Emerging targets in neuroinflammation-driven chronic pain

Chemokine (C-C motif) Receptor 5 Is an Important Pathological Regulator in the Development and Maintenance of Neuropathic Pain

(2014) Katsuyuki Matsushita et al.   ANESTHESIOLOGY

Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain

(2014) Elizabeth A. Old et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion

(2014) Temugin Berta et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1

(2014) Chul-Kyu Park et al.   NEURON

Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma

(2013) Zhen-Zhong Xu et al.   ANNALS OF NEUROLOGY

Small fibre pathology in patients with fibromyalgia syndrome

(2013) Nurcan Üçeyler et al.   BRAIN

Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain

(2013) Satoshi Imai et al.   BRAIN

Neuroinflammation and the generation of neuropathic pain

(2013) A Ellis et al.   BRITISH JOURNAL OF ANAESTHESIA

The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza

(2013) Masayuki Morita et al.   CELL

Cystatin C in Cerebrospinal Fluid is Upregulated in Elderly Patients With Chronic Osteoarthritis Pain and Modulated Through Matrix Metalloproteinase 9–Specific Pathway

(2013) Shu-Lin Guo et al.   CLINICAL JOURNAL OF PAIN

A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia

(2013) Yan Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

WNT signaling underlies the pathogenesis of neuropathic pain in rodents

(2013) Yan-Kai Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt Signaling in the Pathogenesis of Human HIV-Associated Pain Syndromes

(2013) Yuqiang Shi et al.   Journal of Neuroimmune Pharmacology

Peripheral TGF- 1 Signaling Is a Critical Event in Bone Cancer-Induced Hyperalgesia in Rodents

(2013) Q. Xu et al.   JOURNAL OF NEUROSCIENCE

Bacteria activate sensory neurons that modulate pain and inflammation

(2013) Isaac M. Chiu et al.   NATURE

Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis

(2013) Francesco Ferrini et al.   NATURE NEUROSCIENCE

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

(2013) Dimitris N. Xanthos et al.   NATURE REVIEWS NEUROSCIENCE

Chemokine contribution to neuropathic pain: Respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons

(2013) Zhi-Jun Zhang et al.   PAIN

Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: A randomized trial

(2013) Christopher E. Ramsden et al.   PAIN

A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia

(2013) Jarkko Kalliomäki et al.   PAIN

Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion

(2013) Yong Chen et al.   PAIN

Glia and pain: Is chronic pain a gliopathy?

(2013) Ru-Rong Ji et al.   PAIN

TRP-channels as key integrators of lipid pathways in nociceptive neurons

(2013) Marco Sisignano et al.   PROGRESS IN LIPID RESEARCH

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

(2012) Charles N. Serhan et al.   FASEB JOURNAL

Multiple P2Y subtypes in spinal microglia are involved in neuropathic pain after peripheral nerve injury

(2012) Kimiko Kobayashi et al.   GLIA

Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury

(2012) Michael J. Chen et al.   GLIA

Resolvin E1 Inhibits Neuropathic Pain and Spinal Cord Microglial Activation Following Peripheral Nerve Injury

(2012) Zhen-Zhong Xu et al.   Journal of Neuroimmune Pharmacology

Wnt Signaling in the Pathogenesis of Multiple Sclerosis-Associated Chronic Pain

(2012) Subo Yuan et al.   Journal of Neuroimmune Pharmacology

Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain

(2012) Zhi-Jun Zhang et al.   Journal of Neuroinflammation

Chronic-Pain-Associated Astrocytic Reaction in the Spinal Cord Dorsal Horn of Human Immunodeficiency Virus-Infected Patients

(2012) Y. Shi et al.   JOURNAL OF NEUROSCIENCE

Role of P2X7 Receptor-Mediated IL-18/IL-18R Signaling in Morphine Tolerance: Multiple Glial-Neuronal Dialogues in the Rat Spinal Cord

(2012) Meng-Ling Chen et al.   JOURNAL OF PAIN

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

(2012) Robert E Sorge et al.   NATURE MEDICINE

Chemokine signaling involving chemokine (C-C motif) ligand 2 plays a role in descending pain facilitation

(2012) Wei Guo et al.   Neuroscience Bulletin

Chronic Pain States: Pharmacological Strategies to Restore Diminished Inhibitory Spinal Pain Control

(2011) Hanns Ulrich Zeilhofer et al.   Annual Review of Pharmacology and Toxicology

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

(2011) Makoto Tsuda et al.   BRAIN

SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

(2011) Aili L. Lazaar et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats

(2011) JF Lima-Garcia et al.   BRITISH JOURNAL OF PHARMACOLOGY

Airway inflammation evaluated in a human nasal lipopolysaccharide challenge model by investigating the effect of a CXCR2 inhibitor

(2011) R. Virtala et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

(2011) Paul Morgan et al.   DRUG DISCOVERY TODAY

Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development

(2011) Knut Biber et al.   EMBO JOURNAL

Microglial signalling mechanisms: Cathepsin S and Fractalkine

(2011) Anna K. Clark et al.   EXPERIMENTAL NEUROLOGY

The mechanisms of microgliosis and pain following peripheral nerve injury

(2011) Margarita Calvo et al.   EXPERIMENTAL NEUROLOGY

Resolvin D2 Is a Potent Endogenous Inhibitor for Transient Receptor Potential Subtype V1/A1, Inflammatory Pain, and Spinal Cord Synaptic Plasticity in Mice: Distinct Roles of Resolvin D1, D2, and E1

(2011) C.-K. Park et al.   JOURNAL OF NEUROSCIENCE

Resolving TRPV1- and TNF- -Mediated Spinal Cord Synaptic Plasticity and Inflammatory Pain with Neuroprotectin D1

(2011) C.-K. Park et al.   JOURNAL OF NEUROSCIENCE

Peripheral Nerve Injury Alters Blood-Spinal Cord Barrier Functional and Molecular Integrity through a Selective Inflammatory Pathway

(2011) S. Echeverry et al.   JOURNAL OF NEUROSCIENCE

Peripheral Nerve Injury Leads to Working Memory Deficits and Dysfunction of the Hippocampus by Upregulation of TNF-α in Rodents

(2011) Wen-Jie Ren et al.   NEUROPSYCHOPHARMACOLOGY

Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism

(2011) C.A. Christianson et al.   NEUROSCIENCE

Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis

(2011) Christina A. Christianson et al.   PAIN

Attenuation of rodent neuropathic pain by an orally active peptide, RAP-103, which potently blocks CCR2- and CCR5-mediated monocyte chemotaxis and inflammation

(2011) Satyanarayana S.V. Padi et al.   PAIN

Blockade of TNF-α rapidly inhibits pain responses in the central nervous system

(2011) Andreas Hess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging roles of resolvins in the resolution of inflammation and pain

(2011) Ru-Rong Ji et al.   TRENDS IN NEUROSCIENCES

Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception

(2010) S Bang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Central modulation of pain

(2010) Michael H. Ossipov et al.   JOURNAL OF CLINICAL INVESTIGATION

Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents

(2010) Amol M. Patwardhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1

(2010) Nicolas G. Bazan et al.   JOURNAL OF LIPID RESEARCH

P2X7-Dependent Release of Interleukin-1  and Nociception in the Spinal Cord following Lipopolysaccharide

(2010) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Neuregulin-ErbB Signaling Promotes Microglial Proliferation and Chemotaxis Contributing to Microgliosis and Pain after Peripheral Nerve Injury

(2010) M. Calvo et al.   JOURNAL OF NEUROSCIENCE

A p38 Mitogen-Activated Protein Kinase-Dependent Mechanism of Disinhibition in Spinal Synaptic Transmission Induced by Tumor Necrosis Factor- 

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

The Prevalence of Chronic Pain in United States Adults: Results of an Internet-Based Survey

(2010) Catherine B. Johannes et al.   JOURNAL OF PAIN

Omega-3 Essential Fatty Acids Modulate Initiation and Progression of Neurodegenerative Disease

(2010) R. Palacios-Pelaez et al.   MOLECULAR NEUROBIOLOGY

Peripheral Nerve Injury and TRPV1-Expressing Primary Afferent C-Fibers Cause Opening of the Blood-Brain Barrier

(2010) Simon Beggs et al.   Molecular Pain

Overcoming obstacles to developing new analgesics

(2010) Clifford J Woolf   NATURE MEDICINE

Fighting off pain with resolvins

(2010) Claudia Sommer et al.   NATURE MEDICINE

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

(2010) Zhen-Zhong Xu et al.   NATURE MEDICINE

Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior

(2010) Jeong Il Choi et al.   PAIN

Macrophage inflammatory protein-1α mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1β up-regulation

(2010) Norikazu Kiguchi et al.   PAIN

The evidence for pharmacological treatment of neuropathic pain

(2010) Nanna Brix Finnerup et al.   PAIN

Chemokines, neuronal–glial interactions, and central processing of neuropathic pain

(2010) Yong-Jing Gao et al.   PHARMACOLOGY & THERAPEUTICS

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

(2009) Michael Costigan et al.   Annual Review of Neuroscience

Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion

(2009) Isabelle Pineau et al.   BRAIN BEHAVIOR AND IMMUNITY

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects

(2009) O. Holz et al.   EUROPEAN RESPIRATORY JOURNAL

Long-term control of neuropathic pain in a non-viral gene therapy paradigm

(2009) E M Sloane et al.   GENE THERAPY

The Anti-Inflammatory and Proresolving Mediator Resolvin E1 Protects Mice from Bacterial Pneumonia and Acute Lung Injury

(2009) H. Seki et al.   JOURNAL OF IMMUNOLOGY

Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans

(2009) T. Morris et al.   JOURNAL OF IMMUNOLOGY

An engineered CX3CR1 antagonist endowed with anti-inflammatory activity

(2009) Karim Dorgham et al.   JOURNAL OF LEUKOCYTE BIOLOGY

T-Cell Infiltration and Signaling in the Adult Dorsal Spinal Cord Is a Major Contributor to Neuropathic Pain-Like Hypersensitivity

(2009) M. Costigan et al.   JOURNAL OF NEUROSCIENCE

JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

(2009) Y.-J. Gao et al.   JOURNAL OF NEUROSCIENCE

The Liberation of Fractalkine in the Dorsal Horn Requires Microglial Cathepsin S

(2009) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Unmasking the tonic-aversive state in neuropathic pain

(2009) Tamara King et al.   NATURE NEUROSCIENCE

Animal models of pain: progress and challenges

(2009) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Current Challenges in Glia-Pain Biology

(2009) Stephen B. McMahon et al.   NEURON

Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates

(2009) Gareth J. Hathway et al.   PAIN

MAP kinase and pain

(2008) Ru-Rong Ji et al.   BRAIN RESEARCH REVIEWS

CCL2 is a key mediator of microglia activation in neuropathic pain states

(2008) Michael A. Thacker et al.   EUROPEAN JOURNAL OF PAIN

Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease

(2008) Nicolas G. Bazan   JOURNAL OF LIPID RESEARCH

P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury

(2008) H. Tozaki-Saitoh et al.   JOURNAL OF NEUROSCIENCE

Interleukin-18-Mediated Microglia/Astrocyte Interaction in the Spinal Cord Enhances Neuropathic Pain Processing after Nerve Injury

(2008) K. Miyoshi et al.   JOURNAL OF NEUROSCIENCE

P2Y12 Receptor Upregulation in Activated Microglia Is a Gateway of p38 Signaling and Neuropathic Pain

(2008) K. Kobayashi et al.   JOURNAL OF NEUROSCIENCE

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE

Selective Activation of Microglia in Spinal Cord but Not Higher Cortical Regions Following Nerve Injury in Adult Mouse

(2008) Fuxing Zhang et al.   Molecular Pain

Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex

(2008) Xue Jun Liu et al.   NATURE MEDICINE

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

(2008) Yasuhiko Kawasaki et al.   NATURE MEDICINE

Transient receptor potential channels: targeting pain at the source

(2008) Ardem Patapoutian et al.   NATURE REVIEWS DRUG DISCOVERY

Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain

(2007) Stefania Echeverry et al.   PAIN