Connexin 43: insights into candidate pathological mechanisms of depression and its implications in antidepressant therapy

Global Spread of a Local Fire: Transmission of Endoplasmic Reticulum Stress via Connexin 43

(2021) Yoon Mee Yang et al.   Cell Metabolism

Novel antidepressant mechanism of ginsenoside Rg1: Regulating biosynthesis and degradation of connexin43

(2021) Hui-Qin Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Korean red ginseng alleviate depressive disorder by improving astrocyte gap junction function

(2021) Qing-Lian Zheng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Genetic and pharmacological inactivation of astroglial connexin 43 differentially influences the acute response of antidepressant and anxiolytic drugs

(2020) Benjamin Portal et al.   Acta Physiologica

Hormonal Treatments for Major Depressive Disorder: State of the Art

(2020) Jennifer B. Dwyer et al.   AMERICAN JOURNAL OF PSYCHIATRY

Role of Interleukin-6 in Depressive Disorder

(2020) Emily Yi-Chih Ting et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The protective effect of ginsenoside Rg1 on depression may benefit from the gap junction function in hippocampal astrocytes

(2020) Yu-Xia Lou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Working Hypothesis Regarding Identical Pathomechanisms between Clinical Efficacy and Adverse Reaction of Clozapine via the Activation of Connexin43

(2020) Motohiro Okada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism

(2020) Amir Tirosh et al.   Cell Metabolism

Astroglial Connexin43 as a Potential Target for a Mood Stabiliser

(2020) Motohiro Okada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dysfunction of astrocytic connexins 30 and 43 in the medial prefrontal cortex and hippocampus mediates depressive-like behaviours

(2019) Dongming Huang et al.   BEHAVIOURAL BRAIN RESEARCH

Glucocorticoid-Induced Reductions of Myelination and Connexin 43 in Mixed Central Nervous System Cell Cultures Are Prevented by Mifepristone

(2019) José Javier Miguel-Hidalgo et al.   NEUROSCIENCE

Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors

(2018) M Jun et al.   MOLECULAR PSYCHIATRY

Corticosterone impairs gap junctions in the prefrontal cortical and hippocampal astrocytes via different mechanisms

(2018) Cong-Yuan Xia et al.   NEUROPHARMACOLOGY

Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target

(2018) Filippo Caraci et al.   PHARMACOLOGICAL RESEARCH

Thyroid hormone and the brain: Mechanisms of action in development and role in protection and promotion of recovery after brain injury

(2018) Yan-Yun Liu et al.   PHARMACOLOGY & THERAPEUTICS

Fluoxetine-induced androgenic failure impairs the seminiferous tubules integrity and increases ubiquitin carboxyl-terminal hydrolase L1 (UCHL1): Possible androgenic control of UCHL1 in germ cell death?

(2018) Marina L. Câmara et al.   BIOMEDICINE & PHARMACOTHERAPY

An astroglial basis of major depressive disorder? An overview

(2017) Qian Wang et al.   GLIA

Stress and the HPA Axis: Balancing Homeostasis and Fertility

(2017) Dana Joseph et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ginsenoside Rg1 alleviates corticosterone-induced dysfunction of gap junctions in astrocytes

(2017) Cong-Yuan Xia et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effects of stress on behavioral flexibility in rodents

(2017) Jessica L. Hurtubise et al.   NEUROSCIENCE

Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels

(2017) Yeri Kim et al.   Neurotherapeutics

Ginsenoside Rg1-induced antidepressant effects involve the protection of astrocyte gap junctions within the prefrontal cortex

(2017) Can Jin et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies

(2017) Denis Sarrouilhe et al.   Frontiers in Molecular Neuroscience

Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin

(2016) Sandeep K. Singh et al.   CELL

Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis

(2016) S Georgin-Lavialle et al.   MOLECULAR PSYCHIATRY

HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition

(2016) J Keller et al.   MOLECULAR PSYCHIATRY

Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP

(2016) Junhua Yang et al.   eLife

General anesthetics have differential inhibitory effects on gap junction channels and hemichannels in astrocytes and neurons

(2015) Xinhe Liu et al.   GLIA

Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes

(2015) Verónica Abudara et al.   GLIA

Thyroid Hormone and Astroglia: Endocrine Control of the Neural Environment

(2015) R. S. Dezonne et al.   JOURNAL OF NEUROENDOCRINOLOGY

A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder

(2015) M S Milak et al.   MOLECULAR PSYCHIATRY

Stress, the Stress System and the Role of Glucocorticoids

(2015) Nicolas C. Nicolaides et al.   NEUROIMMUNOMODULATION

Hemichannels: New pathways for gliotransmitter release

(2015) T.D. Montero et al.   NEUROSCIENCE

Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection

(2015) Rainer Schulz et al.   PHARMACOLOGY & THERAPEUTICS

Chronobiological hypothalamic–pituitary–thyroid axis status and antidepressant outcome in major depression

(2015) Fabrice Duval et al.   PSYCHONEUROENDOCRINOLOGY

Reduced density of glutamine synthetase immunoreactive astrocytes in different cortical areas in major depression but not in bipolar I disorder

(2015) Hans-Gert Bernstein et al.   Frontiers in Cellular Neuroscience

Attenuated Levels of Hippocampal Connexin 43 and its Phosphorylation Correlate with Antidepressant- and Anxiolytic-Like Activities in Mice

(2015) Gaël Quesseveur et al.   Frontiers in Cellular Neuroscience

Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants

(2015) Alan Pehrson et al.   Drug Design Development and Therapy

High-dose insulin inhibits gap junction intercellular communication in vascular smooth muscle cells

(2015) OU BIAN et al.   Molecular Medicine Reports

Amitriptyline up-regulates connexin43-gap junction in rat cultured cortical astrocytes via activation of the p38 and c-Fos/AP-1 signalling pathway

(2014) N Morioka et al.   BRITISH JOURNAL OF PHARMACOLOGY

The glia/neuron ratio: How it varies uniformly across brain structures and species and what that means for brain physiology and evolution

(2014) Suzana Herculano-Houzel   GLIA

The Significance of an Isolated Elevated TSH Level in a Depressed Patient: A Clinical Commentary

(2014) Russell T. Joffe et al.   INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE

Protein Kinase Cδ-mediated Phosphorylation of Connexin43 Gap Junction Channels Causes Movement within Gap Junctions followed by Vesicle Internalization and Protein Degradation

(2014) Angela C. Cone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Hypothesized Role for Dendritic Remodeling in the Etiology of Mood and Anxiety Disorders

(2014) Jack M. Gorman et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Gap Junctions in the Ventral Hippocampal-Medial Prefrontal Pathway Are Involved in Anxiety Regulation

(2014) T. J. Schoenfeld et al.   JOURNAL OF NEUROSCIENCE

Reduced connexin 43 immunolabeling in the orbitofrontal cortex in alcohol dependence and depression

(2014) José Javier Miguel-Hidalgo et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Differential regulation of the glutamate transporters GLT-1 and GLAST by GSK3β

(2014) Esperanza Jiménez et al.   NEUROCHEMISTRY INTERNATIONAL

The role of pannexin hemichannels in inflammation and regeneration

(2014) Helen P. Makarenkova et al.   Frontiers in Physiology

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

(2013) Undine E. Lang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue

(2013) Grazyna Rajkowska et al.   CURRENT DRUG TARGETS

Time course of the effects of lipopolysaccharide on prepulse inhibition and brain nitrite content in mice

(2013) Charllyany Sabino Custódio et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy

(2013) Elvira Valera et al.   GLIA

Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure

(2013) Vairappan Balasubramaniyan et al.   JOURNAL OF HEPATOLOGY

Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration

(2013) Bruna Stefânia Ferreira Mello et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Astrocyte-derived ATP modulates depressive-like behaviors

(2013) Xiong Cao et al.   NATURE MEDICINE

Antibodies targeting extracellular domain of connexins for studies of hemichannels

(2013) Manuel A. Riquelme et al.   NEUROPHARMACOLOGY

Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules

(2013) Juan A. Orellana et al.   NEUROPHARMACOLOGY

α2 GABAA receptor sub-units in the ventral hippocampus and α5 GABAA receptor sub-units in the dorsal hippocampus mediate anxiety and fear memory

(2013) K. McEown et al.   NEUROSCIENCE

Astrocytic Adenosine 5′-Triphosphate Release Regulates the Proliferation of Neural Stem Cells in the Adult Hippocampus

(2013) Xiong Cao et al.   STEM CELLS

Metabolic disturbances connecting obesity and depression

(2013) Cecile Hryhorczuk et al.   Frontiers in Neuroscience

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

(2012) Jimmy Stehberg et al.   FASEB JOURNAL

Inhibitory effect of the antidepressant imipramine on NF-κB-dependent CXCL1 expression in TNFα-exposed astrocytes

(2012) Young Han Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors

(2012) Nicola J. Allen et al.   NATURE

Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels

(2012) T. Desplantez et al.   PHARMACOLOGICAL RESEARCH

Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration

(2012) Yuta Ohgi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Extracellular Ca2+ Acts as a Mediator of Communication from Neurons to Glia

(2012) A. Torres et al.   Science Signaling

Thyroid Hormones and Depression

(2011) Osvaldo P. Almeida et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Dysfunction of Astrocyte Connexins 30 and 43 in Dorsal Lateral Prefrontal Cortex of Suicide Completers

(2011) Carl Ernst et al.   BIOLOGICAL PSYCHIATRY

1H-[13C]-Nuclear Magnetic Resonance Spectroscopy Measures of Ketamine's Effect on Amino Acid Neurotransmitter Metabolism

(2011) Golam M.I. Chowdhury et al.   BIOLOGICAL PSYCHIATRY

Hemichannels in the Neurovascular Unit and White Matter Under Normal and Inflamed Conditions

(2011) Juan A. Orellana et al.   CNS & Neurological Disorders-Drug Targets

Large-Scale Calcium Waves Traveling through Astrocytic Networks In Vivo

(2011) N. Kuga et al.   JOURNAL OF NEUROSCIENCE

Sertoli cell therapy: A novel possible treatment strategy for treatment-resistant major depressive disorder

(2011) J.M. Loftis   MEDICAL HYPOTHESES

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

(2011) Maurizio Popoli et al.   NATURE REVIEWS NEUROSCIENCE

Gap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats

(2011) Jian-Dong Sun et al.   NEUROPSYCHOPHARMACOLOGY

Central Role of GABA in Neuron–Glia Interactions

(2011) Mateo Vélez-Fort et al.   NEUROSCIENTIST

Immune system to brain signaling: Neuropsychopharmacological implications

(2011) Lucile Capuron et al.   PHARMACOLOGY & THERAPEUTICS

Prolonged Depression-Like Behavior Caused by Immune Challenge: Influence of Mouse Strain and Social Environment

(2011) Evelin Painsipp et al.   PLoS One

Abnormal Cingulate and Prefrontal Cortical Neurochemistry in Major Depression After Electroconvulsive Therapy

(2010) Angela Merkl et al.   BIOLOGICAL PSYCHIATRY

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Downregulation and Upregulation of Glial Connexins May Cause Synaptic Imbalances Responsible for the Pathophysiology of Bipolar Disorder

(2010) Bernhard J. Mitterauer   CNS Neuroscience & Therapeutics

Altered expression of glutamate signaling, growth factor and glia genes in the locus coeruleus of patients with major depression

(2010) R Bernard et al.   MOLECULAR PSYCHIATRY

Palliative care in the undergraduate curriculum: a medical student’s perspective

(2010) Louise Tossell et al.   PALLIATIVE MEDICINE

ATP-mediated cell–cell signaling in the organ of Corti: the role of connexin channels

(2010) Paromita Majumder et al.   Purinergic Signalling

Amitriptyline Suppresses Neuroinflammation-dependent Interleukin-10-p38 Mitogen-activated Protein Kinase-Heme Oxygenase-1 Signaling Pathway in Chronic Morphine-infused Rats

(2009) Yueh-Hua Tai et al.   ANESTHESIOLOGY

Targeting glial physiology and glutamate cycling in the treatment of depression

(2009) Gerald W. Valentine et al.   BIOCHEMICAL PHARMACOLOGY

Monoaminergic Neurotransmission: The History of the Discovery of Antidepressants from 1950s Until Today

(2009) Francisco Lopez-Munoz et al.   CURRENT PHARMACEUTICAL DESIGN

Treatment-Emergent Sexual Dysfunction Related to Antidepressants

(2009) Alessandro Serretti et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior

(2009) M Tfilin et al.   MOLECULAR PSYCHIATRY

Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: Animal and human studies

(2009) Grzegorz R. Juszczak et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

ATP release by way of connexin 36 hemichannels mediates ischemic tolerance in vitro

(2008) Sarah C. Schock et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adaptation of Connexin 43-Hemichannel Prostaglandin Release to Mechanical Loading

(2008) Arlene J. Siller-Jackson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin 43 Hemichannels Are Permeable to ATP

(2008) J. Kang et al.   JOURNAL OF NEUROSCIENCE

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

What Is the Role of Astrocyte Calcium in Neurophysiology?

(2008) Cendra Agulhon et al.   NEURON

Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats

(2008) S. Hossein Fatemi et al.   SCHIZOPHRENIA RESEARCH

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE

Expression of astrocytic markers aquaporin 4 and connexin 43 is altered in brains of subjects with autism

(2008) S. Hossein Fatemi et al.   SYNAPSE