The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow

Cytoplasmic Labile Iron Accumulates in Aging Stem Cells Perturbing a Key Rheostat for Identity Control

(2021) Yun-Ruei Kao et al.   BLOOD

Microbiota Metabolites in Health and Disease

(2020) Justin L. McCarville et al.   Annual Review of Immunology

Hematopoietic Stem Cell Metabolism during Development and Aging

(2020) Ayako Nakamura-Ishizu et al.   DEVELOPMENTAL CELL

Microbiota-derived metabolite promotes HDAC3 activity in the gut

(2020) Shu-en Wu et al.   NATURE

Nociceptive nerves regulate haematopoietic stem cell mobilization

(2020) Xin Gao et al.   NATURE

Haematopoietic stem cell activity and interactions with the niche

(2019) Sandra Pinho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Crosstalk between neutrophils and the microbiota

(2019) Dachuan Zhang et al.   BLOOD

Maea expressed by macrophages, but not erythroblasts, maintains postnatal murine bone marrow erythroblastic islands

(2019) Qiaozhi Wei et al.   BLOOD

Identification and transcriptome analysis of erythroblastic island macrophages

(2019) Wei Li et al.   BLOOD

Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation

(2019) Adam C. Wilkinson et al.   NATURE

Bone marrow CX3CR1+ mononuclear cells relay systemic microbiota signal to control hematopoietic progenitors in mice

(2019) Seungwon Lee et al.   BLOOD

Iron and leukemia: new insights for future treatments

(2019) Fang Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Anemia of Inflammation

(2019) Tomas Ganz   NEW ENGLAND JOURNAL OF MEDICINE

Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis

(2019) Nupur K. Das et al.   Cell Metabolism

Transferrin receptor 1-mediated iron uptake plays an essential role in hematopoiesis

(2019) Shufen Wang et al.   HAEMATOLOGICA

Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice

(2018) Anna Staffas et al.   Cell Host & Microbe

Lineage-Biased Hematopoietic Stem Cells Are Regulated by Distinct Niches

(2018) Sandra Pinho et al.   DEVELOPMENTAL CELL

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

(2018) Marlies Meisel et al.   NATURE

Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow

(2018) Chunliang Xu et al.   Nature Communications

Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism

(2018) Amir Zarrinpar et al.   Nature Communications

Iron and Cancer

(2018) Suzy V. Torti et al.   Annual Review of Nutrition

Thrombopoietin receptor–independent stimulation of hematopoietic stem cells by eltrombopag

(2018) Yun-Ruei Kao et al.   Science Translational Medicine

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

(2018) Zhigang Cai et al.   Cell Stem Cell

Iron overload in myelodysplastic syndromes (MDS)

(2017) Norbert Gattermann   INTERNATIONAL JOURNAL OF HEMATOLOGY

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis

(2017) Aurélie Hérault et al.   NATURE

Differential cytokine contributions of perivascular haematopoietic stem cell niches

(2017) Noboru Asada et al.   NATURE CELL BIOLOGY

Granulocyte-derived TNFα promotes vascular and hematopoietic regeneration in the bone marrow

(2017) Emily Bowers et al.   NATURE MEDICINE

HSC Niche Biology and HSC Expansion Ex Vivo

(2017) Sachin Kumar et al.   TRENDS IN MOLECULAR MEDICINE

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

(2017) Yoshiharu Muto et al.   Nature Communications

Hematopoietic Stem Cell Niche in Health and Disease

(2016) Jonathan Hoggatt et al.   Annual Review of Pathology-Mechanisms of Disease

Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis

(2016) Chiaki Iwamura et al.   BLOOD

Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota

(2016) Kamilla S. Josefsdottir et al.   BLOOD

CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages

(2016) Jin Hur et al.   Cell Stem Cell

Macrophages and Iron Metabolism

(2016) Miguel P. Soares et al.   IMMUNITY

Distinct bone marrow blood vessels differentially regulate haematopoiesis

(2016) Tomer Itkin et al.   NATURE

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

(2016) Igor Theurl et al.   NATURE MEDICINE

Tissue-Resident CD169 + Macrophages Form a Crucial Front Line against Plasmodium Infection

(2016) Pravesh Gupta et al.   Cell Reports

An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography–tandem mass spectrometry

(2015) Jun Han et al.   ANALYTICA CHIMICA ACTA

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

Macrophages and iron trafficking at the birth and death of red cells

(2015) T. Korolnek et al.   BLOOD

The hematopoietic stem cell niche in homeostasis and disease

(2015) L. M. Calvi et al.   BLOOD

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche

(2015) Yubin Luo et al.   Cell Metabolism

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

(2015) Eric M. Pietras et al.   Cell Stem Cell

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

ROS-mediated iron overload injures the hematopoiesis of bone marrow by damaging hematopoietic stem/progenitor cells in mice

(2015) Xiao Chai et al.   Scientific Reports

Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis

(2014) S. Boettcher et al.   BLOOD

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection

(2014) Arya Khosravi et al.   Cell Host & Microbe

Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis

(2014) Nina Cabezas-Wallscheid et al.   Cell Stem Cell

Microbiota-Derived Compounds Drive Steady-State Granulopoiesis via MyD88/TICAM Signaling

(2014) Maria L. Balmer et al.   JOURNAL OF IMMUNOLOGY

G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling

(2014) L G Schuettpelz et al.   LEUKEMIA

Haematopoietic stem cells require a highly regulated protein synthesis rate

(2014) Robert A. J. Signer et al.   NATURE

Identification of erythroferrone as an erythroid regulator of iron metabolism

(2014) Léon Kautz et al.   NATURE GENETICS

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice

(2014) Hitesh S Deshmukh et al.   NATURE MEDICINE

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

(2014) Ingmar Bruns et al.   NATURE MEDICINE

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Of macrophages and red blood cells; a complex love story

(2014) Djuna Z. de Back et al.   Frontiers in Physiology

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

PDGFRα and CD51 mark human Nestin+sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion

(2013) Sandra Pinho et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration

(2013) Daniel Lucas et al.   NATURE MEDICINE

CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress

(2013) Andrew Chow et al.   NATURE MEDICINE

Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation

(2012) M. Roth et al.   BLOOD

Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk

(2012) Elaine Holmes et al.   Cell Metabolism

Less Is More: Unveiling the Functional Core of Hematopoietic Stem Cells through Knockout Mice

(2012) Lara Rossi et al.   Cell Stem Cell

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow

(2012) Aya Ludin et al.   NATURE IMMUNOLOGY

Chronic IFN-  production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis

(2011) S. F. Libregts et al.   BLOOD

Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease

(2011) Seth M. Bloom et al.   Cell Host & Microbe

Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands

(2011) Chao Shi et al.   IMMUNITY

Coordinate regulation of neutrophil homeostasis by liver X receptors in mice

(2011) Cynthia Hong et al.   JOURNAL OF CLINICAL INVESTIGATION

Hemophagocytosis causes a consumptive anemia of inflammation

(2011) Erin E. Zoller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice

(2011) Matthew J. Christopher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Improvement of phylum- and class-specific primers for real-time PCR quantification of bacterial taxa

(2011) Tristano Bacchetti De Gregoris et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment

(2011) F. Notta et al.   SCIENCE

Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype

(2011) Gaetano Cairo et al.   TRENDS IN IMMUNOLOGY

Regulation of steady-state neutrophil homeostasis by macrophages

(2010) C. Gordy et al.   BLOOD

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

(2010) I. G. Winkler et al.   BLOOD

Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia

(2010) Celine Callens et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

(2009) Andrea T. Hooper et al.   Cell Stem Cell

Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis

(2009) D A Hill et al.   Mucosal Immunology

Human gut microbiome adopts an alternative state following small bowel transplantation

(2009) A. L. Hartman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erythroblastic islands: niches for erythropoiesis

(2008) J. A. Chasis et al.   BLOOD

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Development of a real-time PCR method forFirmicutesandBacteroidetesin faeces and its application to quantify intestinal population of obese and lean pigs

(2008) X. Guo et al.   LETTERS IN APPLIED MICROBIOLOGY

Macrophages function as a ferritin iron source for cultured human erythroid precursors

(2007) Moshe J. Leimberg et al.   JOURNAL OF CELLULAR BIOCHEMISTRY