The Multifaceted Role of Astrocyte Connexin 43 in Ischemic Stroke Through Forming Hemichannels and Gap Junctions

Connexin Hemichannels in Astrocytes: Role in CNS Disorders

(2019) LingYan Xing et al.   Frontiers in Molecular Neuroscience

Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke

(2019) Moises Freitas-Andrade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gap junction gene and protein families: Connexins, innexins, and pannexins

(2018) Eric C. Beyer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The connexin 43 C-terminus: A tail of many tales

(2018) Edward Leithe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Connexins and Pannexins in cerebral ischemia

(2018) Yeri Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Reperfusion therapy in acute ischemic stroke: dawn of a new era?

(2018) Sonu Bhaskar et al.   BMC Neurology

Cx43 Channel Gating and Permeation: Multiple Phosphorylation-Dependent Roles of the Carboxyl Terminus

(2018) José Ek-Vitorín et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Roles of astrocytic connexin-43, hemichannels, and gap junctions in oxygen-glucose deprivation/reperfusion injury induced neuroinflammation and the possible regulatory mechanisms of salvianolic acid B and carbenoxolone

(2018) Xiang Yin et al.   Journal of Neuroinflammation

Astrocytic gap junction inhibition by carbenoxolone enhances the protective effects of ischemic preconditioning following cerebral ischemia

(2018) Di Ma et al.   Journal of Neuroinflammation

Role of Nitric Oxide and Hydrogen Sulfide in Ischemic Stroke and the Emergent Epigenetic Underpinnings

(2018) Parimala Narne et al.   MOLECULAR NEUROBIOLOGY

Astrocytes and ischemic tolerance

(2018) Yuri Hirayama et al.   NEUROSCIENCE RESEARCH

Regulatory role of oligodendrocyte gap junctions in inflammatory demyelination

(2018) Christos P. Papaneophytou et al.   GLIA

Effect of mechanical thrombectomy alone or in combination with intravenous thrombolysis for acute ischemic stroke

(2018) Fabrizio Sallustio et al.   JOURNAL OF NEUROLOGY

Oxygen-Glucose Deprivation in Mouse Astrocytes is Associated with Ultrastructural Changes in Connexin 43 Gap Junctions

(2018) Anja Beckmann et al.   NEUROSCIENCE

Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway

(2018) Yingzhu Chen et al.   Frontiers in Cellular Neuroscience

Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword

(2018) Verónica Abudara et al.   Frontiers in Molecular Neuroscience

Microtubule-assisted altered trafficking of astrocytic gap junction protein connexin 43 is associated with depletion of connexin 47 during mouse hepatitis virus infection

(2017) Rahul Basu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of Astroglial Cx43 Hemichannels to the Modulation of Glutamatergic Currents by D-Serine in the Mouse Prefrontal Cortex

(2017) Claire Meunier et al.   JOURNAL OF NEUROSCIENCE

Connexins and pannexins: At the junction of neuro-glial homeostasis & disease

(2017) Andrew S. Lapato et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cell Biology of Astrocyte-Synapse Interactions

(2017) Nicola J. Allen et al.   NEURON

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y 1 Receptor Downregulation

(2017) Youichi Shinozaki et al.   Cell Reports

Functional polarization of neuroglia: Implications in neuroinflammation and neurological disorders

(2016) Mithilesh Kumar Jha et al.   BIOCHEMICAL PHARMACOLOGY

Determinants of Cx43 Channel Gating and Permeation: The Amino Terminus

(2016) José F. Ek Vitorín et al.   BIOPHYSICAL JOURNAL

Localization of nectin-2δ at perivascular astrocytic endfoot processes and degeneration of astrocytes and neurons in nectin-2 knockout mouse brain

(2016) Muneaki Miyata et al.   BRAIN RESEARCH

Gap Junction Blockers: An Overview of their Effects on Induced Seizures in Animal Models

(2016) Joaquín Manjarrez-Marmolejo et al.   Current Neuropharmacology

Movement and structure of mitochondria in oligodendrocytes and their myelin sheaths

(2016) Johanne E. Rinholm et al.   GLIA

Methamphetamine compromises gap junctional communication in astrocytes and neurons

(2016) Paul Castellano et al.   JOURNAL OF NEUROCHEMISTRY

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1

(2016) M. Freitas-Andrade et al.   NEUROSCIENCE

Connexin 43 stabilizes astrocytes in a stroke-like milieu to facilitate neuronal recovery

(2015) Le-yu Wu et al.   ACTA PHARMACOLOGICA SINICA

Inhibition of connexin43 improves functional recovery after ischemic brain injury in neonatal rats

(2015) Xiaojing Li et al.   GLIA

Hemichannels: New pathways for gliotransmitter release

(2015) T.D. Montero et al.   NEUROSCIENCE

Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection

(2015) Rainer Schulz et al.   PHARMACOLOGY & THERAPEUTICS

Restraint stress increases hemichannel activity in hippocampal glial cells and neurons

(2015) Juan A. Orellana et al.   Frontiers in Cellular Neuroscience

Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis

(2015) Jing-Jing Zhou et al.   Neuroscience Bulletin

When astrocytes become harmful: Functional and inflammatory responses that contribute to Alzheimer's disease

(2014) Evangelina Avila-Muñoz et al.   AGEING RESEARCH REVIEWS

Inhibition of the Connexin 43 Elevation May be Involved in the Neuroprotective Activity of Leptin Against Brain Ischemic Injury

(2014) Zi-Hui Deng et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Astroglial Connexin43 Hemichannels Tune Basal Excitatory Synaptic Transmission

(2014) O. Chever et al.   JOURNAL OF NEUROSCIENCE

Electrical synapses and their functional interactions with chemical synapses

(2014) Alberto E. Pereda   NATURE REVIEWS NEUROSCIENCE

Connexin Hemichannel Blockade Is Neuroprotective after Asphyxia in Preterm Fetal Sheep

(2014) Joanne O. Davidson et al.   PLoS One

Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases

(2014) Hideyuki Takeuchi et al.   Frontiers in Cellular Neuroscience

Cx43 expression and function in the nervous system—implications for stem cell mediated regeneration

(2014) Carola Meier et al.   Frontiers in Physiology

Negatively charged residues (Asp378 and Asp379) in the last ten amino acids of the C-terminal tail of Cx43 hemichannels are essential for loop/tail interactions

(2013) Catheleyne D’hondt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Key Role for Connexin Hemichannels in Spreading Ischemic Brain Injury

(2013) Joanne O. Davidson et al.   CURRENT DRUG TARGETS

Connexin47 Protein Phosphorylation and Stability in Oligodendrocytes Depend on Expression of Connexin43 Protein in Astrocytes

(2013) D. May et al.   JOURNAL OF NEUROSCIENCE

Multiple Roles for Astrocytes as Effectors of Cytokines and Inflammatory Mediators

(2013) Michael V. Sofroniew   NEUROSCIENTIST

Protective effects of carbenoxolone are associated with attenuation of oxidative stress in ischemic brain injury

(2013) Lang Zhang et al.   Neuroscience Bulletin

Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles

(2013) Christian Giaume et al.   Frontiers in Pharmacology

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury

(2012) Nan Wang et al.   BASIC RESEARCH IN CARDIOLOGY

Connexin-based intercellular communication and astrocyte heterogeneity

(2012) Martin Theis et al.   BRAIN RESEARCH

Localization of neurones expressing the gap junction protein Connexin45 within the adult spinal dorsal horn: a study using Cx45-eGFP reporter mice

(2012) R. J. Chapman et al.   Brain Structure & Function

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

(2012) Jimmy Stehberg et al.   FASEB JOURNAL

Deleterious Effects of High Dose Connexin 43 Mimetic Peptide Infusion After Cerebral Ischaemia in Near-Term Fetal Sheep

(2012) Joanne O. Davidson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single intravenous low-dose injections of connexin 43 mimetic peptides protect ischemic heart in vivo against myocardial infarction

(2012) Ghayda Hawat et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Connexin hemichannel blockade improves outcomes in a model of fetal ischemia

(2011) Joanne O. Davidson et al.   ANNALS OF NEUROLOGY

Connexins in epidermal homeostasis and skin disease

(2011) Claire A. Scott et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues

(2011) Lucrecia Márquez-Rosado et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

(2011) Juan A. Orellana et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of Oligodendrocyte Development and Myelination by Glucose and Lactate

(2011) J. E. Rinholm et al.   JOURNAL OF NEUROSCIENCE

The effect of a gap-junction blocker, carbenoxolone, on ischemic brain injury and cortical spreading depression

(2011) K. Tamura et al.   NEUROSCIENCE

Role of connexin43 in central nervous system injury

(2010) Shenton S.L. Chew et al.   EXPERIMENTAL NEUROLOGY

Pannexin1 and Pannexin2 Channels Show Quaternary Similarities to Connexons and Different Oligomerization Numbers from Each Other

(2010) Cinzia Ambrosi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intercellular calcium signaling between astrocytes and oligodendrocytes via gap junctions in culture

(2010) B. Parys et al.   NEUROSCIENCE

Connexin 43 mimetic peptide Gap26 confers protection to intact heart against myocardial ischemia injury

(2010) Ghayda Hawat et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The gap junction as a “Biological Rosetta Stone”: implications of evolution, stem cells to homeostatic regulation of health and disease in the Barker hypothesis

(2010) James E. Trosko   Journal of Cell Communication and Signaling

Connexin43 phosphorylation: structural changes and biological effects

(2009) Joell L. Solan et al.   BIOCHEMICAL JOURNAL

Delayed P2X4R expression after hypoxia–ischemia is associated with microglia in the immature rat brain

(2009) Julie A. Wixey et al.   JOURNAL OF NEUROIMMUNOLOGY

Gap Junctions

(2009) D. A. Goodenough et al.   Cold Spring Harbor Perspectives in Biology

Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration

(2008) Juan A. Orellana et al.   ANTIOXIDANTS & REDOX SIGNALING

Connexin43 Mimetic Peptides Reduce Swelling, Astrogliosis, and Neuronal Cell Death after Spinal Cord Injury

(2008) Simon J. O'Carroll et al.   CELL COMMUNICATION AND ADHESION

Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model

(2008) E Decrock et al.   CELL DEATH AND DIFFERENTIATION

Glial connexins and gap junctions in CNS inflammation and disease

(2008) Tammy Kielian   JOURNAL OF NEUROCHEMISTRY

Connexin 43 Hemichannels Are Permeable to ATP

(2008) J. Kang et al.   JOURNAL OF NEUROSCIENCE

Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury

(2008) Michael Cronin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

(2008) Ben A. Barres   NEURON

Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortex

(2008) E. Dere et al.   NEUROSCIENCE