Phase I Metabolism of Pterostilbene, a Dietary Resveratrol Derivative: Metabolite Identification, Species Differences, Isozyme Contribution, and Further Bioactivation

Subacute oral toxicology and toxicokinetics of pterostilbene, a novel Top1/Tdp1 inhibiting anti-tumor reagent

(2022) Changcheng Sun et al.   DRUG AND CHEMICAL TOXICOLOGY

High‐resolution mass spectrometry‐based methodology for the identification of the metabolites of pterostilbene produced by rat, dog and human hepatocytes

(2021) Lingyan Jiang et al.   BIOMEDICAL CHROMATOGRAPHY

Pterostilbene in Cancer Therapy

(2021) Elena Obrador et al.   Antioxidants

Gastrointestinal biotransformation and tissue distribution of pterostilbene after long-term dietary administration in mice

(2021) Yue Sun et al.   FOOD CHEMISTRY

Effect of Pterostilbene, a Natural Derivative of Resveratrol, in the Treatment of Colorectal Cancer through Top1/Tdp1-Mediated DNA Repair Pathway

(2021) Yutian Zhang et al.   Cancers

Oxidative Transformations of 3,4-Dihydroxyphenylacetaldehyde Generate Potential Reactive Intermediates as Causative Agents for Its Neurotoxicity

(2021) Shosuke Ito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pterostilbene: mechanisms of its action as oncostatic agent in cell models and in vivo studies

(2019) Zhiqiang Ma et al.   PHARMACOLOGICAL RESEARCH

Pterostilbene Reduces Liver Steatosis and Modifies Hepatic Fatty Acid Profile in Obese Rats

(2019) Hijona et al.   Nutrients

Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids

(2019) Veronika Leláková et al.   FOOD CHEMISTRY

Anti-tumor properties of methoxylated analogues of resveratrol in malignant MCF-7 but not in non-tumorigenic MCF-10A mammary epithelial cell lines

(2019) Annick D. van den Brand et al.   TOXICOLOGY

Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System

(2019) Treml et al.   Biomolecules

Effects of pterostilbene on diabetes, liver steatosis and serum lipids

(2019) Saioa Gómez-Zorita et al.   CURRENT MEDICINAL CHEMISTRY

Metabolism and pharmacokinetics of resveratrol and pterostilbene

(2018) Pei Wang et al.   BIOFACTORS

Pterostilbene modulates the suppression of multidrug resistance protein�1 and triggers autophagic and apoptotic mechanisms in cisplatin-resistant human oral cancer CAR cells via AKT signaling

(2018) Hui-Ping Chang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism

(2018) Erika N. Allen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity

(2017) Yogesh C. Awasthi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Biological actions and molecular effects of resveratrol, pterostilbene, and 3′-hydroxypterostilbene

(2017) Hui-Yun Tsai et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity

(2017) Yongjie Zhang et al.   TOXICOLOGY LETTERS

Evaluation of 90 day repeated dose oral toxicity and reproductive/developmental toxicity of 3'-hydroxypterostilbene in experimental animals

(2017) Muhammed Majeed et al.   PLoS One

Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation

(2016) Stefan J. Dekker et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pterostilbene exerts an anti-inflammatory effect via regulating endoplasmic reticulum stress in endothelial cells

(2016) Jun Liu et al.   CYTOKINE

Determination of pinostilbene in rat plasma by LC–MS/MS: Application to a pharmacokinetic study

(2016) Wan Chen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Identification of pinostilbene as a major colonic metabolite of pterostilbene and its inhibitory effects on colon cancer cells

(2016) Yue Sun et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells

(2016) Yuanyuan Kong et al.   Scientific Reports

Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells

(2014) Hyun Suk Ko et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pterostilbene, a Dimethyl Ether Derivative of Resveratrol, Reduces Fat Accumulation in Rats Fed an Obesogenic Diet

(2014) Saioa Gómez-Zorita et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pharmacokinetics and tissue distribution of pterostilbene in the rat

(2014) Michele Azzolini et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Differences in the Glucuronidation of Resveratrol and Pterostilbene: Altered Enzyme Specificity and Potential Gender Differences

(2013) Ryan W. Dellinger et al.   Drug Metabolism and Pharmacokinetics

Bioactivation of Drugs: Risk and Drug Design

(2011) John S. Walsh et al.   Annual Review of Pharmacology and Toxicology

Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors

(2011) H. K. Crewe et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Involvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of Troglitazone

(2011) R. Okada et al.   DRUG METABOLISM AND DISPOSITION

Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity

(2011) Siamak Cyrus Khojasteh et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandem mass spectrometry

(2010) Xi Shao et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity

(2007) Connie M. Remsberg et al.   PHYTOTHERAPY RESEARCH