Recent advances in applying G-quadruplex for SARS-CoV-2 targeting and diagnosis: A review

Reliable Fluorometric Detection of SARS-CoV-2 by Targeting the G-Quadruplex through pH-Triggered Conformational Polymorphism

(2022) Sumon Pratihar et al.   ACS Sensors

Binding Properties of RNA Quadruplex of SARS-CoV-2 to Berberine Compared to Telomeric DNA Quadruplex

(2022) Rosario Oliva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection

(2022) Geng Liu et al.   Nature Communications

Targeting nucleolin by RNA G-quadruplex-forming motif

(2021) Joana Figueiredo et al.   BIOCHEMICAL PHARMACOLOGY

G-quadruplex: Flexible Conformational Changes by Cations, pH, Crowding and Its Applications to Biosensing

(2021) Maui Nishio et al.   BIOSENSORS & BIOELECTRONICS

Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms

(2021) Nicholas C. Huston et al.   MOLECULAR CELL

Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions

(2021) Ryan A. Flynn et al.   CELL

CNBP Binds and Unfolds In Vitro G-Quadruplexes Formed in the SARS-CoV-2 Positive and Negative Genome Strands

(2021) Georgina Bezzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translation

(2021) Jian Lei et al.   EMBO JOURNAL

The SARS-CoV-2 RNA interactome

(2021) Sungyul Lee et al.   MOLECULAR CELL

G-Quadruplexes as pathogenic drivers in neurodegenerative disorders

(2021) Ernest Wang et al.   NUCLEIC ACIDS RESEARCH

Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection

(2021) Fabiola Ciccosanti et al.   ANTIVIRAL RESEARCH

G-quadruplex DNA: a novel target for drug design

(2021) Fang-Yuan Teng et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interactomes of SARS‐CoV‐2 and human coronaviruses reveal host factors potentially affecting pathogenesis

(2021) Zhen Chen et al.   EMBO JOURNAL

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction

(2021) Marc Lavigne et al.   NUCLEIC ACIDS RESEARCH

Unlocking G-Quadruplexes as Antiviral Targets

(2021) Ardavan Abiri et al.   PHARMACOLOGICAL REVIEWS

Potential G-quadruplexes and i-Motifs in the SARS-CoV-2

(2021) Efres Belmonte-Reche et al.   PLoS One

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

(2021) Pan Pan et al.   Nature Communications

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

(2021) Joseph A. Newman et al.   Nature Communications

Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2

(2021) Yi-Ting Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

G-Quadruplex Targeting in the Fight against Viruses: An Update

(2021) Emanuela Ruggiero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure and Dynamics of RNA Guanine Quadruplexes in SARS-CoV-2 Genome. Original Strategies against Emerging Viruses

(2021) Tom Miclot et al.   Journal of Physical Chemistry Letters

Molecular Beacon Assay Development for Severe Acute Respiratory Syndrome Coronavirus 2 Detection

(2021) Josué Carvalho et al.   SENSORS

A novel G-quadruplex aptamer-based spike trimeric antigen test for the detection of SARS-CoV-2

(2021) Ankit Gupta et al.   Molecular Therapy-Nucleic Acids

The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China

(2020) David S. Hui et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense

(2020) Frances Taschuk et al.   Viruses-Basel

RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X

(2020) Sundy N. Y. Yang et al.   Cells

Nucleolin Discriminates Drastically between Long-Loop and Short-Loop Quadruplexes

(2020) Abhijit Saha et al.   BIOCHEMISTRY

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19

(2020) Nadia Panera et al.   DRUGS

SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation

(2020) Young-Sheng Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

The regulation and functions of DNA and RNA G-quadruplexes

(2020) Dhaval Varshney et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells

(2020) Jingfang Mu et al.   Science China-Life Sciences

G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies

(2020) Josué Carvalho et al.   TRENDS IN MOLECULAR MEDICINE

Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex

(2020) Cindy K. Miranti et al.   Oncotarget

Inhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression

(2020) Li-Wen Shen et al.   Scientific Reports

Antiviral activity of berberine

(2020) Alicja Warowicka et al.   ARCHIVES OF VIROLOGY

Discovery of G-quadruplex-forming sequences in SARS-CoV-2

(2020) Danyang Ji et al.   BRIEFINGS IN BIOINFORMATICS

Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex

(2020) James Chen et al.   CELL

Role of RNA Guanine Quadruplexes in Favoring the Dimerization of SARS Unique Domain in Coronaviruses

(2020) Cécilia Hognon et al.   Journal of Physical Chemistry Letters

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

Interplay between SARS-CoV-2 and the type I interferon response

(2020) Margarida Sa Ribero et al.   PLoS Pathogens

In-Depth Bioinformatic Analyses of Nidovirales Including Human SARS-CoV-2, SARS-CoV, MERS-CoV Viruses Suggest Important Roles of Non-canonical Nucleic Acid Structures in Their Lifecycles

(2020) Martin Bartas et al.   Frontiers in Microbiology

SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase Activities That Can Be Inhibited by Bismuth Salts

(2020) Ting Shu et al.   VIROLOGICA SINICA

Targeting RNA G‐quadruplex in SARS‐CoV‐2: A Promising Therapeutic Target for COVID‐19?

(2020) Xiaogang Qu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recognition of nucleolin through interaction with RNA G-quadruplex

(2020) Tiago Santos et al.   BIOCHEMICAL PHARMACOLOGY

Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA

(2020) Hui Chen et al.   CELL RESEARCH

Structures of the SARS ‐CoV‐2 nucleocapsid and their perspectives for drug design

(2020) Ya Peng et al.   EMBO JOURNAL

Discovery of COVID-19 Inhibitors Targeting the SARS-CoV-2 Nsp13 Helicase

(2020) Mark Andrew White et al.   Journal of Physical Chemistry Letters

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

(2020) David E. Gordon et al.   SCIENCE

Evasion of Type I Interferon by SARS-CoV-2

(2020) Hongjie Xia et al.   Cell Reports

G-Quadruplexes Are Present in Human Coronaviruses Including SARS-CoV-2

(2020) Haoran Cui et al.   Frontiers in Microbiology

Structure and regulation of coronavirus genomes: state-of-the-art and novel insights from SARS-CoV-2 studies

(2020) Ilaria Manfredonia et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs

(2020) Theodora Myrto Perdikari et al.   EMBO JOURNAL

Polymerase chain reaction-based ultrasensitive detection of HBV DNA via G-quadruplex selective iridium(III) complex luminescent probe

(2020) Zongbing Li et al.   TALANTA

Host DDX Helicases as Possible SARS-CoV-2 Proviral Factors: A Structural Overview of Their Hijacking Through Multiple Viral Proteins

(2020) Flavia Squeglia et al.   Frontiers in Chemistry

Whole Genome Identification of Potential G-Quadruplexes and Analysis of the G-Quadruplex Binding Domain for SARS-CoV-2

(2020) Rongxin Zhang et al.   Frontiers in Genetics

The SARS-CoV-2 RNA–protein interactome in infected human cells

(2020) Nora Schmidt et al.   Nature Microbiology

DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection

(2019) Annalaura Brai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Parasitic Protozoa: Unusual Roles for G-Quadruplexes in Early-Diverging Eukaryotes

(2019) Franck Dumetz et al.   MOLECULES

Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis

(2019) Zhihui Jia et al.   NUCLEIC ACIDS RESEARCH

Human Coronavirus: Host-Pathogen Interaction

(2019) To Sing Fung et al.   Annual Review of Microbiology

Nucleolin-based targeting strategies for cancer therapy: from targeted drug delivery to cytotoxic ligands

(2019) Sofia Romano et al.   DRUG DISCOVERY TODAY

CNBP controls transcription by unfolding DNA G-quadruplex structures

(2019) Aldana P David et al.   NUCLEIC ACIDS RESEARCH

Genetic interactions of G-quadruplexes in humans

(2019) Katherine G Zyner et al.   eLife

DDX5 helicase resolves G-quadruplex and is involved in MYC gene transcriptional activation

(2019) Guanhui Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rich World of p53 DNA Binding Targets: The Role of DNA Structure

(2019) Václav Brázda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LANA and hnRNP A1 regulate the translation of LANA mRNA through G-quadruplexes

(2019) Prerna Dabral et al.   JOURNAL OF VIROLOGY

Coronavirus genomic RNA packaging

(2019) Paul S. Masters   VIROLOGY

HIV-1 Nucleocapsid Protein Unfolds Stable RNA G-Quadruplexes in the Viral Genome and Is Inhibited by G-Quadruplex Ligands

(2019) Elena Butovskaya et al.   ACS Infectious Diseases

Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

(2018) Jian Lei et al.   ANTIVIRAL RESEARCH

RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination

(2018) Claudia Ribeiro de Almeida et al.   MOLECULAR CELL

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy

(2018) Emanuela Ruggiero et al.   NUCLEIC ACIDS RESEARCH

Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts

(2018) Barbara Herdy et al.   NUCLEIC ACIDS RESEARCH

CNBP Homologues Gis2 and Znf9 Interact with a Putative G-Quadruplex-Forming 3′ Untranslated Region, Altering Polysome Association and Stress Tolerance in Cryptococcus neoformans

(2018) Jay Leipheimer et al.   mSphere

Targeting surface nucleolin induces autophagy-dependent cell death in pancreatic cancer via AMPK activation

(2018) Cheng Xu et al.   ONCOGENE

G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide

(2018) Enrico Lavezzo et al.   PLoS Computational Biology

RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF

(2017) Huilin Huang et al.   GENES & DEVELOPMENT

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

(2017) Robert Hänsel-Hertsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human DDX21 binds and unwinds RNA guanine quadruplexes

(2017) Ewan K.S. McRae et al.   NUCLEIC ACIDS RESEARCH

Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA

(2017) María José Lista et al.   Nature Communications

The cellular protein hnRNP A2/B1 enhances HIV-1 transcription by unfolding LTR promoter G-quadruplexes

(2017) Matteo Scalabrin et al.   Scientific Reports

The Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation

(2017) Daniel Benhalevy et al.   Cell Reports

G-quadruplexes and helicases

(2016) Oscar Mendoza et al.   NUCLEIC ACIDS RESEARCH

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLprovia E3 ubiquitin ligase RCHY1

(2016) Yue Ma-Lauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-quadruplex aptamer targeting Protein A and its capability to detect Staphylococcus aureus demonstrated by ELONA

(2016) Regina Stoltenburg et al.   Scientific Reports

A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti-hepatitis C target

(2016) S.-R. Wang et al.   Science Advances

The Nucleocapsid Protein of Coronaviruses Acts as a Viral Suppressor of RNA Silencing in Mammalian Cells

(2015) Lei Cui et al.   JOURNAL OF VIROLOGY

Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription

(2015) Elena Tosoni et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

A G-quadruplex-binding macrodomain within the “SARS-unique domain” is essential for the activity of the SARS-coronavirus replication–transcription complex

(2015) Yuri Kusov et al.   VIROLOGY

The SARS coronavirus nucleocapsid protein – Forms and functions

(2014) Chung-ke Chang et al.   ANTIVIRAL RESEARCH

MERS-CoV: a global challenge

(2013) The Lancet   LANCET

A label-free biosensor for DNA detection based on ligand-responsive G-quadruplex formation

(2013) Yahui Guo et al.   TALANTA

The G4 Genome

(2013) Nancy Maizels et al.   PLoS Genetics

Severe Acute Respiratory Syndrome Coronavirus Replication Inhibitor That Interferes with the Nucleic Acid Unwinding of the Viral Helicase

(2012) Adeyemi O. Adedeji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Unraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs

(2012) Emilie Besnard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A graphene functionalized electrochemical aptasensor for selective label-free detection of cancer cells

(2011) Lingyan Feng et al.   BIOMATERIALS

Essential role for the interaction between hnRNP H/F and a G quadruplex in maintaining p53 pre-mRNA 3'-end processing and function during DNA damage

(2011) A. Decorsiere et al.   GENES & DEVELOPMENT

A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands

(2011) Deepak Koirala et al.   Nature Chemistry

Cellular nucleic-acid-binding protein, a transcriptional enhancer of c-Myc, promotes the formation of parallel G-quadruplexes

(2010) Mariana Borgognone et al.   BIOCHEMICAL JOURNAL

The C-Terminus of Nucleolin Promotes the Formation of the c-MYCG-Quadruplex and Inhibits c-MYCPromoter Activity

(2010) Verónica González et al.   BIOCHEMISTRY

SARS Coronavirus Unique Domain: Three-Domain Molecular Architecture in Solution and RNA Binding

(2010) Margaret A. Johnson et al.   JOURNAL OF MOLECULAR BIOLOGY

SARS-CoV nucleocapsid protein antagonizes IFN-β response by targeting initial step of IFN-β induction pathway, and its C-terminal region is critical for the antagonism

(2010) Xiaolu Lu et al.   VIRUS GENES

Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives

(2009) Chaewoon Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification and Characterization of Nucleolin as a c-mycG-quadruplex-binding Protein

(2009) Verónica González et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes

(2009) Jinzhi Tan et al.   PLoS Pathogens

Differential Inhibitory Activities and Stabilisation of DNA Aptamers against the SARS Coronavirus Helicase

(2008) Ka To Shum et al.   CHEMBIOCHEM

Binding of berberine to human telomeric quadruplex - spectroscopic, calorimetric and molecular modeling studies

(2008) Amit Arora et al.   FEBS Journal