The Metabolic Heterogeneity and Flexibility of Cancer Stem Cells

Amino acids in cancer

(2020) Elizabeth L. Lieu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Targeting glutamine metabolism slows soft tissue sarcoma growth

(2020) Pearl Lee et al.   Nature Communications

Mechanisms of Multidrug Resistance in Cancer Chemotherapy

(2020) Karol Bukowski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria Targeting as an Effective Strategy for Cancer Therapy

(2020) Poorva Ghosh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FoxM1-dependent and fatty acid oxidation-mediated ROS modulation is a cell-intrinsic drug resistance mechanism in cancer stem-like cells

(2020) Hae-Ji Choi et al.   Redox Biology

Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment

(2020) Joe T. Sharick et al.   Frontiers in Oncology

Reciprocal Regulation Between Indoleamine 2,3-Dioxigenase 1 and Notch1 Involved in Radiation Response of Cervical Cancer Stem Cells

(2020) Hui-Ying Low et al.   Cancers

Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer

(2020) Jason R Brown et al.   JCI Insight

Cancer Stem Cells: The Architects of the Tumor Ecosystem

(2019) Briana C. Prager et al.   Cell Stem Cell

Critical role of AMPK in redox regulation under glucose starvation

(2019) Yi Ren et al.   Redox Biology

Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells

(2019) Petra Jagust et al.   Frontiers in Pharmacology

Nrf2 promotes breast cancer cell migration via up-regulation of G6PD/HIF-1α/Notch1 axis

(2019) Hong-Sheng Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inferring cancer dependencies on metabolic genes from large-scale genetic screens

(2019) Shoval Lagziel et al.   BMC BIOLOGY

Exploiting DNA Replication Stress for Cancer Treatment

(2019) Tajinder Ubhi et al.   CANCER RESEARCH

Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism

(2019) Karin Ortmayr et al.   Nature Communications

A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment

(2019) Silvia Cruz-Gil et al.   PLoS One

Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial–mesenchymal transition

(2019) Caihua Wang et al.   Stem Cell Research & Therapy

Elucidating the Reprograming of Colorectal Cancer Metabolism Using Genome-Scale Metabolic Modeling

(2019) Cheng Zhang et al.   Frontiers in Oncology

The Role of the Extracellular Matrix in Cancer Stemness

(2019) Sameera Nallanthighal et al.   Frontiers in Cell and Developmental Biology

Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

(2019) Michal Harel et al.   CELL

Dodecyl-TPP Targets Mitochondria and Potently Eradicates Cancer Stem Cells (CSCs): Synergy With FDA-Approved Drugs and Natural Compounds (Vitamin C and Berberine)

(2019) Ernestina Marianna De Francesco et al.   Frontiers in Oncology

KRAS-Driven Metabolic Rewiring Reveals Novel Actionable Targets in Cancer

(2019) Emanuela Pupo et al.   Frontiers in Oncology

Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization

(2019) Christiaan F. Labuschagne et al.   Cell Metabolism

Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer

(2019) Debasmita Bhattacharya et al.   Frontiers in Endocrinology

CPT1A/2-Mediated FAO Enhancement—A Metabolic Target in Radioresistant Breast Cancer

(2019) Shujun Han et al.   Frontiers in Oncology

New aspects of amino acid metabolism in cancer

(2019) Lisa Vettore et al.   BRITISH JOURNAL OF CANCER

Reprogramming of fatty acid metabolism in cancer

(2019) Nikos Koundouros et al.   BRITISH JOURNAL OF CANCER

Combined Metabolomics and Genome-Wide Transcriptomics Analyses Show Multiple HIF1α-Induced Changes in Lipid Metabolism in Early Stage Clear Cell Renal Cell Carcinoma

(2019) Johannes C. van der Mijn et al.   Translational Oncology

Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner

(2019) Reika Shiratori et al.   Scientific Reports

A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses

(2019) Irina A. Okkelman et al.   Redox Biology

Ketogenic diet in cancer therapy

(2018) Daniela D. Weber et al.   Aging-US

Cancer stem cells (CSCs): metabolic strategies for their identification and eradication

(2018) Ernestina M. De Francesco et al.   BIOCHEMICAL JOURNAL

The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma

(2018) Milica Momcilovic et al.   CANCER CELL

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

(2018) Tina Cascone et al.   Cell Metabolism

Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis

(2018) Pengcheng Bu et al.   Cell Metabolism

Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling

(2018) Ming Luo et al.   Cell Metabolism

Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4a inactivation

(2018) Xiangrui Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways

(2018) Yan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation

(2018) Xiao-xue Li et al.   MOLECULAR CELL

ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells

(2018) Ching-Wen Chang et al.   Cell Death & Disease

PGC1α: Friend or Foe in Cancer?

(2018) Francesca Mastropasqua et al.   Genes

Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy

(2018) Soumaya Kouidhi et al.   Frontiers in Immunology

Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect

(2018) Donika Ivanova et al.   Redox Biology

Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States

(2018) Dongya Jia et al.   Cells

Cancer Stem Cell Metabolism and Potential Therapeutic Targets

(2018) Vusala Snyder et al.   Frontiers in Oncology

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

(2018) William J. Sullivan et al.   CELL

Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies

(2018) Alexander Muir et al.   Disease Models & Mechanisms

Recent developments in topoisomerase targeted cancer chemotherapy

(2018) KirkE. Hevener et al.   Acta Pharmaceutica Sinica B

Novel application of metformin combined with targeted drugs on anticancer treatment

(2018) Jun Deng et al.   CANCER SCIENCE

Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice

(2018) Gunnar Boysen et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Probing carbohydrate metabolism using hyperpolarized 13 C-labeled molecules

(2018) Jaspal Singh et al.   NMR IN BIOMEDICINE

Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

(2018) Michael A. Reid et al.   Nature Communications

Regulators of Oncogenic Mutant TP53 Gain of Function

(2018) Satomi Yamamoto et al.   Cancers

Intermittent calorie restriction enhances epithelial-mesenchymal transition through the alteration of energy metabolism in a mouse tumor model

(2017) Osamu Kusuoka et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

ROS-modulated therapeutic approaches in cancer treatment

(2017) Muhammad Hassan Raza et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells

(2017) Kai Liu et al.   MOLECULAR CELL

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia

(2017) F Peng et al.   ONCOGENE

Reprogramming of the Tumor in the Hypoxic Niche: The Emerging Concept and Associated Therapeutic Strategies

(2017) Guan-Zhong Qiu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress

(2017) Nam Hee Kim et al.   Nature Communications

Novel strategies to prevent the development of multidrug resistance (MDR) in cancer

(2017) Jinglu Wang et al.   Oncotarget

Changes in metabolism affect expression of ABC transporters through ERK5 and depending on p53 status

(2017) Sana Belkahla et al.   Oncotarget

NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting “stemness”

(2017) Gloria Bonuccelli et al.   Oncotarget

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)

(2017) Ernestina Marianna De Francesco et al.   Oncotarget

Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133

(2017) Wonhee Hur et al.   Scientific Reports

Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity

(2017) Takashi Matsumoto et al.   Oncogenesis

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation

(2017) Peiguo Shi et al.   Cell Discovery

Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells

(2017) Xiaoran Li et al.   Scientific Reports

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Ablation of CD44 induces glycolysis-to-oxidative phosphorylation transition via modulation of the c-Src-Akt-LKB1-AMPK  pathway

(2016) K. Nam et al.   BIOCHEMICAL JOURNAL

Hallmarks of cancer stem cell metabolism

(2016) Patricia Sancho et al.   BRITISH JOURNAL OF CANCER

mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells

(2016) Raju V. Pusapati et al.   CANCER CELL

Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis

(2016) Camille Lehuédé et al.   CANCER RESEARCH

Cellular Metabolism and Induced Pluripotency

(2016) Jun Wu et al.   CELL

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer

(2016) Le Zhang et al.   CELL CYCLE

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism

(2016) Chia-Lin Chen et al.   Cell Metabolism

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

(2016) Haobin Ye et al.   Cell Stem Cell

Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

(2016) Gregg L Semenza   EMBO JOURNAL

The Role of PGC1  in Cancer Metabolism and its Therapeutic Implications

(2016) Z. Tan et al.   MOLECULAR CANCER THERAPEUTICS

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance

(2016) In-geun Ryoo et al.   Oxidative Medicine and Cellular Longevity

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

(2016) Amira Elgogary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism

(2016) Samuel N. Rodman et al.   RADIATION RESEARCH

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

(2016) Edoardo Gaude et al.   Nature Communications

NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming

(2016) Kate E. Hawkins et al.   Cell Reports

Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells

(2016) Genki Tanaka et al.   Cancer Medicine

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Cancer Stem Cells in Small Cell Lung Cancer Cell Line H446: Higher Dependency on Oxidative Phosphorylation and Mitochondrial Substrate-Level Phosphorylation than Non-Stem Cancer Cells

(2016) Cuicui Gao et al.   PLoS One

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

The metabolic landscape of cancer stem cells

(2015) Ilaria Dando et al.   IUBMB LIFE

Cross-talk between ER and HER2 regulates c-MYC-mediated glutamine metabolism in aromatase inhibitor resistant breast cancer cells

(2015) Zhike Chen et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The c-Myc–LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer

(2015) Tian-Lin He et al.   MEDICAL ONCOLOGY

Metabolic targeting of oncogene MYC by selective activation of the proton-coupled monocarboxylate family of transporters

(2015) L Gan et al.   ONCOGENE

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling

(2015) Rebecca Lamb et al.   Oncotarget

Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy

(2015) Doudou Li et al.   Oncotarget

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease

(2015) Rebecca Lamb et al.   Oncotarget

High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant

(2015) Gillian Farnie et al.   Oncotarget

Expression of xCT and activity of system x c − are regulated by NRF2 in human breast cancer cells in response to oxidative stress

(2015) Eric Habib et al.   Redox Biology

Key Roles of Hyaluronan and Its CD44 Receptor in the Stemness and Survival of Cancer Stem Cells

(2015) Theerawut Chanmee et al.   Frontiers in Oncology

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation

(2015) Anna Pastò et al.   Oncotarget

Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

(2015) Aritro Nath et al.   Scientific Reports

Metabolic differences in breast cancer stem cells and differentiated progeny

(2014) Erina Vlashi et al.   BREAST CANCER RESEARCH AND TREATMENT

Bioenergetic properties of human sarcoma cells help define sensitivity to metabolic inhibitors

(2014) Sameer H Issaq et al.   CELL CYCLE

Metabolic reprogramming orchestrates cancer stem cell properties in nasopharyngeal carcinoma

(2014) Yao-An Shen et al.   CELL CYCLE

Ovarian tumor-initiating cells display a flexible metabolism

(2014) Angela S. Anderson et al.   EXPERIMENTAL CELL RESEARCH

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Metabolic requirements for the maintenance of self-renewing stem cells

(2014) Keisuke Ito et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism

(2014) Jianqun Liao et al.   PLoS One

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Caloric restriction and cancer: molecular mechanisms and clinical implications

(2014) Ophélie Meynet et al.   TRENDS IN MOLECULAR MEDICINE

Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment

(2014) D Ciavardelli et al.   Cell Death & Disease

Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling

(2014) Wan-Jiun Chen et al.   Nature Communications

Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth

(2014) Lei Wang et al.   Cell Reports

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

(2013) David B. Shackelford et al.   CANCER CELL

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

(2013) Chenfang Dong et al.   CANCER CELL

Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis

(2013) J. R. Doherty et al.   CANCER RESEARCH

Adipocytes Cause Leukemia Cell Resistance to L-Asparaginase via Release of Glutamine

(2013) E. A. Ehsanipour et al.   CANCER RESEARCH

Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism

(2013) Ng Shyh-Chang et al.   CELL

Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway

(2013) P-P Liu et al.   CELL DEATH AND DIFFERENTIATION

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

CD44 Is Associated with the Aggressive Phenotype of Nasopharyngeal Carcinoma through Redox Regulation

(2013) Chien-Hung Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

(2013) J. Fan et al.   Molecular Systems Biology

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Omega-3 Eicosapentaenoic Acid Decreases CD133 Colon Cancer Stem-Like Cell Marker Expression While Increasing Sensitivity to Chemotherapy

(2013) Flavia De Carlo et al.   PLoS One

Tumour-associated mutant p53 drives the Warburg effect

(2013) Cen Zhang et al.   Nature Communications

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

c-Myc and Cancer Metabolism

(2012) D. M. Miller et al.   CLINICAL CANCER RESEARCH

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

Metformin targets ovarian cancer stem cells in vitro and in vivo

(2012) Jessica J. Shank et al.   GYNECOLOGIC ONCOLOGY

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity

(2012) A Arlt et al.   ONCOGENE

c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells

(2012) KEITARO HAYASHI et al.   ONCOLOGY REPORTS

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

 12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice

(2011) S. Hegde et al.   BLOOD

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2

(2011) T. Contractor et al.   CANCER RESEARCH

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types

(2011) D. Iliopoulos et al.   CANCER RESEARCH

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

(2011) Clifford D.L. Folmes et al.   Cell Metabolism

Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells

(2011) Yunfei Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

D-galactose induces necroptotic cell death in neuroblastoma cell lines

(2011) Na Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regulation of reactive oxygen species in stem cells and cancer stem cells

(2011) Chiharu I. Kobayashi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models

(2011) J.-H. Cheong et al.   MOLECULAR CANCER THERAPEUTICS

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts

(2011) Sandra Varum et al.   PLoS One

Glycolysis Inhibition Inactivates ABC Transporters to Restore Drug Sensitivity in Malignant Cells

(2011) Ayako Nakano et al.   PLoS One

Hypoxia inducible factors in cancer stem cells

(2010) J M Heddleston et al.   BRITISH JOURNAL OF CANCER

Heterogeneity of Mitochondrial Membrane Potential: A Novel Tool to Isolate and Identify Cancer Stem Cells from a Tumor Mass?

(2010) Xiao-Qun Ye et al.   Stem Cell Reviews and Reports

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

(2009) Ismael Samudio et al.   JOURNAL OF CLINICAL INVESTIGATION

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE