Emerging role of lipid metabolism alterations in Cancer stem cells

Lipid metabolism and lipophagy in cancer

(2018) Meenu Maan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance

(2018) Tianyi Wang et al.   Cell Metabolism

Targeting Cancer Stem Cells for Chemoprevention of Pancreatic Cancer

(2018) Dharmalingam Subramaniam et al.   CURRENT MEDICINAL CHEMISTRY

Autophagy in stem cells: repair, remodelling and metabolic reprogramming

(2018) Patricia Boya et al.   DEVELOPMENT

Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non‐small cell lung cancer

(2018) Azhar Ali et al.   EMBO Molecular Medicine

The effect of FASN inhibition on the growth and metabolism of a cisplatin-resistant ovarian carcinoma model

(2018) Efthymia Papaevangelou et al.   INTERNATIONAL JOURNAL OF CANCER

Pyruvate kinase M2 interacts with nuclear sterol regulatory element–binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma

(2018) Xiaoping Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ajuba family protein Wtip regulates actomyosin contractility during vertebrate neural tube closure

(2018) Chih-Wen Chu et al.   JOURNAL OF CELL SCIENCE

Abberent expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma

(2018) Shengnan Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Rediscovery of NF-κB signaling in nasopharyngeal carcinoma: How genetic defects of NF-κB pathway interplay with EBV in driving oncogenesis?

(2018) Mei Yi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

In vitro and in vivo antitumor activities of T-3764518, a novel and orally available small molecule stearoyl-CoA desaturase 1 inhibitor

(2017) Satoru Nishizawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nrf2: a potential therapeutic target for naturally occurring anticancer drugs?

(2017) Elena Catanzaro et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6

(2017) Keane K.Y. Lai et al.   GASTROENTEROLOGY

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade

(2017) Hui-wen Lue et al.   GENES & DEVELOPMENT

Chronic inflammation-elicited liver progenitor cell conversion to liver cancer stem cell with clinical significance

(2017) Xiao-Feng Li et al.   HEPATOLOGY

Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism

(2017) Ling Lin et al.   HEPATOLOGY

Cancer Stem Cell–Related Marker NANOG Expression in Ovarian Serous Tumors

(2017) Nataša Kenda Šuster et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Lipid Storage and Autophagy in Melanoma Cancer Cells

(2017) Claudia Giampietri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cancer Cell Plasticity: Rapid Reversal of Chemosensitivity and Expression of Stemness Markers in Lung and Breast Cancer Tumorspheres

(2017) Juan Sebastian Yakisich et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NOR1 Suppresses Cancer Stem-Like Cells Properties of Tumor Cells via the Inhibition of the AKT-GSK-3β-Wnt/β-catenin-ALDH1A1 Signal Circuit

(2017) Wei Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Isolation, identification, and characterization of cancer stem cells: A review

(2017) Mohammad Reza Abbaszadegan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epithelial-mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

(2017) Tong Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer

(2017) Jiahui Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronectin on suspended lung cancer cells independently of apoptosis and suppresses metastasis

(2017) Ying-Jan Wang et al.   Journal of Hematology & Oncology

Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

(2017) Go J. Yoshida   Journal of Hematology & Oncology

Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation

(2017) Mark Kin Fai Ma et al.   JOURNAL OF HEPATOLOGY

Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways

(2017) Jessica Brandi et al.   Journal of Proteomics

Vimentin is a crucial target for anti-metastasis therapy of nasopharyngeal carcinoma

(2017) Wei Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

RNF20 Suppresses Tumorigenesis by Inhibiting the SREBP1c-PTTG1 Axis in Kidney Cancer

(2017) Jae Ho Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells

(2017) Catharina Melzer et al.   Molecular Cancer

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

(2017) Trang Thi Mai et al.   Nature Chemistry

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

(2017) Hitoshi Shimano et al.   Nature Reviews Endocrinology

Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia

(2017) F Peng et al.   ONCOGENE

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

(2017) A Noto et al.   ONCOGENE

Fatty Acids Induce Stemness in the Stromal Cells of a CT26 Mouse Tumor Model

(2017) Isao Kawahara et al.   PATHOBIOLOGY

Metabolic activity induces membrane phase separation in endoplasmic reticulum

(2017) Yihui Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling

(2017) Vincent J. Guen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation

(2017) Heather J. Wright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NANOG as an adverse predictive marker in advanced non–small cell lung cancer treated with platinum-based chemotherapy

(2017) Boksoon Chang et al.   OncoTargets and Therapy

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

(2017) Weinan Du et al.   Nature Communications

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

(2017) Thomas Farge et al.   Cancer Discovery

Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade

(2017) Thomas W. Flaig et al.   Oncotarget

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity

(2017) Marlen Knobloch et al.   Cell Reports

Exploring the inhibitory effect of membrane tension on cell polarization

(2017) Weikang Wang et al.   PLoS Computational Biology

The NOR1/OSCP1 proteins in cancer: from epigenetic silencing to functional characterization of a novel tumor suppressor

