The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment

A distinct hypothalamus-to-β cell circuit modulates insulin secretion

(2022) Ioannis Papazoglou et al.   Cell Metabolism

Chronic tissue inflammation and metabolic disease

(2021) Yun Sok Lee et al.   GENES & DEVELOPMENT

Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity

(2021) Hawley E. Kunz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Unravelling the involvement of gut microbiota in type 2 diabetes mellitus

(2021) Arpita Arora et al.   LIFE SCIENCES

Increase in PPARγ inhibitory phosphorylation by Fetuin—A through the activation of Ras-MEK-ERK pathway causes insulin resistance

(2020) Snehasis Das et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fetuin-A is also an adipokine

(2019) Ishwarlal Jialal et al.   Lipids in Health and Disease

The endocrine function of adipose tissues in health and cardiometabolic disease

(2019) Ludger Scheja et al.   Nature Reviews Endocrinology

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice

(2019) Ismail Syed et al.   JOURNAL OF CLINICAL INVESTIGATION

PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms

(2019) Peng Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

IDF Diabetes Atlas: A review of studies utilising retinal photography on the global prevalence of diabetes related retinopathy between 2015 and 2018

(2019) R.L. Thomas et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The integrative biology of type 2 diabetes

(2019) Michael Roden et al.   NATURE

An Integrated View of Immunometabolism

(2018) Yun Sok Lee et al.   CELL

Triggering and resolution of inflammation in NASH

(2018) Susanne Schuster et al.   Nature Reviews Gastroenterology & Hepatology

Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity

(2018) Wei Ying et al.   Cell Metabolism

Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine

(2018) Osamu Hashimoto et al.   Cell Reports

Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice

(2017) Mitchell Bijnen et al.   GUT

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

(2017) Kathrin Maedler et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

(2017) Ruth C. R. Meex et al.   Nature Reviews Endocrinology

Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammation

(2017) Tom Houben et al.   Scientific Reports

Hepatic chemerin mRNA expression is reduced in human nonalcoholic steatohepatitis

(2016) Rebekka Pohl et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Obesity is an independent risk factor for non-alcoholic fatty liver disease: evidence from a meta-analysis of 21 cohort studies

(2016) L. Li et al.   Obesity Reviews

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

(2015) Robert Caesar et al.   Cell Metabolism

High Prevalence of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus and Normal Plasma Aminotransferase Levels

(2015) Paola Portillo-Sanchez et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The pancreas anatomy conditions the origin and properties of resident macrophages

(2015) Boris Calderon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Leptin in nonalcoholic fatty liver disease: A narrative review

(2015) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Regulation of metabolism by the innate immune system

(2015) Denise E. Lackey et al.   Nature Reviews Endocrinology

Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients

(2014) Kosuke Kamata et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

(2014) Kevin W. Williams et al.   Cell Metabolism

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

(2014) Philippe A. Halban et al.   DIABETES CARE

Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes

(2014) Matthew J. Butcher et al.   DIABETOLOGIA

Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice

(2014) Daniel T. Meier et al.   DIABETOLOGIA

Activated Macrophages Create Lineage-Specific Microenvironments for Pancreatic Acinar- and β-Cell Regeneration in Mice

(2014) Angela Criscimanna et al.   GASTROENTEROLOGY

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Increasing Fatty Acid Oxidation Remodels the Hypothalamic Neurometabolome to Mitigate Stress and Inflammation

(2014) Joseph W. McFadden et al.   PLoS One

M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7

(2014) Xiangwei Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

(2014) Trevor J. Biden et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance

(2014) Eva Tsaousidou et al.   Cell Reports

Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration

(2014) Risheng Ye et al.   eLife

Intraperitoneal Injection of Clodronate Liposomes Eliminates Visceral Adipose Macrophages and Blocks High-fat Diet-induced Weight Gain and Development of Insulin Resistance

(2013) Le Bu et al.   AAPS Journal

Enhanced adiponectin actions by overexpression of adiponectin receptor 1 in macrophages

(2013) Nanlan Luo et al.   ATHEROSCLEROSIS

Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

(2013) Clara Y. Westwell-Roper et al.   DIABETES

Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice

(2013) C. Rancoule et al.   DIABETOLOGIA

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

(2013) Jinghong Wan et al.   HEPATOLOGY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair

(2012) Maciej Lech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Voices from within: gut microbes and the CNS

(2012) Paul Forsythe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TGF  Receptor Signaling Is Essential for Inflammation-Induced but Not  -Cell Workload-Induced  -Cell Proliferation

(2012) X. Xiao et al.   DIABETES

Endoplasmic Reticulum Stress Induces the Expression of Fetuin-A to Develop Insulin Resistance

(2012) Horng-Yih Ou et al.   ENDOCRINOLOGY

Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis

(2012) Saurabh Chatterjee et al.   JOURNAL OF HEPATOLOGY

Unsaturated Fatty Acids Revert Diet-Induced Hypothalamic Inflammation in Obesity

(2012) Dennys E. Cintra et al.   PLoS One

Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis

(2012) Giovanni Musso et al.   PROGRESS IN LIPID RESEARCH

Short chain fatty acids and their receptors: new metabolic targets

(2012) Brian T. Layden et al.   Translational Research

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet-Induced Insulin Resistance

(2011) Y. S. Lee et al.   DIABETES

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Low-Grade Hypothalamic Inflammation Leads to Defective Thermogenesis, Insulin Resistance, and Impaired Insulin Secretion

(2011) Ana Paula Arruda et al.   ENDOCRINOLOGY

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress

(2011) S. Purkayastha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

NF-κB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance

(2010) Suman Dasgupta et al.   BIOCHEMICAL JOURNAL

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

(2010) M. Igoillo-Esteve et al.   DIABETOLOGIA

Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic β-cell function

(2010) Malek El Muayed et al.   JOURNAL OF ENDOCRINOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Cytokine production by islets in health and diabetes: cellular origin, regulation and function

(2010) Marc Y. Donath et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) W. Huang et al.   DIABETES

Islet-associated macrophages in type 2 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

(2009) Marianne Böni-Schnetzler et al.   ENDOCRINOLOGY

Palmitate Attenuates Insulin Signaling and Induces Endoplasmic Reticulum Stress and Apoptosis in Hypothalamic Neurons: Rescue of Resistance and Apoptosis through Adenosine 5′ Monophosphate-Activated Protein Kinase Activation

(2009) Christopher M. Mayer et al.   ENDOCRINOLOGY

Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic β-cells

(2009) James E P Brown et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond

(2009) A. Christine Könner et al.   PHYSIOLOGY & BEHAVIOR

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

(2009) J. A. Ehses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Critical Roles for Macrophages in Islet Angiogenesis and Maintenance During Pancreatic Degeneration

(2008) J. S. Tessem et al.   DIABETES

Fatty Liver

(2007) Anna Kotronen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY