Novel Antidepressant Mechanism of Ginsenoside Rg1 in Regulating the Dysfunction of the Glutamatergic System in Astrocytes

Connexin 43: insights into candidate pathological mechanisms of depression and its implications in antidepressant therapy

(2022) Ning-ning Zhang et al.   ACTA PHARMACOLOGICA SINICA

Mahonia Alkaloids (MA) Ameliorate Depression Induced Gap Junction Dysfunction by miR-205/Cx43 Axis

(2022) Junhui He et al.   NEUROCHEMICAL RESEARCH

Ginsenoside Rg1 in neurological diseases: From bench to bedside

(2022) Shao-jie Yang et al.   ACTA PHARMACOLOGICA SINICA

Downregulation of connexin43 potentiates noradrenaline‐induced expression of brain‐derived neurotrophic factor in primary cultured cortical astrocytes

(2021) Norimitsu Morioka et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Novel antidepressant mechanism of ginsenoside Rg1: Regulating biosynthesis and degradation of connexin43

(2021) Hui-Qin Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ginsenoside Rg1 Ameliorates Neuroinflammation via Suppression of Connexin43 Ubiquitination to Attenuate Depression

(2021) Huiqin Wang et al.   Frontiers in Pharmacology

Neuroinflammation and depression: A review

(2020) Romain Troubat et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation

(2020) Ning Jiang et al.   LIFE SCIENCES

Connexin 43: A novel ginsenoside Rg1-sensitive target in a rat model of depression

(2020) Cong-Yuan Xia et al.   NEUROPHARMACOLOGY

A Working Hypothesis Regarding Identical Pathomechanisms between Clinical Efficacy and Adverse Reaction of Clozapine via the Activation of Connexin43

(2020) Motohiro Okada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astroglial Connexin43 as a Potential Target for a Mood Stabiliser

(2020) Motohiro Okada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ginsenoside Rg1 Prevents PTSD-Like Behaviors in Mice Through Promoting Synaptic Proteins, Reducing Kir4.1 and TNF-α in the Hippocampus

(2020) Zhengrong Zhang et al.   MOLECULAR NEUROBIOLOGY

Connexin Hemichannels in Astrocytes: Role in CNS Disorders

(2019) LingYan Xing et al.   Frontiers in Molecular Neuroscience

Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke

(2019) Moises Freitas-Andrade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRX1 Enhances Glutamate Uptake and Inhibits Glutamate Release by Astrocytes

(2019) Shaimaa Mahmoud et al.   Cells

Ginsenoside Rg1 promotes sleep in rats by modulating the noradrenergic system in the locus coeruleus and serotonergic system in the dorsal raphe nucleus

(2019) Ya-Ping Xu et al.   BIOMEDICINE & PHARMACOTHERAPY

Ginsenoside Rg1 promotes cerebral angiogenesis via the PI3K/Akt/mTOR signaling pathway in ischemic mice

(2019) Junmin Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Connexins-Based Hemichannels/Channels and Their Relationship with Inflammation, Seizures and Epilepsy

(2019) Laura Medina-Ceja et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cx43 Channel Gating and Permeation: Multiple Phosphorylation-Dependent Roles of the Carboxyl Terminus

(2018) José Ek-Vitorín et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis

(2018) Andrea Cipriani et al.   LANCET

Corticosterone impairs gap junctions in the prefrontal cortical and hippocampal astrocytes via different mechanisms

(2018) Cong-Yuan Xia et al.   NEUROPHARMACOLOGY

Ginsenoside Rg1 Prevents Chronic Stress-Induced Depression-Like Behaviors and Neuronal Structural Plasticity in Rats

(2018) Hongluan Yu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

An astroglial basis of major depressive disorder? An overview

(2017) Qian Wang et al.   GLIA

Ginsenoside Rg1 alleviates corticosterone-induced dysfunction of gap junctions in astrocytes

(2017) Cong-Yuan Xia et al.   JOURNAL OF ETHNOPHARMACOLOGY

Evidence for neuroplastic compensation in the cerebral cortex of persons with depressive illness

(2017) R Bansal et al.   MOLECULAR PSYCHIATRY

Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins

(2017) Ingo H. Greger et al.   NEURON

Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications

(2017) Luc Leybaert et al.   PHARMACOLOGICAL REVIEWS

Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies

(2017) Denis Sarrouilhe et al.   Frontiers in Molecular Neuroscience

Regulation of gap junction channels and hemichannels by phosphorylation and redox changes: a revision

(2016) Kristin Pogoda et al.   BMC CELL BIOLOGY

Kinase programs spatiotemporally regulate gap junction assembly and disassembly: Effects on wound repair

(2016) Joell L. Solan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Connexin43 hemichannels contributes to the disassembly of cell junctions through modulation of intracellular oxidative status

(2016) Yuan Chi et al.   Redox Biology

Depression, Neuroimaging and Connectomics: A Selective Overview

(2015) Qiyong Gong et al.   BIOLOGICAL PSYCHIATRY

The connectomics of brain disorders

(2015) Alex Fornito et al.   NATURE REVIEWS NEUROSCIENCE

Hemichannels: New pathways for gliotransmitter release

(2015) T.D. Montero et al.   NEUROSCIENCE

Resting-state functional connectivity in major depressive disorder: A review

(2015) Peter C. Mulders et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Phytochemical constituents as future antidepressants: a comprehensive review

(2015) Roodabeh Bahramsoltani et al.   REVIEWS IN THE NEUROSCIENCES

Reduced density of glutamine synthetase immunoreactive astrocytes in different cortical areas in major depression but not in bipolar I disorder

(2015) Hans-Gert Bernstein et al.   Frontiers in Cellular Neuroscience

Restraint stress increases hemichannel activity in hippocampal glial cells and neurons

(2015) Juan A. Orellana et al.   Frontiers in Cellular Neuroscience

Mental health: A world of depression

(2014) Kerri Smith   NATURE

Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles

(2013) Christian Giaume et al.   Frontiers in Pharmacology

Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus

(2012) Bo Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors

(2012) Nicola J. Allen et al.   NATURE

Blockade of Astrocytic Glutamate Uptake in the Prefrontal Cortex Induces Anhedonia

(2012) Catherine S John et al.   NEUROPSYCHOPHARMACOLOGY

Serum concentrations of CRP, IL-6, TNF-α and cortisol in major depressive disorder with melancholic or atypical features

(2012) Dalibor Karlović et al.   PSYCHIATRY RESEARCH

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

(2012) N Riteau et al.   Cell Death & Disease

Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels

(2011) Juan A. Orellana et al.   GLIA

Gap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats

(2011) Jian-Dong Sun et al.   NEUROPSYCHOPHARMACOLOGY

Effects of Depressive-Like Behavior of Rats on Brain Glutamate Uptake

(2010) Roberto Farina Almeida et al.   NEUROCHEMICAL RESEARCH

Connexin43 phosphorylation: structural changes and biological effects

(2009) Joell L. Solan et al.   BIOCHEMICAL JOURNAL

Targeting glial physiology and glutamate cycling in the treatment of depression

(2009) Gerald W. Valentine et al.   BIOCHEMICAL PHARMACOLOGY

Neurocircuitry of Mood Disorders

(2009) Joseph L Price et al.   NEUROPSYCHOPHARMACOLOGY

Cortical thinning in persons at increased familial risk for major depression

(2009) B. S. Peterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration

(2008) Juan A. Orellana et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutamine Synthetase and Glutamine Synthetase-Like Protein from Human Brain

(2003) Irina S. Boksha et al.   JOURNAL OF NEUROCHEMISTRY