Hepatitis C virus nonstructural protein NS3 unfolds viral G-quadruplex RNA structures

A Helicase Unwinds Hexanucleotide Repeat RNA G-Quadruplexes and Facilitates Repeat-Associated Non-AUG Translation

(2021) Honghe Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Action and function of helicases on RNA G-quadruplexes

(2021) Marco Caterino et al.   METHODS

The regulation and functions of DNA and RNA G-quadruplexes

(2020) Dhaval Varshney et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

G-Quadruplexes Are Present in Human Coronaviruses Including SARS-CoV-2

(2020) Haoran Cui et al.   Frontiers in Microbiology

G-Quadruplex loops regulate PARP-1 enzymatic activation

(2020) Andrea D Edwards et al.   NUCLEIC ACIDS RESEARCH

RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36

(2019) Ramreddy Tippana et al.   Nature Communications

G-Quadruplex Secondary Structure Obtained from Circular Dichroism Spectroscopy

(2018) Rafael del Villar-Guerra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand

(2018) Jaubert Chloé et al.   Scientific Reports

Pif1 helicase unfolding of G-quadruplex DNA is highly dependent on sequence and reaction conditions

(2018) Alicia K. Byrd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide

(2018) Enrico Lavezzo et al.   PLoS Computational Biology

A biochemical and biophysical model of G-quadruplex DNA recognition by positive coactivator of transcription 4

(2017) Wezley C. Griffin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The G-quadruplex (G4) resolvase DHX36 efficiently and specifically disrupts DNA G4s via a translocation-based helicase mechanism

(2017) Philip M. Yangyuoru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NS3 from Hepatitis C Virus Strain JFH-1 Is an Unusually Robust Helicase That Is Primed To Bind and Unwind Viral RNA

(2017) Ting Zhou et al.   JOURNAL OF VIROLOGY

G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV

(2016) Advaitha Madireddy et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and helicases

(2016) Oscar Mendoza et al.   NUCLEIC ACIDS RESEARCH

Zika Virus Genomic RNA Possesses Conserved G-Quadruplexes Characteristic of the Flaviviridae Family

(2016) Aaron M. Fleming et al.   ACS Infectious Diseases

Metal Cations in G-Quadruplex Folding and Stability

(2016) Debmalya Bhattacharyya et al.   Frontiers in Chemistry

A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti-hepatitis C target

(2016) S.-R. Wang et al.   Science Advances

The Herpes Simplex Virus-1 genome contains multiple clusters of repeated G-quadruplex: Implications for the antiviral activity of a G-quadruplex ligand

(2015) Sara Artusi et al.   ANTIVIRAL RESEARCH

Melting of Duplex DNA in the Absence of ATP by the NS3 Helicase Domain through Specific Interaction with a Single-Strand/Double-Strand Junction

(2015) Kimberly A. Reynolds et al.   BIOCHEMISTRY

A Parallel Quadruplex DNA Is Bound Tightly but Unfolded Slowly by Pif1 Helicase

(2015) Alicia K. Byrd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Hepatitis C Virus RNA Replication and Assembly: Living on the Fat of the Land

(2014) David Paul et al.   Cell Host & Microbe

G-quadruplexes regulate Epstein-Barr virus–encoded nuclear antigen 1 mRNA translation

(2014) Pierre Murat et al.   Nature Chemical Biology

Yeast Pif1 Helicase Exhibits a One-base-pair Stepping Mechanism for Unwinding Duplex DNA

(2013) Ramanagouda Ramanagoudr-Bhojappa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Dynamic G-Quadruplex Region Regulates the HIV-1 Long Terminal Repeat Promoter

(2013) Rosalba Perrone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of Loops and G-Quartets on the Stability of RNA G-Quadruplexes

(2013) Satyaprakash Pandey et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

(2013) Troels K H Scheel et al.   NATURE MEDICINE

Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity

(2013) Rosalba Perrone et al.   PLoS One

Binding by the Hepatitis C Virus NS3 Helicase Partially Melts Duplex DNA

(2012) Veronica M. Raney et al.   BIOCHEMISTRY

Superfamily 2 helicases

(2012) Alicia et al.   Frontiers in Bioscience-Landmark

The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary

(2012) E. P. Booy et al.   NUCLEIC ACIDS RESEARCH

Human DHX9 helicase preferentially unwinds RNA-containing displacement loops (R-loops) and G-quadruplexes

(2011) Prasun Chakraborty et al.   DNA REPAIR

Yin Yang 1 contains G-quadruplex structures in its promoter and 5′-UTR and its expression is modulated by G4 resolvase 1

(2011) Weiwei Huang et al.   NUCLEIC ACIDS RESEARCH

Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target

(2010) Kevin D. Raney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circular dichroism and conformational polymorphism of DNA

(2009) J. Kypr et al.   NUCLEIC ACIDS RESEARCH

G4 Resolvase 1 Binds Both DNA and RNA Tetramolecular Quadruplex with High Affinity and Is the Major Source of Tetramolecular Quadruplex G4-DNA and G4-RNA Resolving Activity in HeLa Cell Lysates

(2008) Steven D. Creacy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single Strand Binding Proteins Increase the Processivity of DNA Unwinding by the Hepatitis C Virus Helicase

(2007) Vaishnavi Rajagopal et al.   JOURNAL OF MOLECULAR BIOLOGY