G-Quadruplexes in the Viral Genome: Unlocking Targets for Therapeutic Interventions and Antiviral Strategies

Presence, Location and Conservation of Putative G-Quadruplex Forming Sequences in Arboviruses Infecting Humans

(2023) Giulia Nicoletto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recent advances in applying G-quadruplex for SARS-CoV-2 targeting and diagnosis: A review

(2022) Li-Yan Zhai et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Hepatitis C virus nonstructural protein NS3 unfolds viral G-quadruplex RNA structures

(2022) Binyam Belachew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA G-quadruplex formed in SARS-CoV-2 used for COVID-19 treatment in animal models

(2022) Geng Qin et al.   Cell Discovery

Quindoline-derivatives display potent G-quadruplex-mediated antiviral activity against herpes simplex virus 1

(2022) Ilaria Frasson et al.   ANTIVIRAL RESEARCH

RNA G-quadruplex forming regions from SARS-2, SARS-1 and MERS coronoviruses

(2022) Amani Kabbara et al.   Frontiers in Chemistry

G-quadruplexes in H1N1 influenza genomes

(2021) Václav Brázda et al.   BMC GENOMICS

Inhibition of Zika Virus Replication by G-Quadruplex Binding Ligands

(2021) Prativa Majee et al.   Molecular Therapy-Nucleic Acids

CNBP Binds and Unfolds In Vitro G-Quadruplexes Formed in the SARS-CoV-2 Positive and Negative Genome Strands

(2021) Georgina Bezzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antiviral Activity of the G-Quadruplex Ligand TMPyP4 against Herpes Simplex Virus-1

(2021) Sara Artusi et al.   Viruses-Basel

Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA.

(2021) Vanessa Meier-Stephenson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues

(2021) Enrico Cadoni et al.   NUCLEIC ACIDS RESEARCH

Targeting a Potential G-Quadruplex Forming Sequence Found in the West Nile Virus Genome by Complementary Gamma-Peptide Nucleic Acid Oligomers

(2021) Srijani Sarkar et al.   ACS Infectious Diseases

Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection

(2021) Natália Bohálová et al.   BIOCHIMIE

Identification and Structural Aspects of G-Quadruplex-Forming Sequences from the Influenza A Virus Genome

(2021) Maria Tomaszewska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The effect of hairpin loop on the structure and gene expression activity of the long-loop G-quadruplex

(2021) Subramaniyam Ravichandran et al.   NUCLEIC ACIDS RESEARCH

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction

(2021) Marc Lavigne et al.   NUCLEIC ACIDS RESEARCH

Unlocking G-Quadruplexes as Antiviral Targets

(2021) Ardavan Abiri et al.   PHARMACOLOGICAL REVIEWS

Potential G-quadruplexes and i-Motifs in the SARS-CoV-2

(2021) Efres Belmonte-Reche et al.   PLoS One

G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions

(2021) Tiago Santos et al.   Pharmaceuticals

G-quadruplex binder pyridostatin as an effective multi-target ZIKV inhibitor

(2021) Min Zou et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

G-Quadruplex Targeting in the Fight against Viruses: An Update

(2021) Emanuela Ruggiero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of a G-quadruplex from hepatitis B virus and its stabilization by binding TMPyP4, BRACO19 and PhenDC3

(2021) Orsolya Réka Molnár et al.   Scientific Reports

Custom DNA Microarrays Reveal Diverse Binding Preferences of Proteins and Small Molecules to Thousands of G-Quadruplexes

(2020) Sreejana Ray et al.   ACS Chemical Biology

The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19

(2020) Nadia Panera et al.   DRUGS

Selective targeting of mutually exclusive DNA G-quadruplexes: HIV-1 LTR as paradigmatic model

(2020) Martina Tassinari et al.   NUCLEIC ACIDS RESEARCH

Discovery of G-quadruplex-forming sequences in SARS-CoV-2

(2020) Danyang Ji et al.   BRIEFINGS IN BIOINFORMATICS

Custom G4 Microarrays Reveal Selective G-Quadruplex Recognition of Small Molecule BMVC: A Large-Scale Assessment of Ligand Binding Selectivity

(2020) Guanhui Wu et al.   MOLECULES

Single-molecule visualization of DNA G-quadruplex formation in live cells

(2020) Marco Di Antonio et al.   Nature Chemistry

In-Depth Bioinformatic Analyses of Nidovirales Including Human SARS-CoV-2, SARS-CoV, MERS-CoV Viruses Suggest Important Roles of Non-canonical Nucleic Acid Structures in Their Lifecycles

(2020) Martin Bartas et al.   Frontiers in Microbiology

Targeting RNA G‐quadruplex in SARS‐CoV‐2: A Promising Therapeutic Target for COVID‐19?

(2020) Xiaogang Qu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

G-Quadruplexes Are Present in Human Coronaviruses Including SARS-CoV-2

(2020) Haoran Cui et al.   Frontiers in Microbiology

Analysis of G-quadruplexes upstream of herpesvirus miRNAs: evidence of G-quadruplex mediated regulation of KSHV miR-K12–1-9,11 cluster and HCMV miR-US33

(2020) Shivani Kumar et al.   BMC Molecular and Cell Biology

Whole Genome Identification of Potential G-Quadruplexes and Analysis of the G-Quadruplex Binding Domain for SARS-CoV-2

(2020) Rongxin Zhang et al.   Frontiers in Genetics

Human Papillomavirus G-Rich Regions as Potential Antiviral Drug Targets

(2020) Josué Carvalho et al.   Nucleic Acid Therapeutics

A fluorescence method for homogeneous detection of influenza A (H1N1) DNA sequence based on Guanine(G)‐quadruplex‐ N‐methylmesoporphyrin IX (NMM) complex and Assistance‐DNA (A‐DNA) inhibition

(2019) Yubin Li et al.   JOURNAL OF MEDICAL VIROLOGY

Computational approaches to predict the noncanonical DNAs

(2019) Nazia Parveen et al.   Current Bioinformatics

Towards Understanding of Polymorphism of the G-rich Region of Human Papillomavirus Type 52

(2019) Maja Marušič et al.   MOLECULES

Conserved G-Quadruplexes Regulate the Immediate Early Promoters of Human Alphaherpesviruses

(2019) Ilaria Frasson et al.   MOLECULES

LANA and hnRNP A1 regulate the translation of LANA mRNA through G-quadruplexes

(2019) Prerna Dabral et al.   JOURNAL OF VIROLOGY

HIV-1 Nucleocapsid Protein Unfolds Stable RNA G-Quadruplexes in the Viral Genome and Is Inhibited by G-Quadruplex Ligands

(2019) Elena Butovskaya et al.   ACS Infectious Diseases

Impact of RNA polymerase I inhibitor CX-5461 on viral kinase-dependent and -independent cytomegalovirus replication

(2018) Kristen N. Westdorp et al.   ANTIVIRAL RESEARCH

G-quadruplex virtual drug screening: A review

(2018) Robert C. Monsen et al.   BIOCHIMIE

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy

(2018) Emanuela Ruggiero et al.   NUCLEIC ACIDS RESEARCH

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand

(2018) Jaubert Chloé et al.   Scientific Reports

Pac1 Signals of Human Herpesviruses Contain a Highly Conserved G-Quadruplex Motif

(2018) Banhi Biswas et al.   ACS Infectious Diseases

Ligand design to acquire specificity to intended G-quadruplex structures

(2018) Sefan Asamitsu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Genome-wide analysis of regulatory G-quadruplexes affecting gene expression in human cytomegalovirus

(2018) Subramaniyam Ravichandran et al.   PLoS Pathogens

Major G-Quadruplex Form of HIV-1 LTR Reveals a (3 + 1) Folding Topology Containing a Stem-Loop

(2018) Elena Butovskaya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication

(2018) Wen-Xiu Bian et al.   NUCLEIC ACIDS RESEARCH

High-resolution three-dimensional NMR structure of theKRASproto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation

(2017) Abdelaziz Kerkour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms

(2017) Marta M. Fay et al.   JOURNAL OF MOLECULAR BIOLOGY

Stabilization of Telomere G-Quadruplexes Interferes with Human Herpesvirus 6A Chromosomal Integration

(2017) Shella Gilbert-Girard et al.   JOURNAL OF VIROLOGY

A G-quadruplex motif in an envelope gene promoter regulates transcription and virion secretion in HBV genotype B

(2017) Banhi Biswas et al.   NUCLEIC ACIDS RESEARCH

The function of DNA binding protein nucleophosmin in AAV replication

(2017) Stifani Satkunanathan et al.   VIROLOGY

Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA

(2017) María José Lista et al.   Nature Communications

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

(2017) Hong Xu et al.   Nature Communications

A Dual-Specific Targeting Approach Based on the Simultaneous Recognition of Duplex and Quadruplex Motifs

(2017) Thi Quynh Ngoc Nguyen et al.   Scientific Reports

The cellular protein hnRNP A2/B1 enhances HIV-1 transcription by unfolding LTR promoter G-quadruplexes

(2017) Matteo Scalabrin et al.   Scientific Reports

A core extended naphtalene diimide G-quadruplex ligand potently inhibits herpes simplex virus 1 replication

(2017) Sara Callegaro et al.   Scientific Reports

Genome-wide analysis of G-quadruplexes in herpesvirus genomes

(2016) Banhi Biswas et al.   BMC GENOMICS

G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV

(2016) Advaitha Madireddy et al.   NUCLEIC ACIDS RESEARCH

Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome

(2016) Beatrice De Nicola et al.   NUCLEIC ACIDS RESEARCH

QuadBase2: web server for multiplexed guanine quadruplex mining and visualization

(2016) Parashar Dhapola et al.   NUCLEIC ACIDS RESEARCH

Zika Virus Genomic RNA Possesses Conserved G-Quadruplexes Characteristic of the Flaviviridae Family

(2016) Aaron M. Fleming et al.   ACS Infectious Diseases

A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti-hepatitis C target

(2016) S.-R. Wang et al.   Science Advances

The Immunology of Epstein-Barr Virus–Induced Disease

(2015) Graham S. Taylor et al.   Annual Review of Immunology

The Herpes Simplex Virus-1 genome contains multiple clusters of repeated G-quadruplex: Implications for the antiviral activity of a G-quadruplex ligand

(2015) Sara Artusi et al.   ANTIVIRAL RESEARCH

Identification of a selective G-quadruplex DNA binder using a multistep virtual screening approach

(2015) Jin-Qiang Hou et al.   CHEMICAL COMMUNICATIONS

Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes

(2015) Rosalba Perrone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Visualization of RNA-Quadruplexes in Live Cells

(2015) Aurélien Laguerre et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription

(2015) Elena Tosoni et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes with (4n - 1) guanines in the G-tetrad core: formation of a G-triad·water complex and implication for small-molecule binding

(2015) Brahim Heddi et al.   NUCLEIC ACIDS RESEARCH

Duplex stem-loop-containing quadruplex motifs in the human genome: a combined genomic and structural study

(2015) K. W. Lim et al.   NUCLEIC ACIDS RESEARCH

A G-quadruplex-binding macrodomain within the “SARS-unique domain” is essential for the activity of the SARS-coronavirus replication–transcription complex

(2015) Yuri Kusov et al.   VIROLOGY

U3 Region in the HIV-1 Genome Adopts a G-Quadruplex Structure in Its RNA and DNA Sequence

(2014) Dorota Piekna-Przybylska et al.   BIOCHEMISTRY

Anti-HIV-1 activity of the G-quadruplex ligand BRACO-19

(2014) R. Perrone et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Topology of a DNA G-Quadruplex Structure Formed in the HIV-1 Promoter: A Potential Target for Anti-HIV Drug Development

(2014) Samir Amrane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-quadruplexes regulate Epstein-Barr virus–encoded nuclear antigen 1 mRNA translation

(2014) Pierre Murat et al.   Nature Chemical Biology

G-quadruplex conformation and dynamics are determined by loop length and sequence

(2014) Ramreddy Tippana et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes in viruses: function and potential therapeutic applications

(2014) Mathieu Métifiot et al.   NUCLEIC ACIDS RESEARCH

mRNA Structural Constraints on EBNA1 Synthesis Impact on In Vivo Antigen Presentation and Early Priming of CD8+ T Cells

(2014) Judy T. Tellam et al.   PLoS Pathogens

Fluorescent-Ligand-Mediated Screening of G-Quadruplex Structures Using a DNA Microarray

(2013) Keisuke Iida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Human Papillomavirus G-Quadruplexes

(2013) Katarína Tlučková et al.   BIOCHEMISTRY

A Dynamic G-Quadruplex Region Regulates the HIV-1 Long Terminal Repeat Promoter

(2013) Rosalba Perrone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bulges in G-Quadruplexes: Broadening the Definition of G-Quadruplex-Forming Sequences

(2013) Vineeth Thachappilly Mukundan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emerging trends in G-quadruplex biology – role in epigenetic and evolutionary events

(2013) Aradhita Baral et al.   Molecular BioSystems

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Detection of G-quadruplex DNA in mammalian cells

(2013) A. Henderson et al.   NUCLEIC ACIDS RESEARCH

Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity

(2013) Rosalba Perrone et al.   PLoS One

Interaction of human telomeric DNA with N- methyl mesoporphyrin IX

(2012) John M. Nicoludis et al.   NUCLEIC ACIDS RESEARCH

The porphyrin TmPyP4 unfolds the extremely stable G-quadruplex in MT3-MMP mRNA and alleviates its repressive effect to enhance translation in eukaryotic cells

(2012) Mark J. Morris et al.   NUCLEIC ACIDS RESEARCH

G4LDB: a database for discovering and studying G-quadruplex ligands

(2012) Qian Li et al.   NUCLEIC ACIDS RESEARCH

Genome-wide study predicts promoter-G4 DNA motifs regulate selective functions in bacteria: radioresistance of D. radiodurans involves G4 DNA-mediated regulation

(2012) Nicolas Beaume et al.   NUCLEIC ACIDS RESEARCH

HIV-1 Nucleocapsid Protein Increases Strand Transfer Recombination by Promoting Dimeric G-quartet Formation

(2011) Wen Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulatec-KITExpression in Human Gastric Carcinoma Cells

(2011) Keith I. E. McLuckie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antisense-Induced Guanine Quadruplexes Inhibit Reverse Transcription by HIV-1 Reverse Transcriptase

(2010) Masaki Hagihara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-B DB: a database of predicted non-B DNA-forming motifs in mammalian genomes

(2010) R. Z. Cer et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplex DNA Sequences Are Evolutionarily Conserved and Associated with Distinct Genomic Features in Saccharomyces cerevisiae

(2010) John A. Capra et al.   PLoS Computational Biology

Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes

(2009) Nicolas Smargiasso et al.   BMC GENOMICS

G-quadruplex nucleic acids as therapeutic targets

(2009) Shankar Balasubramanian et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Role for G-Quadruplex RNA Binding by Epstein-Barr Virus Nuclear Antigen 1 in DNA Replication and Metaphase Chromosome Attachment

(2009) J. Norseen et al.   JOURNAL OF VIROLOGY

Simian Virus 40 Large T-Antigen G-Quadruplex DNA Helicase Inhibition by G-Quadruplex DNA-Interactive Agents†

(2008) Bodin Tuesuwan et al.   BIOCHEMISTRY

Genome-Wide Computational and Expression Analyses Reveal G-Quadruplex DNA Motifs as Conservedcis-Regulatory Elements in Human and Related Species

(2008) Anjali Verma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates

(2008) James E. Redman et al.   ORGANIC & BIOMOLECULAR CHEMISTRY