Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress

Inflammation in obesity, diabetes, and related disorders

(2022) Theresa V. Rohm et al.   IMMUNITY

β-cell mitochondria in diabetes mellitus: a missing puzzle piece in the generation of hPSC-derived pancreatic β-cells?

(2022) Abdoulaye Diane et al.   Journal of Translational Medicine

Txnip deficiency promotes β-cell proliferation in the HFD-induced obesity mouse model

(2022) Zhandong Lei et al.   Endocrine Connections

The role of interleukin-1β in type 2 diabetes mellitus: A systematic review and meta-analysis

(2022) Hend Alfadul et al.   Frontiers in Endocrinology

Link between Insulin Resistance and Obesity—From Diagnosis to Treatment

(2022) Jakub Gołacki et al.   Diagnostics

β‐cell dysfunction and insulin resistance in relation to prediabetes and diabetes among adults in north‐western Tanzania: a cross‐sectional study

(2021) George PrayGod et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes

(2021) Natsuki Eguchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Innate Immunity Mediated Inflammation and Beta Cell Function: Neighbors or Enemies?

(2021) Antonio Citro et al.   Frontiers in Endocrinology

The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death

(2021) Bastian Krümmel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Is time ready for combination therapy at diagnosis of type 2 diabetes?

(2021) Francesco Prattichizzo et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Role of Cellular Senescence in Type II Diabetes

(2021) Akilavalli Narasimhan et al.   ENDOCRINOLOGY

Therapeutic Strategies for Diabetes: Immune Modulation in Pancreatic β Cells

(2021) Sugyeong Jo et al.   Frontiers in Endocrinology

Epigenetic Regulation of β Cell Identity and Dysfunction

(2021) Xiaoqiang Sun et al.   Frontiers in Endocrinology

Thioredoxin-Interacting Protein as a Novel Potential Therapeutic Target in Diabetes Mellitus and Its Underlying Complications

(2020) Dawit Zewdu Wondafrash et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Elevated T-helper 2 cytokine levels in high fat diet-fed C57BL/6 mice are attenuated by short-term 6-week treatment with a combination of low-dose aspirin and metformin

(2020) Thabsile J. Mahlangu et al.   CYTOKINE

Metformin and heart failure–related outcomes in patients with or without diabetes: a systematic review of randomized controlled trials

(2020) Phiwayinkosi V. Dludla et al.   HEART FAILURE REVIEWS

Exploring the Comparative Efficacy of Metformin and Resveratrol in the Management of Diabetes-Associated Complications: A Systematic Review of Preclinical Studies

(2020) Phiwayinkosi V. Dludla et al.   Nutrients

Quantifying Fibrinogen-dependent Aggregation of Red Blood Cells in Type 2 Diabetes Mellitus

(2020) Yixiang Deng et al.   BIOPHYSICAL JOURNAL

Correlation Between Thioredoxin-Interacting Protein and Nerve Conduction Velocity in Patients With Type 2 Diabetes Mellitus

(2020) Yuan Gao et al.   Frontiers in Neurology

Natural killer cell levels in adults living with type 2 diabetes: a systematic review and meta-analysis of clinical studies

(2020) Vuyolwethu Mxinwa et al.   BMC IMMUNOLOGY

Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications

(2020) Yohannes Tsegyie Wondmkun   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Nrf2: The Master and Captain of Beta Cell Fate

(2020) Sharon Baumel-Alterzon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pancreatic β-cells detoxify H2O2 through the peroxiredoxin/thioredoxin antioxidant system

(2019) Jennifer S. Stancill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sera of Obese Type 2 Diabetic Patients Undergoing Metabolic Surgery Instead of Conventional Treatment Exert Beneficial Effects on Beta Cell Survival and Function: Results of a Randomized Clinical Study

(2019) Alina Constantin et al.   OBESITY SURGERY

C-reactive protein exacerbates epithelial-mesenchymal transition through Wnt/β-catenin and ERK signaling in streptozocin-induced diabetic nephropathy

(2019) Lin Zhang et al.   FASEB JOURNAL

Circulating Oxidative Stress Biomarkers in Clinical Studies on Type 2 Diabetes and Its Complications

(2019) Elisabetta Bigagli et al.   Oxidative Medicine and Cellular Longevity

Islet inflammation in type 2 diabetes

(2019) Marianne Böni-Schnetzler et al.   Seminars in Immunopathology

The Effect of Iranian Propolis on Glucose Metabolism, Lipid Profile, Insulin Resistance, Renal Function and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Clinical Trial

(2019) Mehrnoosh Zakerkish et al.   Scientific Reports

C-reactive protein promotes inflammation through TLR4/NF-κB/TGF-β pathway in HL-1 cells

(2019) Weiping Sun et al.   BIOSCIENCE REPORTS

The effects of chromium and vitamin D3 co-supplementation on insulin resistance and tumor necrosis factor-alpha in type 2 diabetes: a randomized placebo-controlled trial

(2019) Fatemeh Imanparast et al.   Applied Physiology Nutrition and Metabolism

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

(2019) Vaishali Aggarwal et al.   Biomolecules

T-cell activation and cardiovascular risk in adults with type 2 diabetes mellitus: A systematic review and meta-analysis

