Immunomodulation by helminths: Similar impact on type 1 and type 2 diabetes?

Combination of worm antigen and proinsulin prevents type 1 diabetes in NOD mice after the onset of insulitis

(2016) Jesuthas Ajendra et al.   CLINICAL IMMUNOLOGY

Parasitic helminth infections and the control of human allergic and autoimmune disorders

(2016) R.M. Maizels   CLINICAL MICROBIOLOGY AND INFECTION

Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling

(2016) Marten A. Hoeksema et al.   FASEB JOURNAL

The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33– and group 2 innate lymphoid cell–dependent mechanism

(2016) Emily Hams et al.   FASEB JOURNAL

Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice

(2016) Afiat Berbudi et al.   Journal of Innate Immunity

Effect of Wuchereria bancrofti infection on HIV incidence in southwest Tanzania: a prospective cohort study

(2016) Inge Kroidl et al.   LANCET

Viral infections in type 1 diabetes mellitus — why the β cells?

(2016) Anne Op de Beeck et al.   Nature Reviews Endocrinology

Helminth infection promotes colonization resistance via type 2 immunity

(2016) Deepshika Ramanan et al.   SCIENCE

Helminth-Tuberculosis Co-infection: An Immunologic Perspective

(2016) Subash Babu et al.   TRENDS IN IMMUNOLOGY

IL-1β reciprocally regulates chemokine and insulin secretion in pancreatic β-cells via NF-κB

(2015) Susan J. Burke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Immunity to Helminths: Resistance, Regulation, and Susceptibility to Gastrointestinal Nematodes

(2015) Richard K. Grencis   Annual Review of Immunology

Helminth infections and type 2 diabetes: a cluster-randomized placebo controlled SUGARSPIN trial in Nangapanda, Flores, Indonesia

(2015) Dicky L Tahapary et al.   BMC INFECTIOUS DISEASES

Unraveling the Hygiene Hypothesis of helminthes and autoimmunity: origins, pathophysiology, and clinical applications

(2015) Mathilde Versini et al.   BMC Medicine

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

(2015) Min-Woo Lee et al.   CELL

Gut Microbiota Orchestrates Energy Homeostasis during Cold

(2015) Claire Chevalier et al.   CELL

Immune Regulation of Metabolic Homeostasis in Health and Disease

(2015) Jonathan R. Brestoff et al.   CELL

Gut microbiota and obesity

(2015) Philippe Gérard   CELLULAR AND MOLECULAR LIFE SCIENCES

One week treatment with the IL-1 receptor antagonist anakinra leads to a sustained improvement in insulin sensitivity in insulin resistant patients with type 1 diabetes mellitus

(2015) Edwin J.P. van Asseldonk et al.   CLINICAL IMMUNOLOGY

Does Strongyloides stercoralis infection protect against type 2 diabetes in humans? Evidence from Australian Aboriginal adults

(2015) Russell Hays et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Parasitic helminths and their beneficial impact on type 1 and type 2 diabetes

(2015) Afiat Berbudi et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Type 1 diabetes is not associated with an increased prevalence of hepatic steatosis

(2015) J.-M. Petit et al.   DIABETIC MEDICINE

Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice

(2015) Leonie Hussaarts et al.   FASEB JOURNAL

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

(2015) Mario M. Zaiss et al.   IMMUNITY

The Schistosoma mansoni T2 ribonuclease omega-1 modulates inflammasome-dependent IL-1β secretion in macrophages

(2015) Brian J. Ferguson et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Blocking high-fat diet-induced obesity, insulin resistance and fatty liver by overexpression of Il-13 gene in mice

(2015) P Darkhal et al.   INTERNATIONAL JOURNAL OF OBESITY

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

(2015) Justyna Rzepecka et al.   JOURNAL OF AUTOIMMUNITY

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus

(2015) D T Rodgers et al.   LUPUS

Interactions between multiple helminths and the gut microbiota in wild rodents

(2015) Jakub Kreisinger et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Infection with Soil-Transmitted Helminths Is Associated with Increased Insulin Sensitivity

(2015) Aprilianto E. Wiria et al.   PLoS One

Chronic Filarial Infection Provides Protection against Bacterial Sepsis by Functionally Reprogramming Macrophages

(2015) Fabian Gondorf et al.   PLoS Pathogens

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

Helminths in the hygiene hypothesis: sooner or later?

(2014) R. M. Maizels et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

B-1a Lymphocytes Attenuate Insulin Resistance

(2014) Lei Shen et al.   DIABETES

Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes

(2014) Clara Westwell-Roper et al.   IMMUNOLOGY AND CELL BIOLOGY

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

Targeting inflammation in the treatment of type 2 diabetes: time to start

(2014) Marc Y. Donath   NATURE REVIEWS DRUG DISCOVERY

Secreted Proteins from the Helminth Fasciola hepatica Inhibit the Initiation of Autoreactive T Cell Responses and Prevent Diabetes in the NOD Mouse

(2014) Maria E. Lund et al.   PLoS One

Helminth Colonization Is Associated with Increased Diversity of the Gut Microbiota

(2014) Soo Ching Lee et al.   PLoS Neglected Tropical Diseases

Helminth Infections, Type-2 Immune Response, and Metabolic Syndrome

(2014) Aprilianto E. Wiria et al.   PLoS Pathogens

Heligmosomoides polygyrus infection reduces severity of type 1 diabetes induced by multiple low-dose streptozotocin in mice via STAT6- and IL-10-independent mechanisms

(2013) Yoshio Osada et al.   EXPERIMENTAL PARASITOLOGY

Previous contact with Strongyloides venezuelensis contributed to prevent insulitis in MLD-STZ diabetes

(2013) Raphael Sanches Peres et al.   EXPERIMENTAL PARASITOLOGY

Reprogramming macrophages to an anti-inflammatory phenotype by helminth antigens reduces murine atherosclerosis

(2013) Ine M. J. Wolfs et al.   FASEB JOURNAL

Parasitic Nematode-Induced Modulation of Body Weight and Associated Metabolic Dysfunction in Mouse Models of Obesity

(2013) Zhonghan Yang et al.   INFECTION AND IMMUNITY

Helminth mediated modulation of Type 1 diabetes (T1D)

(2013) Paola Zaccone et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Chronic Opisthorchis felineus infection attenuates atherosclerosis – An autopsy study

(2013) Eli Magen et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-25 Elicits Innate Lymphoid Type 2 and Type II NKT Cells That Regulate Obesity in Mice

(2013) E. Hams et al.   JOURNAL OF IMMUNOLOGY

Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis

(2013) J. I. Odegaard et al.   SCIENCE

The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance

(2013) Triantafyllos Chavakis et al.   THROMBOSIS AND HAEMOSTASIS

Virus Infections in Type 1 Diabetes

(2013) K. T. Coppieters et al.   Cold Spring Harbor Perspectives in Medicine

Immune Regulation during Helminth Infections

(2013) Natasha M. Girgis et al.   PLoS Pathogens

IL-1β Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity

(2013) Mario M. Zaiss et al.   PLoS Pathogens

Helminths and their implication in sepsis - a new branch of their immunomodulatory behaviour?

(2013) Marc P. Hübner et al.   Pathogens and Disease

The ‘Hygiene hypothesis’ and the sharp gradient in the incidence of autoimmune and allergic diseases between Russian Karelia and Finland

(2012) Anita Kondrashova et al.   APMIS

Adipose Tissue, Hormones, and Treatment of Type 1 Diabetes

(2012) Subhadra C. Gunawardana   Current Diabetes Reports

Anti-Inflammatory Therapy in Type 1 Diabetes

(2012) Bernd Baumann et al.   Current Diabetes Reports

Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant

(2012) S. C. Gunawardana et al.   DIABETES

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs  -Cell Function

(2012) S. A. Long et al.   DIABETES

Adoptive Transfer of Immunomodulatory M2 Macrophages Prevents Type 1 Diabetes in NOD Mice

(2012) R. Parsa et al.   DIABETES

Toll-like receptor 4 on islet β cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes

(2012) Min Li et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance

(2012) Shawn Winer et al.   IMMUNOLOGY AND CELL BIOLOGY

Association of Previous Schistosome Infection With Diabetes and Metabolic Syndrome: A Cross-Sectional Study in Rural China

(2012) Yuhong Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Direct control of hepatic glucose production by interleukin-13 in mice

(2012) Kristopher J. Stanya et al.   JOURNAL OF CLINICAL INVESTIGATION

Alternatively Activated Macrophages in Types 1 and 2 Diabetes

(2012) Arlett Espinoza-Jiménez et al.   MEDIATORS OF INFLAMMATION

Prevention of type 1 diabetes through infection with an intestinal nematode parasite requires IL-10 in the absence of a Th2-type response

(2012) P K Mishra et al.   Mucosal Immunology

Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways

(2012) Prerna Bhargava et al.   NATURE MEDICINE

Adaptive immunity in obesity and insulin resistance

(2012) Henrike Sell et al.   Nature Reviews Endocrinology

Dietary Weight Loss and Exercise Effects on Insulin Resistance in Postmenopausal Women

(2011) Caitlin Mason et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis

(2011) Humberto M Garay-Malpartida et al.   BMC IMMUNOLOGY

Anti-FcεR1 antibody injections activate basophils and mast cells and delay Type 1 diabetes onset in NOD mice

(2011) Marc P. Hübner et al.   CLINICAL IMMUNOLOGY

Filariasis in Africa—treatment challenges and prospects

(2011) A. Hoerauf et al.   CLINICAL MICROBIOLOGY AND INFECTION

Elimination of the NLRP3-ASC Inflammasome Protects against Chronic Obesity-Induced Pancreatic Damage

(2011) Yun-Hee Youm et al.   ENDOCRINOLOGY

The S. mansoni glycoprotein ω-1 induces Foxp3 expression in NOD mouse CD4+ T cells

(2011) Paola Zaccone et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Helminth Infection Does Not Reduce Risk for Chronic Inflammatory Disease in a Population-Based Cohort Study

(2011) Peter Bager et al.   GASTROENTEROLOGY

Helminth Protection against Autoimmune Diabetes in Nonobese Diabetic Mice Is Independent of a Type 2 Immune Shift and Requires TGF- 

(2011) M. P. Hubner et al.   JOURNAL OF IMMUNOLOGY

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Preliminary studies related to anti-interleukin-1β therapy in children with newly diagnosed type 1 diabetes

(2011) Kathryn M. Sumpter et al.   PEDIATRIC DIABETES

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Decreased Prevalence of Lymphatic Filariasis Among Subjects with Type-1 Diabetes

(2010) Vivekanandhan Aravindhan et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Interactions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes

(2010) Giovanni Musso et al.   Annual Review of Medicine

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Diabetes and Cancer: A Consensus Report

(2010) E. Giovannucci et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group

(2010) J. B. Matthews et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Diabetes and Cancer: A consensus report

(2010) E. Giovannucci et al.   DIABETES CARE

Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrus

(2010) Seth T. Walk et al.   INFLAMMATORY BOWEL DISEASES

Taenia crassicepsInfection Attenuates Multiple Low-Dose Streptozotocin-Induced Diabetes

(2010) Arlett Espinoza-Jiménez et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Immune Modulation bySchistosoma mansoniAntigens in NOD Mice: Effects on Both Innate and Adaptive Immune Systems

(2010) Paola Zaccone et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Lymphatic filariasis and onchocerciasis

(2010) Mark J Taylor et al.   LANCET

Leptin therapy in insulin-deficient type I diabetes

(2010) M.-y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses

(2010) M. Ritter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Prevalence of Lymphatic Filariasis among Diabetic Subjects Associated with a Diminished Pro-Inflammatory Cytokine Response (CURES 83)

(2010) Vivekanandhan Aravindhan et al.   PLoS Neglected Tropical Diseases

Effects of Schistosoma mansoni worms and eggs on circulating cholesterol and liver lipids in mice

(2009) Ronald G. Stanley et al.   ATHEROSCLEROSIS

Infection and type 1 diabetes mellitus — A two edged sword?

(2009) Elad Goldberg et al.   AUTOIMMUNITY REVIEWS

Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia

(2009) Dario A. Gutierrez et al.   Current Diabetes Reports

Immunotherapy for the Prevention and Treatment of Type 1 Diabetes: Human trials and a look into the future

(2009) M. Rewers et al.   DIABETES CARE

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

(2009) C. M. Larsen et al.   DIABETES CARE

Abnormal liver function tests in patients with Type 1 diabetes mellitus: prevalence, clinical correlations and underlying pathologies

(2009) J. S. Leeds et al.   DIABETIC MEDICINE

Schistosoma mansoniegg antigens induce Treg that participate in diabetes prevention in NOD mice

(2009) Paola Zaccone et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Helminth Infection Can Reduce Insulitis and Type 1 Diabetes through CD25- and IL-10-Independent Mechanisms

(2009) Q. Liu et al.   INFECTION AND IMMUNITY

The Pathologic Continuum of Diabetic Vascular Disease

(2009) Gabriela Orasanu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study

(2009) Christopher C Patterson et al.   LANCET

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

(2009) E. Fabbrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages, cytokines and β-cell death in Type 2 diabetes: Figure 1

(2008) Jan A. Ehses et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Islet Inflammation in Type 2 Diabetes: From metabolic stress to therapy

(2008) M. Y. Donath et al.   DIABETES CARE

The Rising Incidence of Type 1 Diabetes Is Accounted for by Cases With Lower-Risk Human Leukocyte Antigen Genotypes

(2008) S. Fourlanos et al.   DIABETES CARE

Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages

(2008) Sheila Donnelly et al.   FASEB JOURNAL

Inhibition of type 1 diabetes in filaria-infected non-obese diabetic mice is associated with a T helper type 2 shift and induction of FoxP3+regulatory T cells

(2008) Marc P. Hübner et al.   IMMUNOLOGY

Review series on helminths, immune modulation and the hygiene hypothesis: Immunity against helminths and immunological phenomena in modern human populations: coevolutionary legacies?

(2008) Joseph A. Jackson et al.   IMMUNOLOGY