Discovery of G-quadruplex-forming sequences in SARS-CoV-2

Recent discovery and development of inhibitors targeting coronaviruses

(2020) Thanigaimalai Pillaiyar et al.   DRUG DISCOVERY TODAY

Structure-Mediated RNA Decay by UPF1 and G3BP1

(2020) Joseph W. Fischer et al.   MOLECULAR CELL

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Evolutionary Trajectory for the Emergence of Novel Coronavirus SARS-CoV-2

(2020) Saif ur Rehman et al.   Pathogens

Whole genome experimental maps of DNA G-quadruplexes in multiple species

(2019) Giovanni Marsico et al.   NUCLEIC ACIDS RESEARCH

Recent Advances in Aptamer Discovery and Applications

(2019) Yang Zhang et al.   MOLECULES

The Presence and Localization of G-Quadruplex Forming Sequences in the Domain of Bacteria

(2019) Martin Bartas et al.   MOLECULES

Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis

(2019) Zhihui Jia et al.   NUCLEIC ACIDS RESEARCH

DDX5 helicase resolves G-quadruplex and is involved in MYC gene transcriptional activation

(2019) Guanhui Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells

(2019) Justin J. Montoya et al.   BMC CANCER

DDX5 RNA Helicases: Emerging Roles in Viral Infection

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents

(2018) Efres Belmonte-Reche et al.   JOURNAL OF MEDICINAL CHEMISTRY

Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome

(2018) Chun Kit Kwok et al.   Cold Spring Harbor Perspectives in Biology

Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts

(2018) Barbara Herdy et al.   NUCLEIC ACIDS RESEARCH

SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death

(2018) Yuan Yue et al.   Cell Death & Disease

The G-quadruplex (G4) resolvase DHX36 efficiently and specifically disrupts DNA G4s via a translocation-based helicase mechanism

(2017) Philip M. Yangyuoru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA substrate recognition and processing by the full-length human UPF1 helicase

(2017) Saba Dehghani-Tafti et al.   NUCLEIC ACIDS RESEARCH

Human DDX21 binds and unwinds RNA guanine quadruplexes

(2017) Ewan K.S. McRae et al.   NUCLEIC ACIDS RESEARCH

HDOCK: a web server for protein–protein and protein–DNA/RNA docking based on a hybrid strategy

(2017) Yumeng Yan et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplexes: Prediction, Characterization, and Biological Application

(2017) Chun Kit Kwok et al.   TRENDS IN BIOTECHNOLOGY

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

(2017) Hong Xu et al.   Nature Communications

Structural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid Quercetin

(2017) Arpita Tawani et al.   Scientific Reports

Real-Time Monitoring of G-Quadruplex Formation during Transcription

(2016) Tamaki Endoh et al.   ANALYTICAL CHEMISTRY

rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome

(2016) Chun Kit Kwok et al.   NATURE METHODS

G-quadruplexes and helicases

(2016) Oscar Mendoza et al.   NUCLEIC ACIDS RESEARCH

Zika Virus Genomic RNA Possesses Conserved G-Quadruplexes Characteristic of the Flaviviridae Family

(2016) Aaron M. Fleming et al.   ACS Infectious Diseases

Biochemical Characterization of Middle East Respiratory Syndrome Coronavirus Helicase

(2016) Adeyemi O. Adedeji et al.   mSphere

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplexes in Pathogens: A Common Route to Virulence Control?

(2015) Lynne M. Harris et al.   PLoS Pathogens

Evaluation of SSYA10-001 as a Replication Inhibitor of Severe Acute Respiratory Syndrome, Mouse Hepatitis, and Middle East Respiratory Syndrome Coronaviruses

(2014) Adeyemi O. Adedeji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

G-quadruplexes regulate Epstein-Barr virus–encoded nuclear antigen 1 mRNA translation

(2014) Pierre Murat et al.   Nature Chemical Biology

G-quadruplexes in viruses: function and potential therapeutic applications

(2014) Mathieu Métifiot et al.   NUCLEIC ACIDS RESEARCH

The folding of 5'-UTR human G-quadruplexes possessing a long central loop

(2014) R. Jodoin et al.   RNA

Antiviral drugs specific for coronaviruses in preclinical development

(2014) Adeyemi O Adedeji et al.   Current Opinion in Virology

Human Papillomavirus G-Quadruplexes

(2013) Katarína Tlučková et al.   BIOCHEMISTRY

Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression

(2013) J. Karn et al.   Cold Spring Harbor Perspectives in Medicine

Severe Acute Respiratory Syndrome Coronavirus Replication Inhibitor That Interferes with the Nucleic Acid Unwinding of the Viral Helicase

(2012) Adeyemi O. Adedeji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Nucleic Acid Unwinding by SARS-CoV Helicase

(2012) Adeyemi O. Adedeji et al.   PLoS One

Molecular Interaction Studies Using Microscale Thermophoresis

(2011) Moran Jerabek-Willemsen et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Human DHX9 helicase preferentially unwinds RNA-containing displacement loops (R-loops) and G-quadruplexes

(2011) Prasun Chakraborty et al.   DNA REPAIR

2,6-Bis-arylmethyloxy-5-hydroxychromones with antiviral activity against both hepatitis C virus (HCV) and SARS-associated coronavirus (SCV)

(2011) Mi Kyoung Kim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SF1 and SF2 helicases: family matters

(2010) Margaret E Fairman-Williams et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

SARS Coronavirus Unique Domain: Three-Domain Molecular Architecture in Solution and RNA Binding

(2010) Margaret A. Johnson et al.   JOURNAL OF MOLECULAR BIOLOGY

How long is too long? Effects of loop size on G-quadruplex stability

(2010) Aurore Guédin et al.   NUCLEIC ACIDS RESEARCH

Cooperative translocation enhances the unwinding of duplex DNA by SARS coronavirus helicase nsP13

(2010) Na-Ra Lee et al.   NUCLEIC ACIDS RESEARCH

Interaction between SARS-CoV helicase and a multifunctional cellular protein (Ddx5) revealed by yeast and mammalian cell two-hybrid systems

(2009) Jin-Yan Chen et al.   ARCHIVES OF VIROLOGY

Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes

(2009) Nicolas Smargiasso et al.   BMC GENOMICS

Differential Inhibitory Activities and Stabilisation of DNA Aptamers against the SARS Coronavirus Helicase

(2008) Ka To Shum et al.   CHEMBIOCHEM

Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/Helicase

(2007) Kyoung Jin Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS