Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease

Gap junction gene and protein families: Connexins, innexins, and pannexins

(2018) Eric C. Beyer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Human diseases associated with connexin mutations

(2018) Miduturu Srinivas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The connexin 43 C-terminus: A tail of many tales

(2018) Edward Leithe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Spatio-temporal regulation of connexin43 phosphorylation and gap junction dynamics

(2018) Joell L. Solan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Altered translation initiation of Gja1 limits gap junction formation during epithelial–mesenchymal transition

(2018) Carissa C. James et al.   MOLECULAR BIOLOGY OF THE CELL

Cooperative regulation of Gja1 expression by members of the AP-1 family cJun and cFos in TM3 Leydig and TM4 Sertoli cells

(2017) Firas Ghouili et al.   GENE

Myosin VI facilitates connexin 43 gap junction accretion

(2017) Bennett J. Waxse et al.   JOURNAL OF CELL SCIENCE

Localization of phosphorylated connexin 43 using serial section immunogold electron microscopy

(2017) Rachael P. Norris et al.   JOURNAL OF CELL SCIENCE

The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions

(2017) Max Z. Totland et al.   JOURNAL OF CELL SCIENCE

Regulation of Cx37 channel and growth-suppressive properties by phosphorylation

(2017) Nicole L. Jacobsen et al.   JOURNAL OF CELL SCIENCE

A Multicenter Randomized Controlled Trial Evaluating a Cx43-Mimetic Peptide in Cutaneous Scarring

(2017) Christina L. Grek et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Intramolecular signaling in a cardiac connexin: Role of cytoplasmic domain dimerization

(2017) Andrew J. Trease et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phosphorylation regulates connexin43/ZO-1 binding and release, an important step in gap junction turnover

(2017) Anastasia F. Thévenin et al.   MOLECULAR BIOLOGY OF THE CELL

Joint diseases: from connexins to gap junctions

(2017) Henry J. Donahue et al.   Nature Reviews Rheumatology

Deletion of P2 promoter of GJB1 gene a cause of Charcot-Marie-Tooth disease

(2017) R. Kulshrestha et al.   NEUROMUSCULAR DISORDERS

Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications

(2017) Luc Leybaert et al.   PHARMACOLOGICAL REVIEWS

Connexins and Disease

(2017) Mario Delmar et al.   Cold Spring Harbor Perspectives in Biology

MicroRNA-144-3p inhibits bone formation in distraction osteogenesis through targeting Connexin 43

(2017) Yu-Xin Sun et al.   Oncotarget

Cx43 Isoform GJA1-20k Promotes Microtubule Dependent Mitochondrial Transport

(2017) Ying Fu et al.   Frontiers in Physiology

Regulation of connexin signaling by the epigenetic machinery

(2016) Mathieu Vinken   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The “tail” of Connexin43: An unexpected journey from alternative translation to trafficking

(2016) Wassim Basheer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of gap junction channels and hemichannels by phosphorylation and redox changes: a revision

(2016) Kristin Pogoda et al.   BMC CELL BIOLOGY

The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses

(2016) Viviana M. Berthoud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Studies of the Nedd4 WW Domains and Their Selectivity for the Connexin43 (Cx43) Carboxyl Terminus

(2016) Gaelle Spagnol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gefitinib enhances oxaliplatin-induced apoptosis mediated by Src and PKC-modulated gap junction function

(2016) Jian-Feng Wu et al.   ONCOLOGY REPORTS

Regulation of gap junction conductance by calcineurin through Cx43 phosphorylation: implications for action potential conduction

(2016) Rita I Jabr et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Connexin channels in congenital skin disorders

(2016) Evelyn Lilly et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Translating connexin biology into therapeutics

(2016) David L. Becker et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Kinase programs spatiotemporally regulate gap junction assembly and disassembly: Effects on wound repair

(2016) Joell L. Solan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Next-Generation Connexin and Pannexin Cell Biology

(2016) Jessica L. Esseltine et al.   TRENDS IN CELL BIOLOGY

Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions

(2016) Barbara Schlingmann et al.   Nature Communications

Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes

(2016) Ana González-Sánchez et al.   Oncotarget

The Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approaches

(2016) Pui Wong et al.   Frontiers in Physiology

Extracellular Cysteine in Connexins: Role as Redox Sensors

(2016) Mauricio A. Retamal et al.   Frontiers in Physiology

Connexin 32-mediated cell-cell communication is essential for hepatic differentiation from human embryonic stem cells

(2016) Jinhua Qin et al.   Scientific Reports

The connexin 43/ZO-1 complex regulates cerebral endothelial F-actin architecture and migration

(2015) Cheng-Hung Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lens ion homeostasis relies on the assembly and/or stability of large connexin 46 gap junction plaques on the broad sides of differentiating fiber cells

(2015) Catherine Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Junctional abnormalities in human airway epithelial cells expressing F508del CFTR

(2015) Samuel A. Molina et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The relative balance of GM-CSF and TGF-β1 regulates lung epithelial barrier function

(2015) Christian E. Overgaard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Complementary expression and phosphorylation of Cx46 and Cx50 during development and following gene deletion in mouse and in normal and orchitic mink testes

(2015) R.-Marc Pelletier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Post-transcriptional regulation of connexins: Figure 1

(2015) Clàudia Salat-Canela et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The role of IRES trans-acting factors in carcinogenesis

(2015) Mame Daro Faye et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

New cellular mechanisms of gap junction degradation and recycling

(2015) Diane Carette et al.   BIOLOGY OF THE CELL

Identification of miR-200a as a novel suppressor of connexin 43 in breast cancer cells

(2015) J. Ming et al.   BIOSCIENCE REPORTS

Connexins and pannexins in the integumentary system: the skin and appendages

(2015) Chrysovalantou Faniku et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Two-color fluorescent analysis of connexin 36 turnover: relationship to functional plasticity

(2015) H. Y. Wang et al.   JOURNAL OF CELL SCIENCE

Connexin 43 deficiency accelerates skin wound healing and extracellular matrix remodeling in mice

(2015) Bruno Cogliati et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis

(2015) Wassim A. Basheer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Acetylation mediates Cx43 reduction caused by electrical stimulation

(2015) Viviana Meraviglia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CRTC2 and Nedd4 ligase involvement in FSH and TGFβ1 upregulation of connexin43 gap junction

(2015) Wei-Ling Fang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Effects of rotigaptide (ZP123) on connexin43 remodeling in canine ventricular fibrillation

(2015) GUO-YING SU et al.   Molecular Medicine Reports

Phosphorylation of Connexin 43 by Cdk5 Modulates Neuronal Migration During Embryonic Brain Development

(2015) Guang-Jian Qi et al.   MOLECULAR NEUROBIOLOGY

Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection

(2015) Rainer Schulz et al.   PHARMACOLOGY & THERAPEUTICS

cAMP Promotes Cell Migration Through Cell Junctional Complex Dynamics and Actin Cytoskeleton Remodeling: Implications in Skin Wound Healing

(2015) Mi Ok Kim et al.   STEM CELLS AND DEVELOPMENT

The carboxy-terminal domain of connexin 43 (CT-Cx43) modulates the expression of p53 by altering miR-125b expression in low-grade human breast cancers

(2015) Raihana Maqbool et al.   CELLULAR ONCOLOGY

RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes

(2015) María Sol Recouvreux et al.   Oncotarget

Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer

(2015) Shaohua Chen et al.   FEBS Open Bio

miR-23a impairs bone differentiation in osteosarcoma via down-regulation of GJA1

(2015) Yevgeniy Gindin et al.   Frontiers in Genetics

Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication

(2015) Tobias Forster et al.   Oncotarget

Cholesterol modulates function of connexin 43 gap junction channel via PKC pathway in H9c2 cells

(2014) Jun Zou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Characterization of the Connexin45 Carboxyl-Terminal Domain Structure and Interactions with Molecular Partners

(2014) Jennifer L. Kopanic et al.   BIOPHYSICAL JOURNAL

Connexins: junctional and non-junctional modulators of proliferation

(2014) Trond Aasen   CELL AND TISSUE RESEARCH

Mechanisms linking connexin mutations to human diseases

(2014) John J. Kelly et al.   CELL AND TISSUE RESEARCH

NO, via its target Cx37, modulates calcium signal propagation selectively at myoendothelial gap junctions

(2014) Kristin Pogoda et al.   Cell Communication and Signaling

Internal translation of the connexin 43 transcript

(2014) Clàudia Salat-Canela et al.   Cell Communication and Signaling

Specific Cx43 phosphorylation events regulate gap junction turnover in vivo

(2014) Joell L. Solan et al.   FEBS LETTERS

Mix and match: Investigating heteromeric and heterotypic gap junction channels in model systems and native tissues

(2014) Michael Koval et al.   FEBS LETTERS

Hunting for connexin hemichannels

(2014) Juan C. Sáez et al.   FEBS LETTERS

Cardiac to cancer: Connecting connexins to clinical opportunity

(2014) Christina L. Grek et al.   FEBS LETTERS

Structural Determinants and Proliferative Consequences of Connexin 37 Hemichannel Function in Insulinoma Cells

(2014) Miranda E. Good et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Internal Ribosomal Entry Site (IRES) Activity Generates Endogenous Carboxyl-terminal Domains of Cx43 and Is Responsive to Hypoxic Conditions

(2014) Mahboob Ul-Hussain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin 31.1 degradation requires the Clathrin-mediated autophagy in NSCLC cell H1299

(2014) Xingli Zhu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Connexins modulate autophagosome biogenesis

(2014) Eloy Bejarano et al.   NATURE CELL BIOLOGY

Desmosome Assembly and Disassembly Are Membrane Raft-Dependent

(2014) Sara N. Stahley et al.   PLoS One

Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina

(2014) HONGYAN LI et al.   VISUAL NEUROSCIENCE

Connexin 32and43promoter methylation inHelicobacter pylori-associated gastric tumorigenesis

(2014) Yu Wang   WORLD JOURNAL OF GASTROENTEROLOGY

LASAGNA-Search: an integrated web tool for transcription factor binding site search and visualization

(2013) Chih Lee et al.   BIOTECHNIQUES

RNA-Binding Proteins Impacting on Internal Initiation of Translation

(2013) Encarnación Martínez-Salas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Phosphorylation on the Structure and Backbone Dynamics of the Intrinsically Disordered Connexin43 C-terminal Domain

(2013) Rosslyn Grosely et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size

(2013) C. A. Dunn et al.   JOURNAL OF CELL SCIENCE

Myocardin and microRNA-1 modulate bladder activity through connexin 43 expression during post-natal development

(2013) Masaaki Imamura et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Connexin47 Protein Phosphorylation and Stability in Oligodendrocytes Depend on Expression of Connexin43 Protein in Astrocytes

(2013) D. May et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells

(2013) Kristen E. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

The antiarrhythmic dipeptide ZP1609 (danegaptide) when given at reperfusion reduces myocardial infarct size in pigs

(2013) Andreas Skyschally et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels

(2013) Xavier F. Figueroa et al.   NEUROPHARMACOLOGY

A Novel Splice-Site Mutation in the GJB2 Gene Causing Mild Postlingual Hearing Impairment

(2013) Marta Gandía et al.   PLoS One

PKCɛ mediates serine phosphorylation of connexin43 induced by lysophosphatidylcholine in neonatal rat cardiomyocytes

(2013) Chih-Kai Liao et al.   TOXICOLOGY

Expression of Cx43-related microRNAs in patients with tetralogy of Fallot

(2013) Yao Wu et al.   World Journal of Pediatrics

Autoregulation of Connexin43 Gap Junction Formation by Internally Translated Isoforms

(2013) James W. Smyth et al.   Cell Reports

The effects of the histone deacetylase inhibitor 4-phenylbutyrate on gap junction conductance and permeability

(2013) Joshua Kaufman et al.   Frontiers in Pharmacology

Histone deacetylase inhibition reduces cardiac connexin43 expression and gap junction communication

(2013) Qin Xu et al.   Frontiers in Pharmacology

Managing the complexity of communication: regulation of gap junctions by post-translational modification

(2013) Lene N. Axelsen et al.   Frontiers in Pharmacology

Internalized gap junctions are degraded by autophagy

(2012) John T. Fong et al.   Autophagy

Connexin multi-site phosphorylation: Mass spectrometry-based proteomics fills the gap

(2012) Vincent C. Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural basis for the selective permeability of channels made of communicating junction proteins

(2012) Jose F. Ek-Vitorin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Regulation of connexin expression by transcription factors and epigenetic mechanisms

(2012) Masahito Oyamada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Chemical shift assignments of the connexin45 carboxyl terminal domain: monomer and dimer conformations

(2012) Jennifer L. Kopanic et al.   Biomolecular NMR Assignments

1H, 13C, and 15N backbone resonance assignments of the connexin43 carboxyl terminal domain attached to the 4th transmembrane domain in detergent micelles

(2012) Rosslyn Grosely et al.   Biomolecular NMR Assignments

Connexins and Cap-independent translation: Role of internal ribosome entry sites

(2012) Mahboob Ul-Hussain et al.   BRAIN RESEARCH

Suppression of CX43 expression by miR-20a in the progression of human prostate cancer

(2012) Xin Li et al.   CANCER BIOLOGY & THERAPY

Residual Cx45 and its relationship to Cx43 in murine ventricular myocardium

(2012) Mingwei Bao et al.   Channels

Actin Cytoskeleton Rest Stops Regulate Anterograde Traffic of Connexin 43 Vesicles to the Plasma Membrane

(2012) James W. Smyth et al.   CIRCULATION RESEARCH

MAPK Phosphorylation of Connexin 43 Promotes Binding of Cyclin E and Smooth Muscle Cell Proliferation

(2012) Scott R. Johnstone et al.   CIRCULATION RESEARCH

The unfolded protein response is activated in connexin 50 mutant mouse lenses

(2012) Bhagwat V. Alapure et al.   EXPERIMENTAL EYE RESEARCH

A new framework for understanding IRES-mediated translation

(2012) Anton A. Komar et al.   GENE

The role of the C-terminus in functional expression and internalization of rat connexin46 (rCx46)

(2012) Barbara Schlingmann et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The Gap Junction Channel Protein Connexin 43 Is Covalently Modified and Regulated by SUMOylation

(2012) Ane Kjenseth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43

(2012) Tone Aase Fykerud et al.   JOURNAL OF CELL SCIENCE

Pelizaeus-Merzbacher–Like Disease in a Family With Variable Phenotype and a Novel Splicing GJC2 Mutation

(2012) Said Ali Al-Yahyaee et al.   JOURNAL OF CHILD NEUROLOGY

Extracellular Loop Cysteine Mutant of Cx37 Fails to Suppress Proliferation of Rat Insulinoma Cells

(2012) Miranda E. Good et al.   JOURNAL OF MEMBRANE BIOLOGY

Posttranslational Modifications in Connexins and Pannexins

(2012) Scott R. Johnstone et al.   JOURNAL OF MEMBRANE BIOLOGY

Cytoplasmic Amino Acids within the Membrane Interface Region Influence Connexin Oligomerization

(2012) Tekla D. Smith et al.   JOURNAL OF MEMBRANE BIOLOGY

Degradation of Endocytosed Gap Junctions by Autophagosomal and Endo-/lysosomal Pathways: A Perspective

(2012) Matthias M. Falk et al.   JOURNAL OF MEMBRANE BIOLOGY

Association of Connexin43 with E3 Ubiquitin Ligase TRIM21 Reveals a Mechanism for Gap Junction Phosphodegron Control

(2012) Vincent C. Chen et al.   JOURNAL OF PROTEOME RESEARCH

Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function

(2012) Oscar Jara et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

(2012) Eloy Bejarano et al.   MOLECULAR BIOLOGY OF THE CELL

miR-221/222 is the regulator of Cx43 expression in human glioblastoma cells

(2012) Peiyu Pu   ONCOLOGY REPORTS

So you want to know if your message has an IRES?

(2012) Sunnie R. Thompson   Wiley Interdisciplinary Reviews-RNA

Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal

(2011) Steve Catarino et al.   BIOCHEMICAL JOURNAL

Connexins in epidermal homeostasis and skin disease

(2011) Claire A. Scott et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Endocytosis and post-endocytic sorting of connexins

(2011) Edward Leithe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Connexins in wound healing; perspectives in diabetic patients

(2011) David L. Becker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A Peptide Mimetic of the Connexin43 Carboxyl Terminus Reduces Gap Junction Remodeling and Induced Arrhythmia Following Ventricular Injury

(2011) Michael P. O'Quinn et al.   CIRCULATION RESEARCH

DNA methylation analyses of the connexin gene family reveal silencing ofGJC1(Connexin45) by promoter hypermethylation in colorectal cancer

(2011) Solveig Sirnes et al.   Epigenetics

The perinexus: A new feature of Cx43 gap junction organization

(2011) Joshua Matthew Rhett et al.   HEART RHYTHM

Suppression of lung cancer cell invasion and metastasis by connexin43 involves the secretion of follistatin-like 1 mediated via histone acetylation

(2011) Wei Zhao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Phosphorylation of Connexin 50 by Protein Kinase A Enhances Gap Junction and Hemichannel Function

(2011) Jialu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigation of the Reciprocal Relationship between the Expression of Two Gap Junction Connexin Proteins, Connexin46 and Connexin43

(2011) Debarshi Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Akt, Not Connexin 43 Protein Ubiquitination, Regulates Gap Junction Stability

(2011) Clarence A. Dunn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERp29 Regulates ΔF508 and Wild-type Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Trafficking to the Plasma Membrane in Cystic Fibrosis (CF) and Non-CF Epithelial Cells

(2011) Laurence Suaud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A functional channel is necessary for growth suppression by Cx37

(2011) M. E. Good et al.   JOURNAL OF CELL SCIENCE

Autophagy: a pathway that contributes to connexin degradation

(2011) A. Lichtenstein et al.   JOURNAL OF CELL SCIENCE

A novel mutation in the nerve-specific 5′UTR of the GJB1 gene causes X-linked Charcot-Marie-Tooth disease

(2011) Sinéad M. Murphy et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1

(2011) J. Matthew Rhett et al.   MOLECULAR BIOLOGY OF THE CELL

Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia

(2011) Alan S. Fanning et al.   MOLECULAR BIOLOGY OF THE CELL

Misregulation of miR-1 processing is associated with heart defects in myotonic dystrophy

(2011) Frédérique Rau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N -lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart

(2011) C. Colussi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZO-1 determines adherens and gap junction localization at intercalated disks

(2010) Joseph A. Palatinus et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells

(2010) Michael J. LaFemina et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Compartmentalized Connexin 43 S -Nitrosylation/Denitrosylation Regulates Heterocellular Communication in the Vessel Wall

(2010) Adam C. Straub et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Unexpected role for the human Cx37 C1019T polymorphism in tumour cell proliferation

(2010) S. Morel et al.   CARCINOGENESIS

The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice

(2010) Claudia Colussi et al.   CARDIOVASCULAR RESEARCH

Optimizing the Solution Conditions to Solve the Structure of the Connexin43 Carboxyl Terminus Attached to the 4thTransmembrane Domain in Detergent Micelles

(2010) Rosslyn Grosely et al.   CELL COMMUNICATION AND ADHESION

Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2

(2010) Alexandra Kadl et al.   CIRCULATION RESEARCH

Ultrastructure and Regulation of Lateralized Connexin43 in the Failing Heart

(2010) Geoffrey G. Hesketh et al.   CIRCULATION RESEARCH

Sent to Destroy

(2010) Monte S. Willis et al.   CIRCULATION RESEARCH

Novel mutations in the connexin43 (GJA1) and GJA1 pseudogene may contribute to nonsyndromic hearing loss

(2010) Hui-Mei Hong et al.   HUMAN GENETICS

Amino Acid Residue Val362Plays a Critical Role in Maintaining the Structure of C Terminus of Connexin 50 and in Lens Epithelial-fiber Differentiation

(2010) Qian Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells

(2010) Simone Pollok et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Desmosome Disassembly in Response to Pemphigus Vulgaris IgG Occurs in Distinct Phases and Can Be Reversed by Expression of Exogenous Dsg3

(2010) Jean M. Jennings et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification of CaMKII Phosphorylation Sites in Connexin43 by High-Resolution Mass Spectrometry

(2010) Richard Y−C. Huang et al.   JOURNAL OF PROTEOME RESEARCH

Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess

(2010) Kathryn E. Wellen et al.   MOLECULAR CELL

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Trafficking and Recycling of the Connexin43 Gap Junction Protein during Mitosis

(2010) Daniela Boassa et al.   TRAFFIC

Expression of connexin genes in the human retina

(2010) Goran Söhl et al.   BMC Ophthalmology

Trafficking abnormality and ER stress underlie functional deficiency of hearing impairmentassociated connexin-31 mutants

(2010) Kun Xia et al.   Protein & Cell

Oxidized Phospholipid Species Promote in Vivo Differential Cx43 Phosphorylation and Vascular Smooth Muscle Cell Proliferation

(2009) Scott R. Johnstone et al.   AMERICAN JOURNAL OF PATHOLOGY

Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication

(2009) Solveig Sirnes et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Post-translational modifications of connexin26 revealed by mass spectrometry

(2009) Darren Locke et al.   BIOCHEMICAL JOURNAL

Connexin43 phosphorylation: structural changes and biological effects

(2009) Joell L. Solan et al.   BIOCHEMICAL JOURNAL

Overexpression of Protease-Activated Receptor-1 Contributes to Melanoma Metastasis via Regulation of Connexin 43

(2009) G. J. Villares et al.   CANCER RESEARCH

Src-Induced Cisplatin Resistance Mediated by Cell-to-Cell Communication

(2009) E. Peterson-Roth et al.   CANCER RESEARCH

Phosphorylation of connexin-43 at serine 262 promotes a cardiac injury-resistant state

(2009) Wattamon Srisakuldee et al.   CARDIOVASCULAR RESEARCH

Oxidized Phospholipids Induce Type VIII Collagen Expression and Vascular Smooth Muscle Cell Migration

(2009) Olga A. Cherepanova et al.   CIRCULATION RESEARCH

The TSG101 protein binds to connexins and is involved in connexin degradation

(2009) Tanja Auth et al.   EXPERIMENTAL CELL RESEARCH

Eps15 interacts with ubiquitinated Cx43 and mediates its internalization

(2009) Henrique Girão et al.   EXPERIMENTAL CELL RESEARCH

Nitric oxide deficiency determines global chromatin changes in Duchenne muscular dystrophy

(2009) Claudia Colussi et al.   FASEB JOURNAL

Phosphorylation of connexin43 on serine 306 regulates electrical coupling

(2009) Kristina Procida et al.   HEART RHYTHM

HuR regulates gap junctional intercellular communication by controlling β-catenin levels and adherens junction integrity

(2009) Niloofar Ale-Agha et al.   HEPATOLOGY

EKV mutant connexin 31 associated cell death is mediated by ER stress

(2009) Daniel Tattersall et al.   HUMAN MOLECULAR GENETICS

Characterization of the Structure and Intermolecular Interactions between the Connexin40 and Connexin43 Carboxyl-terminal and Cytoplasmic Loop Domains

(2009) Denis Bouvier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N Terminus of Connexin37 Contains an α-Helix That Is Required for Channel Function

(2009) John W. Kyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoreceptor Coupling Is Controlled by Connexin 35 Phosphorylation in Zebrafish Retina

(2009) H. Li et al.   JOURNAL OF NEUROSCIENCE

Site-Specific Connexin Phosphorylation Is Associated with Reduced Heterocellular Communication between Smooth Muscle and Endothelium

(2009) Adam C. Straub et al.   JOURNAL OF VASCULAR RESEARCH

ERp29 Restricts Connexin43 Oligomerization in the Endoplasmic Reticulum

(2009) Shamie Das et al.   MOLECULAR BIOLOGY OF THE CELL

ZO-1 Stabilizes the Tight Junction Solute Barrier through Coupling to the Perijunctional Cytoskeleton

(2009) Christina M. Van Itallie et al.   MOLECULAR BIOLOGY OF THE CELL

Connexin43 pseudogene in breast cancer cells offers a novel therapeutic target

(2009) A. Bier et al.   MOLECULAR CANCER THERAPEUTICS

The Connexin43 Carboxyl-Terminal Peptide ACT1 Modulates the Biological Response to Silicone Implants

(2009) Brent L. Soder et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Gap Junctions

(2009) D. A. Goodenough et al.   Cold Spring Harbor Perspectives in Biology

Characterization of the internal IRES element of the zebrafish connexin55.5 reveals functional implication of the polypyrimidine tract binding protein

(2008) Mahboob Ul-Hussain et al.   BMC MOLECULAR BIOLOGY

IRES-mediated translation of the carboxy-terminal domain of the horizontal cell specific connexin Cx55.5 in vivo and in vitro

(2008) Mahboob Ul-Hussain et al.   BMC MOLECULAR BIOLOGY

Identification of rab20 as a Potential Regulator of Connexin43 Trafficking

(2008) Jayasri Das Sarma et al.   CELL COMMUNICATION AND ADHESION

Structural Changes in the Carboxyl Terminus of the Gap Junction Protein Connexin40 Caused by the Interaction with c-Src and Zonula Occludens-1

(2008) Denis Bouvier et al.   CELL COMMUNICATION AND ADHESION

The Second PDZ Domain of Zonula Occludens-1 Is Dispensable for Targeting to Connexin43 Gap Junctions

(2008) Andrew W. Hunter et al.   CELL COMMUNICATION AND ADHESION

The cytoplasmic accumulations of the cataract-associated mutant, Connexin50P88S, are long-lived and form in the endoplasmic reticulum

(2008) Alexandra Lichtenstein et al.   EXPERIMENTAL EYE RESEARCH

Phosphorylation in the C-terminus of the rat connexin46 (rCx46) and regulation of the conducting activity of the formed connexons

(2008) Wilhelm J. Walter et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Localized expression of an Ins(1,4,5)P3 receptor at the myoendothelial junction selectively regulates heterocellular Ca2+ communication

(2008) B. E. Isakson   JOURNAL OF CELL SCIENCE

Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: Insights from mathematical modeling

(2008) Thomas J. Hund et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY