Cancer stem cells: advances in the glucose, lipid and amino acid metabolism

Targeting Breast Cancer Stem Cells

(2023) Lu Zhang et al.   International Journal of Biological Sciences

The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow

(2022) Dachuan Zhang et al.   Cell Stem Cell

Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy

(2022) Xuanhua P. Xie et al.   DEVELOPMENTAL CELL

Fusobacterium nucleatum Promotes Colorectal Cancer Cell to Acquire Stem Cell‐Like Features by Manipulating Lipid Droplet‐Mediated Numb Degradation

(2022) Haiyang Liu et al.   Advanced Science

Emerging Role of cAMP/AMPK Signaling

(2022) Muhammad Aslam et al.   Cells

Metabolic regulation of somatic stem cells in vivo

(2022) Corbin E. Meacham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Correlation between amino acid metabolism and self-renewal of cancer stem cells: Perspectives in cancer therapy

(2022) Qi Zhang et al.   World Journal of Stem Cells

Cell–matrix interface regulates dormancy in human colon cancer stem cells

(2022) Yuki Ohta et al.   NATURE

Tumor microenvironment enriches the stemness features: the architectural event of therapy resistance and metastasis

(2022) Palanisamy Nallasamy et al.   Molecular Cancer

Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma

(2021) Chiara Raggi et al.   JOURNAL OF HEPATOLOGY

PKA and AMPK Signaling Pathways Differentially Regulate Luteal Steroidogenesis

(2021) Emilia Przygrodzka et al.   ENDOCRINOLOGY

Stem Cell Impairment at the Host-Microbiota Interface in Colorectal Cancer

(2021) Marinella Marzano et al.   Cancers

Cancer stem cells in hepatocellular carcinoma — from origin to clinical implications

(2021) Terence Kin-Wah Lee et al.   Nature Reviews Gastroenterology & Hepatology

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

(2021) Srivatsan Raghavan et al.   CELL

Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape

(2021) Giulia Salvadori et al.   Cell Metabolism

Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice

(2020) Guohao Wang et al.   Nature Communications

Spatial and biochemical interactions between bone marrow adipose tissue and hematopoietic stem and progenitor cells in rhesus macaques

(2020) Jacob J. Robino et al.   BONE

Amino Acid Oncometabolism and Immunomodulation of the Tumor Microenvironment in Lung Cancer

(2020) Johannes F. Fahrmann et al.   Frontiers in Oncology

Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer

(2020) Jason R Brown et al.   JCI Insight

Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells

(2020) Courtney L. Jones et al.   Cell Stem Cell

Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting CSCs compartment via YAP inhibition

(2020) Federica Iannelli et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells

(2020) Sandra Valle et al.   Nature Communications

The Metabolic Heterogeneity and Flexibility of Cancer Stem Cells

(2020) Atsushi Tanabe et al.   Cancers

Targeting the Wnt/β-catenin signaling pathway in cancer

(2020) Ya Zhang et al.   Journal of Hematology & Oncology

Revisiting the Warburg effect: historical dogma versus current understanding

(2020) Peter Vaupel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Partial acquisition of stemness properties in tumorspheres obtained from interleukin-8-treated MCF-7 cells

(2020) Natalia Ospina-Muñoz et al.   TUMOR BIOLOGY

A regulatory circuitry locking pluripotent stemness to embryonic stem cell: Interaction between threonine catabolism and histone methylation

(2019) Guohua Chen et al.   SEMINARS IN CANCER BIOLOGY

Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways

(2019) Dongya Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-10 derived from M2 macrophage promotes cancer stemness via JAK1/STAT1/NF-κB/Notch1 pathway in non-small cell lung cancer

(2019) Li Yang et al.   INTERNATIONAL JOURNAL OF CANCER

Regulation of the proline regulatory axis and autophagy modulates stemness in TP73/p73 deficient cancer stem-like cells

(2019) Tanveer Sharif et al.   Autophagy

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

(2019) Courtney L. Jones et al.   BLOOD

The ionophore antibiotic gramicidin A inhibits pancreatic cancer stem cells associated with CD47 down-regulation

(2019) Rui-Qi Wang et al.   Cancer Cell International

Targeting AMP ‐activated kinase impacts hepatocellular cancer stem cells induced by long‐term treatment with sorafenib

(2019) Alicia Bort et al.   Molecular Oncology

Methionine is a metabolic dependency of tumor-initiating cells

(2019) Zhenxun Wang et al.   NATURE MEDICINE

The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival

(2019) Joseph A. Combs et al.   Cancers

Insights into new mechanisms and models of cancer stem cell multidrug resistance

(2019) Y. Garcia-Mayea et al.   SEMINARS IN CANCER BIOLOGY

Crypt- and Mucosa-Associated Core Microbiotas in Humans and Their Alteration in Colon Cancer Patients

(2019) Azadeh Saffarian et al.   mBio

Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome

(2019) Sidse Ehmsen et al.   Cell Reports

CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth

(2019) Victoria M.-Y. Wang et al.   NATURE CELL BIOLOGY

Concise review: Aberrant lipid metabolism as an emerging therapeutic strategy to target cancer stem cells

(2019) Malini Visweswaran et al.   STEM CELLS

2-Hydroxyglutarate in Cancer Cells

(2019) Petr Ježek   ANTIOXIDANTS & REDOX SIGNALING

Activation of Tyrosine Metabolism in CD13+ Cancer Stem Cells Drives Relapse in Hepatocellular Carcinoma

(2019) Li Sun et al.   Cancer Research and Treatment

LW106, a novel indoleamine 2,3-dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma-immune crosstalk and cancer stem cell enrichment in tumour micro-environment

(2018) Rong Fu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling

(2018) Ming Luo et al.   Cell Metabolism

JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance

(2018) Tianyi Wang et al.   Cell Metabolism

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

(2018) Maria M. Mihaylova et al.   Cell Stem Cell

Cancer stem cells and hypoxia-inducible factors (Review)

(2018) Wei-Wei Tong et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Emerging role of lipid metabolism alterations in Cancer stem cells

(2018) Mei Yi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation

(2018) Xiao-xue Li et al.   MOLECULAR CELL

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

Metabolic features of cancer stem cells: the emerging role of lipid metabolism

(2018) Rita Mancini et al.   ONCOGENE

PrLZ increases prostate cancer docetaxel resistance by inhibiting LKB1/AMPK-mediated autophagy

(2018) Jin Zeng et al.   Theranostics

Short-Chain Fatty Acids Differentially Affect Intracellular Lipolysis in a Human White Adipocyte Model

(2018) Johan W. E. Jocken et al.   Frontiers in Endocrinology

Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States

(2018) Dongya Jia et al.   Cells

Histone variant macroH2A1 rewires carbohydrate and lipid metabolism of hepatocellular carcinoma cells towards cancer stem cells

(2018) Oriana Lo Re et al.   Epigenetics

Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer

(2018) Michitaka Nakano et al.   ONCOGENE

TDO2 Overexpression Is Associated with Cancer Stem Cells and Poor Prognosis in Esophageal Squamous Cell Carcinoma

(2018) Quoc Thang Pham et al.   ONCOLOGY

Metabolomic Studies of Live Single Cancer Stem Cells Using Mass Spectrometry

(2018) Mei Sun et al.   ANALYTICAL CHEMISTRY

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

(2018) Courtney L. Jones et al.   CANCER CELL

Infiltrative and drug‐resistant slow‐cycling cells support metabolic heterogeneity in glioblastoma

(2018) Lan B Hoang‐Minh et al.   EMBO JOURNAL

Betulinic acid inhibits stemness and EMT of pancreatic cancer cells via activation of AMPK signaling

(2018) Liankang Sun et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

(2018) Daniel A. Pollyea et al.   NATURE MEDICINE

Toward understanding cancer stem cell heterogeneity in the tumor microenvironment

(2018) Federico Bocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A subtype of cancer-associated fibroblasts with lower expression of alpha-smooth muscle actin suppresses stemness through BMP4 in oral carcinoma

(2018) Ankit Kumar Patel et al.   Oncogenesis

Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism

(2017) Ling Lin et al.   HEPATOLOGY

Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways

(2017) Jessica Brandi et al.   Journal of Proteomics

Epigenetics in cancer stem cells

(2017) Tan Boon Toh et al.   Molecular Cancer

Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

(2017) Jianwei Liao et al.   Molecular Cancer

Endothelial cells activate the cancer stem cell-associated NANOGP8 pathway in colorectal cancer cells in a paracrine fashion

(2017) Rui Wang et al.   Molecular Oncology

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

(2017) Elodie M Kuntz et al.   NATURE MEDICINE

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model

(2017) Shunsuke Shibao et al.   NEURO-ONCOLOGY

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophilalarvae synthesize the putative oncometabolite L-2-hydroxyglutarate during normal developmental growth

(2017) Hongde Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic reprogramming of carcinoma-associated fibroblasts and its impact on metabolic heterogeneity of tumors

(2017) Duojiao Wu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development

(2017) Lindsay Wilde et al.   SEMINARS IN ONCOLOGY

The Short-Chain Fatty Acid Propionate Inhibits Adipogenic Differentiation of Human Chorion-Derived Mesenchymal Stem Cells Through the Free Fatty Acid Receptor 2

(2017) Judit Iván et al.   STEM CELLS AND DEVELOPMENT

Cytoprotective effect of neuropeptides on cancer stem cells: vasoactive intestinal peptide-induced antiapoptotic signaling

(2017) Konduru S Sastry et al.   Cell Death & Disease

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

(2017) Weinan Du et al.   Nature Communications

Metabolomic mapping of cancer stem cells for reducing and exploiting tumor heterogeneity

(2017) Elisabet Cuyàs et al.   Oncotarget

Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia

(2017) Xiaodong Zhang et al.   eLife

Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment

(2017) Pedro M. Aponte et al.   Stem Cells International

The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand

(2017) Tamir Epstein et al.   PLoS One

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis

(2016) J. A. Menard et al.   CANCER RESEARCH

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

(2016) Gerard E. Kaiko et al.   CELL

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

(2016) Haobin Ye et al.   Cell Stem Cell

Cancer stem cells

(2016) Jeremy N. Rich   MEDICINE

AMPK Phosphorylates Desnutrin/ATGL and Hormone-Sensitive Lipase To Regulate Lipolysis and Fatty Acid Oxidation within Adipose Tissue

(2016) Sun-Joong Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Cancer stem cell metabolism: a potential target for cancer therapy

(2016) Abhijeet Deshmukh et al.   Molecular Cancer

Dedifferentiation of Glioma Cells to Glioma Stem-like Cells By Therapeutic Stress-induced HIF Signaling in the Recurrent GBM Model

(2016) Gina Lee et al.   MOLECULAR CANCER THERAPEUTICS

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

(2016) Edoardo Gaude et al.   Nature Communications

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-Myc in prostate cancer

(2016) Xiangyan Li et al.   Oncotarget

The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing

(2016) Nils Degrauwe et al.   Cell Reports

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells

(2016) Yuki Yasumoto et al.   PLoS One

Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila

(2015) Andrew P. Bailey et al.   CELL

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells

(2015) ZhengMing Wu et al.   Cell Stem Cell

The metabolic state of cancer stem cells—a valid target for cancer therapy?

(2015) Erina Vlashi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of AMP-activated protein kinase in metabolic depression in animals

(2015) Mark H. Rider   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPα Facilitate Apoptotic Cell Clearance by Macrophages

(2015) Zhiyuan Lv et al.   JOURNAL OF IMMUNOLOGY

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia-inducible factors in cancer stem cells and inflammation

(2015) Gong Peng et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

HIF2 -Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma

(2015) B. Qiu et al.   Cancer Discovery

Metabolic activation of mitochondria in glioma stem cells promotes cancer development through a reactive oxygen species-mediated mechanism

(2015) Shuqiang Yuan et al.   Stem Cell Research & Therapy

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation

(2015) Anna Pastò et al.   Oncotarget

Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells

(2014) K S R Sastry et al.   CELL DEATH AND DIFFERENTIATION

The Cytosolic Bacterial Peptidoglycan Sensor Nod2 Affords Stem Cell Protection and Links Microbes to Gut Epithelial Regeneration

(2014) Giulia Nigro et al.   Cell Host & Microbe

Targeting the Metabolic Plasticity of Multiple Myeloma with FDA-Approved Ritonavir and Metformin

(2014) S. Dalva-Aydemir et al.   CLINICAL CANCER RESEARCH

Commensal bacteria drive endogenous transformation and tumour stem cell marker expression through a bystander effect

(2014) Xingmin Wang et al.   GUT

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

(2014) Haihui Lu et al.   NATURE CELL BIOLOGY

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Lipid Droplets: A New Player in Colorectal Cancer Stem Cells Unveiled by Spectroscopic Imaging

(2014) Luca Tirinato et al.   STEM CELLS

Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling

(2014) Wan-Jiun Chen et al.   Nature Communications

Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting

(2014) Florian Wilfling et al.   eLife

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

(2014) Alexander A Shestov et al.   eLife

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

Cancer metabolism, stemness and tumor recurrence

(2013) Joseph M. Curry et al.   CELL CYCLE

Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway

(2013) P-P Liu et al.   CELL DEATH AND DIFFERENTIATION

Symbiotic lactobacilli stimulate gut epithelial proliferationviaNox-mediated generation of reactive oxygen species

(2013) Rheinallt M Jones et al.   EMBO JOURNAL

Host–microbiota interaction and intestinal stem cells in chronic inflammation and colorectal cancer

(2013) Shirin Moossavi et al.   Expert Review of Clinical Immunology

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species

(2013) Jin Zhou et al.   TOXICOLOGY LETTERS

Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

(2012) Wen Cai Zhang et al.   CELL

Metabolic reprogramming and two-compartment tumor metabolism

(2012) Barbara Chiavarina et al.   CELL CYCLE

Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk

(2012) Elaine Holmes et al.   Cell Metabolism

HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition

(2012) Wenyu Zhou et al.   EMBO JOURNAL

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

(2012) S. J. Conley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination of salinomycin and gemcitabine eliminates pancreatic cancer cells

(2011) Guan-Nan Zhang et al.   CANCER LETTERS

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

(2011) Clifford D.L. Folmes et al.   Cell Metabolism

Unsaturated fatty acids induce mesenchymal stem cells to increase secretion of angiogenic mediators

(2011) Andria N. Smith et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Breast cancer stem cells, cytokine networks, and the tumor microenvironment

(2011) Hasan Korkaya et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models

(2011) J.-H. Cheong et al.   MOLECULAR CANCER THERAPEUTICS

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reciprocal Activation of Prostate Cancer Cells and Cancer-Associated Fibroblasts Stimulates Epithelial-Mesenchymal Transition and Cancer Stemness

(2010) E. Giannoni et al.   CANCER RESEARCH

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Acidic stress promotes a glioma stem cell phenotype

(2010) A B Hjelmeland et al.   CELL DEATH AND DIFFERENTIATION

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Cancer stem cells: Back to Darwin?

(2010) Mel Greaves   SEMINARS IN CANCER BIOLOGY

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Regulation of AMP-activated protein kinase by cAMP in adipocytes: Roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis

(2009) Bilal Omar et al.   CELLULAR SIGNALLING

PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis

(2009) Nabil Djouder et al.   EMBO JOURNAL

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Mechanisms of Asymmetric Stem Cell Division

(2008) Juergen A. Knoblich   CELL

CD44 and EpCAM: Cancer-Initiating Cell Markers

(2008) Rachid Marhaba et al.   CURRENT MOLECULAR MEDICINE

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL