The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages

Th2 and eosinophil responses suppress inflammatory arthritis

(2016) Zhu Chen et al.   Nature Communications

Parasitic helminths and their beneficial impact on type 1 and type 2 diabetes

(2015) Afiat Berbudi et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

A parasitic helminth-derived peptide that targets the macrophage lysosome is a novel therapeutic option for autoimmune disease

(2015) Raquel Alvarado et al.   IMMUNOBIOLOGY

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Fasciola hepatica vaccine: We may not be there yet but we’re on the right road

(2015) Verónica Molina-Hernández et al.   VETERINARY PARASITOLOGY

Gene Expression Profile in the Liver of BALB/c Mice Infected with Fasciola hepatica

(2015) Jose Rojas-Caraballo et al.   PLoS One

Helminth Infections, Type-2 Immune Response, and Metabolic Syndrome

(2014) Aprilianto E. Wiria et al.   PLoS Pathogens

Excretory/secretory products of Fasciola hepatica but not recombinant phosphoglycerate kinase induce death of human hepatocyte cells

(2013) Piotr Bąska et al.   ACTA PARASITOLOGICA

Reprogramming macrophages to an anti-inflammatory phenotype by helminth antigens reduces murine atherosclerosis

(2013) Ine M. J. Wolfs et al.   FASEB JOURNAL

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

IL-1β Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity

(2013) Mario M. Zaiss et al.   PLoS Pathogens

A helminth cathelicidin-like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase

(2012) Mark W. Robinson et al.   FASEB JOURNAL

Control of innate and adaptive immunity by the inflammasome

(2012) Ceren Ciraci et al.   MICROBES AND INFECTION

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

(2012) Haitao Wen et al.   NATURE IMMUNOLOGY

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines

(2011) M. Lienhard Schmitz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sensing damage by the NLRP3 inflammasome

(2011) Jaklien C. Leemans et al.   IMMUNOLOGICAL REVIEWS

The impact of parasite infections on the course of multiple sclerosis

(2011) Jorge Correale et al.   JOURNAL OF NEUROIMMUNOLOGY

Effect of Fasciola hepatica proteins on the functioning of rat hepatocytes

(2011) Agnieszka Wesołowska et al.   PARASITOLOGY RESEARCH

NLRP3 inflammasomes link inflammation and metabolic disease

(2011) Dominic De Nardo et al.   TRENDS IN IMMUNOLOGY

A Family of Helminth Molecules that Modulate Innate Cell Responses via Molecular Mimicry of Host Antimicrobial Peptides

(2011) Mark W. Robinson et al.   PLoS Pathogens

Inflammasomes: current understanding and open questions

(2010) Franz Bauernfeind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis

(2010) Olivier Gavet et al.   DEVELOPMENTAL CELL

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sodium Overload and Water Influx Activate the NALP3 Inflammasome

(2010) Christine Schorn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

(2010) D. Gris et al.   JOURNAL OF IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Inflammasomes and autoimmunity

(2010) Patrick J. Shaw et al.   TRENDS IN MOLECULAR MEDICINE

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Oxidative Modifications of Rat Liver Cell Components DuringFasciola hepaticaInfection

(2008) Ewa Siemieniuk et al.   TOXICOLOGY MECHANISMS AND METHODS

Insight into the inflammasome and caspase-activating mechanisms

(2007) Olivier Gaide et al.   Expert Review of Clinical Immunology