Type 1 diabetes induction in humanized mice

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

(2017) Maria J L Kracht et al.   NATURE MEDICINE

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes

(2016) Aaron W. Michels et al.   DIABETES

Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice

(2015) J. Babad et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A Humanized Mouse Model of Autoimmune Insulitis

(2014) Ashley A. Viehmann Milam et al.   DIABETES

Xenograft Tolerance and Immune Function of Human T Cells Developing in Pig Thymus Xenografts

(2014) H. Kalscheuer et al.   JOURNAL OF IMMUNOLOGY

Immune modulation in humans: implications for type 1 diabetes mellitus

(2014) Bart O. Roep et al.   Nature Reviews Endocrinology

Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenic CD4+T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes

(2013) James F. Mohan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Human lymphohematopoietic reconstitution and immune function in immunodeficient mice receiving cotransplantation of human thymic tissue and CD34+ cells

(2012) Zheng Hu et al.   Cellular & Molecular Immunology

Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading

(2012) Suchitra Prasad et al.   JOURNAL OF AUTOIMMUNITY

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The problems and promises of research into human immunology and autoimmune disease

(2012) Bart O Roep et al.   NATURE MEDICINE

Xenogeneic Graft-versus-Host-Disease in NOD-scid IL-2Rγnull Mice Display a T-Effector Memory Phenotype

(2012) Niwa Ali et al.   PLoS One

Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice

(2012) Wendy W. J. Unger et al.   PLoS One

HLA-A2-Matched Peripheral Blood Mononuclear Cells From Type 1 Diabetic Patients, but Not Nondiabetic Donors, Transfer Insulitis to NOD-scid/ cnull/HLA-A2 Transgenic Mice Concurrent With the Expansion of Islet-Specific CD8+ T cells

(2011) F. Whitfield-Larry et al.   DIABETES

Functional consequences of HLA-DQ8 homozygosity versus heterozygosity for islet autoimmunity in type 1 diabetes

(2011) P Eerligh et al.   GENES AND IMMUNITY

Structure-Based Selection of Small Molecules To Alter Allele-Specific MHC Class II Antigen Presentation

(2011) A. W. Michels et al.   JOURNAL OF IMMUNOLOGY

Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model

(2010) Yong Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Homeostatic Expansion and Phenotypic Conversion of Human T Cells Depend on Peripheral Interactions with APCs

(2010) T. Onoe et al.   JOURNAL OF IMMUNOLOGY

Genetics, pathogenesis and clinical interventions in type 1 diabetes

(2010) Jeffrey A. Bluestone et al.   NATURE

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model

(2008) N. Tonomura et al.   BLOOD

The Barrier of Hypoglycemia in Diabetes

(2008) P. E. Cryer   DIABETES

Pig islet xenograft rejection in a mouse model with an established human immune system

(2008) Noriko Tonomura et al.   XENOTRANSPLANTATION