Enzymes in Cancer Chemoprevention

(2012) Snehasis Jana et al.   CURRENT DRUG METABOLISM

A new target for gold(I) compounds: Glutathione-S-transferase inhibition by auranofin

(2012) Anastasia De Luca et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis and Study of 2-(Pyrrolesulfonylmethyl)-N-arylimines: A New Class of Inhibitors for Human Glutathione Transferase A1-1

(2012) Georgia E. Koutsoumpli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

(2012) Marcus D Hanwell et al.   Journal of Cheminformatics

Glutathione transferases and development of new principles to overcome drug resistance

(2010) Andrea Sau et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death

(2010) E Laborde   CELL DEATH AND DIFFERENTIATION

DNA Duplex Stability: The Role of Preorganized Electrostatics

(2010) Urban Bren et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A conserved hydrogen-bond network stabilizes the structure of Beta class glutathione S-transferases

(2009) Luca Federici et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of human glutathioneS-transferases by curcumin and analogues

(2009) R. Appiah-Opong et al.   XENOBIOTICA

Synthesis and Anti-bacterial Properties of Mono-carbonyl Analogues of Curcumin

(2008) Guang Liang et al.   CHEMICAL & PHARMACEUTICAL BULLETIN