Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

Beta-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Post-Transcriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1

(2020) Sofia Thomaidou et al.   DIABETES

Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis

(2020) Pia Leete et al.   DIABETOLOGIA

The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

(2020) Xiaoxiao Wan et al.   NATURE IMMUNOLOGY

Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells

(2019) Maikel L. Colli et al.   Journal of Innate Immunity

Location, location, location: Tissue resident memory T cells in mice and humans

(2019) Peter A. Szabo et al.   Science Immunology

The Immunoreactive Platform of the Pancreatic Islets Influences the Development of Autoreactivity

(2019) Emil R. Unanue et al.   DIABETES

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

(2019) Manuela Battaglia et al.   DIABETES CARE

miR-409-3p is reduced in plasma and islet immune infiltrates of NOD diabetic mice and is differentially expressed in people with type 1 diabetes

(2019) Giuliana Ventriglia et al.   DIABETOLOGIA

The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

(2019) Mireia Ramos-Rodríguez et al.   NATURE GENETICS

Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

(2019) Alice E. Wiedeman et al.   JOURNAL OF CLINICAL INVESTIGATION

Prospective virome analyses in young children at increased genetic risk for type 1 diabetes

(2019) Kendra Vehik et al.   NATURE MEDICINE

Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance

(2018) Eddie A. James et al.   DIABETES

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes

(2018) Deborah Kronenberg-Versteeg et al.   DIABETES

Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors

(2018) Angeliki M. Stamatouli et al.   DIABETES

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

(2018) Alexandra Coomans de Brachène et al.   DIABETOLOGIA

Verapamil and beta cell function in adults with recent-onset type 1 diabetes

(2018) Fernando Ovalle et al.   NATURE MEDICINE

Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes

(2018) Kevin C. Osum et al.   Scientific Reports

Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

(2018) Sergio Gonzalez-Duque et al.   Cell Metabolism

The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms

(2018) Pia Leete et al.   Current Diabetes Reports

Biomarkers of islet beta cell stress and death in type 1 diabetes

(2018) Emily K. Sims et al.   DIABETOLOGIA

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides

(2018) Xiaoxiao Wan et al.   NATURE

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

(2018) Maikel L. Colli et al.   EBioMedicine

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study

(2018) Tommi Vatanen et al.   NATURE

Temporal development of the gut microbiome in early childhood from the TEDDY study

(2018) Christopher J. Stewart et al.   NATURE

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

(2017) Maria J L Kracht et al.   NATURE MEDICINE

Characterization of resident lymphocytes in human pancreatic islets

(2016) M. Radenkovic et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity

(2016) Chiara Cianciaruso et al.   DIABETES

Viral infections in type 1 diabetes mellitus — why the β cells?

(2016) Anne Op de Beeck et al.   Nature Reviews Endocrinology

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

(2016) T. Delong et al.   SCIENCE

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

Not-So-Negative Selection

(2015) Mark M. Davis   IMMUNITY

Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells

(2015) Anthony N. Vomund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Population dynamics of islet-infiltrating cells in autoimmune diabetes

(2015) Angela M. Magnuson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

(2015) Laura Marroqui et al.   EBioMedicine

BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic  -Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2

(2014) L. Marroqui et al.   DIABETES

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

(2014) Ania Skowera et al.   DIABETES

A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

(2014) R. C. Ferreira et al.   DIABETES

Innate Immune Activity Is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility

(2014) H. Kallionpaa et al.   DIABETES

Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes

(2014) Matthew J. Butcher et al.   DIABETOLOGIA

Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors

(2014) L. C. Anton et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation andβ-cell apoptosis

(2013) I. Santin et al.   DIABETES OBESITY & METABOLISM

Restoration of the Unfolded Protein Response in Pancreatic   Cells Protects Mice Against Type 1 Diabetes

(2013) F. Engin et al.   Science Translational Medicine

Through the Fog: Recent Clinical Trials to Preserve  -Cell Function in Type 1 Diabetes

(2012) C. J. Greenbaum et al.   DIABETES

Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

(2012) D. L. Eizirik et al.   DIABETOLOGIA

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

Age- and Islet Autoimmunity–Associated Differences in Amino Acid and Lipid Metabolites in Children at Risk for Type 1 Diabetes

(2011) Maren Pflueger et al.   DIABETES

Antidiabetic Actions of Endogenous and Exogenous GLP-1 in Type 1 Diabetic Patients With and Without Residual  -Cell Function

(2011) U. Kielgast et al.   DIABETES

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic  -Cell Apoptosis

(2009) F. Moore et al.   DIABETES

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology