Trazodone regulates neurotrophic/growth factors, mitogen-activated protein kinases and lactate release in human primary astrocytes

So depression is an inflammatory disease, but where does the inflammation come from?

(2016) Michael Berk et al.   BMC Medicine

Mechanism of Action of Trazodone: a Multifunctional Drug

(2016) Stephen M. Stahl   CNS SPECTRUMS

Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK

(2015) Simona Daniele et al.   CELLULAR SIGNALLING

♦Copper (II) ions modulate Angiogenin activity in human endothelial cells

(2015) Chiara Giacomelli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

When astrocytes become harmful: Functional and inflammatory responses that contribute to Alzheimer's disease

(2014) Evangelina Avila-Muñoz et al.   AGEING RESEARCH REVIEWS

Does GRK–β arrestin machinery work as a “switch on” for GPR17-mediated activation of intracellular signaling pathways?

(2014) Simona Daniele et al.   CELLULAR SIGNALLING

Fluoxetine and all other SSRIs are 5-HT2B Agonists - Importance for their Therapeutic Effects

(2014) Liang Peng et al.   Current Neuropharmacology

β2-adrenergic agonists modulate TNF-α induced astrocytic inflammatory gene expression and brain inflammatory cell populations

(2014) Guy Laureys et al.   Journal of Neuroinflammation

Paroxetine ameliorates lipopolysaccharide-induced microglia activation via differential regulation of MAPK signaling

(2014) Rong-Pei Liu et al.   Journal of Neuroinflammation

Antidepressant-like effects of Chaihu-Shugan-San via SAPK/JNK signal transduction in rat models of depression

(2014) Yun-Hui Li et al.   Pharmacognosy Magazine

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

(2014) Nils C. Gassen et al.   PLOS MEDICINE

Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses

(2013) Bhavya Voleti et al.   BIOLOGICAL PSYCHIATRY

Inhibition of astroglial NF-kappaB enhances oligodendrogenesis following spinal cord injury

(2013) Valerie Bracchi-Ricard et al.   Journal of Neuroinflammation

Astrocytes as a 5-HT2B-Mediated SERT-Independent SSRI Target, Slowly Altering Depression-Associated Genes and Function

(2012) Leif Hertz et al.   Current Signal Transduction Therapy

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT3 receptor antagonism

(2012) Cécile Bétry et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways

(2012) Tao Pang et al.   Journal of Neuroinflammation

Tricyclic Antidepressant Amitriptyline Activates Fibroblast Growth Factor Receptor Signaling in Glial Cells

(2011) Kazue Hisaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Necrosis Factor-alpha and the Roles it Plays in Homeostatic and Degenerative Processes Within the Central Nervous System

(2011) Sara L. Montgomery et al.   Journal of Neuroimmune Pharmacology

The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes

(2011) Lucia Lisi et al.   Journal of Neuroinflammation

5-HT2B receptors are required for serotonin-selective antidepressant actions

(2011) S L Diaz et al.   MOLECULAR PSYCHIATRY

N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: A putative cellular mechanism for quetiapine as antidepressant

(2011) Barbara Di Benedetto et al.   NEUROPHARMACOLOGY

Antidepressant Drugs Diversely Affect Autophagy Pathways in Astrocytes and Neurons—Dissociation from Cholesterol Homeostasis

(2011) Jürgen Zschocke et al.   NEUROPSYCHOPHARMACOLOGY

Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes

(2011) Igor Allaman et al.   PSYCHOPHARMACOLOGY

Beyond cAMP: the regulation of Akt and GSK3 by dopamine receptors

(2011) Jean-Martin Beaulieu   Frontiers in Molecular Neuroscience

Protective effect of desipramine, venlafaxine and trazodone against experimental animal model of transient global ischemia: Possible involvement of NO–cGMP pathway

(2010) Vaibhav Gaur et al.   BRAIN RESEARCH

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

5-HT1A receptor-regulated signal transduction pathways in brain

(2010) Abigail M. Polter et al.   CELLULAR SIGNALLING

Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid

(2010) Sabien van Neerven et al.   JOURNAL OF NEUROIMMUNOLOGY

Melatonin Induces Akt Phosphorylation through Melatonin Receptor- and PI3K-Dependent Pathways in Primary Astrocytes

(2010) Pil-Jae Kong et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Interaction of glia activation and neurotransmission in hippocampus of neuropathic rats treated with mirtazapine.

(2009) Juan Zhu et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation

(2009) Baoman Li et al.   PSYCHOPHARMACOLOGY

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

(2008) Mounira Banasr et al.   BIOLOGICAL PSYCHIATRY

Antidepressant-like effects of intracerebroventricular FGF2 in rats

(2008) Cortney A. Turner et al.   BRAIN RESEARCH

Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons

(2008) B Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Modulation of astrocytic metabolic phenotype by proinflammatory cytokines

(2008) Mathilde Gavillet et al.   GLIA

Inhibition of 5‐HT1Areceptor‐dependent cell survival by cAMP/protein kinase A: Role of protein phosphatase 2A and Bax

(2008) Shu‐chi Hsiung et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants

(2008) Jaegyu Hwang et al.   NEUROPHARMACOLOGY

Region-specific changes in 5-HT1A agonist-induced Extracellular signal-Regulated Kinases 1/2 phosphorylation in rat brain: A quantitative ELISA study

(2008) Jaroslava Buritova et al.   NEUROPHARMACOLOGY

Role of GSK3  in behavioral abnormalities induced by serotonin deficiency

(2008) J.-M. Beaulieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation

(2008) Baoman Li et al.   PSYCHOPHARMACOLOGY

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE

Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders

(2007) Jacques De Keyser et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Noradrenergic stimulation of BDNF synthesis in astrocytes: Mediation via α1- and β1/β2-adrenergic receptors

(2007) Damijana Mojca Jurič et al.   NEUROCHEMISTRY INTERNATIONAL