Good Cop, Bad Cop: The Opposing Effects of Macrophage Activation State on Maintaining or Damaging Functional β-Cell Mass

Secretory Functions of Macrophages in the Human Pancreatic Islet Are Regulated by Endogenous Purinergic Signaling

(2020) Jonathan R. Weitz et al.   DIABETES

Macrophage Modification Strategies for Efficient Cell Therapy

(2020) Anastasiya S. Poltavets et al.   Cells

Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

(2020) Roberto Mallone et al.   DIABETOLOGIA

HGF-MET Signaling Shifts M1 Macrophages Toward an M2-Like Phenotype Through PI3K-Mediated Induction of Arginase-1 Expression

(2020) Nao Nishikoba et al.   Frontiers in Immunology

Monocytes of newly diagnosed juvenile DM1 patients are prone to differentiate into regulatory IL-10+ M2 macrophages

(2019) Ulana Juhas et al.   IMMUNOLOGIC RESEARCH

Macrophage alterations in islets of obese mice linked to beta cell disruption in diabetes

(2019) Jeng Yie Chan et al.   DIABETOLOGIA

Concise Review: Beta-Cell Dedifferentiation in Type 2 Diabetes

(2019) Shimon Efrat   STEM CELLS

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1β is associated with changes in expression of beta-cell maturity genes and associated histone modifications

(2019) Adriana Ibarra Urizar et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Evidence of Tissue Repair in Human Donor Pancreas After Prolonged Duration of Stay in Intensive Care

(2019) Silke Smeets et al.   DIABETES

The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities

(2019) Wei Ying et al.   Nature Reviews Endocrinology

Macrophage-associated pro-inflammatory state in human islets from obese individuals

(2019) Wei He et al.   Nutrition & Diabetes

P2X receptor-ion channels in the inflammatory response in adipose tissue and pancreas — potential triggers in onset of type 2 diabetes?

(2018) Ivana Novak et al.   CURRENT OPINION IN IMMUNOLOGY

Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity

(2018) Petr Ježek et al.   MOLECULES

Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish

(2018) Sharan Janjuha et al.   eLife

Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation

(2018) Susan J. Burke et al.   Molecular Metabolism

Apoptotic beta-cells induce macrophage reprogramming under diabetic conditions

(2018) Meliza G. Ward et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR4 triggered complex inflammation in human pancreatic islets

(2018) Wei He et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity

(2018) Wei Ying et al.   Cell Metabolism

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production

(2017) Elise Dalmas et al.   IMMUNITY

Islet inflammation in type 2 diabetes and physiology

(2017) Kosei Eguchi et al.   JOURNAL OF CLINICAL INVESTIGATION

Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation

(2017) Marta Riera-Borrull et al.   JOURNAL OF IMMUNOLOGY

M1 Means Kill; M2 Means Heal

(2017) Klaus Ley   JOURNAL OF IMMUNOLOGY

Pancreatic islet inflammation: an emerging role for chemokines

(2017) J Jason Collier et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The Role of Inflammation in β-cell Dedifferentiation

(2017) Thierry M. Nordmann et al.   Scientific Reports

Dual Role of Nitric Oxide in Regulating the Response of β Cells to DNA Damage

(2017) Bryndon J. Oleson et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox-Sensitive Innate Immune Pathways During Macrophage Activation in Type 1 Diabetes

(2017) Ashley R. Burg et al.   ANTIOXIDANTS & REDOX SIGNALING

Short-term high-fat feeding induces islet macrophage infiltration and β-cell replication independently of insulin resistance in mice

(2016) David C. Woodland et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial network regulation and its potential interference with inflammatory signals in pancreatic beta cells

(2016) Simone Baltrusch   DIABETOLOGIA

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Replicative capacity of β-cells and type 1 diabetes

(2016) Diane Saunders et al.   JOURNAL OF AUTOIMMUNITY

LIGHT/IFN-γ triggers β cells apoptosisviaNF-κB/Bcl2-dependent mitochondrial pathway

(2016) Quan-You Zheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Insulitis in the pathogenesis of type 1 diabetes

(2016) Alberto Pugliese   PEDIATRIC DIABETES

Considerations for Defining Cytokine Dose, Duration, and Milieu That Are Appropriate for Modeling Chronic Low-Grade Inflammation in Type 2 Diabetes

(2016) Craig S. Nunemaker   Journal of Diabetes Research

High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice

(2015) Rockann E. Mosser et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

IL-1β reciprocally regulates chemokine and insulin secretion in pancreatic β-cells via NF-κB

(2015) Susan J. Burke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

(2015) Flora Brozzi et al.   DIABETOLOGIA

STAT1-Mediated Down-Regulation of Bcl-2 Expression Is Involved in IFN-γ/TNF-α–Induced Apoptosis in NIT-1 Cells

(2015) Zhao-hui Cao et al.   PLoS One

Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration

(2015) Naomi Van Gassen et al.   Stem Cells Translational Medicine

The Many Alternative Faces of Macrophage Activation

(2015) David A. Hume   Frontiers in Immunology

Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury

(2015) Kimberly G. Riley et al.   Molecular Metabolism

Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients

(2014) Kosuke Kamata et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Islet Microenvironment, Modulated by Vascular Endothelial Growth Factor-A Signaling, Promotes β Cell Regeneration

(2014) Marcela Brissova et al.   Cell Metabolism

Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding

(2014) R. B. Reinert et al.   DEVELOPMENT

Loss of NADPH Oxidase–Derived Superoxide Skews Macrophage Phenotypes to Delay Type 1 Diabetes

(2014) Lindsey E. Padgett et al.   DIABETES

Angiotensin II Induces Interleukin-1β–Mediated Islet Inflammation and β-Cell Dysfunction Independently of Vasoconstrictive Effects

(2014) Nadine S. Sauter et al.   DIABETES

Pancreatic duct cells as a source of VEGF in mice

(2014) Xiangwei Xiao et al.   DIABETOLOGIA

TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6

(2014) Dominika Nackiewicz et al.   DIABETOLOGIA

Macrophages and  -cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes

(2014) J. Diana et al.   EMBO Molecular Medicine

Activated Macrophages Create Lineage-Specific Microenvironments for Pancreatic Acinar- and β-Cell Regeneration in Mice

(2014) Angela Criscimanna et al.   GASTROENTEROLOGY

Transplantation of mesenchymal stem cells recruits trophic macrophages to induce pancreatic beta cell regeneration in diabetic mice

(2014) Xiaocang Cao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Barrier function of the coelomic epithelium in the developing pancreas

(2014) Ping Guo et al.   MECHANISMS OF DEVELOPMENT

Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and/or cell-tagging dyes

(2014) Xiangwei Xiao et al.   Nature Protocols

Macrophage Contact Dependent and Independent TLR4 Mechanisms Induce β-Cell Dysfunction and Apoptosis in a Mouse Model of Type 2 Diabetes

(2014) Helena Cucak et al.   PLoS One

M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7

(2014) Xiangwei Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-6 in Inflammation, Immunity, and Disease

(2014) T. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

(2014) Wenxian Fu et al.   eLife

Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity

(2013) Marc Y. Donath et al.   Cell Metabolism

Smad signaling pathways regulate pancreatic endocrine development

(2013) Yousef El-Gohary et al.   DEVELOPMENTAL BIOLOGY

Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

(2013) Clara Y. Westwell-Roper et al.   DIABETES

A Smad Signaling Network Regulates Islet Cell Proliferation

(2013) Y. El-Gohary et al.   DIABETES

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

(2013) Miriam Cnop et al.   DIABETES

Hepatocyte Growth Factor/c-Met Signaling Is Required for  -Cell Regeneration

(2013) J. C. Alvarez-Perez et al.   DIABETES

Macrophages and islet inflammation in type 2 diabetes

(2013) K. Eguchi et al.   DIABETES OBESITY & METABOLISM

IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets

(2013) Fabio A. Grieco et al.   DIABETOLOGIA

Circulating Levels of IL-1B+IL-6 Cause ER Stress and Dysfunction in Islets From Prediabetic Male Mice

(2013) Christina M. O'Neill et al.   ENDOCRINOLOGY

Nitric Oxide Is a Mediator of Antiproliferative Effects Induced by Proinflammatory Cytokines on Pancreatic Beta Cells

(2013) Laura Quintana-Lopez et al.   MEDIATORS OF INFLAMMATION

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

(2013) Tony Jourdan et al.   NATURE MEDICINE

Reduction in ATP Levels Triggers Immunoproteasome Activation by the 11S (PA28) Regulator during Early Antiviral Response Mediated by IFNβ in Mouse Pancreatic β-Cells

(2013) Wieke Freudenburg et al.   PLoS One

Connecting Type 1 and Type 2 Diabetes through Innate Immunity

(2013) J. I. Odegaard et al.   Cold Spring Harbor Perspectives in Medicine

Thioredoxin-1 Promotes Anti-Inflammatory Macrophages of the M2 Phenotype and Antagonizes Atherosclerosis

(2012) Khadija El Hadri et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Adoptive Transfer of Immunomodulatory M2 Macrophages Prevents Type 1 Diabetes in NOD Mice

(2012) R. Parsa et al.   DIABETES

Modulation of macrophage activation and programming in immunity

(2012) Guangwei Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction

(2012) G. Zizzo et al.   JOURNAL OF IMMUNOLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Regulation of Macrophage Polarization and Wound Healing

(2012) Christopher J. Ferrante et al.   Advances in Wound Care

Oxidative Stress and Redox Modulation Potential in Type 1 Diabetes

(2011) Meghan M. Delmastro et al.   Clinical & Developmental Immunology

Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: Evidence of Improved Immune Regulation

(2011) V. Ablamunits et al.   DIABETES

Duct Cells Contribute to Regeneration of Endocrine and Acinar Cells Following Pancreatic Damage in Adult Mice

(2011) Angela Criscimanna et al.   GASTROENTEROLOGY

FoxO1 and SIRT1 Regulate β-Cell Responses to Nitric Oxide

(2011) Katherine J. Hughes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction

(2011) C. Westwell-Roper et al.   JOURNAL OF IMMUNOLOGY

Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus

(2011) Dong Zheng et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Regulation of interleukin-1β by interferon-γ is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production

(2010) Seth L Masters et al.   EMBO REPORTS

Physiological levels of TNF  stimulation induce stochastic dynamics of NF- B responses in single living cells

(2010) D. A. Turner et al.   JOURNAL OF CELL SCIENCE

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients

(2010) Jason L. Gaglia et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Suppression of PLCβ2 by Endotoxin Plays a Role in the Adenosine A2A Receptor-Mediated Switch of Macrophages from an Inflammatory to an Angiogenic Phenotype

(2009) Stan Grinberg et al.   AMERICAN JOURNAL OF PATHOLOGY

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in  -Cells

(2009) L. G. Grunnet et al.   DIABETES

Interferon regulatory factor-1 is a key transcription factor in murine beta cells under immune attack

(2009) C. Gysemans et al.   DIABETOLOGIA

Islet-associated macrophages in type 2 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Association of T-cell reactivity with β-cell function in recent onset type 1 diabetes patients

(2009) Christian Pfleger et al.   JOURNAL OF AUTOIMMUNITY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

(2009) J. A. Ehses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Roles for Macrophages in Islet Angiogenesis and Maintenance During Pancreatic Degeneration

(2008) J. S. Tessem et al.   DIABETES

Rab GTPase-Activating Protein AS160 Is a Major Downstream Effector of Protein Kinase B/Akt Signaling in Pancreatic  -Cells

(2008) K. Bouzakri et al.   DIABETES

Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells

(2008) Kleber L A Souza et al.   JOURNAL OF ENDOCRINOLOGY