(2017) Mei Yi et al.   Journal of Cancer

An Overview of Lipid Droplets in Cancer and Cancer Stem Cells

(2017) L. Tirinato et al.   Stem Cells International

Metabolic Plasticity of Stem Cells and Macrophages in Cancer

(2017) Jelena Krstic et al.   Frontiers in Immunology

Fatty Acid Oxidation Compensates for Lipopolysaccharide-Induced Warburg Effect in Glucose-Deprived Monocytes

(2017) Nora Raulien et al.   Frontiers in Immunology

Cancer Stem Cells in Oral Cavity Squamous Cell Carcinoma: A Review

(2017) Ranui Baillie et al.   Frontiers in Oncology

Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway

(2017) Chiara Cilibrasi et al.   PLoS One

N − 3PUFA differentially modulate palmitate-induced lipotoxicity through alterations of its metabolism in C2C12 muscle cells

(2016) Alexandre Pinel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Stearoyl-CoA desaturase 1 deficiency reduces lipid accumulation in the heart by activating lipolysis independently of peroxisome proliferator-activated receptor α

(2016) Tomasz Bednarski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in breast cancer prevention

(2016) Justin A. Colacino et al.   BREAST CANCER RESEARCH AND TREATMENT

Candidate Antimetastasis Drugs Suppress the Metastatic Capacity of Breast Cancer Cells by Reducing Membrane Fluidity

(2016) Weina Zhao et al.   CANCER RESEARCH

Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis

(2016) J. A. Menard et al.   CANCER RESEARCH

The cancer stem-cell signaling network and resistance to therapy

(2016) A. Carnero et al.   CANCER TREATMENT REVIEWS

The phosphorylation-dependent regulation of nuclear SREBP1 during mitosis links lipid metabolism and cell growth

(2016) Maria Teresa Bengoechea-Alonso et al.   CELL CYCLE

NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism

(2016) Chia-Lin Chen et al.   Cell Metabolism

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Burning Fat Fuels Leukemic Stem Cell Heterogeneity

(2016) Daniel Thomas et al.   Cell Stem Cell

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

(2016) Haobin Ye et al.   Cell Stem Cell

Lipid desaturation - the next step in targeting lipogenesis in cancer?

(2016) Barrie Peck et al.   FEBS Journal

Hormetic shifting of redox environment by pro-oxidative resveratrol protects cells against stress

(2016) Annabell Plauth et al.   FREE RADICAL BIOLOGY AND MEDICINE

MicroRNA-200c delivered by solid lipid nanoparticles enhances the effect of paclitaxel on breast cancer stem cell

(2016) Jingwen Liu et al.   International Journal of Nanomedicine

Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma

(2016) Huabo Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interaction between Cancer Stem Cell Marker CD133 and Src Protein Promotes Focal Adhesion Kinase (FAK) Phosphorylation and Cell Migration

(2016) Chanjuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Modification in Gastrointestinal Cancer Stem Cells: Characteristics and Therapeutic Approaches

(2016) Angela Maria Di Francesco et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered

(2016) William B. Kinlaw et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting autophagy to sensitive glioma to temozolomide treatment

(2016) Yuanliang Yan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The role of fatty acid β-oxidation in lymphangiogenesis

(2016) Brian W. Wong et al.   NATURE

The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila

(2016) Shree Ram Singh et al.   NATURE

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

(2016) Roman Camarda et al.   NATURE MEDICINE

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance

(2016) K. Ito et al.   SCIENCE

Carnitine palmitoyl transferase-1A (CPT1A): a new tumor specific target in human breast cancer

(2016) Sabina Pucci et al.   Oncotarget

Redox Regulation of Stem-like Cells Though the CD44v-xCT Axis in Colorectal Cancer: Mechanisms and Therapeutic Implications

(2016) Huai-Qiang Ju et al.   Theranostics

Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions

(2016) Hui Zhang et al.   Cell Reports

Inborn Errors of Long-Chain Fatty Acid β-Oxidation Link Neural Stem Cell Self-Renewal to Autism

(2016) Zhigang Xie et al.   Cell Reports

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

Betulinic Acid Kills Colon Cancer Stem Cells

(2016) Lisette Potze et al.   Current Stem Cell Research & Therapy

Tackling Cancer Stem Cells via Inhibition of EMT Transcription Factors

(2016) Megan Mladinich et al.   Stem Cells International

High Expression of CPT1A Predicts Adverse Outcomes: A Potential Therapeutic Target for Acute Myeloid Leukemia

(2016) Jinlong Shi et al.   EBioMedicine

Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells

(2016) Yuki Yasumoto et al.   PLoS One

Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis

(2016) Ling Chen et al.   Scientific Reports

Impact of MYC in regulation of tumor cell metabolism

(2015) Therese Wahlström et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias

(2015) M. R. Ricciardi et al.   BLOOD

17β-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells

(2015) Anissa Belkaid et al.   BMC CANCER

Stearoyl-CoA desaturase 1 and paracrine diffusible signals have a major role in the promotion of breast cancer cell migration induced by cancer-associated fibroblasts

(2015) C Angelucci et al.   BRITISH JOURNAL OF CANCER

SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway

(2015) Guang-Ming Huang et al.   CANCER LETTERS

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

(2015) E. A. Lee et al.   CANCER RESEARCH

Therapeutic strategies targeting cancer stem cells

(2015) Go J. Yoshida et al.   CANCER SCIENCE

Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila

(2015) Andrew P. Bailey et al.   CELL

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Chronic Oxidative Stress Leads to Malignant Transformation Along With Acquisition of Stem Cell Characteristics, and Epithelial to Mesenchymal Transition in Human Renal Epithelial Cells

(2015) Prathap Kumar S. Mahalingaiah et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

(2015) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic β-cells

(2015) Justyna Janikiewicz et al.   JOURNAL OF LIPID RESEARCH

Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine

(2015) Ming-Chen Yang et al.   Molecular Cancer

SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme

(2015) C A Lewis et al.   ONCOGENE

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

(2015) S J H Ricoult et al.   ONCOGENE

Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells

(2015) Stefano Bartesaghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SREBP1 regulates tumorigenesis and prognosis of pancreatic cancer through targeting lipid metabolism

(2015) Yan Sun et al.   TUMOR BIOLOGY

Metabolic stress induces a Wnt-dependent cancer stem cell-like state transition

(2015) E Lee et al.   Cell Death & Disease

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer

(2015) Huanjie Shao et al.   Oncotarget

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation

(2015) Anna Pastò et al.   Oncotarget

Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells

(2015) Bruna Corominas-Faja et al.   Oncotarget

Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity

(2014) Peng Sun et al.   BMC CANCER

Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: Improving the safety of iPS cell transplantation to myocardium

(2014) Lan Zhang et al.   CELL CYCLE

Mitochondrial metabolism directs stemness and differentiation in P19 embryonal carcinoma stem cells

(2014) I Vega-Naredo et al.   CELL DEATH AND DIFFERENTIATION

Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth

(2014) Alexander Pietras et al.   Cell Stem Cell

Stearoyl-CoA Desaturase 1 Activity Is Required for Autophagosome Formation

(2014) Yuta Ogasawara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty Acid Composition of Tissue Cultured Breast Carcinoma and the Effect of Stearoyl-CoA Desaturase 1 Inhibition

(2014) Fatemeh Mohammadzadeh et al.   Journal of Breast Cancer

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

(2014) I. R. Schlaepfer et al.   MOLECULAR CANCER THERAPEUTICS

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

Metabolic requirements for the maintenance of self-renewing stem cells

(2014) Keisuke Ito et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities

(2014) María Cristina Estañ et al.   PLoS One

Cancer Stem Cell-Specific Scavenger Receptor CD36 Drives Glioblastoma Progression

(2014) James S. Hale et al.   STEM CELLS

Lipid Droplets: A New Player in Colorectal Cancer Stem Cells Unveiled by Spectroscopic Imaging

(2014) Luca Tirinato et al.   STEM CELLS

Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance

(2013) Wen Yue et al.   Autophagy

Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation

(2013) Go J. Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The eradication of breast cancer cells and stem cells by 8-hydroxyquinoline-loaded hyaluronan modified mesoporous silica nanoparticle-supported lipid bilayers containing docetaxel

(2013) Dong Wang et al.   BIOMATERIALS

Heterogeneity of Neoplastic Stem Cells: Theoretical, Functional, and Clinical Implications

(2013) P. Valent et al.   CANCER RESEARCH

ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

(2013) E. Charafe-Jauffret et al.   CANCER RESEARCH

Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway

(2013) P-P Liu et al.   CELL DEATH AND DIFFERENTIATION

Lipid Metabolism Greases the Stem Cell Engine

(2013) Clifford D.L. Folmes et al.   Cell Metabolism

Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway

(2013) Ai-Mei Gao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

(2013) C. A. von Roemeling et al.   CLINICAL CANCER RESEARCH

Stem cell metabolism in tissue development and aging

(2013) N. Shyh-Chang et al.   DEVELOPMENT

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells

(2013) RISA SHIRAGAMI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma

(2013) Samiksha Bansal et al.   JOURNAL OF SURGICAL RESEARCH

Carnitine-Acyltransferase System Inhibition, Cancer Cell Death, and Prevention of Myc-Induced Lymphomagenesis

(2013) Annalisa Pacilli et al.   JNCI-Journal of the National Cancer Institute

Multistep Targeted Nano Drug Delivery System Aiming at Leukemic Stem Cells and Minimal Residual Disease

(2013) Yongping Shi et al.   MOLECULAR PHARMACEUTICS

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

SCD1 Expression Is Dispensable for Hepatocarcinogenesis Induced by AKT and Ras Oncogenes in Mice

(2013) Lei Li et al.   PLoS One

Very Long-Chain Acyl-CoA Synthetase 3: Overexpression and Growth Dependence in Lung Cancer

(2013) Zhengtong Pei et al.   PLoS One

Sirtuin-2 Activity is Required for Glioma Stem Cell Proliferation Arrest but not Necrosis Induced by Resveratrol

(2013) Salwa Sayd et al.   Stem Cell Reviews and Reports

Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells

(2013) A Noto et al.   Cell Death & Disease

Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts

(2013) Adam D Pfefferle et al.   GENOME BIOLOGY

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: Increased expression of a CD44 variant isoform after chemotherapy

(2012) Go J Yoshida et al.   BMC CANCER

The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells

(2012) Dongming Liang et al.   BMC CANCER

A distinct subpopulation within CD133 positive brain tumor cells shares characteristics with endothelial progenitor cells

(2012) Seung Ah Choi et al.   CANCER LETTERS

FGFR3 Stimulates Stearoyl CoA Desaturase 1 Activity to Promote Bladder Tumor Growth

(2012) X. Du et al.   CANCER RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Energy transfer in "parasitic" cancer metabolism

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis

(2012) Weihua Li et al.   CELL CYCLE

The critical role of mast cell-derived hypoxia-inducible factor-1α in human and mice melanoma growth

(2012) Hyun-Ja Jeong et al.   INTERNATIONAL JOURNAL OF CANCER

Identification of Glycoprotein Markers for Pancreatic Cancer CD24+CD44+ Stem-like Cells Using Nano-LC–MS/MS and Tissue Microarray

(2012) Jianhui Zhu et al.   JOURNAL OF PROTEOME RESEARCH

Scd1 Plays a Tumor-Suppressive Role in Survival of Leukemia Stem Cells and the Development of Chronic Myeloid Leukemia

(2012) H. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

(2012) Marlen Knobloch et al.   NATURE

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

NANOG modulates stemness in human colorectal cancer

(2012) J Zhang et al.   ONCOGENE

Elevated lipogenesis in epithelial stem-like cell confers survival advantage in ductal carcinoma in situ of breast cancer

(2012) P R Pandey et al.   ONCOGENE

Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells

(2012) C Gong et al.   ONCOGENE

SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids

(2012) Paul Mason et al.   PLoS One

Cell polarity: mechanochemical patterning

(2012) Nathan W. Goehring et al.   TRENDS IN CELL BIOLOGY

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

(2012) Toshifumi Yae et al.   Nature Communications

Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms

(2011) Francesca Nicolau-Galmés et al.   APOPTOSIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Unsaturated fatty acids induce mesenchymal stem cells to increase secretion of angiogenic mediators

(2011) Andria N. Smith et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase

(2010) Puspa R. Pandey et al.   BREAST CANCER RESEARCH AND TREATMENT

Hypoxia inducible factors in cancer stem cells

(2010) J M Heddleston et al.   BRITISH JOURNAL OF CANCER

Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized

(2010) Elsa Quintana et al.   CANCER CELL

TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma

(2010) Judit Anido et al.   CANCER CELL

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

(2010) Marie Zbinden et al.   EMBO JOURNAL

Rapamycin Regulates Stearoyl CoA Desaturase 1 Expression in Breast Cancer

(2010) D. Luyimbazi et al.   MOLECULAR CANCER THERAPEUTICS

Acyl-CoA Synthetase VL3 Knockdown Inhibits Human Glioma Cell Proliferation and Tumorigenicity

(2009) Z. Pei et al.   CANCER RESEARCH

A Phosphorylation Cascade Controls the Degradation of Active SREBP1

(2009) Maria T. Bengoechea-Alonso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

(2009) Ismael Samudio et al.   JOURNAL OF CLINICAL INVESTIGATION

The xc− cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance

(2008) M Lo et al.   BRITISH JOURNAL OF CANCER

Identification and Characterization of Ovarian Cancer-Initiating Cells from Primary Human Tumors

(2008) S. Zhang et al.   CANCER RESEARCH

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Efficient tumour formation by single human melanoma cells

(2008) Elsa Quintana et al.   NATURE

Small interfering RNA–mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema

(2008) Nicolai E Savaskan et al.   NATURE MEDICINE