High-resolution three-dimensional NMR structure of theKRASproto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation

G4 DNA in ras genes and its potential in cancer therapy

(2016) Susanna Cogoi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Platinum(II) phenanthroimidazole G-quadruplex ligand induces selective telomere shortening in A549 cancer cells

(2016) Johanna Mancini et al.   BIOCHIMIE

Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs

(2016) Adam Stanton et al.   BMC GENOMICS

K-Ras protein as a drug target

(2016) Frank McCormick   JOURNAL OF MOLECULAR MEDICINE-JMM

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

(2016) Jutta Zimmer et al.   MOLECULAR CELL

G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV

(2016) Advaitha Madireddy et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes as novel cis-elements controlling transcription during embryonic development

(2016) Aldana P. David et al.   NUCLEIC ACIDS RESEARCH

Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome

(2016) Beatrice De Nicola et al.   NUCLEIC ACIDS RESEARCH

Re-evaluation of G-quadruplex propensity with G4Hunter

(2016) Amina Bedrat et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplexes in DNA Replication: A Problem or a Necessity?

(2016) Anne-Laure Valton et al.   TRENDS IN GENETICS

Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

(2016) Philipp M. Cromm et al.   Nature Communications

Multivalent L Kγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexes

(2015) Pankaj Gupta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Indolo[3,2-c]quinoline G-Quadruplex Stabilizers: a Structural Analysis of Binding to the Human Telomeric G-Quadruplex

(2015) João Lavrado et al.   ChemMedChem

Spectroscopic, biological, and molecular modeling studies on the interactions of [Fe(III)-meloxicam] with G-quadruplex DNA and investigation of its release from bovine serum albumin (BSA) nanoparticles

(2015) Malihe Ebrahimi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

In-silico modeling studies of G-quadruplex with soy isoflavones having anticancerous activity

(2015) Jyoti Singh Tomar   JOURNAL OF MOLECULAR MODELING

An intramolecular G-quadruplex structure formed in the human MET promoter region and its biological relevance

(2015) Jing Yan et al.   MOLECULAR CARCINOGENESIS

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

Thermodynamic fingerprints of ligand binding to human telomeric G-quadruplexes

(2015) Matjaž Bončina et al.   NUCLEIC ACIDS RESEARCH

KRASpromoter oligonucleotide with decoy activity dimerizes into a unique topology consisting of two G-quadruplex units

(2015) Peter Podbevšek et al.   NUCLEIC ACIDS RESEARCH

The molecular mechanism of ligand unbinding from the human telomeric G-quadruplex by steered molecular dynamics and umbrella sampling simulations

(2015) Jia-Kai Zhou et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives

(2015) Hugo Brito et al.   PLoS One

Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

(2015) Elizaveta S. Leshchiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound

(2015) Patrick Merle et al.   Scientific Reports

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines

(2015) João Lavrado et al.   Scientific Reports

U3 Region in the HIV-1 Genome Adopts a G-Quadruplex Structure in Its RNA and DNA Sequence

(2014) Dorota Piekna-Przybylska et al.   BIOCHEMISTRY

Oncogenic KRAS signalling in pancreatic cancer

(2014) S Eser et al.   BRITISH JOURNAL OF CANCER

Ligand 5,10,15,20-Tetra(N-methyl-4-pyridyl)porphine (TMPyP4) Prefers the Parallel Propeller-Type Human Telomeric G-Quadruplex DNA over Its Other Polymorphs

(2014) Asfa Ali et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A Twice-As-Smart Synthetic G-Quartet: PyroTASQ Is Both a Smart Quadruplex Ligand and a Smart Fluorescent Probe

(2014) Aurélien Laguerre et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanistic insight into ligand binding to G-quadruplex DNA

(2014) Francesco Saverio Di Leva et al.   NUCLEIC ACIDS RESEARCH

Involvement of G-quadruplex structures in regulation of human RET gene expression by small molecules in human medullary thyroid carcinoma TT cells

(2014) Y-J Shin et al.   ONCOGENE

Targeting pathways downstream of KRAS in lung adenocarcinoma

(2014) Zehua Zhu et al.   PHARMACOGENOMICS

Multi-kinase modulation for colon cancer therapy

(2013) Paul Dent   CANCER BIOLOGY & THERAPY

Bulges in G-Quadruplexes: Broadening the Definition of G-Quadruplex-Forming Sequences

(2013) Vineeth Thachappilly Mukundan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice

(2013) Susanna Cogoi et al.   NUCLEIC ACIDS RESEARCH

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

G-quadruplexes: targets and tools in anticancer drug design

(2012) Markus Düchler   JOURNAL OF DRUG TARGETING

Interaction of human telomeric DNA with N- methyl mesoporphyrin IX

(2012) John M. Nicoludis et al.   NUCLEIC ACIDS RESEARCH

Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops

(2012) Maja Marušič et al.   NUCLEIC ACIDS RESEARCH

Antisense Knockdown of Kras Inhibits Fibrosis in a Rat Model of Unilateral Ureteric Obstruction

(2011) Jia-Hui Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Primer extension reactions as a tool to uncover folding motifs within complex G-rich sequences: analysis of the human KRAS NHE

(2011) Manikandan Paramasivam et al.   CHEMICAL COMMUNICATIONS

G-quadruplex-induced instability during leading-strand replication

(2011) Judith Lopes et al.   EMBO JOURNAL

Rapid Stoichiometric Analysis of G-Quadruplexes in Solution

(2010) Patrick Groves et al.   CHEMISTRY-A EUROPEAN JOURNAL

Therapeutic modulation of k-ras signaling in colorectal cancer

(2010) Lisanne L. Krens et al.   DRUG DISCOVERY TODAY

TheKRASPromoter Responds to Myc-associated Zinc Finger and Poly(ADP-ribose) Polymerase 1 Proteins, Which Recognize a Critical Quadruplex-formingGA-element

(2010) Susanna Cogoi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How long is too long? Effects of loop size on G-quadruplex stability

(2010) Aurore Guédin et al.   NUCLEIC ACIDS RESEARCH

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Predicting and understanding the stability of G-quadruplexes

(2009) Oliver Stegle et al.   BIOINFORMATICS

G-quadruplex nucleic acids as therapeutic targets

(2009) Shankar Balasubramanian et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Human telomeric G-quadruplex: structures of DNA and RNA sequences

(2009) Anh Tuân Phan   FEBS Journal

E. coli Transports Aggregated Proteins to the Poles by a Specific and Energy-Dependent Process

(2009) Assaf Rokney et al.   JOURNAL OF MOLECULAR BIOLOGY

A G-Rich Sequence within thec-kitOncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics

(2009) Shang-Te Danny Hsu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription

(2009) Manikandan Paramasivam et al.   NUCLEIC ACIDS RESEARCH

Identification of a New G-Quadruplex Motif in theKRASPromoter and Design of Pyrene-Modified G4-Decoys with Antiproliferative Activity in Pancreatic Cancer Cells

(2008) Susanna Cogoi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins

(2008) Susanna Cogoi et al.   NUCLEIC ACIDS RESEARCH