Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis

What Is the Sweetest UPR Flavor for the β-cell? That Is the Question

(2021) Alina Lenghel et al.   Frontiers in Endocrinology

Stem Cell-Based Clinical Trials for Diabetes Mellitus

(2021) Eleonora de Klerk et al.   Frontiers in Endocrinology

Targeting citrullination in autoimmunity: insights learned from preclinical mouse models

(2021) Ylke Bruggeman et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets

(2021) Teresa Rodriguez-Calvo et al.   Frontiers in Immunology

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

(2021) Catherine C. Robertson et al.   NATURE GENETICS

Hypoimmune induced pluripotent stem cell–derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice

(2021) Tobias Deuse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes

(2021) Xi Wang et al.   Science Translational Medicine

Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

(2021) Stephen E Gitelman et al.   Lancet Diabetes & Endocrinology

The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis

(2020) Sandra Dedrick et al.   Frontiers in Endocrinology

Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes

(2020) Joan Camunas-Soler et al.   Cell Metabolism

Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis

(2020) Pia Leete et al.   DIABETOLOGIA

Next steps in the identification of gene targets for type 1 diabetes

(2020) Struan F. A. Grant et al.   DIABETOLOGIA

Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

(2020) Roberto Mallone et al.   DIABETOLOGIA

Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation

(2020) Brendan Reed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune-evasive human islet-like organoids ameliorate diabetes

(2020) Eiji Yoshihara et al.   NATURE

Pancreatic Alpha-Cells Contribute Together With Beta-Cells to CXCL10 Expression in Type 1 Diabetes

(2020) Laura Nigi et al.   Frontiers in Endocrinology

Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice

(2020) Fernanda M.C. Sodré et al.   DIABETES

Pharmacological Targeting of Endoplasmic Reticulum Stress in Pancreatic Beta Cells

(2020) Sara Bilekova et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score

(2019) Suna Onengut-Gumuscu et al.   DIABETES CARE

Pancreatic β-cells detoxify H2O2 through the peroxiredoxin/thioredoxin antioxidant system

(2019) Jennifer S. Stancill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

(2019) Tobias Deuse et al.   NATURE BIOTECHNOLOGY

HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of islet β-Cells from Donors with Type 1 Diabetes

(2019) Mark A. Russell et al.   DIABETES

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes

(2019) Yue J. Wang et al.   Cell Metabolism

Generation of hypoimmunogenic human pluripotent stem cells

(2019) Xiao Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Bile Acid TUDCA Improves Beta-Cell Mass and Reduces Insulin Degradation in Mice With Early-Stage of Type-1 Diabetes

(2019) Gabriela Alves Bronczek et al.   Frontiers in Physiology

Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

(2019) Denarda Dangaj et al.   CANCER CELL

Hybrid Insulin Peptides are Autoantigens in Type 1 Diabetes

(2019) R.L. Baker et al.   DIABETES

WITHDRAWN: IDF Diabetes Atlas: Worldwide Estimates of Incidence, Prevalence and Mortality of Type 1 Diabetes in Children and Adolescents: Results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Christopher C. Patterson et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Hybrid insulin peptides are neo-epitopes for CD4 T cells in autoimmune diabetes

(2019) Rocky L. Baker et al.   Current Opinion in Endocrinology Diabetes and Obesity

CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma

(2019) Ruyi Xu et al.   Cell Death & Disease

The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells

(2019) Irina X Zhang et al.   ENDOCRINOLOGY

Calcium Signaling in ß-cell Physiology and Pathology: A Revisit

(2019) Christiane Klec et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis

(2019) Martha Gschwandtner et al.   Frontiers in Immunology

Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications

(2018) John Sidney et al.   BMC IMMUNOLOGY

Deciphering Pancreatic Islet β Cell and α Cell Maturation Pathways and Characteristic Features at the Single-Cell Level

(2018) Wei-Lin Qiu et al.   Cell Metabolism

Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+T Cells in Patients With Type 1 Diabetes

(2018) Meghan L. Marre et al.   DIABETES

Verapamil and beta cell function in adults with recent-onset type 1 diabetes

(2018) Fernando Ovalle et al.   NATURE MEDICINE

Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation

(2018) Atsushi Miki et al.   PLoS One

Cytokine-mediated changes in K+ channel activity promotes an adaptive Ca2+ response that sustains β-cell insulin secretion during inflammation

(2018) Matthew T. Dickerson et al.   Scientific Reports

Islet stress, degradation and autoimmunity

(2018) Sofia Thomaidou et al.   DIABETES OBESITY & METABOLISM

Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas

(2018) Lydia Farack et al.   DEVELOPMENTAL CELL

WASH Regulates Glucose Homeostasis by Facilitating Glut2 Receptor Recycling in Pancreatic β-Cells

(2018) Li Ding et al.   DIABETES

Identification of Hybrid Insulin Peptides (HIPs) in Mouse and Human Islets by Mass Spectrometry

(2018) T. Aaron Wiles et al.   JOURNAL OF PROTEOME RESEARCH

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study

(2018) Tommi Vatanen et al.   NATURE

Temporal development of the gut microbiome in early childhood from the TEDDY study

(2018) Christopher J. Stewart et al.   NATURE

Autoreactive T cells in type 1 diabetes

(2017) Alberto Pugliese   JOURNAL OF CLINICAL INVESTIGATION

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

(2017) Maria J L Kracht et al.   NATURE MEDICINE

mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors

(2017) Clare F. Malone et al.   Cancer Discovery

Dual Role of Nitric Oxide in Regulating the Response of β Cells to DNA Damage

(2017) Bryndon J. Oleson et al.   ANTIOXIDANTS & REDOX SIGNALING

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   Cell Metabolism

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

(2016) Pia Leete et al.   DIABETES

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

(2016) Sarah J. Richardson et al.   DIABETOLOGIA

Life and death of β cells in Type 1 diabetes: A comprehensive review

(2016) Nicholas S. Wilcox et al.   JOURNAL OF AUTOIMMUNITY

Inherent ER stress in pancreatic islet β cells causes self-recognition by autoreactive T cells in type 1 diabetes

(2016) Meghan L. Marré et al.   JOURNAL OF AUTOIMMUNITY

Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset

(2016) Frederico R.C. Costa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Emerging roles of GLIS3 in neonatal diabetes, type 1 and type 2 diabetes

(2016) Xianjie Wen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Environmental risk factors for type 1 diabetes

(2016) Marian Rewers et al.   LANCET

Nitric Oxide Suppresses β-Cell Apoptosis by Inhibiting the DNA Damage Response

(2016) Bryndon J. Oleson et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

Insulitis in the pathogenesis of type 1 diabetes

(2016) Alberto Pugliese   PEDIATRIC DIABETES

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

(2016) T. Delong et al.   SCIENCE

Pancreatic islet blood flow and its measurement

(2016) Leif Jansson et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Generation of stem cell-derived β-cells from patients with type 1 diabetes

(2016) Jeffrey R. Millman et al.   Nature Communications

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

A Single-Cell Transcriptome Atlas of the Human Pancreas

(2016) Mauro J. Muraro et al.   Cell Systems

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure

(2016) Maayan Baron et al.   Cell Systems

Tauroursodeoxycholic acid reduces ER stress by regulating of Akt-dependent cellular prion protein

(2016) Yeo Min Yoon et al.   Scientific Reports

IL-1β reciprocally regulates chemokine and insulin secretion in pancreatic β-cells via NF-κB

(2015) Susan J. Burke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

T Cell Epitopes and Post-Translationally Modified Epitopes in Type 1 Diabetes

(2015) John W. McGinty et al.   Current Diabetes Reports

Serum levels of the adipokine Pref-1 in gestational diabetes mellitus

(2015) Ulrike Wurst et al.   CYTOKINE

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

(2015) Laura Marroqui et al.   DIABETES

Association of 32 type 1 diabetes risk loci in Pakistani patients

(2015) Aysha Karim Kiani et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Single‐cell transcriptomes reveal characteristic features of human pancreatic islet cell types

(2015) Jin Li et al.   EMBO REPORTS

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

(2015) Suna Onengut-Gumuscu et al.   NATURE GENETICS

Population dynamics of islet-infiltrating cells in autoimmune diabetes

(2015) Angela M. Magnuson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota regulates type 1 diabetes through Toll-like receptors

(2015) Michael P. Burrows et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

The Diabetes Susceptibility Gene Clec16a Regulates Mitophagy

(2014) Scott A. Soleimanpour et al.   CELL

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes

(2014) Sefina Arif et al.   DIABETES

The Biological Functions, Structure and Sources of CXCL10 and Its Outstanding Part in the Pathophysiology of Multiple Sclerosis

(2014) Reza Vazirinejad et al.   NEUROIMMUNOMODULATION

A low-frequency GLIS3 variant associated with resistance to Japanese type 1 diabetes

(2013) Takuya Awata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expression of CC Chemokines CCL2, CCL5, and CCL11 is Associated with Duration of Disease and Complications in Type-1 Diabetes: A Study on Iranian Diabetic Patients

(2013) Zahra Jamali et al.   Clinical Laboratory

HLA Class II Genotyping of African American Type 1 Diabetic Patients Reveals Associations Unique to African Haplotypes