(2019) Tawanda Maurice Nyambuya et al.   CLINICAL IMMUNOLOGY

A systematic review on the functional role of Th1/Th2 cytokines in type 2 diabetes and related metabolic complications

(2019) Thabsile Mahlangu et al.   CYTOKINE

The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities

(2019) Wei Ying et al.   Nature Reviews Endocrinology

Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response

(2018) Michelle R. Marasco et al.   DIABETES

Exenatide Increases IL-1RA Concentration and Induces Nrf-2‒Keap-1‒Regulated Antioxidant Enzymes: Relevance to β-Cell Function

(2018) Paresh Dandona et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lipid accumulation product and triglycerides/glucose index are useful predictors of insulin resistance

(2018) Mohsen Mazidi et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

l -Carnosine supplementation attenuated fasting glucose, triglycerides, advanced glycation end products, and tumor necrosis factor– α levels in patients with type 2 diabetes: a double-blind placebo-controlled randomized clinical trial

(2018) Shiva Houjeghani et al.   NUTRITION RESEARCH

Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms

(2018) Madhura Panse et al.   PLoS One

Comparison of glycemic control and β-cell function in new onset T2DM patients with PCOS of metformin and saxagliptin monotherapy or combination treatment

(2018) Tao Tao et al.   BMC Endocrine Disorders

Association of NF-E2 Related Factor 2 (Nrf2) and inflammatory cytokines in recent onset Type 2 Diabetes Mellitus

(2018) Dornadula Sireesh et al.   Scientific Reports

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Role of C-Reactive Protein at Sites of Inflammation and Infection

(2018) Nicola R. Sproston et al.   Frontiers in Immunology

CD4+ T Helper Cells Play a Key Role in Maintaining Diabetogenic CD8+ T Cell Function in the Pancreas

(2018) Gabriel Espinosa-Carrasco et al.   Frontiers in Immunology

Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled study

(2018) Jan Oscarsson et al.   Journal of Clinical Lipidology

Pleiotropic effects of metformin: Shaping the microbiome to manage type 2 diabetes and postpone ageing

(2018) Francesco Prattichizzo et al.   AGEING RESEARCH REVIEWS

The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders

(2018) Anuradha Tarafdar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels

(2018) Qin-Fen Chen et al.   International Journal of Endocrinology

Inflammation and Oxidative Stress in an Obese State and the Protective Effects of Gallic Acid

(2018) Phiwayinkosi Dludla et al.   Nutrients

Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy

(2017) Amelia K. Linnemann et al.   FASEB JOURNAL

Amelioration of streptozotocin‑induced pancreatic β cell damage by morin: Involvement of the AMPK‑FOXO3‑catalase signaling pathway

(2017) Ning Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Ectopic fat accumulation in the pancreas and its clinical relevance: A systematic review, meta-analysis, and meta-regression

(2017) Ruma G. Singh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Aspalathin Protects the Heart against Hyperglycemia-Induced Oxidative Damage by Up-Regulating Nrf2 Expression

(2017) Phiwayinkosi Dludla et al.   MOLECULES

Oxidative Stress in Pancreatic Beta Cell Regeneration

(2017) Jingjing Wang et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress: Harms and Benefits for Human Health

(2017) Gabriele Pizzino et al.   Oxidative Medicine and Cellular Longevity

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

(2017) Chang Xia et al.   Journal of Diabetes Research

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus

(2017) Joshua A. David et al.   Journal of Diabetes Research

Distinct Levels of Reactive Oxygen Species Coordinate Metabolic Activity with Beta-cell Mass Plasticity

(2017) Ezzaldin Ahmed Alfar et al.   Scientific Reports

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

(2016) F Martín-Sánchez et al.   CELL DEATH AND DIFFERENTIATION

Changes in beta cell function occur in prediabetes and early disease in the Lepr db mouse model of diabetes

(2016) Oanh H. Do et al.   DIABETOLOGIA

Diabetes mellitus and oxidative stress—A concise review

(2016) Ullah Asmat et al.   SAUDI PHARMACEUTICAL JOURNAL

The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway

(2016) Nicola J. Maclaine et al.   Aging-US

The Role of Markers of Low-Grade Inflammation for the Early Time Course of Glycemic Control, Glucose Disappearance Rate, and β-Cell Function in Recently Diagnosed Type 1 and Type 2 Diabetes

(2015) Katharina S. Weber et al.   DIABETES CARE

Mechanisms of human autoimmunity

(2015) Michael D. Rosenblum et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of vildagliptin on hsCRP and arterial stiffness in patients with type 2 diabetes mellitus

(2014) Ioanna Zografou et al.   Hormones-International Journal of Endocrinology and Metabolism

Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes

(2014) Tom L. Van Belle et al.   JOURNAL OF AUTOIMMUNITY

The Acute Effects of Low-Dose TNF-αon Glucose Metabolism andβ-Cell Function in Humans

(2014) Tobias Ibfelt et al.   MEDIATORS OF INFLAMMATION

Effects of Combined Calcium and Vitamin D Supplementation on Insulin Secretion, Insulin Sensitivity and β-Cell Function in Multi-Ethnic Vitamin D-Deficient Adults at Risk for Type 2 Diabetes: A Pilot Randomized, Placebo-Controlled Trial

(2014) Claudia Gagnon et al.   PLoS One

IL-6 in Inflammation, Immunity, and Disease

(2014) T. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

T Cell–Macrophage Interactions and Granuloma Formation in Vasculitis

(2014) Marc Hilhorst et al.   Frontiers in Immunology

Diabetes Mellitus and Inflammation

(2013) Eric Lontchi-Yimagou et al.   Current Diabetes Reports

What causes the insulin resistance underlying obesity?

(2013) Olga T. Hardy et al.   Current Opinion in Endocrinology Diabetes and Obesity

Obesity and Inflammation: Epidemiology, Risk Factors, and Markers of Inflammation

(2013) Heriberto Rodríguez-Hernández et al.   International Journal of Endocrinology

Correlation of fibrinogen-like protein 2 with disease progression in patients with severe acute pancreatitis

(2013) XIAOHUA YE et al.   Experimental and Therapeutic Medicine

Beta Cell Dysfunction and Insulin Resistance

(2013) Marlon E. Cerf   Frontiers in Endocrinology

A Systematic Review of Oxidative Stress and Safety of Antioxidants in Diabetes: Focus on Islets and Their Defense

(2013) Udayakumar Karunakaran et al.   Diabetes & Metabolism Journal

Deterioration of glucose homeostasis in type 2 diabetic patients one year after beginning of statins therapy

(2012) Alfonso Bellia et al.   ATHEROSCLEROSIS

CD4+T Cells: Differentiation and Functions

(2012) Rishi Vishal Luckheeram et al.   Clinical & Developmental Immunology

Attenuation of islet-specific T cell responses is associated with C-peptide improvement in autoimmune type 2 diabetes patients

(2012) B. M. Brooks-Worrell et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Vildagliptin action on some adipocytokine levels in type 2 diabetic patients: a 12-month, placebo-controlled study

(2012) Giuseppe Derosa et al.   EXPERT OPINION ON PHARMACOTHERAPY

Mitochondrial dysfunction in pancreatic β cells

(2012) Sachin Supale et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes

(2011) Ashok Kumar Sharma et al.   BRITISH JOURNAL OF NUTRITION

PIOfix-Study: Effects of Pioglitazone/Metformin Fixed Combination in Comparison with a Combination of Metformin with Glimepiride on Diabetic Dyslipidemia

(2011) Andreas Pfützner et al.   Diabetes Technology & Therapeutics

A Study of Plasma Fibrinogen Level in Type-2 Diabetes Mellitus and its Relation to Glycemic Control

(2011) Archana Sachin Bembde   INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION

Cytokines Tumor Necrosis Factor-α and Interferon-γ Induce Pancreatic β-Cell Apoptosis through STAT1-mediated Bim Protein Activation

(2011) Jenny Barthson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the Inflammasome, IL-1β, and IL-18 in Bacterial Infections

(2011) Manoranjan Sahoo et al.   TheScientificWorldJOURNAL

Circulating dendritic cell number and intracellular TNF-α production in women with type 2 diabetes

(2010) Sally E. Blank et al.   ACTA DIABETOLOGICA

Two Tales of Antioxidant Enzymes on β Cells and Diabetes

(2010) Xin Gen Lei et al.   ANTIOXIDANTS & REDOX SIGNALING

Knockouts of SOD1 and GPX1 Exert Different Impacts on Murine Islet Function and Pancreatic Integrity

(2010) Xiaodan Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Oxidative stress and beta-cell dysfunction

(2010) Gisela Drews et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-Cells via JNK, p38 MAPK and p53 Pathways

(2010) Huiping Yuan et al.   PLoS One

Cytokines in the Progression of Pancreaticβ-Cell Dysfunction

(2010) Chunjiong Wang et al.   International Journal of Endocrinology

β-Cell-Specific Overexpression of Glutathione Peroxidase Preserves Intranuclear MafA and Reverses Diabetes indb/dbMice

(2009) Jamie S. Harmon et al.   ENDOCRINOLOGY

Elevated Levels of Plasma Fibrinogen in Patients With Pancreatic Cancer

(2009) Qingqu Guo et al.   PANCREAS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

The association of plasma fibrinogen concentration with diabetic microvascular complications in young adults with early-onset of type 2 diabetes

(2008) Duc Son N.T. Le et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice

(2008) X. D. Wang et al.   DIABETOLOGIA

Reactive Oxygen Species-Mediated Pancreatic β-Cell Death Is Regulated by Interactions between Stress-Activated Protein Kinases, p38 and c-Jun N-Terminal Kinase, and Mitogen-Activated Protein Kinase Phosphatases

(2008) Ni Hou et al.   ENDOCRINOLOGY

Fibrinogen induces cytokine and collagen production in pancreatic stellate cells

(2008) A Masamune et al.   GUT