Glutathione S-Transferases Mediate In Vitro and In Vivo Inactivation of Genipin: Implications for an Underlying Detoxification Mechanism

Influence of cytochrome P450 and glutathione S transferase polymorphisms on response to nilotinib therapy among chronic myeloidleukemia patients from Pakistan

(2022) Samina Naz Mukry et al.   BMC CANCER

A review of the ethnopharmacology, phytochemistry, pharmacology and toxicology of Fructus Gardeniae (Zhi-zi)

(2022) Jingzhuo Tian et al.   JOURNAL OF ETHNOPHARMACOLOGY

Updated Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of Natural Product Geniposide

(2022) Liping Liu et al.   MOLECULES

GSTP1 c.313A > G mutation is an independent risk factor for neutropenia hematotoxicity induced by anthracycline-/paclitaxel-based chemotherapy in breast cancer patients

(2022) Juanzi Zeng et al.   World Journal of Surgical Oncology

Geniposide restricts angiogenesis in experimentary arthritis via inhibiting Dnmt1-mediated PTEN hypermethylation

(2022) Yanhong Bu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Geniposide protects depression through BTK/JAK2/STAT1 signaling pathway in lipopolysaccharide-induced depressive mice

(2021) Menglin Zheng et al.   BRAIN RESEARCH BULLETIN

Characterization of Cytosolic Glutathione S-Transferases Involved in the Metabolism of the Aromatase Inhibitor, Exemestane

(2021) Irina Teslenko et al.   DRUG METABOLISM AND DISPOSITION

Geniposide Attenuates Hyperglycemia-Induced Oxidative Stress and Inflammation by Activating the Nrf2 Signaling Pathway in Experimental Diabetic Retinopathy

(2021) Yuanyuan Tu et al.   Oxidative Medicine and Cellular Longevity

Metabolic Activation of the Toxic Natural Products From Herbal and Dietary Supplements Leading to Toxicities

(2021) Yi-Kun Wang et al.   Frontiers in Pharmacology

Identification and Functional Analysis of a Delta Class Glutathione S-Transferase Gene Associated with Insecticide Detoxification in Bradysia odoriphaga

(2019) Bowen Tang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Role of intestinal microbiota-mediated genipin dialdehyde intermediate formation in geniposide-induced hepatotoxicity in rats

(2019) Yi Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

(2018) Nerino Allocati et al.   Oncogenesis

Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity

(2017) Yongjie Zhang et al.   TOXICOLOGY LETTERS

Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation

(2016) Stefan J. Dekker et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Comprehensive Evaluation of the Metabolism of Genipin-1-β-d-gentiobioside in Vitro and in Vivo by Using HPLC-Q-TOF

(2016) Pei Jiang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Simulation of interindividual differences in inactivation of reactive para -benzoquinone imine metabolites of diclofenac by glutathione S -transferases in human liver cytosol

(2016) Michiel W. den Braver et al.   TOXICOLOGY LETTERS

Geniposide protects against acute alcohol-induced liver injury in mice via up-regulating the expression of the main antioxidant enzymes

(2015) Junming Wang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Inhibition of Glutathione S-Transferase by Ethacrynic Acid Augments Ischemia-Reperfusion Damage and Apoptosis and Attenuates the Positive Effect of Ischemic Postconditioning in a Bilateral Acute Hindlimb Ischemia Rat Model

(2015) Tibor Nagy et al.   JOURNAL OF VASCULAR RESEARCH

Effects of Intestinal Microbiota on the Bioavailability of Geniposide in Rats

(2014) Ming Ji Jin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen

(2013) Sanja Dragovic et al.   TOXICOLOGY LETTERS

Potential hepatotoxicity of geniposide, the major iridoid glycoside in dried ripe fruits ofGardenia jasminoides(Zhi-zi)

(2012) Yue Ding et al.   NATURAL PRODUCT RESEARCH

Biotransformation of geniposide by human intestinal microflora on cytotoxicity against HepG2 cells

(2012) Tilak Khanal et al.   TOXICOLOGY LETTERS

Involvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of Troglitazone

(2011) R. Okada et al.   DRUG METABOLISM AND DISPOSITION

GlutathioneS-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury

(2008) M. Isabel Lucena et al.   HEPATOLOGY