Mechanistic Study of Icaritin-Induced Inactivation of Cytochrome P450 2C9

Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminate in Mechanism-Based Inactivation of Cytochrome P450 3A

(2022) Lloyd Wei Tat Tang et al.   DRUG METABOLISM AND DISPOSITION

Changes in Pharmacodynamic Parameters during Co-administration of 5-FU with Warfarin: A Retrospective Case Series

(2022) Jose Carlos S. Tayag et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Phase I Metabolism of Pterostilbene, a Dietary Resveratrol Derivative: Metabolite Identification, Species Differences, Isozyme Contribution, and Further Bioactivation

(2022) Ying Li et al.   Journal of Agricultural and Food Chemistry

Mechanism-based Inactivation of Cytochrome P450 3A4 by Benzbromarone

(2021) Lloyd Wei Tat Tang et al.   MOLECULAR PHARMACOLOGY

Icaritin promotes apoptosis and inhibits proliferation by down-regulating AFP gene expression in hepatocellular carcinoma

(2021) Hui Li et al.   BMC CANCER

Reversible and irreversible inhibition of cytochrome P450 enzymes by methylophiopogonanone A

(2021) Dong-Zhu Tu et al.   DRUG METABOLISM AND DISPOSITION

In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor

(2021) Heather Zhang et al.   Pharmacology Research & Perspectives

Structure-Based Reactivity Profiles of Reactive Metabolites with Glutathione

(2020) Xiaomei Liu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Molecular and cellular basis of the anticancer activity of the prenylated flavonoid icaritin in hepatocellular carcinoma

(2020) Christian Bailly   CHEMICO-BIOLOGICAL INTERACTIONS

Drug–drug interaction risk assessment of esaxerenone as a perpetrator by in vitro studies, and static and physiologically based pharmacokinetic models

(2020) Makiko Yamada et al.   DRUG METABOLISM AND DISPOSITION

NADPH-Independent Inactivation of CYP2B6 and NADPH-Dependent Inactivation of CYP3A4/5 by PBD: Potential Implication for Assessing Covalent Modulators for Time-Dependent Inhibition

(2020) Mika Kosaka et al.   DRUG METABOLISM AND DISPOSITION

Rapid intestinal glucuronidation and hepatic glucuronide recycling contributes significantly to the enterohepatic circulation of icaritin and its glucuronides in vivo

(2020) Yi Rong et al.   ARCHIVES OF TOXICOLOGY

First-in-class immune-modulating small molecule Icaritin in advanced hepatocellular carcinoma: preliminary results of safety, durable survival and immune biomarkers

(2019) Ying Fan et al.   BMC CANCER

Identification of Quinone Methide Intermediate Resulting from Metabolic Activation of Icaritin in Vitro and in Vivo

(2019) Yan Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Piperine is a Mechanism-based inactivator of CYP3A

(2019) Tiantian Cui et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of drug–drug interactions in drug metabolism: Differences and harmonization in guidance/guidelines

(2019) Takafumi Iwatsubo   Drug Metabolism and Pharmacokinetics

Metabolite Profiling and Reaction Phenotyping for the in Vitro Assessment of the Bioactivation of Bromfenac

(2019) Aprajita S. Yadav et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Inter-individual Variability in Activity of the Major Drug Metabolizing Enzymes in Liver Homogenates of 20 Individuals

(2018) Shalenie P. den Braver-Sewradj et al.   CURRENT DRUG METABOLISM

Application of ultra high-performance liquid chromatography tandem mass spectrometry to investigate the regioselective glucuronidation of icaritin in vitro

(2018) Yi Rong et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

(2018) Yongjie Zhang et al.   Frontiers in Pharmacology

Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity

(2017) Yongjie Zhang et al.   TOXICOLOGY LETTERS

Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes

(2017) Li Wang et al.   XENOBIOTICA

Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole

(2017) Ai-Hong Yang et al.   XENOBIOTICA

Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation

(2016) Stefan J. Dekker et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Targeted cancer therapy: interactions with other medicines

(2016) D. Conde-Estévez   Clinical & Translational Oncology

Simulation of interindividual differences in inactivation of reactive para -benzoquinone imine metabolites of diclofenac by glutathione S -transferases in human liver cytosol

(2016) Michiel W. den Braver et al.   TOXICOLOGY LETTERS

Mechanism-based inactivation of CYP2C9 by linderane

(2015) Hui Wang et al.   XENOBIOTICA

The Antiosteoporotic Activity of Central-Icaritin (CIT) on Bone Metabolism of Ovariectomized Rats

(2014) Jun Jiang et al.   MOLECULES

Mechanism-based Inhibition of CYP450: An Indicator of Drug-induced Hepatotoxicity

(2013) Shan Feng et al.   CURRENT DRUG METABOLISM

Inhibitory effects of sanguinarine on human liver cytochrome P450 enzymes

(2013) Xiao-Yi Qi et al.   FOOD AND CHEMICAL TOXICOLOGY

Assessment of drug–drug interactions caused by metabolism-dependent cytochrome P450 inhibition

(2012) Ji-Yoon Lee et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Drug-Drug Interactions Potential of Icariin and Its Intestinal Metabolites via Inhibition of Intestinal UDP-Glucuronosyltransferases

(2012) Yun-Feng Cao et al.   Evidence-based Complementary and Alternative Medicine

Oral absorption and excretion of icaritin, an aglycone and also active metabolite of prenylflavonoids from the Chinese medicine Herba Epimedii in rats

(2012) Qi Chang et al.   PHYTOMEDICINE

Glutathione S-transferases as molecular markers of tumour progression and prognosis in renal cell carcinoma

(2011) Lydia Searchfield et al.   HISTOPATHOLOGY

New Insights into the Structural Features and Functional Relevance of Human Cytochrome P450 2C9. Part II

(2010) Sui-Lin Mo et al.   CURRENT DRUG METABOLISM

Identifying and Characterizing Binding Sites and Assessing Druggability

(2009) Thomas A. Halgren   Journal of Chemical Information and Modeling

Coordinated Upregulation of a Series of Endogenous Antioxidants and Phase 2 Enzymes as a Novel Strategy for Protecting Renal Tubular Cells from Oxidative and Electrophilic Stress

(2008) Hong Zhu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE