Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels

Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer’s disease

(2016) C Yi et al.   CELL DEATH AND DIFFERENTIATION

Connexins and their channels in inflammation

(2016) Joost Willebrords et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice

(2016) Sheu-Ran Choi et al.   NEUROPHARMACOLOGY

Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?

(2015) Elke Decrock et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neuroprotection in the treatment of glaucoma – A focus on connexin43 gap junction channel blockers

(2015) Ying-Shan Chen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells

(2015) Simon J. O’Carroll et al.   Journal of Neuroinflammation

Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1  and TNF- 

(2015) E. Hennessy et al.   JOURNAL OF NEUROSCIENCE

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

(2014) Gang Chen et al.   BRAIN

Astroglial Connexin43 Hemichannels Tune Basal Excitatory Synaptic Transmission

(2014) O. Chever et al.   JOURNAL OF NEUROSCIENCE

Connexin Hemichannel Blockade Is Neuroprotective after Asphyxia in Preterm Fetal Sheep

(2014) Joanne O. Davidson et al.   PLoS One

Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia

(2013) Michael G. Kozoriz et al.   NEUROPHARMACOLOGY

Connexin43 mimetic peptide is neuroprotective and improves function following spinal cord injury

(2013) Simon J. O’Carroll et al.   NEUROSCIENCE RESEARCH

Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation

(2012) Nan Wang et al.   BASIC RESEARCH IN CARDIOLOGY

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury

(2012) Nan Wang et al.   BASIC RESEARCH IN CARDIOLOGY

Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemia

(2012) Helen V. Danesh-Meyer et al.   BRAIN

Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)

(2012) Meir Bialer et al.   EPILEPSY RESEARCH

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

(2012) Jimmy Stehberg et al.   FASEB JOURNAL

Regulation of Connexin43 Gap Junction Protein Triggers Vascular Recovery and Healing in Human Ocular Persistent Epithelial Defect Wounds

(2012) Susan Ormonde et al.   JOURNAL OF MEMBRANE BIOLOGY

Critical Role of Connexin 43 in Secondary Expansion of Traumatic Spinal Cord Injury

(2012) C. Huang et al.   JOURNAL OF NEUROSCIENCE

Anoxia-Induced NMDA Receptor Activation Opens Pannexin Channels via Src Family Kinases

(2012) N. L. Weilinger et al.   JOURNAL OF NEUROSCIENCE

Role of Gap Junction Protein Connexin43 in Astrogliosis Induced by Brain Injury

(2012) Nicolas Theodoric et al.   PLoS One

Extracellular Ca2+ Acts as a Mediator of Communication from Neurons to Glia

(2012) A. Torres et al.   Science Signaling

Thrombin-induced ATP release from human umbilical vein endothelial cells

(2011) Stefanie Gödecke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Connexin hemichannel blockade improves outcomes in a model of fetal ischemia

(2011) Joanne O. Davidson et al.   ANNALS OF NEUROLOGY

Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex

(2011) J. P. Dreier et al.   BRAIN

Connexin Channels Provide a Target to Manipulate Brain Endothelial Calcium Dynamics and Blood—Brain Barrier Permeability

(2011) Marijke De Bock et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease

(2011) Hideyuki Takeuchi et al.   PLoS One

Synaptic Transmission from Horizontal Cells to Cones Is Impaired by Loss of Connexin Hemichannels

(2011) Lauw J. Klaassen et al.   PLOS BIOLOGY

The Connexin43 C-Terminal Region Mediates Neuroprotection During Stroke

(2010) Michael G. Kozoriz et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Temporal and Spatial Profile of Phosphorylated Connexin43 after Traumatic Brain Injury in Rats

(2010) Atsushi Ohsumi et al.   JOURNAL OF NEUROTRAUMA

Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective

(2010) Nicolas Froger et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells

(2009) Elke De Vuyst et al.   CELL CALCIUM

Neurological Mechanisms of Migraine: Potential of the Gap-Junction Modulator Tonabersat in Prevention of Migraine

(2009) PL Durham et al.   CEPHALALGIA

Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Study of the Cortical Spreading Depression Inhibiting Agent Tonabersat in Migraine Prophylaxis

(2009) PJ Goadsby et al.   CEPHALALGIA

Efficacy and Safety of Tonabersat, a Gap-Junction Modulator, in the Acute Treatment of Migraine: A Double-Blind, Parallel-group, Randomized Study

(2009) CGH Dahlö et al.   CEPHALALGIA

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

(2009) William R. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of the NLRP3 Inflammasome in Innate and Humoral Adaptive Immune Responses to Fungal  -Glucan

(2009) H. Kumar et al.   JOURNAL OF IMMUNOLOGY

Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study

(2009) Anne W Hauge et al.   LANCET NEUROLOGY

Spreading depolarizations occur in human ischemic stroke with high incidence

(2008) Christian Dohmen et al.   ANNALS OF NEUROLOGY

Connexin43 Mimetic Peptides Reduce Swelling, Astrogliosis, and Neuronal Cell Death after Spinal Cord Injury

(2008) Simon J. O'Carroll et al.   CELL COMMUNICATION AND ADHESION

Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model

(2008) E Decrock et al.   CELL DEATH AND DIFFERENTIATION

ATP release by cardiac myocytes in a simulated ischaemia model

(2008) Thomas C. Clarke et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tonabersat Inhibits Trigeminal Ganglion Neuronal-Satellite Glial Cell Signaling

(2008) Srikanth Damodaram et al.   HEADACHE

Glial connexins and gap junctions in CNS inflammation and disease

(2008) Tammy Kielian   JOURNAL OF NEUROCHEMISTRY

Connexin 43 Hemichannels Are Permeable to ATP

(2008) J. Kang et al.   JOURNAL OF NEUROSCIENCE

Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury

(2008) Michael Cronin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE