Selective targeting of mutually exclusive DNA G-quadruplexes: HIV-1 LTR as paradigmatic model

Characterization of highly conserved G-quadruplex motifs as potential drug targets in Streptococcus pneumoniae

(2019) Subodh Kumar Mishra et al.   Scientific Reports

Naphthalene Diimides as Multimodal G-Quadruplex-Selective Ligands

(2019) Valentina Pirota et al.   MOLECULES

A Photoresponsive Stiff-Stilbene Ligand Fuels the Reversible Unfolding of G-Quadruplex DNA

(2019) Michael P. O'Hagan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hybrid-type and two-tetrad antiparallel telomere DNA G-quadruplex structures in living human cells

(2019) Hong-Liang Bao et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplex DNA Motifs in the Malaria Parasite Plasmodium falciparum and Their Potential as Novel Antimalarial Drug Targets

(2018) Lynne M. Harris et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

(2018) C. Saintomé et al.   CHEMICAL COMMUNICATIONS

Simultaneous Binding of Hybrid Molecules Constructed with Dual DNA-Binding Components to a G-Quadruplex and Its Proximal Duplex

(2018) Sefan Asamitsu et al.   CHEMISTRY-A EUROPEAN JOURNAL

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy

(2018) Emanuela Ruggiero et al.   NUCLEIC ACIDS RESEARCH

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome

(2018) Chun Kit Kwok et al.   Cold Spring Harbor Perspectives in Biology

Characterizations of distinct parallel and antiparallel G-quadruplexes formed by two-repeat ALS and FTD related GGGGCC sequence

(2018) Bo Zhou et al.   Scientific Reports

Ligand design to acquire specificity to intended G-quadruplex structures

(2018) Sefan Asamitsu et al.   CHEMISTRY-A EUROPEAN JOURNAL

DNA-unwinding activity of Saccharomyces cerevisiae Pif1 is modulated by thermal stability, folding conformation, and loop lengths of G-quadruplex DNA

(2018) Lei Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Major G-Quadruplex Form of HIV-1 LTR Reveals a (3 + 1) Folding Topology Containing a Stem-Loop

(2018) Elena Butovskaya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex

(2018) David R. Calabrese et al.   Nature Communications

G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide

(2018) Enrico Lavezzo et al.   PLoS Computational Biology

A Dual-Specific Targeting Approach Based on the Simultaneous Recognition of Duplex and Quadruplex Motifs

(2017) Thi Quynh Ngoc Nguyen et al.   Scientific Reports

Mapping and characterization of G-quadruplexes in Mycobacterium tuberculosis gene promoter regions

(2017) Rosalba Perrone et al.   Scientific Reports

Quadruplex nucleic acids as targets for anticancer therapeutics

(2017) Stephen Neidle   Nature Reviews Chemistry

Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe

(2016) Shuo-Bin Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome

(2016) Beatrice De Nicola et al.   NUCLEIC ACIDS RESEARCH

A novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes

(2016) Zi-Fu Wang et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplexes in DNA Replication: A Problem or a Necessity?

(2016) Anne-Laure Valton et al.   TRENDS IN GENETICS

Assessment of selectivity of G-quadruplex ligands via an optimised FRET melting assay

(2015) Aurore De Rache et al.   BIOCHIMIE

Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery

(2015) Concetta Avitabile et al.   BIOCONJUGATE CHEMISTRY

A naphthalene diimide dyad for fluorescence switch-on detection of G-quadruplexes

(2015) F. Doria et al.   CHEMICAL COMMUNICATIONS

Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes

(2015) Rosalba Perrone et al.   JOURNAL OF MEDICINAL CHEMISTRY

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Hybridization of G-Quadruplex-Forming Peptide Nucleic Acids to Guanine-Rich DNA Templates Inhibits DNA Polymerase η Extension

(2014) Connor T. Murphy et al.   BIOCHEMISTRY

Long-range charge transport in single G-quadruplex DNA molecules

(2014) Gideon I. Livshits et al.   Nature Nanotechnology

An Improved Model for the hTERT Promoter Quadruplex

(2014) Jonathan B. Chaires et al.   PLoS One

A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma

(2013) Jonathan E. Rosenberg et al.   INVESTIGATIONAL NEW DRUGS

A Dynamic G-Quadruplex Region Regulates the HIV-1 Long Terminal Repeat Promoter

(2013) Rosalba Perrone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Water-Soluble Naphthalene Diimides as Singlet Oxygen Sensitizers

(2013) Filippo Doria et al.   JOURNAL OF ORGANIC CHEMISTRY

Solution Structure of an Intramolecular (3 + 1) Human Telomeric G-Quadruplex Bound to a Telomestatin Derivative

(2013) Wan Jun Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Detection of G-quadruplex DNA in mammalian cells

(2013) A. Henderson et al.   NUCLEIC ACIDS RESEARCH

Cell Cycle Regulation of G-Quadruplex DNA Structures at Telomeres

(2012) Stefan A. Juranek et al.   CURRENT PHARMACEUTICAL DESIGN

5'-UTR RNA G-quadruplexes: translation regulation and targeting

(2012) A. Bugaut et al.   NUCLEIC ACIDS RESEARCH

Water soluble extended naphthalene diimides as pH fluorescent sensors and G-quadruplex ligands

(2012) Filippo Doria et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region

(2011) M. I. Onyshchenko et al.   NUCLEIC ACIDS RESEARCH

Structure, location and interactions of G-quadruplexes

(2010) Julian L. Huppert   FEBS Journal

A Contractile Electronic Switch Made of DNA

(2010) Yu Chuan Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nucleic Acid Aptamers Based on the G-Quadruplex Structure: Therapeutic and Diagnostic Potential

(2009) B. Gatto et al.   CURRENT MEDICINAL CHEMISTRY

The structures of quadruplex nucleic acids and their drug complexes

(2009) Stephen Neidle   CURRENT OPINION IN STRUCTURAL BIOLOGY

Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer

(2009) Stephen Neidle   FEBS Journal

Substituted Heterocyclic Naphthalene Diimides with Unexpected Acidity. Synthesis, Properties, and Reactivity

(2009) Filippo Doria et al.   JOURNAL OF ORGANIC CHEMISTRY

Loop and Backbone Modifications of Peptide Nucleic Acid Improve G-Quadruplex Binding Selectivity

(2009) Sabrina Lusvarghi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs

(2009) Mykola I. Onyshchenko et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands

(2008) Francisco Cuenca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Combining G-Quadruplex Targeting Motifs on a Single Peptide Nucleic Acid Scaffold: A Hybrid (3+1) PNA-DNA Bimolecular Quadruplex

(2008) Alexis Paul et al.   CHEMISTRY-A EUROPEAN JOURNAL

Genome-Wide Computational and Expression Analyses Reveal G-Quadruplex DNA Motifs as Conservedcis-Regulatory Elements in Human and Related Species

(2008) Anjali Verma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates

(2008) James E. Redman et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY