Astroglial Connexin 43-Mediated Gap Junctions and Hemichannels: Potential Antidepressant Mechanisms and the Link to Neuroinflammation

Necroptotic kinases are involved in the reduction of depression-induced astrocytes and fluoxetine’s inhibitory effects on necroptotic kinases

(2023) Salman Zeb et al.   Frontiers in Pharmacology

Connexin 43: insights into candidate pathological mechanisms of depression and its implications in antidepressant therapy

(2022) Ning-ning Zhang et al.   ACTA PHARMACOLOGICA SINICA

Glutamatergic receptor and neuroplasticity in depression: Implications for ketamine and rapastinel as the rapid-acting antidepressants

(2022) Ya-Ting Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High S100B levels predict antidepressant response in patients with major depression even when considering inflammatory and metabolic markers

(2022) Ricard Navinés et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Impact of 5-HT7 receptor inverse agonism of lurasidone on monoaminergic tripartite synaptic transmission and pathophysiology of lower risk of weight gain

(2022) Kouji Fukuyama et al.   BIOMEDICINE & PHARMACOTHERAPY

Downregulation of connexin 43 potentiates amitriptyline-induced brain-derived neurotrophic factor expression in primary astrocytes through lysophosphatidic acid receptor1/3, Src, and extracellular signal-regulated kinase

(2022) Nozomi Tokunaga et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice

(2022) Rui Dong et al.   Journal of Neuroinflammation

A new perspective on depression and neuroinflammation: Non-coding RNA

(2022) Shanyao Zhou et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Interleukin-10 Attenuates Behavioral, Immune and Neurotrophin Changes Induced by Chronic Central Administration of Interleukin-1β in Rats

(2022) Yong-Ping Zhang et al.   NEUROIMMUNOMODULATION

Astroglia in the Vulnerability to and Maintenance of Stress-Mediated Neuropathology and Depression

(2022) José Javier Miguel-Hidalgo   Frontiers in Cellular Neuroscience

Sex-Specific Brain Transcriptional Signatures in Human MDD and Their Correlates in Mouse Models of Depression

(2022) Maureen Touchant et al.   Frontiers in Behavioral Neuroscience

Astrocyte Activation, but not Microglia, Is Associated with the Experimental Mouse Model of Schizophrenia Induced by Chronic Ketamine

(2022) Ying Wei et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Chronic Stress Impairs the Structure and Function of Astrocyte Networks in an Animal Model of Depression

(2022) Sydney Aten et al.   NEUROCHEMICAL RESEARCH

Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder

(2022) Reza Rahimian et al.   Frontiers in Psychiatry

Inhibition of connexin hemichannels alleviates neuroinflammation and hyperexcitability in temporal lobe epilepsy

(2022) Anni Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Antidepressant Mechanism of Ginsenoside Rg1 in Regulating the Dysfunction of the Glutamatergic System in Astrocytes

(2022) Ningning Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Is depression the missing link between inflammatory mediators and cancer?

(2022) Barbara Polityńska et al.   PHARMACOLOGY & THERAPEUTICS

Role of Astrocytes in Major Neuropsychiatric Disorders

(2021) Xiaolu Zhang et al.   NEUROCHEMICAL RESEARCH

Brain Disorders and Chemical Pollutants: A Gap Junction Link?

(2021) Marc Mesnil et al.   Biomolecules

Downregulation of connexin43 potentiates noradrenaline‐induced expression of brain‐derived neurotrophic factor in primary cultured cortical astrocytes

(2021) Norimitsu Morioka et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Satellite Glial Cells and Astrocytes, a Comparative Review

(2021) Menachem Hanani et al.   NEUROCHEMICAL RESEARCH

Connexins as therapeutic targets in neurological and neuropsychiatric disorders

(2021) M. Charvériat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Implication of cerebral astrocytes in major depression: A review of fine neuroanatomical evidence in humans

(2021) Liam Anuj O'Leary et al.   GLIA

Decreased connexin43 expression in the hippocampus is related to the antidepressant effect of amitriptyline in neuropathic pain mice

(2021) Norimitsu Morioka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The many ways astroglial connexins regulate neurotransmission and behavior

(2021) David Mazaud et al.   GLIA

Effects of Atypical Antipsychotics, Clozapine, Quetiapine and Brexpiprazole on Astroglial Transmission Associated with Connexin43

(2021) Kouji Fukuyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long‐term effects of stress resilience: Hippocampal neuroinflammation and behavioral approach in male rats

(2021) Iván D. Bravo‐Tobar et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Novel rapid-acting glutamatergic modulators: Targeting the synaptic plasticity in depression

(2021) Ya-Ting Wang et al.   PHARMACOLOGICAL RESEARCH

A synaptic locus for TrkB signaling underlying ketamine rapid antidepressant action

(2021) Pei-Yi Lin et al.   Cell Reports

Reduced Oligodendrocyte Precursor Cell Impairs Astrocytic Development in Early Life Stress

(2021) Yuxin Wang et al.   Advanced Science

Ketamine Alters Functional Plasticity of Astroglia: An Implication for Antidepressant Effect

(2021) Matjaž Stenovec   Life-Basel

Blood–Brain Barrier Dysfunction in the Pathogenesis of Major Depressive Disorder

(2021) Shusheng Wu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Korean red ginseng alleviate depressive disorder by improving astrocyte gap junction function

(2021) Qing-Lian Zheng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Connexin43 hemichannels contribute to working memory and excitatory synaptic transmission of pyramidal neurons in the prefrontal cortex of rats

(2021) Xiao-Dong Tao et al.   LIFE SCIENCES

Fluoxetine modulates the pro-inflammatory process of IL-6, IL-1β and TNF-α levels in individuals with depression: a systematic review and meta-analysis

(2021) María Lourdes García-García et al.   PSYCHIATRY RESEARCH

Cx43 carboxyl terminal domain determines AQP4 and Cx30 endfoot organization and blood brain barrier permeability

(2021) Antonio Cibelli et al.   Scientific Reports

Is the Exposome Involved in Brain Disorders through the Serotoninergic System?

(2021) Denis Sarrouilhe et al.   Biomedicines

Alterations of Astrocytes in the Context of Schizophrenic Dementia

(2020) Vadim V. Tarasov et al.   Frontiers in Pharmacology

The Role of BDNF on Neural Plasticity in Depression

(2020) Tao Yang et al.   Frontiers in Cellular Neuroscience

Connexin 43: A novel ginsenoside Rg1-sensitive target in a rat model of depression

(2020) Cong-Yuan Xia et al.   NEUROPHARMACOLOGY

Characterization of Vimentin-Immunoreactive Astrocytes in the Human Brain

(2020) Liam Anuj O’Leary et al.   Frontiers in Neuroanatomy

The Multifaceted Role of Astrocyte Connexin 43 in Ischemic Stroke Through Forming Hemichannels and Gap Junctions

(2020) Zhen Liang et al.   Frontiers in Neurology

Chronic optogenetic manipulation of basolateral amygdala astrocytes rescues stress-induced anxiety

(2020) Qian Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Working Hypothesis Regarding Identical Pathomechanisms between Clinical Efficacy and Adverse Reaction of Clozapine via the Activation of Connexin43

(2020) Motohiro Okada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astrocytes-induced neuronal inhibition contributes to depressive-like behaviors during chronic stress

(2020) Tianpao Hao et al.   LIFE SCIENCES

Microglia in depression: current perspectives

(2020) Xiaoning Jia et al.   Science China-Life Sciences

Synaptic Plasticity After Focal Cerebral Ischemia Was Attenuated by Gap26 but Enhanced by GAP-134

(2020) Kailing Yang et al.   Frontiers in Neurology

Increased serum peripheral C-reactive protein is associated with reduced brain barriers permeability of TSPO radioligands in healthy volunteers and depressed patients: implications for inflammation and depression

(2020) Federico E. Turkheimer et al.   BRAIN BEHAVIOR AND IMMUNITY

Astroglial Connexin43 as a Potential Target for a Mood Stabiliser

(2020) Motohiro Okada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pathophysiological implications of neuroinflammation mediated HPA axis dysregulation in the prognosis of cancer and depression

(2020) Mir Hilal Ahmad et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The gap junction inhibitor INI-0602 attenuates mechanical allodynia and depression-like behaviors induced by spared nerve injury in rats

(2019) Xiao-Min Zhang et al.   NEUROREPORT

Dysfunction of astrocytic connexins 30 and 43 in the medial prefrontal cortex and hippocampus mediates depressive-like behaviours

(2019) Dongming Huang et al.   BEHAVIOURAL BRAIN RESEARCH

NLRX1 Enhances Glutamate Uptake and Inhibits Glutamate Release by Astrocytes

(2019) Shaimaa Mahmoud et al.   Cells

Markers of central inflammation in major depressive disorder: A systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue

(2019) Daniela Enache et al.   BRAIN BEHAVIOR AND IMMUNITY

Expression and role of CaMKII and Cx43 in a rat model of post‑stroke depression

(2019) Shuiliang Tao et al.   Experimental and Therapeutic Medicine

Reduced Neuronal cAMP in the Nucleus Accumbens Damages Blood-Brain Barrier Integrity and Promotes Stress Vulnerability

(2019) Yue Zhang et al.   BIOLOGICAL PSYCHIATRY

Neurochemical regulation of the expression and function of glial fibrillary acidic protein in astrocytes

(2019) Dongyang Li et al.   GLIA

Corticosterone and progesterone differentially regulate HPA axis and neuroimmune responses to stress in male rats

(2019) Cara M. Hueston et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

The Opening of Connexin 43 Hemichannels Alters Hippocampal Astrocyte Function and Neuronal Survival in Prenatally LPS-Exposed Adult Offspring

(2019) Carolina E. Chávez et al.   Frontiers in Cellular Neuroscience

The protective effect of carbenoxolone on gap junction damage in the hippocampal CA1 area of a temporal lobe epilepsy rat model

(2019) Yi Shu et al.   Annals of Translational Medicine

Increasing doses of ketamine curtail antidepressant responses and suppress associated synaptic signaling pathways

(2019) Ji-Woon Kim et al.   BEHAVIOURAL BRAIN RESEARCH

Mifepristone attenuates depression-like changes induced by chronic central administration of interleukin-1β in rats

(2018) Yong-Ping Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability

(2018) Balázs Pál   CELLULAR AND MOLECULAR LIFE SCIENCES

A novel mechanism of depression: role for connexins

(2018) Cong-Yuan Xia et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease

(2018) Trond Aasen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Electroacupuncture Rescued the Impairment of Hippocampal Neurons in Perimenopausal Depression Rats via Activating the CREB/BDNF Pathway

(2018) Jing-Xian Yang et al.   International Journal of Pharmacology

Loss of Cx43-Mediated Functional Gap Junction Communication in Meningeal Fibroblasts Following Mouse Hepatitis Virus Infection

(2018) Abhishek Bose et al.   MOLECULAR NEUROBIOLOGY

Antidepressant-like effects of embelin and its possible mechanisms of action in chronic unpredictable stress-induced mice

(2018) Bailing Wang et al.   NEUROLOGICAL RESEARCH

Corticosterone impairs gap junctions in the prefrontal cortical and hippocampal astrocytes via different mechanisms

(2018) Cong-Yuan Xia et al.   NEUROPHARMACOLOGY

Astrocytes activation contributes to the antidepressant-like effect of ketamine but not scopolamine

(2018) Yun Wang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Hippocampal astrocyte atrophy in a mouse depression model induced by corticosterone is reversed by fluoxetine instead of benzodiazepine diazepam

(2018) Yunan Zhao et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Fluoxetine is Neuroprotective in Early Brain Injury via its Anti-inflammatory and Anti-apoptotic Effects in a Rat Experimental Subarachnoid Hemorrhage Model

(2018) Hui-Min Hu et al.   Neuroscience Bulletin

Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes

(2018) Manao Kinoshita et al.   EBioMedicine

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation

(2018) Lige Leng et al.   NEURON

Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex

(2018) Hyeonwi Son et al.   NEUROPHARMACOLOGY

Glucocorticoid receptor activation induces decrease of hippocampal astrocyte number in rats

(2018) Yu-Xia Lou et al.   PSYCHOPHARMACOLOGY

Glutamatergic Neurotransmission: Pathway to Developing Novel Rapid-Acting Antidepressant Treatments

(2018) Bashkim Kadriu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Inhibition of activated astrocyte ameliorates lipopolysaccharide- induced depressive-like behaviors

(2018) Yun Wang et al.   JOURNAL OF AFFECTIVE DISORDERS

Therapeutic Targeting of Connexin Channels: New Views and Challenges

(2018) Tinneke Delvaeye et al.   TRENDS IN MOLECULAR MEDICINE

An astroglial basis of major depressive disorder? An overview

(2017) Qian Wang et al.   GLIA

Depression hurts, depression costs: The medical spending attributable to depression and depressive symptoms in China

(2017) Chee-Ruey Hsieh et al.   HEALTH ECONOMICS

Ginsenoside Rg1 alleviates corticosterone-induced dysfunction of gap junctions in astrocytes

(2017) Cong-Yuan Xia et al.   JOURNAL OF ETHNOPHARMACOLOGY

Mast cells in neuroinflammation and brain disorders

(2017) Erik Hendriksen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels

(2017) Yeri Kim et al.   Neurotherapeutics

Repeated co-treatment with antidepressants and risperidone increases BDNF mRNA and protein levels in rats

(2017) Zofia Rogóż et al.   Pharmacological Reports

Epigenetic mechanisms of major depression: Targeting neuronal plasticity

(2017) Shusaku Uchida et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Gap junction channels as potential targets for the treatment of major depressive disorder

(2017) Qian Ren et al.   PSYCHOPHARMACOLOGY

Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies

(2017) Denis Sarrouilhe et al.   Frontiers in Molecular Neuroscience

Tumor Necrosis Factor-Alpha and Mast Cells: Revisited Study

(2017) A. Saggini et al.   European Journal of Inflammation

Regulation of gap junction channels and hemichannels by phosphorylation and redox changes: a revision

(2016) Kristin Pogoda et al.   BMC CELL BIOLOGY

Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia

(2016) Kazue Hisaoka-Nakashima et al.   BRAIN RESEARCH

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

(2016) Ji-chun Zhang et al.   Current Neuropharmacology

Inflammation in Depression and the Potential for Anti-Inflammatory Treatment

(2016) Ole Kohler et al.   Current Neuropharmacology

Glial-endothelial crosstalk regulates blood–brain barrier function

(2016) Lara Cheslow et al.   CURRENT OPINION IN PHARMACOLOGY

High glucocorticoid levels during gestation activate the inflammasome in hippocampal oligodendrocytes of the offspring

(2016) Carola J. Maturana et al.   Developmental Neurobiology

Effects of chronic mild stress on behavioral and neurobiological parameters — Role of glucocorticoid

(2016) Jiao Chen et al.   HORMONES AND BEHAVIOR

Repression of Astrocytic Connexins in Cortical and Subcortical Brain Regions and Prefrontal Enrichment of H3K9me3 in Depression and Suicide

(2016) Corina Nagy et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Hippocampal volume in vulnerability and resilience to depression

(2016) Stella W.Y. Chan et al.   JOURNAL OF AFFECTIVE DISORDERS

Radiopharmaceuticals for PET imaging of neuroinflammation

(2016) A.C. Dupont et al.   Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique

Inflammation, Glutamate and Glia: A Trio of Trouble in Mood Disorders

(2016) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Sex differences in the outcome of juvenile social isolation on HPA axis function in rats

(2016) M.G. Pisu et al.   NEUROSCIENCE

Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder

(2016) J.A. Cobb et al.   NEUROSCIENCE

Astrocytes: Orchestrating synaptic plasticity?

(2016) M. De Pittà et al.   NEUROSCIENCE

The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression

(2016) Yong-Ku Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Reelin and Neuropsychiatric Disorders

(2016) Kazuhiro Ishii et al.   Frontiers in Cellular Neuroscience

Antidepressants Impact Connexin 43 Channel Functions in Astrocytes

(2016) Tiffany Jeanson et al.   Frontiers in Cellular Neuroscience

Neuropathology of mood disorders: do we see the stigmata of inflammation?

(2016) N Mechawar et al.   Translational Psychiatry

Connexin 43 stabilizes astrocytes in a stroke-like milieu to facilitate neuronal recovery

(2015) Le-yu Wu et al.   ACTA PHARMACOLOGICA SINICA

Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?

(2015) Elke Decrock et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting astrocytes in major depression

(2015) Liang Peng et al.   Expert Review of Neurotherapeutics

General anesthetics have differential inhibitory effects on gap junction channels and hemichannels in astrocytes and neurons

(2015) Xinhe Liu et al.   GLIA

Astrocyte development: A Guide for the Perplexed

(2015) Anna Victoria Molofsky et al.   GLIA

Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes

(2015) Verónica Abudara et al.   GLIA

Trazodone regulates neurotrophic/growth factors, mitogen-activated protein kinases and lactate release in human primary astrocytes

(2015) Simona Daniele et al.   Journal of Neuroinflammation

Glial fibrillary acidic protein is differentially expressed across cortical and subcortical regions in healthy brains and downregulated in the thalamus and caudate nucleus of depressed suicides

(2015) S G Torres-Platas et al.   MOLECULAR PSYCHIATRY

Attenuated Levels of Hippocampal Connexin 43 and its Phosphorylation Correlate with Antidepressant- and Anxiolytic-Like Activities in Mice

(2015) Gaël Quesseveur et al.   Frontiers in Cellular Neuroscience

Restraint stress increases hemichannel activity in hippocampal glial cells and neurons

(2015) Juan A. Orellana et al.   Frontiers in Cellular Neuroscience

Targeting astrocytes in major depression

(2015) Liang Peng et al.   Expert Review of Neurotherapeutics

Amitriptyline up-regulates connexin43-gap junction in rat cultured cortical astrocytes via activation of the p38 and c-Fos/AP-1 signalling pathway

(2014) N Morioka et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hunting for connexin hemichannels

(2014) Juan C. Sáez et al.   FEBS LETTERS

TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation

(2014) Diana M. Norden et al.   GLIA

Astrocytic abnormalities and global DNA methylation patterns in depression and suicide

(2014) C Nagy et al.   MOLECULAR PSYCHIATRY

Medical research: If depression were cancer

(2014) Heidi Ledford   NATURE

Emerging targets in neuroinflammation-driven chronic pain

(2014) Ru-Rong Ji et al.   NATURE REVIEWS DRUG DISCOVERY

Astroglial connexin 43 sustains glutamatergic synaptic efficacy

(2014) O. Chever et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Altered Connexin 43 and Connexin 45 protein expression in the heart as a function of social and environmental stress in the prairie vole

(2014) Angela J. Grippo et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Lurasidone as Adjunctive Therapy With Lithium or Valproate for the Treatment of Bipolar I Depression: A Randomized, Double-Blind, Placebo-Controlled Study

(2013) Antony Loebel et al.   AMERICAN JOURNAL OF PSYCHIATRY

A Key Role for Connexin Hemichannels in Spreading Ischemic Brain Injury

(2013) Joanne O. Davidson et al.   CURRENT DRUG TARGETS

Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue

(2013) Grazyna Rajkowska et al.   CURRENT DRUG TARGETS

Serum S100B Represents a New Biomarker for Mood Disorders

(2013) Matthias Schroeter et al.   CURRENT DRUG TARGETS

Epigenetics and depression: return of the repressed

(2013) Victoria S. Dalton et al.   JOURNAL OF AFFECTIVE DISORDERS

Fluoxetine inhibits transient global ischemia-induced hippocampal neuronal death and memory impairment by preventing blood–brain barrier disruption

(2013) Jee Y. Lee et al.   NEUROPHARMACOLOGY

BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities

(2013) G Quesseveur et al.   Translational Psychiatry

The Action of Antidepressants on the Glutamate System: Regulation of Glutamate Release and Glutamate Receptors

(2012) Laura Musazzi et al.   BIOLOGICAL PSYCHIATRY

Curious and contradictory roles of glial connexins and pannexins in epilepsy

(2012) Peter L. Carlen   BRAIN RESEARCH

Antidepressants act directly on astrocytes: Evidences and functional consequences

(2012) Boldizsár Czéh et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

(2012) Jimmy Stehberg et al.   FASEB JOURNAL

Deletion of Astroglial Connexins Weakens the Blood–Brain Barrier

(2012) Pascal Ezan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroinflammation, Neurodegeneration, and Depression

(2012) Laura L. Hurley et al.   NEUROTOXICITY RESEARCH

Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke

(2011) Kim M. Baeten et al.   Developmental Neurobiology

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Gap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats

(2011) Jian-Dong Sun et al.   NEUROPSYCHOPHARMACOLOGY

Brain-derived neurotrophic factor and suicide pathogenesis

(2010) Yogesh Dwivedi   ANNALS OF MEDICINE

Amygdala astrocyte reduction in subjects with major depressive disorder but not bipolar disorder

(2010) Lori L Altshuler et al.   BIPOLAR DISORDERS

Epigenetics and depression: current challenges and new therapeutic options

(2010) Marc Schroeder et al.   CURRENT OPINION IN PSYCHIATRY

Role of connexin43 in central nervous system injury

(2010) Shenton S.L. Chew et al.   EXPERIMENTAL NEUROLOGY

Gap junctions and connexins as therapeutic targets in cancer

(2010) Mustapha Kandouz et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Hippocampal astrocytes are necessary for antidepressant treatment of learned helplessness rats

(2010) Masaaki Iwata et al.   HIPPOCAMPUS

Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective

(2010) Nicolas Froger et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression

(2010) Hiroshi Kunugi et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments

(2009) Nicolas Froger et al.   JOURNAL OF NEUROCHEMISTRY

Glial connexins and gap junctions in CNS inflammation and disease

(2008) Tammy Kielian   JOURNAL OF NEUROCHEMISTRY

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

(2008) Michael Maes et al.   METABOLIC BRAIN DISEASE

Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior

(2008) M. Bergami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats

(2008) S. Hossein Fatemi et al.   SCHIZOPHRENIA RESEARCH

Expression of astrocytic markers aquaporin 4 and connexin 43 is altered in brains of subjects with autism

(2008) S. Hossein Fatemi et al.   SYNAPSE