Bis‐conjugation of Bioactive Molecules to Cisplatin‐like Complexes through (2,2′‐Bipyridine)‐4,4′‐Dicarboxylic Acid with Optimal Cytotoxicity Profile Provided by the Combination Ethacrynic Acid/Flurbiprofen

Recent advances in platinum-based chemotherapeutics that exhibit inhibitory and targeted mechanisms of action

(2020) Aleen Khoury et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

(2019) Reece G. Kenny et al.   CHEMICAL REVIEWS

Targeting Energy Metabolism by a Platinum(IV) Prodrug as an Alternative Pathway for Cancer Suppression

(2019) Suxing Jin et al.   INORGANIC CHEMISTRY

Fuplatin: An Efficient and Low-Toxic Dual-Prodrug

(2019) Ran Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ruthenium–Cyclopentadienyl Bipyridine–Biotin Based Compounds: Synthesis and Biological Effect

(2019) Leonor Côrte-Real et al.   INORGANIC CHEMISTRY

A view on multi-action Pt(IV) antitumor prodrugs

(2019) Mauro Ravera et al.   INORGANICA CHIMICA ACTA

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

(2019) Francis L. Munier et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Expanding the Arsenal of PtIV Anticancer Agents: Multi-action PtIV Anticancer Agents with Bioactive Ligands Possessing a Hydroxy Functional Group

(2019) Thirumal Yempala et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Classification of Metal-Based Drugs according to Their Mechanisms of Action

(2019) Eszter Boros et al.   Chem

A Gold(III) Pincer Ligand Scaffold for the Synthesis of Binuclear and Bioconjugated Complexes: Synthesis and Anticancer Potential

(2018) Benoît Bertrand et al.   CHEMISTRY-A EUROPEAN JOURNAL

Platinum drugs, copper transporters and copper chelators

(2018) Fabio Arnesano et al.   COORDINATION CHEMISTRY REVIEWS

An innovative and efficient route to the synthesis of metal-based glycoconjugates: proof-of-concept and potential applications

(2018) Andrea Pettenuzzo et al.   DALTON TRANSACTIONS

Ruthenium(ii) arene NSAID complexes: inhibition of cyclooxygenase and antiproliferative activity against cancer cell lines

(2018) Poulami Mandal et al.   DALTON TRANSACTIONS

The side effects of platinum-based chemotherapy drugs: a review for chemists

(2018) Rabbab Oun et al.   DALTON TRANSACTIONS

Biotin conjugated organic molecules and proteins for cancer therapy: A review

(2018) Santanu Maiti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anticancer metallodrugs: where is the next cisplatin?

(2018) Muhammad Hanif et al.   Future Medicinal Chemistry

Role of Seroalbumin in the Cytotoxicity of cis-Dichloro Pt(II) Complexes with (N^N)-Donor Ligands Bearing Functionalized Tails

(2018) Cristina Pérez-Arnaiz et al.   INORGANIC CHEMISTRY

Effective platinum(IV) prodrugs conjugated with lonidamine as a functional group working on the mitochondria

(2018) Hong Chen et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A Carrier-Free Nanostructure Based on Platinum(IV) Prodrug Enhances Cellular Uptake and Cytotoxicity

(2018) Jingjie Tan et al.   MOLECULAR PHARMACEUTICS

α-Diimine Homologues of Cisplatin: Synthesis, Speciation in DMSO/Water and Cytotoxicity

(2018) Lorenzo Biancalana et al.   NEW JOURNAL OF CHEMISTRY

Multi-action Pt(IV) anticancer agents; do we understand how they work?

(2018) Dan Gibson   JOURNAL OF INORGANIC BIOCHEMISTRY

Conjugation of platinum(IV) complexes with chlorambucil to overcome cisplatin resistance via a “joint action” mode toward DNA

(2017) Xiaodong Qin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Ru(II) and Pt(II) Complexes Bearing Carboxyl Groups as Potential Anticancer Targeted Drugs

(2017) M Ángeles Martínez et al.   INORGANIC CHEMISTRY

Novel Antitumor Platinum(II) Conjugates Containing the Nonsteroidal Anti-inflammatory Agent Diclofenac: Synthesis and Dual Mechanisms of Antiproliferative Effects

(2017) Francesco Paolo Intini et al.   INORGANIC CHEMISTRY

Biotin-Pt (IV)-indomethacin hybrid: A targeting anticancer prodrug providing enhanced cancer cellular uptake and reversing cisplatin resistance

(2017) Weiwei Hu et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Varying the metal to ethacrynic acid ratio in ruthenium(ii)/osmium(ii)- p -cymene conjugates

(2017) Emilia Păunescu et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Organometallic Glutathione S-Transferase Inhibitors

(2017) Emilia Păunescu et al.   ORGANOMETALLICS

The medicinal chemistry of ferrocene and its derivatives

(2017) Malay Patra et al.   Nature Reviews Chemistry

A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells

(2016) Malay Patra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

Nonsteroidal Anti-inflammatory—Organometallic Anticancer Compounds

(2016) Emilia Păunescu et al.   INORGANIC CHEMISTRY

Synthesis, characterization, DNA binding studies andin vitrocytotoxicity of platinum(II)-dihalogenido complexes containing bidentate chelatingN-donor ligands

(2016) Radka Křikavová et al.   JOURNAL OF COORDINATION CHEMISTRY

The state-of-play and future of platin drugs

(2015) M. Apps et al.   ENDOCRINE-RELATED CANCER

Retinoblastoma. Fifty Years of Progress. The LXXI Edward Jackson Memorial Lecture

(2014) Hans E. Grossniklaus   AMERICAN JOURNAL OF OPHTHALMOLOGY

The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells

(2014) Qinqin Cheng et al.   CHEMICAL COMMUNICATIONS

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

(2013) Wolfgang Kandioller et al.   CHEMICAL COMMUNICATIONS

Design of a platinum–acridine–endoxifen conjugate targeted at hormone-dependent breast cancer

(2013) Song Ding et al.   CHEMICAL COMMUNICATIONS

Ferrocene–Biotin Conjugates Targeting Cancer Cells: Synthesis, Interaction with Avidin, Cytotoxic Properties and the Crystal Structure of the Complex of Avidin with a Biotin–Linker–Ferrocene Conjugate

(2013) Damian Plażuk et al.   ORGANOMETALLICS

New palladium and platinum complexes with bioactive 3,5-diacetyl-1,2,4-triazol bis(4-cyclohexyl thiosemicarbazone) ligand: chemistry, antiproliferative activity and preliminary toxicity studies

(2012) Ana I. Matesanz et al.   DALTON TRANSACTIONS

Synthesis, characterization, interaction with DNA and cytotoxicity of Pd(ii) and Pt(ii) complexes containing pyridine carboxylic acid ligands

(2012) Ya-guang Sun et al.   DALTON TRANSACTIONS

Solvolysis of a Series of Cisplatin-Like Complexes - Comparison between DNA-Biosensor and Conductivity Data

(2012) James A. Platts et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Pentacoordinate [PtCl2(η2-C2H4)(N–N′)] complexes with asymmetrically hindered nitrogen donor chelates. Stereospecific synthesis of syn- and anti-[PtCl(η1-CH2CH2OMe)(Mebpy)]

(2012) Michele Benedetti et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Identification of [PtCl2(phen)] Binding Modes in Amyloid-β Peptide and the Mechanism of Aggregation Inhibition

(2011) Guolin Ma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ruthenium–Arene Complexes of Curcumin: X-Ray and Density Functional Theory Structure, Synthesis, and Spectroscopic Characterization, in Vitro Antitumor Activity, and DNA Docking Studies of (p-Cymene)Ru(curcuminato)chloro

(2011) Francesco Caruso et al.   JOURNAL OF MEDICINAL CHEMISTRY

Avidin-biotin technology in targeted therapy

(2010) Hanna P Lesch et al.   Expert Opinion on Drug Delivery

Platinum(II) Complexes with Bioactive Carrier Ligands Having High Affinity for the Translocator Protein

(2010) Nicola Margiotta et al.   JOURNAL OF MEDICINAL CHEMISTRY

NMR Chemical Shifts of Trace Impurities: Common Laboratory Solvents, Organics, and Gases in Deuterated Solvents Relevant to the Organometallic Chemist

(2010) Gregory R. Fulmer et al.   ORGANOMETALLICS

Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity

(2010) Kathleen M Knights et al.   Expert Review of Clinical Pharmacology

Modulation of the Biological Properties of Aspirin by Formation of a Bioorganometallic Derivative

(2009) Ingo Ott et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rational Design of an Organometallic Glutathione Transferase Inhibitor

(2009) Wee Han Ang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tramadol and Flurbiprofen Depress the Cytotoxicity of Cisplatin via Their Effects on Gap Junctions

(2009) B. He et al.   CLINICAL CANCER RESEARCH

The mechanism of action of platinum anticancer agents—what do we really know about it?

(2009) Dan Gibson   DALTON TRANSACTIONS

Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate

(2009) Shanta Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioactive fragments synergically involved in the design of new generation Pt(ii) and Pd(ii)-based anticancer compounds

(2008) Daniela Pucci et al.   DALTON TRANSACTIONS