Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage

Chitin Activates Parallel Immune Modules that Direct Distinct Inflammatory Responses via Innate Lymphoid Type 2 and γδ T Cells

(2014) Steven J. Van Dyken et al.   IMMUNITY

YKL-40 Is Elevated in Patients with Chronic Obstructive Pulmonary Disease and Activates Alveolar Macrophages

(2014) S. Letuve et al.   JOURNAL OF IMMUNOLOGY

IL-1 -Dependent Activation of Dendritic Epidermal T Cells in Contact Hypersensitivity

(2014) M. M. Nielsen et al.   JOURNAL OF IMMUNOLOGY

Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

(2014) L. C. Osborne et al.   SCIENCE

Diverse pathological implications of YKL-40: Answers may lie in ‘outside-in’ signaling

(2013) Mansi Prakash et al.   CELLULAR SIGNALLING

Immunomodulatory effects of IL-23 and IL-17 in a mouse model of allergic rhinitis

(2013) M. Wang et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Th17-mediated inflammation in asthma

(2013) Dawn C Newcomb et al.   CURRENT OPINION IN IMMUNOLOGY

Human and Mouse Macrophages Collaborate with Neutrophils To Kill Larval Strongyloides stercoralis

(2013) Sandra Bonne-Année et al.   INFECTION AND IMMUNITY

The chitinase-like protein YKL-40: A possible biomarker of inflammation and airway remodeling in severe pediatric asthma

(2013) Jon R. Konradsen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation

(2013) Jan-Eric Turner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Damage-Associated Molecular Patterns Control Neutrophil Recruitment

(2013) Keir Pittman et al.   Journal of Innate Immunity

Interleukin-17–producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

(2013) Hye Young Kim et al.   NATURE MEDICINE

Chitinase 3-like-1 Promotes Streptococcus pneumoniae Killing and Augments Host Tolerance to Lung Antibacterial Responses

(2012) Charles S. Dela Cruz et al.   Cell Host & Microbe

Cutting Edge: IL-17-Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection

(2012) A. Gladiator et al.   JOURNAL OF IMMUNOLOGY

Acute injury in the peripheral nervous system triggers an alternative macrophage response

(2012) Elke Ydens et al.   Journal of Neuroinflammation

An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection

(2012) Fei Chen et al.   NATURE MEDICINE

Chitinase Dependent Control of Protozoan Cyst Burden in the Brain

(2012) J. Philip Nance et al.   PLoS Pathogens

Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury

(2011) Chun Geun Lee et al.   Annual Review of Physiology

TH17 cells in asthma and inflammation

(2011) Shean J. Aujla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus

(2011) Chenggang Li et al.   CELL RESEARCH

Analyzing Airway Inflammation with Chemical Biology: Dissection of Acidic Mammalian Chitinase Function with a Selective Drug-like Inhibitor

(2011) Tara E. Sutherland et al.   CHEMISTRY & BIOLOGY

Interleukin-23 and T helper 17-type responses in intestinal inflammation: from cytokines to T-cell plasticity

(2011) Peter J. Morrison et al.   IMMUNOLOGY

Major Basic Protein from Eosinophils and Myeloperoxidase from Neutrophils Are Required for Protective Immunity to Strongyloides stercoralis in Mice

(2011) Amy E. O'Connell et al.   INFECTION AND IMMUNITY

Caspase-1-Processed Cytokines IL-1  and IL-18 Promote IL-17 Production by    and CD4 T Cells That Mediate Autoimmunity

(2011) S. J. Lalor et al.   JOURNAL OF IMMUNOLOGY

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(2011) Jochen Grommes et al.   MOLECULAR MEDICINE

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

Overexpression of Chitinase 3-Like 1/YKL-40 in Lung-Specific IL-18-Transgenic Mice, Smokers and COPD

(2011) Yuki Sakazaki et al.   PLoS One

The Chitinase-Like Protein YKL-40 Modulates Cystic Fibrosis Lung Disease

(2011) Andreas Hector et al.   PLoS One

The Chitinase-like Proteins Breast Regression Protein-39 and YKL-40 Regulate Hyperoxia-induced Acute Lung Injury

(2010) Myung Hyun Sohn et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TH17 Cells in Asthma and COPD

(2010) John F. Alcorn et al.   Annual Review of Physiology

Inefficient Lymph Node Sensitization during Respiratory Viral Infection Promotes IL-17-Mediated Lung Pathology

(2010) L. E. Kallal et al.   JOURNAL OF IMMUNOLOGY

Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma

(2010) Stephane Lajoie et al.   NATURE IMMUNOLOGY

Chitinases and chitinase-like proteins: potential therapeutic targets for the treatment of T-helper type 2 allergies

(2009) T. E. Sutherland et al.   CLINICAL AND EXPERIMENTAL ALLERGY

TH17-associated cytokines (IL-17A and IL-17F) in severe asthma

(2009) Wisam Al-Ramli et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis

(2009) Chun Geun Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE