Connexins as therapeutic targets in neurological and neuropsychiatric disorders

Genetic and pharmacological inactivation of astroglial connexin 43 differentially influences the acute response of antidepressant and anxiolytic drugs

(2020) Benjamin Portal et al.   Acta Physiologica

Recently Approved and Upcoming Treatments for Narcolepsy

(2020) Michael J. Thorpy   CNS DRUGS

Intercellular communication and ion channels in neuropathic pain chronicization

(2020) Nunzio Vicario et al.   INFLAMMATION RESEARCH

Functional ultrasound imaging to study brain dynamics: Application of pharmaco-fUS to atomoxetine

(2020) Benjamin Vidal et al.   NEUROPHARMACOLOGY

Astroglia-specific contributions to the regulation of synapses, cognition and behaviour

(2020) Marcus Augusto-Oliveira et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Efficacy of THN201, a Combination of Donepezil and Mefloquine, to Reverse Neurocognitive Deficits in Alzheimer’s Disease

(2020) Marine Droguerre et al.   Frontiers in Neuroscience

Connexin Hemichannels in Astrocytes: Role in CNS Disorders

(2019) LingYan Xing et al.   Frontiers in Molecular Neuroscience

Ionic signalling in astroglia beyond calcium

(2019) Alexei Verkhratsky et al.   JOURNAL OF PHYSIOLOGY-LONDON

High-Content Screening Identifies New Inhibitors of Connexin 43 Gap Junctions

(2019) Christèle Picoli et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Connexin30 and Connexin43 show a time-of-day dependent expression in the mouse suprachiasmatic nucleus and modulate rhythmic locomotor activity in the context of chronodisruption

(2019) Amira A. H. Ali et al.   Cell Communication and Signaling

Efficacy of THN102 (a combination of modafinil and flecainide) on vigilance and cognition during 40‐hour total sleep deprivation in healthy subjects: Glial connexins as a therapeutic target

(2019) Fabien Sauvet et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Astroglial atrophy in Alzheimer’s disease

(2019) Alexei Verkhratsky et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Inhibition of gap junctional intercellular communication by an anti-migraine agent, flunarizine

(2019) Joo Hye Yeo et al.   PLoS One

Flecainide: Electrophysiological properties, clinical indications, and practical aspects

(2019) Enrico Paolini et al.   PHARMACOLOGICAL RESEARCH

A New Tool for In Vivo Study of Astrocyte Connexin 43 in Brain

(2019) Marine Droguerre et al.   Scientific Reports

Direct posttranslational modification of astrocytic connexin 43 proteins by the general anesthetic propofol in the cerebral cortex

(2018) Mutsuo Nuriya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Gap Junctions: New Insights in the Treatment of Major Depressive Disorde

(2018) Denis Sarrouilhe et al.   CURRENT MEDICINAL CHEMISTRY

Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice

(2018) Ryan S. Tonkin et al.   EXPERIMENTAL NEUROLOGY

Inhibition of astroglial connexin43 hemichannels with TAT-Gap19 exerts anticonvulsant effects in rodents

(2018) Laura Walrave et al.   GLIA

Cortico-Amygdala-Striatal Activation by Modafinil/Flecainide Combination

(2018) Dominique Vodovar et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Astrocyte pathology in the ventral prefrontal white matter in depression

(2018) Grazyna Rajkowska et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Clasmatodendrosis is associated with dendritic spines and does not represent autophagic astrocyte death in influenza-associated encephalopathy

(2018) Masaya Tachibana et al.   BRAIN & DEVELOPMENT

A review of clinical treatment considerations of donepezil in severe Alzheimer's disease

(2018) Aida Adlimoghaddam et al.   CNS Neuroscience & Therapeutics

Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

(2018) Atsushi Fujita et al.   Journal of Neuroinflammation

Gambogic Acid and Its Analogs Inhibit Gap Junctional Intercellular Communication

(2018) Eun J. Choi et al.   Frontiers in Pharmacology

The role of spinal interleukin-1β and astrocyte connexin 43 in the development of mirror-image pain in an inflammatory pain model

(2017) Hoon-Seong Choi et al.   EXPERIMENTAL NEUROLOGY

Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease

(2017) Chenju Yi et al.   GLIA

Multiple Nav1.5 isoforms are functionally expressed in the brain and present distinct expression patterns compared with cardiac Nav1.5

(2017) Jun Wang et al.   Molecular Medicine Reports

Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle

(2017) Jerome Clasadonte et al.   NEURON

Gap junctions, pannexins and pain

(2017) David C. Spray et al.   NEUROSCIENCE LETTERS

Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications

(2017) Luc Leybaert et al.   PHARMACOLOGICAL REVIEWS

Inhibitors of connexin and pannexin channels as potential therapeutics

(2017) Joost Willebrords et al.   PHARMACOLOGY & THERAPEUTICS

Astrocyte Function is Modified by Alzheimer's Disease-like Pathology in Aged Mice

(2017) Oliver Peters et al.   JOURNAL OF ALZHEIMERS DISEASE

Complex and Differential Glial Responses in Alzheimers Disease and Ageing

(2016) José J. Rodríguez et al.   Current Alzheimer Research

Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis

(2016) Akshata A. Almad et al.   GLIA

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Propofol depresses cisplatin cytotoxicity via the inhibition of gap junctions

(2016) YUAN ZHANG et al.   Molecular Medicine Reports

Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders

(2016) Alexei Verkhratsky et al.   NEUROBIOLOGY OF DISEASE

The homeostatic astroglia emerges from evolutionary specialization of neural cells

(2016) Alexei Verkhratsky et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Impact of Astroglial Connexins on Modafinil Pharmacological Properties

(2016) Adeline Duchêne et al.   SLEEP

Terbinafine inhibits gap junctional intercellular communication

(2016) Ju Yeun Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Next-Generation Connexin and Pannexin Cell Biology

(2016) Jessica L. Esseltine et al.   TRENDS IN CELL BIOLOGY

Impact of Astroglial Connexins on Modafinil Pharmacological Properties

(2016) Adeline Duchêne et al.   SLEEP

Potentiation of Amitriptyline Anti-Hyperalgesic-Like Action By Astroglial Connexin 43 Inhibition in Neuropathic Rats

(2016) Tiffany Jeanson et al.   Scientific Reports

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

Astrocyte uncoupling as a cause of human temporal lobe epilepsy

(2015) Peter Bedner et al.   BRAIN

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

(2015) Elly M Hol et al.   CURRENT OPINION IN CELL BIOLOGY

General anesthetics have differential inhibitory effects on gap junction channels and hemichannels in astrocytes and neurons

(2015) Xinhe Liu et al.   GLIA

Expression Changes of MicroRNA-1 and its Targets Connexin 43 and Brain-Derived Neurotrophic Factor in the Peripheral Nervous System of Chronic Neuropathic Rats

(2015) Elena Neumann et al.   Molecular Pain

Attenuated Levels of Hippocampal Connexin 43 and its Phosphorylation Correlate with Antidepressant- and Anxiolytic-Like Activities in Mice

(2015) Gaël Quesseveur et al.   Frontiers in Cellular Neuroscience

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

(2014) Gang Chen et al.   BRAIN

Amitriptyline up-regulates connexin43-gap junction in rat cultured cortical astrocytes via activation of the p38 and c-Fos/AP-1 signalling pathway

(2014) N Morioka et al.   BRITISH JOURNAL OF PHARMACOLOGY

Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model

(2014) Yiwen Cui et al.   Journal of Neuroinflammation

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Suppression of spinal connexin 43 expression attenuates mechanical hypersensitivity in rats after an L5 spinal nerve injury

(2014) Qian Xu et al.   NEUROSCIENCE LETTERS

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

Daytime Sleepiness in Parkinson’s Disease: A Reappraisal

(2014) Valérie Cochen De Cock et al.   PLoS One

Hemichannels: new roles in astroglial function

(2014) Juan A. Orellana et al.   Frontiers in Physiology

Involvement of gap junction channels in the pathophysiology of migraine with aura

(2014) Denis Sarrouilhe et al.   Frontiers in Physiology

Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue

(2013) Grazyna Rajkowska et al.   CURRENT DRUG TARGETS

Glia and epilepsy: Experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation

(2013) Hannes Dambach et al.   EPILEPSIA

Gastrodin ameliorates Parkinson’s disease by downregulating connexin 43

(2013) YU WANG et al.   Molecular Medicine Reports

The psychostimulant modafinil enhances gap junctional communication in cortical astrocytes

(2013) Xinhe Liu et al.   NEUROPHARMACOLOGY

Connexin channel modulators and their mechanisms of action

(2013) Vytas K. Verselis et al.   NEUROPHARMACOLOGY

Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles

(2013) Christian Giaume et al.   Frontiers in Pharmacology

Gap junction pathology in multiple sclerosis lesions and normal-appearing white matter

(2012) Kyriaki Markoullis et al.   ACTA NEUROPATHOLOGICA

A High-Throughput Assay for Connexin 43 (Cx43, GJA1) Gap Junctions Using Codon-Optimized Aequorin

(2012) Nazia Haq et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Curious and contradictory roles of glial connexins and pannexins in epilepsy

(2012) Peter L. Carlen   BRAIN RESEARCH

Role of Leaky Neuronal Ryanodine Receptors in Stress- Induced Cognitive Dysfunction

(2012) Xiaoping Liu et al.   CELL

Glial cells in (patho)physiology

(2012) Vladimir Parpura et al.   JOURNAL OF NEUROCHEMISTRY

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Alexander Disease

(2012) A. Messing et al.   JOURNAL OF NEUROSCIENCE

Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

(2012) N. Egawa et al.   Science Translational Medicine

Connexin26 expression in brain parenchymal cells demonstrated by targeted connexin ablation in transgenic mice

(2011) J. I. Nagy et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels

(2011) Juan A. Orellana et al.   GLIA

Calcium signalling in astroglia

(2011) Alexei Verkhratsky et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Gap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats

(2011) Jian-Dong Sun et al.   NEUROPSYCHOPHARMACOLOGY

Sleep deprivation and sleep recovery modifies connexin36 and connexin43 protein levels in rat brain

(2011) Javier Franco-Pérez et al.   NEUROREPORT

Connexins: Key Mediators of Endocrine Function

(2011) Domenico Bosco et al.   PHYSIOLOGICAL REVIEWS

Plasticity of astroglial networks in olfactory glomeruli

(2011) L. Roux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased susceptibility to ischemia-induced ventricular tachyarrhythmias in depressed rats: Involvement of reduction of connexin 43

(2011) WEI WU et al.   Experimental and Therapeutic Medicine

Connexins and the kidney

(2010) Fiona Hanner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Astrocytic Gap Junctional Communication is Reduced in Amyloid-β-Treated Cultured Astrocytes, but not in Alzheimer's Disease Transgenic Mice

(2010) Nancy F Cruz et al.   ASN Neuro

Regulation of gap junction intercellular communication by the ubiquitin system

(2010) Ane Kjenseth et al.   CELLULAR SIGNALLING

Connexin Modulators and Their Potential Targets under the Magnifying Glass

(2010) S. B. Bodendiek et al.   CURRENT MEDICINAL CHEMISTRY

Functional heterotypic interactions between astrocyte and oligodendrocyte connexins

(2010) Laura M. Magnotti et al.   GLIA

Astroglial networks: a step further in neuroglial and gliovascular interactions

(2010) Christian Giaume et al.   NATURE REVIEWS NEUROSCIENCE

Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice

(2010) X. Mei et al.   NEUROSCIENCE

Excitatory effects of gap junction blockers on cerebral cortex seizure-like activity in rats and mice

(2009) Logan J. Voss et al.   EPILEPSIA

Hippocampal seizures alter the expression of the pannexin and connexin transcriptome

(2009) Shanthini Mylvaganam et al.   JOURNAL OF NEUROCHEMISTRY

Differential expression of connexins in trigeminal ganglion neurons and satellite glial cells in response to chronic or acute joint inflammation

(2009) Filip G. Garrett et al.   Neuron Glia Biology

Modulation of connexin 43 in rotenone-induced model of Parkinson's disease

(2009) A. Kawasaki et al.   NEUROSCIENCE

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration

(2008) Juan A. Orellana et al.   ANTIOXIDANTS & REDOX SIGNALING

Advantages and limitations of commonly used methods to assay the molecular permeability of gap junctional intercellular communication

(2008) Muriel Abbaci et al.   BIOTECHNIQUES

Connexin43 Mimetic Peptides Reduce Swelling, Astrogliosis, and Neuronal Cell Death after Spinal Cord Injury

(2008) Simon J. O'Carroll et al.   CELL COMMUNICATION AND ADHESION

Connexin 43 mimetic peptides inhibit spontaneous epileptiform activity in organotypic hippocampal slice cultures

(2008) Marina Samoilova et al.   EXPERIMENTAL NEUROLOGY

Gap Junctions Couple Astrocytes and Oligodendrocytes

(2008) Jennifer L. Orthmann-Murphy et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Evidence for a Role of Connexin 43 in Trigeminal Pain Using RNA Interference In Vivo

(2008) Peter T. Ohara et al.   JOURNAL OF NEUROPHYSIOLOGY

Gap Junction-Mediated Astrocytic Networks in the Mouse Barrel Cortex

(2008) V. Houades et al.   JOURNAL OF NEUROSCIENCE

Implications of antiinflammatory properties of the anticonvulsant drug levetiracetam in astrocytes

(2008) Aiden Haghikia et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats

(2008) S. Hossein Fatemi et al.   SCHIZOPHRENIA RESEARCH

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE

Neuroglia: the 150 years after

(2008) Helmut Kettenmann et al.   TRENDS IN NEUROSCIENCES