Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

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A gene–environment-induced epigenetic program initiates tumorigenesis

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Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

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Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

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Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

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Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

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GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

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Lineage tracing meets single-cell omics: opportunities and challenges

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Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche

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HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

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Cumulus provides cloud-based data analysis for large-scale single-cell and single-nucleus RNA-seq

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Intraductal transplantation models of human pancreatic ductal adenocarcinoma reveal progressive transition of molecular subtypes

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Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies

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Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

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Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

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Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases

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Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

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Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer

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An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

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Single-Cell RNA Sequencing in Cancer: Lessons Learned and Emerging Challenges

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Resolving medulloblastoma cellular architecture by single-cell genomics

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Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

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A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity

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Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma

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Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing

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Linking transcriptional and genetic tumor heterogeneity through allele analysis of single-cell RNA-seq data

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Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine

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Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

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Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

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Single Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression

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TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma

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Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors

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Roles of Wnt Target Genes in the Journey of Cancer Stem Cells

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Toil enables reproducible, open source, big biomedical data analyses

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Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

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Genomic analyses identify molecular subtypes of pancreatic cancer

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Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

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Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs

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Pericyte–fibroblast transition promotes tumor growth and metastasis

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Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

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Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms

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