How do parasitic worms prevent diabetes? An exploration of their influence on macrophage and β-cell crosstalk

Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes

(2023) Stephan Culemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dietary fatty acids differentially affect secretion of pro-inflammatory cytokines in human THP-1 monocytes

(2023) Hao-Chang Hung et al.   Scientific Reports

Macrophage: Key player in the pathogenesis of autoimmune diseases

(2023) Shuang Yang et al.   Frontiers in Immunology

Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress

(2023) Phiwayinkosi V Dludla et al.   World Journal of Diabetes

Multi-Organ Crosstalk with Endocrine Pancreas: A Focus on How Gut Microbiota Shapes Pancreatic Beta-Cells

(2022) Elisa Fernández-Millán et al.   Biomolecules

The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment

(2022) Danni Gao et al.   CYTOKINE & GROWTH FACTOR REVIEWS

GLP-1 and GIP receptor signaling in beta cells – A review of receptor interactions and co-stimulation

(2022) Ashok Mayendraraj et al.   PEPTIDES

Redefining inflammatory macrophage phenotypes across stages and tissues by single-cell transcriptomics

(2022) P’ng Loke et al.   Science Immunology

Gut Microbiota, Macrophages and Diet: An Intriguing New Triangle in Intestinal Fibrosis

(2022) Asma Amamou et al.   Microorganisms

Tissue-specific immunity in helminth infections

(2022) Francesco Vacca et al.   Mucosal Immunology

Probiotic Mechanisms Affecting Glucose Homeostasis: A Scoping Review

(2022) Maša Pintarič et al.   Life-Basel

Helminths and Bacterial Microbiota: The Interactions of Two of Humans’ “Old Friends”

(2022) Kevin Llinás-Caballero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes

(2022) Xiaoxiao Yuan et al.   Nature Communications

The helminth glycoprotein omega‐1 improves metabolic homeostasis in obese mice through type 2 immunity‐independent inhibition of food intake

(2021) Hendrik J.P. Zande et al.   FASEB JOURNAL

Crosstalk between Macrophages and Pancreatic β-Cells in Islet Development, Homeostasis and Disease

(2021) Cristina Cosentino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial

(2021) Matthias von Herrath et al.   Lancet Diabetes & Endocrinology

Gastrointestinal Helminth Infection Improves Insulin Sensitivity, Decreases Systemic Inflammation, and Alters the Composition of Gut Microbiota in Distinct Mouse Models of Type 2 Diabetes

(2021) Zainab Khudhair et al.   Frontiers in Endocrinology

The Role of β Cell Stress and Neo-Epitopes in the Immunopathology of Type 1 Diabetes

(2021) Jon D. Piganelli et al.   Frontiers in Endocrinology

Adipocyte-derived extracellular vesicles regulate survival and function of pancreatic β cells

(2021) Iacopo Gesmundo et al.   JCI Insight

Beta‐cell failure in diabetes: common susceptibility and mechanisms shared between type 1 and type 2 diabetes

(2021) Hiroshi Ikegami et al.   Journal of Diabetes Investigation

Metabolic Homeostasis in Chronic Helminth Infection Is Sustained by Organ-Specific Metabolic Rewiring

(2021) Daria Kokova et al.   ACS Infectious Diseases

Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot’s Print

(2021) Henner Zirpel et al.   Frontiers in Endocrinology

The Interplay of Glucagon-Like Peptide-1 Receptor Trafficking and Signalling in Pancreatic Beta Cells

(2021) Amaara Marzook et al.   Frontiers in Endocrinology

M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt/GSK-3β/β-catenin pathway in mice

(2021) Bin Qian et al.   DIABETOLOGIA

The parasite-derived peptide FhHDM-1 activates the PI3K/Akt pathway to prevent cytokine-induced apoptosis of β-cells

(2021) Inah Camaya et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Immunotherapy: Building a bridge to a cure for type 1 diabetes

(2021) Jeffrey A. Bluestone et al.   SCIENCE

Breaking and restoring immune tolerance to pancreatic beta-cells in type 1 diabetes

(2021) Neslihan Erdem et al.   Current Opinion in Endocrinology Diabetes and Obesity

Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis

(2021) Eliana Toren et al.   Frontiers in Immunology

Socio-medical studies of individuals self-treating with helminths provide insight into clinical trial design for assessing helminth therapy

(2021) Aarushi Venkatakrishnan et al.   PARASITOLOGY INTERNATIONAL

IL‐33 is essential to prevent high fat diet‐induced obesity in mice infected with an intestinal helminth

(2020) Seiji Obi et al.   PARASITE IMMUNOLOGY

Mechanisms of Macrophage Polarization in Insulin Signaling and Sensitivity

(2020) Lucie Orliaguet et al.   Frontiers in Endocrinology

Secretory Functions of Macrophages in the Human Pancreatic Islet Are Regulated by Endogenous Purinergic Signaling

(2020) Jonathan R. Weitz et al.   DIABETES

Interactions between macrophages and helminths

(2020) Gillian Coakley et al.   PARASITE IMMUNOLOGY

Harnessing helminth-driven immunoregulation in the search for novel therapeutic modalities

(2020) Stephanie M. Ryan et al.   PLoS Pathogens

TLR4 signals through islet macrophages to alter cytokine secretion during diabetes

(2020) Manesh Chittezhath et al.   JOURNAL OF ENDOCRINOLOGY

Gut microbiota and diabetes: From correlation to causality and mechanism

(2020) Wei-Zheng Li et al.   World Journal of Diabetes

Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

(2020) Roberto Mallone et al.   DIABETOLOGIA

Risk factors for type 1 diabetes, including environmental, behavioural and gut microbial factors: a case–control study

(2020) Deborah Traversi et al.   Scientific Reports

Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes

(2020) Marie Wiedemann et al.   Frontiers in Immunology

Impact of Helminth Infection on Metabolic and Immune Homeostasis in Non-diabetic Obesity

(2020) Anuradha Rajamanickam et al.   Frontiers in Immunology

Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)

(2020) Bart O. Roep et al.   Nature Reviews Endocrinology

Golimumab and Beta-Cell Function in Youth with New-Onset Type 1 Diabetes

(2020) Teresa Quattrin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Good Cop, Bad Cop: The Opposing Effects of Macrophage Activation State on Maintaining or Damaging Functional β-Cell Mass

(2020) Daelin M. Jensen et al.   Metabolites

A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry

(2019) Nicolas Damond et al.   Cell Metabolism

Twenty Years on: Metabolomics in Helminth Research

(2019) Daria Kokova et al.   TRENDS IN PARASITOLOGY

Hybrid Insulin Peptides are Autoantigens in Type 1 Diabetes

(2019) R.L. Baker et al.   DIABETES

Islet macrophages are associated with islet vascular remodeling and compensatory hyperinsulinemia during diabetes.

(2019) Manesh Chittezhath et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes

(2019) Laura I. Hudish et al.   JOURNAL OF CLINICAL INVESTIGATION

Environmental and genetic contributions to diabetes

(2019) Johanne Tremblay et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Immune Regulation of Metabolic Homeostasis by Helminths and Their Molecules

(2019) Hendrik J.P. van der Zande et al.   TRENDS IN PARASITOLOGY

Pancreatic β‐cells express major histocompatibility complex class II: Do diabetic β‐cells have the capacity of antigen‐presenting cells?

(2019) Hiroyuki Sano et al.   Journal of Diabetes Investigation

Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes

(2018) Michela Miani et al.   Cell Metabolism

The resident macrophages in murine pancreatic islets are constantly probing their local environment, capturing beta cell granules and blood particles

(2018) Bernd H. Zinselmeyer et al.   DIABETOLOGIA

Helminth infection in mice improves insulin sensitivity via modulation of gut microbiota and fatty acid metabolism

(2018) Fernanda Pace et al.   PHARMACOLOGICAL RESEARCH

Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation

(2018) Atsushi Miki et al.   PLoS One

Helminth infection protects against high fat diet-induced obesity via induction of alternatively activated macrophages

(2018) Chien wen Su et al.   Scientific Reports

Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells

(2018) Claudia Cristina Motran et al.   Frontiers in Immunology

Macrophage Clearance of Apoptotic Cells: A Critical Assessment

(2018) Siamon Gordon et al.   Frontiers in Immunology

Apoptotic beta-cells induce macrophage reprogramming under diabetic conditions

(2018) Meliza G. Ward et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokine-Induced Macrophage Polarization in Inflammatory Conditions

(2018) Pieter Ruytinx et al.   Frontiers in Immunology

Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity

(2018) Wei Ying et al.   Cell Metabolism

Schistosoma japonicum soluble egg antigen inhibits TNF-α-induced IL-34 expression in hepatic stellate cells

(2018) Liuting Chen et al.   PARASITOLOGY RESEARCH

Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection

(2018) Tara E. Sutherland et al.   PLoS Pathogens

Dual genetic absence of STAT6 and IL-10 does not abrogate anti-hyperglycemic effects of Schistosoma mansoni in streptozotocin-treated diabetic mice

(2017) Yoshio Osada et al.   EXPERIMENTAL PARASITOLOGY

The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages

(2017) Raquel Alvarado et al.   FASEB JOURNAL

From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions

(2017) Tiziana Caputo et al.   FEBS LETTERS

Taenia crassiceps Antigens Control Experimental Type 1 Diabetes by Inducing Alternatively Activated Macrophages

(2017) Arlett Espinoza-Jiménez et al.   MEDIATORS OF INFLAMMATION

Type 1 diabetes induction in humanized mice

(2017) Shulian Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice

(2017) Javier A. Carrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge

(2017) Olga Spadaro et al.   Cell Reports

Helminth Immunomodulation in Autoimmune Disease

(2017) Taylor B. Smallwood et al.   Frontiers in Immunology

The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33– and group 2 innate lymphoid cell–dependent mechanism

(2016) Emily Hams et al.   FASEB JOURNAL

Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice

(2016) Afiat Berbudi et al.   Journal of Innate Immunity

Immunomodulation by helminths: Similar impact on type 1 and type 2 diabetes?

(2016) J. Surendar et al.   PARASITE IMMUNOLOGY

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

(2016) T. Delong et al.   SCIENCE

An Update on the Effect of Incretin-Based Therapies on β-Cell Function and Mass

(2016) Suk Chon et al.   Diabetes & Metabolism Journal

A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis

(2016) Maria E. Lund et al.   Scientific Reports

Parasitic helminths and their beneficial impact on type 1 and type 2 diabetes

(2015) Afiat Berbudi et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Mouse pancreatic beta cells express MHC class II and stimulate CD4+T cells to proliferate

(2015) Yuxing Zhao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice

(2015) Leonie Hussaarts et al.   FASEB JOURNAL

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

(2015) Johanna A. Knipper et al.   IMMUNITY

A parasitic helminth-derived peptide that targets the macrophage lysosome is a novel therapeutic option for autoimmune disease

(2015) Raquel Alvarado et al.   IMMUNOBIOLOGY

The pancreas anatomy conditions the origin and properties of resident macrophages

(2015) Boris Calderon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Helminths and the microbiota: parts of the hygiene hypothesis

(2015) P. Loke et al.   PARASITE IMMUNOLOGY

A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

(2014) R. C. Ferreira et al.   DIABETES

Lactobacillus plantarum CLP-0611 ameliorates colitis in mice by polarizing M1 to M2-like macrophages

(2014) Se-Eun Jang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Secretory products of helminth parasites as immunomodulators

(2014) William Harnett   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Systemic impact of intestinal helminth infections

(2014) P K Mishra et al.   Mucosal Immunology

Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage

(2014) Tara E Sutherland et al.   NATURE IMMUNOLOGY

Secreted Proteins from the Helminth Fasciola hepatica Inhibit the Initiation of Autoreactive T Cell Responses and Prevent Diabetes in the NOD Mouse

(2014) Maria E. Lund et al.   PLoS One

M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7

(2014) Xiangwei Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colon Macrophages Polarized by Commensal Bacteria Cause Colitis and Cancer through the Bystander Effect

(2014) Yonghong Yang et al.   Translational Oncology

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

(2013) Clara Y. Westwell-Roper et al.   DIABETES

Global estimates of diabetes prevalence for 2013 and projections for 2035

(2013) L. Guariguata et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Effect of nematode Trichinella infection on glucose tolerance and status of macrophage in obese mice

(2013) Hideyuki Okada et al.   ENDOCRINE JOURNAL

Heligmosomoides polygyrus infection reduces severity of type 1 diabetes induced by multiple low-dose streptozotocin in mice via STAT6- and IL-10-independent mechanisms

(2013) Yoshio Osada et al.   EXPERIMENTAL PARASITOLOGY

Parasitic Nematode-Induced Modulation of Body Weight and Associated Metabolic Dysfunction in Mouse Models of Obesity

(2013) Zhonghan Yang et al.   INFECTION AND IMMUNITY

Antiinflammatory effects of apoptotic cells

(2013) Peter M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health

(2013) G. A. Rook   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Commensal Microbes as Immune Modulators

(2012) Ivaylo I. Ivanov et al.   Cell Host & Microbe

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Toll-like receptor 4 on islet β cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes

(2012) Min Li et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance

(2012) Shawn Winer et al.   IMMUNOLOGY AND CELL BIOLOGY

An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection

(2012) Fei Chen et al.   NATURE MEDICINE

Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways

(2012) Prerna Bhargava et al.   NATURE MEDICINE

Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis

(2011) Humberto M Garay-Malpartida et al.   BMC IMMUNOLOGY

Expression and Regulation of Chemokines in Murine and Human Type 1 Diabetes

(2011) S. A. Sarkar et al.   DIABETES

Phagocytic Activity Is Impaired in Type 2 Diabetes Mellitus and Increases after Metabolic Improvement

(2011) Albert Lecube et al.   PLoS One

99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: Darwinian medicine and the ‘hygiene’ or ‘old friends’ hypothesis

(2010) G. A. W. Rook   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cytokine production by islets in health and diabetes: cellular origin, regulation and function

(2010) Marc Y. Donath et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cytokines in the Progression of Pancreaticβ-Cell Dysfunction

(2010) Chunjiong Wang et al.   International Journal of Endocrinology

CXCL10 Impairs β Cell Function and Viability in Diabetes through TLR4 Signaling

(2009) Fabienne T. Schulthess et al.   Cell Metabolism

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

(2009) Marianne Böni-Schnetzler et al.   ENDOCRINOLOGY

Helminth Infection Can Reduce Insulitis and Type 1 Diabetes through CD25- and IL-10-Independent Mechanisms

(2009) Q. Liu et al.   INFECTION AND IMMUNITY

Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Proinflammatory Cytokines Inducing Th17 Cells

(2009) E. M. Bradshaw et al.   JOURNAL OF IMMUNOLOGY

Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes

(2008) A. P. Martin et al.   DIABETES

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES

Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation

(2008) Marianne Böni-Schnetzler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM