A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

Innate Immune Activity Is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility

(2014) H. Kallionpaa et al.   DIABETES

Interferon-  Suppresses cAMP to Disarm Human Regulatory T Cells

(2013) N. Bacher et al.   CANCER RESEARCH

Coxsackievirus B1 Is Associated With Induction of  -Cell Autoimmunity That Portends Type 1 Diabetes

(2013) O. H. Laitinen et al.   DIABETES

Blood RNA profiling in a large cohort of multiple sclerosis patients and healthy controls

(2013) Dorothee Nickles et al.   HUMAN MOLECULAR GENETICS

Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children

(2013) Anette G. Ziegler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Defining the Transcriptional and Cellular Landscape of Type 1 Diabetes in the NOD Mouse

(2013) Javier A. Carrero et al.   PLoS One

Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

(2013) Ricardo C. Ferreira et al.   PLoS Genetics

Whole Blood Gene Expression Profiles to Assess Pathogenesis and Disease Severity in Infants with Respiratory Syncytial Virus Infection

(2013) Asuncion Mejias et al.   PLOS MEDICINE

Integrative genomic analysis of the human immune response to influenza vaccination

(2013) Luis M Franco et al.   eLife

Respiratory Infections in Early Life and the Development of Islet Autoimmunity in Children at Increased Type 1 Diabetes Risk

(2013) Andreas Beyerlein et al.   JAMA Pediatrics

Timing and Magnitude of Type I Interferon Responses by Distinct Sensors Impact CD8 T Cell Exhaustion and Chronic Viral Infection

(2012) Yaming Wang et al.   Cell Host & Microbe

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD8 T Cell Priming in the Presence of IFN-  Renders CTLs with Improved Responsiveness to Homeostatic Cytokines and Recall Antigens: Important Traits for Adoptive T Cell Therapy

(2012) S. Hervas-Stubbs et al.   JOURNAL OF IMMUNOLOGY

SIGLEC1 and SIGLEC7 expression in circulating monocytes of patients with multiple sclerosis

(2012) S Malhotra et al.   Multiple Sclerosis Journal

Patterns of Cis Regulatory Variation in Diverse Human Populations

(2012) Barbara E. Stranger et al.   PLoS Genetics

Association of endogenous anti-interferon-α autoantibodies with decreased interferon-pathway and disease activity in patients with systemic lupus erythematosus

(2011) Alyssa M. Morimoto et al.   ARTHRITIS AND RHEUMATISM

Metagenomics and Personalized Medicine

(2011) Herbert W. Virgin et al.   CELL

Type 1 Diabetes and Interferon Therapy: A nationwide survey in Japan

(2011) K. Nakamura et al.   DIABETES CARE

Primary Dietary Intervention Study to Reduce the Risk of Islet Autoimmunity in Children at Increased Risk for Type 1 Diabetes: The BABYDIET study

(2011) S. Hummel et al.   DIABETES CARE

Virus Infections: Lessons from Pancreas Histology

(2010) Francesco Dotta et al.   Current Diabetes Reports

Specific gene expression signature associated with development of autoimmune type-I diabetes using whole-blood microarray analysis

(2010) F Reynier et al.   GENES AND IMMUNITY

Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling

(2010) Laura L. Elo et al.   JOURNAL OF AUTOIMMUNITY

Type I interferon: friend or foe?

(2010) Giorgio Trinchieri   JOURNAL OF EXPERIMENTAL MEDICINE

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

(2010) Matthias Heinig et al.   NATURE

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

Dissecting Interferon-Induced Transcriptional Programs in Human Peripheral Blood Cells

(2010) Simon J. Waddell et al.   PLoS One

Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes

(2010) Kate Downes et al.   PLoS One

Type I interferon in organ-targeted autoimmune and inflammatory diseases

(2010) Mary K Crow   ARTHRITIS RESEARCH & THERAPY

A type I interferon signature in monocytes is associated with poor response to interferon-β in multiple sclerosis

(2009) M. Comabella et al.   BRAIN

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus

(2008) Robert Biesen et al.   ARTHRITIS AND RHEUMATISM

A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus

(2008) Damien Chaussabel et al.   IMMUNITY

Interferon-  initiates type 1 diabetes in nonobese diabetic mice

(2008) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA