Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues

Specific Binding of a d -RNA G-Quadruplex Structure with an l -RNA Aptamer

(2020) Chun-Yin Chan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The regulation and functions of DNA and RNA G-quadruplexes

(2020) Dhaval Varshney et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selective targeting of mutually exclusive DNA G-quadruplexes: HIV-1 LTR as paradigmatic model

(2020) Martina Tassinari et al.   NUCLEIC ACIDS RESEARCH

Structure of two G-quadruplexes in equilibrium in the KRAS promoter

(2020) Julien Marquevielle et al.   NUCLEIC ACIDS RESEARCH

Discovery of G-quadruplex-forming sequences in SARS-CoV-2

(2020) Danyang Ji et al.   BRIEFINGS IN BIOINFORMATICS

Selective Targeting of Guanine-Vacancy-Bearing G-Quadruplexes by G-Quartet Complementation and Stabilization with a Guanine–Peptide Conjugate

(2020) Yi-de He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-molecule visualization of DNA G-quadruplex formation in live cells

(2020) Marco Di Antonio et al.   Nature Chemistry

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects

(2020) Claudia Riccardi et al.   PHARMACOLOGY & THERAPEUTICS

A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

(2020) Bishnu P Paudel et al.   eLife

Specific suppression of D-RNA G-quadruplex–protein interaction with an L-RNA aptamer

(2020) Mubarak I Umar et al.   NUCLEIC ACIDS RESEARCH

Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back

(2020) Prakash Kharel et al.   NUCLEIC ACIDS RESEARCH

Whole Genome Identification of Potential G-Quadruplexes and Analysis of the G-Quadruplex Binding Domain for SARS-CoV-2

(2020) Rongxin Zhang et al.   Frontiers in Genetics

Multifunctional Delivery Systems for Peptide Nucleic Acids

(2020) Stefano Volpi et al.   Pharmaceuticals

PNA-functionalized adenoviral vectors targeting G-quadruplexes in the P1 promoter of Bcl-2 proto-oncogene: a new tool for gene modulation in anti-cancer therapy

(2019) Andrea Patrizia Falanga et al.   BIOCONJUGATE CHEMISTRY

Impact of Oxidative Lesions on the Human Telomeric G-quadruplex

(2019) Stasė Bielskutė et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quadruplex-forming oligonucleotide targeted to the VEGF promoter inhibits growth of non-small cell lung cancer cells

(2019) David Muench et al.   PLoS One

Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction

(2019) Zhi-Yin Sun et al.   MOLECULES

Specific stabilization of DNA G-quadruplex structures with a chemically modified complementary probe

(2019) Min Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Presence and Localization of G-Quadruplex Forming Sequences in the Domain of Bacteria

(2019) Martin Bartas et al.   MOLECULES

Binding and Beyond: What Else Can G-Quadruplex Ligands Do?

(2019) Michael P. O'Hagan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

RNA G-quadruplex as supramolecular carrier for cancer-selective delivery

(2019) Tiago Santos et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Therapeutic applications of AS1411 aptamer, an update review

(2019) Rezvan Yazdian-Robati et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Solution Structures of a G-Quadruplex Bound to Linear- and Cyclic-Dinucleotides

(2019) Fernaldo Richtia Winnerdy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting of G-Quadruplex Harboring Pre-miRNA 92b by LNA Rescues PTEN Expression in NSCL Cancer Cells

(2018) Gayan Mirihana Arachchilage et al.   ACS Chemical Biology

Multi-targeted effects of G4-aptamers and their antiproliferative activity against cancer cells

(2018) Anna M. Ogloblina et al.   BIOCHIMIE

Design of Modular G-quadruplex Ligands

(2018) Ana Rita Duarte et al.   ChemMedChem

Recovery of the Formation and Function of Oxidized G-Quadruplexes by a Pyrene-Modified Guanine Tract

(2018) Shuntaro Takahashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand design to acquire specificity to intended G-quadruplex structures

(2018) Sefan Asamitsu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Targeting Canine KIT Promoter by Candidate DNA G-Quadruplex Ligands

(2018) Eleonora Zorzan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Major G-Quadruplex Form of HIV-1 LTR Reveals a (3 + 1) Folding Topology Containing a Stem-Loop

(2018) Elena Butovskaya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter

(2018) Anjali Sengar et al.   NUCLEIC ACIDS RESEARCH

RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms

(2017) Marta M. Fay et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural switch from a multistranded G-quadruplex to single strands as a consequence of point mutation in the promoter of the human GRIN1 gene

(2017) Swati Chaudhary et al.   Molecular BioSystems

Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs

(2017) Xiulong Shen et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplexes influence pri-microRNA processing

(2017) Samuel G. Rouleau et al.   RNA Biology

Homologous PNA Hybridization to Noncanonical DNA G-Quadruplexes

(2016) Karen A. Kormuth et al.   BIOCHEMISTRY

RNA G-Quadruplex Invasion and Translation Inhibition by Antisense γ-Peptide Nucleic Acid Oligomers

(2016) Stanley N. Oyaghire et al.   BIOCHEMISTRY

Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe

(2016) Shuo-Bin Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-quadruplex structures mark human regulatory chromatin

(2016) Robert Hänsel-Hertsch et al.   NATURE GENETICS

Nucleic acid clamp-mediated recognition and stabilization of the physiologically relevant MYC promoter G-quadruplex

(2016) Taisen Hao et al.   NUCLEIC ACIDS RESEARCH

Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome

(2016) Beatrice De Nicola et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and helicases

(2016) Oscar Mendoza et al.   NUCLEIC ACIDS RESEARCH

Probing the G‑quadruplex from hsa-miR-3620-5p and inhibition of its interaction with the target sequence

(2016) Wei Tan et al.   TALANTA

Metal Cations in G-Quadruplex Folding and Stability

(2016) Debmalya Bhattacharyya et al.   Frontiers in Chemistry

Genome-wide discovery of G-quadruplex forming sequences and their functional relevance in plants

(2016) Rohini Garg et al.   Scientific Reports

G-Quadruplex DNA- and RNA-Specific-Binding Proteins Engineered from the RGG Domain of TLS/FUS

(2015) Kentaro Takahama et al.   ACS Chemical Biology

Multivalent L Kγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexes

(2015) Pankaj Gupta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Potassium Ion-Dependent RNA Structural Switch Regulates Human Pre-miRNA 92b Maturation

(2015) Gayan Mirihana Arachchilage et al.   CHEMISTRY & BIOLOGY

Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites

(2015) A. Piazza et al.   EMBO JOURNAL

Targeting G-quadruplex nucleic acids with heterocyclic alkaloids and their derivatives

(2015) Yun-Xia Xiong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription

(2015) Elena Tosoni et al.   NUCLEIC ACIDS RESEARCH

KRASpromoter oligonucleotide with decoy activity dimerizes into a unique topology consisting of two G-quadruplex units

(2015) Peter Podbevšek et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes with (4n - 1) guanines in the G-tetrad core: formation of a G-triad·water complex and implication for small-molecule binding

(2015) Brahim Heddi et al.   NUCLEIC ACIDS RESEARCH

RMBase: a resource for decoding the landscape of RNA modifications from high-throughput sequencing data

(2015) Wen-Ju Sun et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

The tale of RNA G-quadruplex

(2015) Prachi Agarwala et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Guanine-vacancy–bearing G-quadruplexes responsive to guanine derivatives

(2015) Xin-min Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleic Acid Targeted Therapy: G4 Oligonucleotides Downregulate HRAS in Bladder Cancer Cells through a Decoy Mechanism

(2015) Giulia Miglietta et al.   ACS Medicinal Chemistry Letters

G-Quadruplex Formation Between G-Rich PNA and Homologous Sequences in Oligonucleotides and Supercoiled Plasmid DNA

(2015) Timur I. Gaynutdinov et al.   Nucleic Acid Therapeutics

Rationally Induced RNA:DNA G-Quadruplex Structures Elicit an Anticancer Effect by Inhibiting Endogenous eIF-4E Expression

(2014) Debmalya Bhattacharyya et al.   BIOCHEMISTRY

Hybridization of G-Quadruplex-Forming Peptide Nucleic Acids to Guanine-Rich DNA Templates Inhibits DNA Polymerase η Extension

(2014) Connor T. Murphy et al.   BIOCHEMISTRY

PPG Peptide Nucleic Acids that Promote DNA Guanine Quadruplexes

(2014) Ethan A. Englund et al.   CHEMBIOCHEM

G-Quadruplex Structures and Their Interaction Diversity with Ligands

(2014) Sulin Zhang et al.   ChemMedChem

Small antisense oligonucleotides against G-quadruplexes: specific mRNA translational switches

(2014) Samuel G. Rouleau et al.   NUCLEIC ACIDS RESEARCH

The folding of 5'-UTR human G-quadruplexes possessing a long central loop

(2014) R. Jodoin et al.   RNA

The G-Triplex DNA

(2013) Vittorio Limongelli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MiR-92b regulates the cell growth, cisplatin chemosensitivity of A549 non small cell lung cancer cell line and target PTEN

(2013) Yan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The G-Quadruplex Augments Translation in the 5′ Untranslated Region of Transforming Growth Factor β2

(2013) Prachi Agarwala et al.   BIOCHEMISTRY

Strand Invasion of DNA Quadruplexes by PNA: Comparison of Homologous and Complementary Hybridization

(2013) Anisha Gupta et al.   CHEMBIOCHEM

A Dynamic G-Quadruplex Region Regulates the HIV-1 Long Terminal Repeat Promoter

(2013) Rosalba Perrone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice

(2013) Susanna Cogoi et al.   NUCLEIC ACIDS RESEARCH

Co-transcriptional formation of DNA:RNA hybrid G-quadruplex and potential function as constitutional cis element for transcription control

(2013) Ke-wei Zheng et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes for luminescent sensing and logic gates

(2013) H.-Z. He et al.   NUCLEIC ACIDS RESEARCH

Development of a Universal Colorimetric Indicator for G-Quadruplex Structures by the Fusion of Thiazole Orange and Isaindigotone Skeleton

(2012) Jin-Wu Yan et al.   ANALYTICAL CHEMISTRY

G-Rich Sequence-Specific Recognition and Scission of Human Genome by PNA/DNA Hybrid G-Quadruplex Formation

(2012) Takumi Ishizuka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel anticancer therapeutics targeting telomerase

(2012) Maria Ruden et al.   CANCER TREATMENT REVIEWS

Targeting G-Quadruplex Structure in the Human c-Kit Promoter with Short PNA Sequences

(2011) Jussara Amato et al.   BIOCONJUGATE CHEMISTRY

Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes

(2011) Subhadeep Roy et al.   CHEMICAL COMMUNICATIONS

Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals

(2011) Meghan A. Campbell et al.   CHEMICAL SOCIETY REVIEWS

Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils

(2011) Davide Torti et al.   EMBO Molecular Medicine

Genomic c-Myc Quadruplex DNA Selectively Kills Leukemia

(2011) K. C. Sedoris et al.   MOLECULAR CANCER THERAPEUTICS

Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region

(2011) M. I. Onyshchenko et al.   NUCLEIC ACIDS RESEARCH

Polymorphism and resolution of oncogene promoter quadruplex-forming sequences

(2011) M. Clarke Miller et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

G4-DNA Formation in the HRAS Promoter and Rational Design of Decoy Oligonucleotides for Cancer Therapy

(2011) Alexandro Membrino et al.   PLoS One

DNA-Templated Synthesis of Trimethine Cyanine Dyes: A Versatile Fluorogenic Reaction for Sensing G-Quadruplex Formation

(2010) Kamel Meguellati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Monomorphic RNA G-Quadruplex and Polymorphic DNA G-Quadruplex Structures Responding to Cellular Environmental Factors

(2010) Dong-Hao Zhang et al.   BIOCHEMISTRY

Dual Sensing of Hairpin and Quadruplex DNA Structures Using Multicolored Peptide Nucleic Acid Fluorescent Probes

(2010) Girish Koripelly et al.   BIOCONJUGATE CHEMISTRY

TheKRASPromoter Responds to Myc-associated Zinc Finger and Poly(ADP-ribose) Polymerase 1 Proteins, Which Recognize a Critical Quadruplex-formingGA-element

(2010) Susanna Cogoi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An RNA G-Quadruplex Is Essential for Cap-Independent Translation Initiation in Human VEGF IRES

(2010) Mark J. Morris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antisense-Induced Guanine Quadruplexes Inhibit Reverse Transcription by HIV-1 Reverse Transcriptase

(2010) Masaki Hagihara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae

(2010) Aurèle Piazza et al.   NUCLEIC ACIDS RESEARCH

How long is too long? Effects of loop size on G-quadruplex stability

(2010) Aurore Guédin et al.   NUCLEIC ACIDS RESEARCH

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex

(2010) Gavin W. Collie et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplex DNA Sequences Are Evolutionarily Conserved and Associated with Distinct Genomic Features in Saccharomyces cerevisiae

(2010) John A. Capra et al.   PLoS Computational Biology

G-quadruplex nucleic acids as therapeutic targets

(2009) Shankar Balasubramanian et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

TERRA: telomeric repeat-containing RNA

(2009) Brian Luke et al.   EMBO JOURNAL

The Importance of Negative Superhelicity in Inducing the Formation of G-Quadruplex and i-Motif Structures in the c-Myc Promoter: Implications for Drug Targeting and Control of Gene Expression

(2009) Daekyu Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Loop and Backbone Modifications of Peptide Nucleic Acid Improve G-Quadruplex Binding Selectivity

(2009) Sabrina Lusvarghi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human Telomeric DNA Sequence-Specific Cleaving by G-Quadruplex Formation

(2009) Yan Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs

(2009) Mykola I. Onyshchenko et al.   NUCLEIC ACIDS RESEARCH

Dramatic effect of single-base mutation on the conformational dynamics of human telomeric G-quadruplex

(2009) Ja Yil Lee et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

(2009) Cyril Ribeyre et al.   PLoS Genetics

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Silencing c-MYCExpression by Targeting Quadruplex in P1 Promoter Using Locked Nucleic Acid Trap†

(2008) Niti Kumar et al.   BIOCHEMISTRY

Hunting G-quadruplexes

(2008) J.L. Huppert   BIOCHIMIE

Combining G-Quadruplex Targeting Motifs on a Single Peptide Nucleic Acid Scaffold: A Hybrid (3+1) PNA-DNA Bimolecular Quadruplex

(2008) Alexis Paul et al.   CHEMISTRY-A EUROPEAN JOURNAL

G-Quadruplexes: Targets in Anticancer Drug Design

(2008) Tian-miao Ou et al.   ChemMedChem

A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres

(2008) Raphaël Rodriguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents

(2008) D. Sun et al.   MOLECULAR CANCER THERAPEUTICS

Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins

(2008) Susanna Cogoi et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes: the beginning and end of UTRs

(2008) Julian Leon Huppert et al.   NUCLEIC ACIDS RESEARCH

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY