Socio-medical studies of individuals self-treating with helminths provide insight into clinical trial design for assessing helminth therapy

Helminth Therapy – From the Parasite Perspective

(2019) Kateřina Sobotková et al.   TRENDS IN PARASITOLOGY

Safety of P28GST, a Protein Derived from a Schistosome Helminth Parasite, in Patients with Crohn’s Disease: A Pilot Study (ACROHNEM)

(2019) Monique Capron et al.   Journal of Clinical Medicine

Intestinal worms eating neuropsychiatric disorders? Apparently so

(2018) Henry H. Kou et al.   BRAIN RESEARCH

Evolution of the hygiene hypothesis into biota alteration theory: what are the paradigms and where are the clinical applications?

(2018) Chantal Villeneuve et al.   MICROBES AND INFECTION

Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells

(2018) Claudia Cristina Motran et al.   Frontiers in Immunology

Trichuris suis ova therapy in inflammatory bowel disease

(2018) Xing Huang et al.   MEDICINE

Safety and efficacy of the rSh28GST urinary schistosomiasis vaccine: A phase 3 randomized, controlled trial in Senegalese children

(2018) Gilles Riveau et al.   PLoS Neglected Tropical Diseases

Saliva pH affects the sweetness sense

(2017) Ken-ichi Aoyama et al.   NUTRITION

Exploiting Helminth–Host Interactomes through Big Data

(2017) Javier Sotillo et al.   TRENDS IN PARASITOLOGY

Helminths as an alternative therapy for intestinal diseases

(2017) Aytan Miranda Sipahi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Helminth Immunomodulation in Autoimmune Disease

(2017) Taylor B. Smallwood et al.   Frontiers in Immunology

Production and Use of Hymenolepis diminuta Cysticercoids as Anti-Inflammatory Therapeutics

(2017) Kendra Smyth et al.   Journal of Clinical Medicine

Got worms? Perinatal exposure to helminths prevents persistent immune sensitization and cognitive dysfunction induced by early-life infection

(2016) Lauren L. Williamson et al.   BRAIN BEHAVIOR AND IMMUNITY

Whipworms in humans and pigs: origins and demography

(2016) Mohamed B. F. Hawash et al.   Parasites & Vectors

Human helminth therapy to treat inflammatory disorders- where do we stand?

(2015) Helena Helmby   BMC IMMUNOLOGY

Bacteria-induced egg hatching differs for Trichuris muris and Trichuris suis

(2015) Nermina Vejzagić et al.   Parasites & Vectors

The Evolution of Stomach Acidity and Its Relevance to the Human Microbiome

(2015) DeAnna E. Beasley et al.   PLoS One

Harnessing the Helminth Secretome for Therapeutic Immunomodulators

(2014) Dana Ditgen et al.   Biomed Research International

Prerequisites for the pharmaceutical industry to develop and commercialise helminths and helminth-derived product therapy

(2013) Cornelia Tilp et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Influence of physico-chemistry and mineralogy on the occurrence of geohelminths in geophagic soils from selected communities in the Eastern Cape, South Africa, and their possible implication on human health

(2013) Irene U. Sumbele et al.   INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH

Autoimmune disease: Patients self-treat with parasitic worms

(2013) Stephen Flowers et al.   NATURE

Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae

(2013) David Wimmersberger et al.   Parasites & Vectors

A prescription for clinical immunology: the pills are available and ready for testing. A review

(2012) William Parker et al.   CURRENT MEDICAL RESEARCH AND OPINION

Safety and Immunogenicity of rSh28GST Antigen in Humans: Phase 1 Randomized Clinical Study of a Vaccine Candidate against Urinary Schistosomiasis

(2012) Gilles Riveau et al.   PLoS Neglected Tropical Diseases

The impact of parasite infections on the course of multiple sclerosis

(2011) Jorge Correale et al.   JOURNAL OF NEUROIMMUNOLOGY

Effect of Hookworm Infection on Wheat Challenge in Celiac Disease – A Randomised Double-Blinded Placebo Controlled Trial

(2011) A. James Daveson et al.   PLoS One

Experimental hookworm infection: a randomized placebo-controlled trial in asthma

(2010) J. R. Feary et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development

(2010) Hamid A. Merchant et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IL-22+ CD4+ T Cells Are Associated with Therapeutic Trichuris trichiura Infection in an Ulcerative Colitis Patient

(2010) M. J. Broadhurst et al.   Science Translational Medicine

Safety of hookworm infection in individuals with measurable airway responsiveness: a randomized placebo-controlled feasibility study

(2009) J. Feary et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Trichuris suis ova therapy for allergic rhinitis: A randomized, double-blind, placebo-controlled clinical trial

(2009) Peter Bager et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity

(2009) James P. Hewitson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Helminths and our immune system: Friend or foe?

(2009) Helena Helmby   PARASITOLOGY INTERNATIONAL

Helminth infections associated with multiple sclerosis induce regulatory B cells

(2008) Jorge Correale et al.   ANNALS OF NEUROLOGY

Review series on helminths, immune modulation and the hygiene hypothesis: The broader implications of the hygiene hypothesis

(2008) Graham A. W. Rook   IMMUNOLOGY