The parasite-derived peptide FhHDM-1 activates the PI3K/Akt pathway to prevent cytokine-induced apoptosis of β-cells

Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals

(2021) Emily K. Sims et al.   Science Translational Medicine

A cathelicidin-related antimicrobial peptide suppresses cardiac hypertrophy induced by pressure overload by regulating IGFR1/PI3K/AKT and TLR9/AMPKα

(2020) Xiaofang Wang et al.   Cell Death & Disease

Upregulation of FOXO3 in New-Onset Type 1 Diabetes Mellitus

(2020) Magdalena Zurawek et al.   Journal of Immunology Research

Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)

(2020) Bart O. Roep et al.   Nature Reviews Endocrinology

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

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α-Helix or β-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4

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Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

(2018) Roger W. Hunter et al.   NATURE MEDICINE

Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes

(2018) Charles J. Kroger et al.   Frontiers in Immunology

The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages

(2017) Raquel Alvarado et al.   FASEB JOURNAL

FGF7/FGFR2 signal promotes invasion and migration in human gastric cancer through upregulation of thrombospondin-1

(2017) Tingting Huang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Transcriptional Regulation by Nrf2

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Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK–NRF2 pathway

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Cathelicidins positively regulate pancreatic β-cell functions

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Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

(2016) Melissa F. Brereton et al.   Nature Communications

A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis

(2016) Maria E. Lund et al.   Scientific Reports

Mouse pancreatic beta cells express MHC class II and stimulate CD4+T cells to proliferate

(2015) Yuxing Zhao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota

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Strategic Approaches to Optimizing Peptide ADME Properties

(2014) Li Di   AAPS Journal

In vivo activation of the PI3K–Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes

(2014) Elina Hakonen et al.   DIABETOLOGIA

Secreted Proteins from the Helminth Fasciola hepatica Inhibit the Initiation of Autoreactive T Cell Responses and Prevent Diabetes in the NOD Mouse

(2014) Maria E. Lund et al.   PLoS One

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Wnt3a regulates proliferation, apoptosis and function of pancreatic NIT-1 beta cells via activation of IRS2/PI3K signaling

(2013) Shuyan Gui et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Depressed Levels of Prostaglandin F2  in Mice Lacking Akr1b7 Increase Basal Adiposity and Predispose to Diet-Induced Obesity

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A helminth cathelicidin-like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase

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Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer

(2012) Karim Nacerddine et al.   JOURNAL OF CLINICAL INVESTIGATION

GAD65 Antigen Therapy in Recently Diagnosed Type 1 Diabetes Mellitus

(2012) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Erythropoietin Protects Pancreatic β-cell Line NIT-1 Cells Against Cytokine-Induced Apoptosis via Phosphatidylinositol 3-Kinase/Akt Signaling

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A Family of Helminth Molecules that Modulate Innate Cell Responses via Molecular Mimicry of Host Antimicrobial Peptides

(2011) Mark W. Robinson et al.   PLoS Pathogens

GLP-1 protects β-cells against apoptosis by enhancing the activity of an IGF-2/IGF1-receptor autocrine loop

(2010) Marion Cornu et al.   Islets

Anti-CD3 mAbs for treatment of type 1 diabetes

(2009) Adam Kaufman et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

(2009) Christina Rye Underwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

E-cadherin directly contributes to PI3K/AKT activation by engaging the PI3K-p85 regulatory subunit to adherens junctions of ovarian carcinoma cells

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