(2013) Janelle A. Noble et al.   DIABETES

The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells

(2013) Richard A. Oram et al.   DIABETOLOGIA

Gender Bias in Autoimmunity Is Influenced by Microbiota

(2013) Leonid Yurkovetskiy et al.   IMMUNITY

Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

(2013) J. G. M. Markle et al.   SCIENCE

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance

(2013) M Miani et al.   Cell Death & Disease

Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E

(2012) Lucia Russo et al.   ACTA DIABETOLOGICA

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Human Islets Express a Marked Proinflammatory Molecular Signature Prior to Transplantation

(2012) Mark J. Cowley et al.   CELL TRANSPLANTATION

Preventing  -Cell Loss and Diabetes With Calcium Channel Blockers

(2012) G. Xu et al.   DIABETES

Islet  -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

(2012) S. A. Tersey et al.   DIABETES

The biology of chemokines and their receptors

(2012) Sergio A. Lira et al.   IMMUNOLOGIC RESEARCH

Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids

(2012) P Newsholme et al.   JOURNAL OF ENDOCRINOLOGY

Conditional deletions refine the embryonic requirement for Dlk1

(2012) Oliver K. Appelbe et al.   MECHANISMS OF DEVELOPMENT

An IP-10 (CXCL10)-Derived Peptide Inhibits Angiogenesis

(2012) Cecelia C. Yates-Binder et al.   PLoS One

Regulation of the CCL2 Gene in Pancreatic β-Cells by IL-1β and Glucocorticoids: Role of MKP-1

(2012) Susan J. Burke et al.   PLoS One

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Transglutaminase 2: A molecular Swiss army knife

(2011) Soner Gundemir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The central role of calcium in the effects of cytokines on beta-cell function: Implications for type 1 and type 2 diabetes

(2011) James W. Ramadan et al.   CELL CALCIUM

How Does Type 1 Diabetes Develop?: The Notion of Homicide or  -Cell Suicide Revisited

(2011) M. A. Atkinson et al.   DIABETES

Expression and Regulation of Chemokines in Murine and Human Type 1 Diabetes

(2011) S. A. Sarkar et al.   DIABETES

The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice

(2011) Y. Yang et al.   DIABETOLOGIA

Subcellular Localization of Peptidylarginine Deiminase 2 and Citrullinated Proteins in Brains of Scrapie-Infected Mice: Nuclear Localization of PAD2 and Membrane Fraction-Enriched Citrullinated Proteins

(2011) Byungki Jang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Pancreatic β-Cell Death in Response to Pro-Inflammatory Cytokines Is Distinct from Genuine Apoptosis

(2011) J. Jason Collier et al.   PLoS One

Endoplasmic reticulum stress and pancreatic β-cell death

(2011) Sonya G. Fonseca et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Two Tales of Antioxidant Enzymes on β Cells and Diabetes

(2010) Xin Gen Lei et al.   ANTIOXIDANTS & REDOX SIGNALING

Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling

(2010) Stacey B. Dula et al.   CELL CALCIUM

Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells

(2010) M. Elsner et al.   DIABETES

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Peptidylarginine Deiminase 2 Suppresses Inhibitory κB Kinase Activity in Lipopolysaccharide-stimulated RAW 264.7 Macrophages

(2010) Hye Jeong Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic β-cell function

(2010) Malek El Muayed et al.   JOURNAL OF ENDOCRINOLOGY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Oxidative stress and beta-cell dysfunction

(2010) Gisela Drews et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Immunocytochemical localization of cleaved caspase-3 in pancreatic islets from type 1 diabetic subjects

(2010) Tatsuo Tomita   Islets

Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis

(2009) E N Gurzov et al.   CELL DEATH AND DIFFERENTIATION

CXCL10 Impairs β Cell Function and Viability in Diabetes through TLR4 Signaling

(2009) Fabienne T. Schulthess et al.   Cell Metabolism

Imatinib Mesylate Reduces Endoplasmic Reticulum Stress and Induces Remission of Diabetes in db/db Mice

(2009) M. S. Han et al.   DIABETES

A murine model of neonatal diabetes mellitus inGlis3-deficient mice

(2009) Naoki Watanabe et al.   FEBS LETTERS

Transcription Factor Glis3, a Novel Critical Player in the Regulation of Pancreatic  -Cell Development and Insulin Gene Expression

(2009) H. S. Kang et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription

(2009) Yisheng Yang et al.   NUCLEIC ACIDS RESEARCH

ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function

(2009) Jingbo Pi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

CXCL10 and autoimmune diseases

(2008) Eun Young Lee et al.   AUTOIMMUNITY REVIEWS

Cytokine-Induced  -Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

(2008) M. C. Akerfeldt et al.   DIABETES

Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes

(2008) A. P. Martin et al.   DIABETES

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

The expanding genetic overlap between multiple sclerosis and type I diabetes

(2008)   GENES AND IMMUNITY

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Polymorphisms inCLEC16AandCIITAat 16p13 Are Associated with Primary Adrenal Insufficiency

(2008) Beate Skinningsrud et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE