Targeting astrocytes in major depression

Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift

(2015) Leif Hertz et al.   Frontiers in Behavioral Neuroscience

Astrocyte glutamine synthetase: pivotal in health and disease

(2015) Christopher F. Rose et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Glutamate as a neurotransmitter in the healthy brain

(2014) Y. Zhou et al.   JOURNAL OF NEURAL TRANSMISSION

Cytosolic phospholipase A2 inhibition is involved in the protective effect of nortriptyline in primary astrocyte cultures exposed to combined oxygen-glucose deprivation

(2014) Bożena Gabryel et al.   Pharmacological Reports

Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue

(2013) Grazyna Rajkowska et al.   CURRENT DRUG TARGETS

Astrocyte-derived ATP modulates depressive-like behaviors

(2013) Xiong Cao et al.   NATURE MEDICINE

Expression of Nucleoside Transporter in Freshly Isolated Neurons and Astrocytes from Mouse Brain

(2013) B. Li et al.   NEUROCHEMICAL RESEARCH

Importance of ‘inflammatory molecules’, but not necessarily of inflammation, in the pathophysiology of bipolar disorder and in the mechanisms of action of anti-bipolar drugs

(2013) Leif Hertz et al.   NEUROLOGY PSYCHIATRY AND BRAIN RESEARCH

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

Store-operated calcium entry in neuroglia

(2013) Alexei Verkhratsky et al.   Neuroscience Bulletin

BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities

(2013) G Quesseveur et al.   Translational Psychiatry

Effect of diclofenac and antidepressants on the inflammatory response in astrocyte cell culture

(2013) Md. Mamun Al-Amin et al.   INFLAMMOPHARMACOLOGY

Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels

(2012) Nicole Zimmermann et al.   BIOCHEMICAL JOURNAL

Astrocytes as a 5-HT2B-Mediated SERT-Independent SSRI Target, Slowly Altering Depression-Associated Genes and Function

(2012) Leif Hertz et al.   Current Signal Transduction Therapy

Antidepressants act directly on astrocytes: Evidences and functional consequences

(2012) Boldizsár Czéh et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Effect of fluoxetine and pergolide on expression of nucleoside transporters and nucleic-related enzymes in mouse brain

(2012) Katsuhito Nagai et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Inhibitory effect of the antidepressant imipramine on NF-κB-dependent CXCL1 expression in TNFα-exposed astrocytes

(2012) Young Han Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Differential BDNF Responses of Triple Versus Dual Reuptake Inhibition in Neuronal and Astrocytoma Cells as well as in Rat Hippocampus and Prefrontal Cortex

(2012) Jos Prickaerts et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Imipramine Induces Brain-Derived Neurotrophic Factor mRNA Expression in Cultured Astrocytes

(2012) Katsura Takano et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Glial K+ Clearance and Cell Swelling: Key Roles for Cotransporters and Pumps

(2012) Nanna MacAulay et al.   NEUROCHEMICAL RESEARCH

Cell Type-Specific Gene Expression and Editing Responses to Chronic Fluoxetine Treatment in the In Vivo Mouse Brain and Their Relevance for Stress-Induced Anhedonia

(2012) Baoman Li et al.   NEUROCHEMICAL RESEARCH

Requirement of Glycogenolysis for Uptake of Increased Extracellular K+ in Astrocytes: Potential Implications for K+ Homeostasis and Glycogen Usage in Brain

(2012) Junnan Xu et al.   NEUROCHEMICAL RESEARCH

Antidepressant Acts on Astrocytes Leading to an Increase in the Expression of Neurotrophic/Growth Factors: Differential Regulation of FGF-2 by Noradrenaline

(2012) Naoto Kajitani et al.   PLoS One

Sodium dynamics: another key to astroglial excitability?

(2012) Sergei Kirischuk et al.   TRENDS IN NEUROSCIENCES

Expression of Monoamine Transporters, Nitric Oxide Synthase 3, and Neurotrophin Genes in Antidepressant-Stimulated Astrocytes

(2012) Sarah Kittel-Schneider et al.   Frontiers in Psychiatry

Riluzole-induced glial cell line-derived neurotrophic factor production is regulated through fibroblast growth factor receptor signaling in rat C6 glioma cells

(2011) Mami Tsuchioka et al.   BRAIN RESEARCH

Effects of chronic treatment with fluoxetine on receptor-stimulated increase of [Ca2+]i in astrocytes mimic those of acute inhibition of TRPC1 channel activity

(2011) Baoman Li et al.   CELL CALCIUM

Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes

(2011) Masaru Yoshizumi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression

(2011) Philippe A. Melas et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Tricyclic Antidepressant Amitriptyline Activates Fibroblast Growth Factor Receptor Signaling in Glial Cells

(2011) Kazue Hisaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluoxetine affects GluK2 editing, glutamate-evoked Ca2+ influx and extracellular signal-regulated kinase phosphorylation in mouse astrocytes

(2011) Baoman Li   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Astrocytic energy metabolism and glutamate formation — relevance for 13C-NMR spectroscopy and importance of cytosolic/mitochondrial trafficking

(2011) Leif Hertz   MAGNETIC RESONANCE IMAGING

Calcium signalling in astroglia

(2011) Alexei Verkhratsky et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

5-HT2B receptors are required for serotonin-selective antidepressant actions

(2011) S L Diaz et al.   MOLECULAR PSYCHIATRY

Chronic Stress and Lithium Treatments Alter Hippocampal Glutamate Uptake and Release in the Rat and Potentiate Necrotic Cellular Death After Oxygen and Glucose Deprivation

(2011) Ana Paula S. de Vasconcellos-Bittencourt et al.   NEUROCHEMICAL RESEARCH

Riluzole elevates GLT-1 activity and levels in striatal astrocytes

(2011) Marica Carbone et al.   NEUROCHEMISTRY INTERNATIONAL

Towards a glutamate hypothesis of depression

(2011) Gerard Sanacora et al.   NEUROPHARMACOLOGY

Gap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats

(2011) Jian-Dong Sun et al.   NEUROPSYCHOPHARMACOLOGY

Imipramine activates glial cell line-derived neurotrophic factor via early growth response gene 1 in astrocytes

(2011) Yeni Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Antidepressant-like properties of oral riluzole and utility of incentive disengagement models of depression in mice

(2011) Shannon L. Gourley et al.   PSYCHOPHARMACOLOGY

Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains

(2011) Cristina S. Benton et al.   PSYCHOPHARMACOLOGY

Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes

(2011) Igor Allaman et al.   PSYCHOPHARMACOLOGY

Recent advances in (patho)physiology of astroglia

(2010) Alexei Verkhratsky et al.   ACTA PHARMACOLOGICA SINICA

Ca2+ sources for the exocytotic release of glutamate from astrocytes

(2010) Vladimir Parpura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Die Bedeutung des glutamatergen Systems für Pathophysiologie und Pharmakotherapie der Depression: präklinische und klinische Daten

(2010) G. Paslakis et al.   FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE

Drug screening to identify suppressors of GFAP expression

(2010) Woosung Cho et al.   HUMAN MOLECULAR GENETICS

Antidepressants act on glial cells: SSRIs and serotonin elicit astrocyte calcium signaling in the mouse prefrontal cortex

(2010) Carola G. Schipke et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Altered expression of glutamate signaling, growth factor and glia genes in the locus coeruleus of patients with major depression

(2010) R Bernard et al.   MOLECULAR PSYCHIATRY

Effects of Depressive-Like Behavior of Rats on Brain Glutamate Uptake

(2010) Roberto Farina Almeida et al.   NEUROCHEMICAL RESEARCH

Blockade of Astrocytic Glutamate Uptake in Rats Induces Signs of Anhedonia and Impaired Spatial Memory

(2010) Anita J Bechtholt-Gompf et al.   NEUROPSYCHOPHARMACOLOGY

Differential regulation of neurotrophin S100B and BDNF in two rat models of depression

(2010) Kai-Ren Luo et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Effects of repeated citalopram treatment on kainic acid-induced neurogenesis in adult mouse hippocampus

(2009) Külli Jaako et al.   BRAIN RESEARCH

Mutational and In Silico Analyses for Antidepressant Block of Astroglial Inward-Rectifier Kir4.1 Channel

(2009) K. Furutani et al.   MOLECULAR PHARMACOLOGY

Bioenergetics of cerebral ischemia: A cellular perspective

(2008) Leif Hertz   NEUROPHARMACOLOGY

Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants

(2008) Jaegyu Hwang et al.   NEUROPHARMACOLOGY

Requirement of AQP4 for Antidepressive Efficiency of Fluoxetine: Implication in Adult Hippocampal Neurogenesis

(2008) Hui Kong et al.   NEUROPSYCHOPHARMACOLOGY

Secretion of S100B, an astrocyte-derived neurotrophic protein, is stimulated by fluoxetine via a mechanism independent of serotonin

(2008) Ana Carolina Tramontina et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Antidepressant drug treatments induce glial cell line-derived neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells

(2003) Kazue Hisaoka et al.   JOURNAL OF NEUROCHEMISTRY