Ketamine Alters Functional Plasticity of Astroglia: An Implication for Antidepressant Effect

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Astrocytes in rapid ketamine antidepressant action

(2020) Matjaž Stenovec et al.   NEUROPHARMACOLOGY

Astroglial Mechanisms of Ketamine Action Include Reduced Mobility of Kir4.1-Carrying Vesicles

(2019) Matjaž Stenovec et al.   NEUROCHEMICAL RESEARCH

Fingolimod Suppresses the Proinflammatory Status of Interferon-γ-Activated Cultured Rat Astrocytes

(2019) Saša Trkov Bobnar et al.   MOLECULAR NEUROBIOLOGY

Ketamine Within Clinically Effective Range Inhibits Glutamate Transmission From Astrocytes to Neurons and Disrupts Synchronization of Astrocytic SICs

(2019) Yu Zhang et al.   Frontiers in Cellular Neuroscience

Astrocyte Specific Remodeling of Plasmalemmal Cholesterol Composition by Ketamine Indicates a New Mechanism of Antidepressant Action

(2019) Eva Lasič et al.   Scientific Reports

Astrocytes are direct cellular targets of lithium treatment: novel roles for lysyl oxidase and peroxisome-proliferator activated receptor-γ as astroglial targets of lithium

(2019) Andrea D. Rivera et al.   Translational Psychiatry

Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study

(2018) Carla M. Canuso et al.   AMERICAN JOURNAL OF PSYCHIATRY

Astroglial 5-HT2B receptor in mood disorders

(2018) Liang Peng et al.   Expert Review of Neurotherapeutics

Ångstrom-size exocytotic fusion pore: Implications for pituitary hormone secretion

(2018) Marko Kreft et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

NMDAR-independent, cAMP-dependent antidepressant actions of ketamine

(2018) Nathan H. Wray et al.   MOLECULAR PSYCHIATRY

Mechanisms of ketamine action as an antidepressant

(2018) P Zanos et al.   MOLECULAR PSYCHIATRY

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

(2018) Panos Zanos et al.   PHARMACOLOGICAL REVIEWS

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

Potassium and sodium microdomains in thin astroglial processes: A computational model study

(2018) Kevin Breslin et al.   PLoS Computational Biology

Astroglial 5-HT2B receptor in mood disorders

(2018) Liang Peng et al.   Expert Review of Neurotherapeutics

Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression

(2018) Ella J. Daly et al.   JAMA Psychiatry

Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

(2018) Yihui Cui et al.   NATURE

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

(2018) Yan Yang et al.   NATURE

Important Shapeshifter: Mechanisms Allowing Astrocytes to Respond to the Changing Nervous System During Development, Injury and Disease

(2018) Juliane Schiweck et al.   Frontiers in Cellular Neuroscience

Affinity of Ketamine to Clinically Relevant Transporters

(2017) Markus Keiser et al.   MOLECULAR PHARMACEUTICS

Common general anesthetic propofol impairs kinesin processivity

(2017) Brandon M. Bensel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glial GLT-1 blockade in infralimbic cortex as a new strategy to evoke rapid antidepressant-like effects in rats

(2017) J Gasull-Camós et al.   Translational Psychiatry

The role of glial-specific Kir4.1 in normal and pathological states of the CNS

(2016) Sinifunanya E. Nwaobi et al.   ACTA NEUROPATHOLOGICA

Placebo-controlled pilot trial testing dose titration and intravenous, intramuscular and subcutaneous routes for ketamine in depression

(2016) C. K. Loo et al.   ACTA PSYCHIATRICA SCANDINAVICA

Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study

(2016) Jaskaran B. Singh et al.   BIOLOGICAL PSYCHIATRY

Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia

(2016) Kazue Hisaoka-Nakashima et al.   BRAIN RESEARCH

Novel insights into gliotransmitters

(2016) Francesco Petrelli et al.   CURRENT OPINION IN PHARMACOLOGY

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

(2016) A. Verkhratsky et al.   EMBO JOURNAL

Targeting astrocytes in bipolar disorder

(2016) Liang Peng et al.   Expert Review of Neurotherapeutics

Subanesthetic doses of ketamine stabilize the fusion pore in a narrow flickering state in astrocytes

(2016) Eva Lasič et al.   JOURNAL OF NEUROCHEMISTRY

Prefrontal changes in the glutamate-glutamine cycle and neuronal/glial glutamate transporters in depression with and without suicide

(2016) J. Zhao et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Evidence for alterations of the glial syncytial function in major depressive disorder

(2016) Adriana Medina et al.   JOURNAL OF PSYCHIATRIC RESEARCH

cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor

(2016) M Fujita et al.   MOLECULAR PSYCHIATRY

Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects

(2016) G M I Chowdhury et al.   MOLECULAR PSYCHIATRY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol

(2016) Shu-Lin Liu et al.   Nature Chemical Biology

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

Functional diversity of astrocytes in neural circuit regulation

(2016) Lucile Ben Haim et al.   NATURE REVIEWS NEUROSCIENCE

Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention

(2016) Beatrice Vignoli et al.   NEURON

BDNF – a key transducer of antidepressant effects

(2016) Carl Björkholm et al.   NEUROPHARMACOLOGY

Astrocytic vesicles and gliotransmitters: Slowness of vesicular release and synaptobrevin2-laden vesicle nanoarchitecture

(2016) R. Zorec et al.   NEUROSCIENCE

Differences among astrocytes

(2016) B. Stevens et al.   SCIENCE

Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling

(2016) W. T. Farmer et al.   SCIENCE

Depression as a Glial-Based Synaptic Dysfunction

(2016) Daniel Rial et al.   Frontiers in Cellular Neuroscience

Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain

(2016) Hiromu Monai et al.   Nature Communications

Targeting astrocytes in bipolar disorder

(2016) Liang Peng et al.   Expert Review of Neurotherapeutics

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

Ketamine Inside Neurons?

(2015) Henry A. Lester et al.   AMERICAN JOURNAL OF PSYCHIATRY

Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression

(2015) D. Jeffrey Newport et al.   AMERICAN JOURNAL OF PSYCHIATRY

Chronic treatment with anti-bipolar drugs suppresses glutamate release from astroglial cultures

(2015) Zhuo Liu et al.   AMINO ACIDS

Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics

(2015) Chadi G. Abdallah et al.   Annual Review of Medicine

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

(2015) Elly M Hol et al.   CURRENT OPINION IN CELL BIOLOGY

How does ketamine elicit a rapid antidepressant response?

(2015) Ege T Kavalali et al.   CURRENT OPINION IN PHARMACOLOGY

Morphological plasticity of astroglia: Understanding synaptic microenvironment

(2015) Janosch P. Heller et al.   GLIA

Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and Genome-wide expression analysis

(2015) Magdalena Götz et al.   GLIA

Ketamine Inhibits ATP-Evoked Exocytotic Release of Brain-Derived Neurotrophic Factor from Vesicles in Cultured Rat Astrocytes

(2015) Matjaž Stenovec et al.   MOLECULAR NEUROBIOLOGY

A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder

(2015) M S Milak et al.   MOLECULAR PSYCHIATRY

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

Cell type-specific in vivo expression of genes encoding signalling molecules in the brain in response to chronic mild stress and chronic treatment with fluoxetine

(2015) Lu Dong et al.   PSYCHOPHARMACOLOGY

Regulation of glutamate transporter 1 via BDNF-TrkB signaling plays a role in the anti-apoptotic and antidepressant effects of ketamine in chronic unpredictable stress model of depression

(2015) Wen-Xue Liu et al.   PSYCHOPHARMACOLOGY

Fluoxetine induces alkalinization of astroglial cytosol through stimulation of sodium-hydrogen exchanger 1: dissection of intracellular signaling pathways

(2015) Jienan Ren et al.   Frontiers in Cellular Neuroscience

Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift

(2015) Leif Hertz et al.   Frontiers in Behavioral Neuroscience

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

(2015) C Yang et al.   Translational Psychiatry

The glia/neuron ratio: How it varies uniformly across brain structures and species and what that means for brain physiology and evolution

(2014) Suzana Herculano-Houzel   GLIA

Pharmacological characterization of BDNF promoters I, II and IV reveals that serotonin and norepinephrine input is sufficient for transcription activation

(2014) L. Musazzi et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Astroglial cradle in the life of the synapse

(2014) A. Verkhratsky et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Glutamine synthetase in astrocytes from entorhinal cortex of the triple transgenic animal model of Alzheimer’s disease is not affected by pathological progression

(2013) Chia-Yu Yeh et al.   BIOGERONTOLOGY

Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings)

(2013) Georges Mion et al.   CNS Neuroscience & Therapeutics

Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue

(2013) Grazyna Rajkowska et al.   CURRENT DRUG TARGETS

Gene expression deficits in pontine locus coeruleus astrocytes in men with major depressive disorder

(2013) Michelle Chandley et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

Astrogliopathology

(2013) Alexei Verkhratsky et al.   NEUROSCIENTIST

Depressive behavior in the forced swim test can be induced by TRPV1 receptor activity and is dependent on NMDA receptors

(2013) Ramy E. Abdelhamid et al.   PHARMACOLOGICAL RESEARCH

Physiological Roles of Aquaporin-4 in Brain

(2013) Erlend A. Nagelhus et al.   PHYSIOLOGICAL REVIEWS

The role of neurotrophins in major depressive disorder

(2013) Cheng Jiang et al.   Translational Neuroscience

Glutamine Synthetase as an Astrocytic Marker: Its Cell Type and Vesicle Localization

(2013) Enrico Anlauf et al.   Frontiers in Endocrinology

Astroglial Excitability and Gliotransmission: An Appraisal of Ca2+ as a Signalling Route

(2012) Robert Zorec et al.   ASN Neuro

Neurological Diseases as Primary Gliopathies: A Reassessment of Neurocentrism

(2012) Alexei Verkhratsky et al.   ASN Neuro

Relationship of Ketamine's Plasma Metabolites with Response, Diagnosis, and Side Effects in Major Depression

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

Functions of S100 Proteins

(2012) R. Donato et al.   CURRENT MOLECULAR MEDICINE

Astrocytes as a 5-HT2B-Mediated SERT-Independent SSRI Target, Slowly Altering Depression-Associated Genes and Function

(2012) Leif Hertz et al.   Current Signal Transduction Therapy

Antidepressants act directly on astrocytes: Evidences and functional consequences

(2012) Boldizsár Czéh et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Isolation and characterization of living primary astroglial cells using the new GLAST-specific monoclonal antibody ACSA-1

(2012) Melanie Jungblut et al.   GLIA

Imipramine Induces Brain-Derived Neurotrophic Factor mRNA Expression in Cultured Astrocytes

(2012) Katsura Takano et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

(2012) Wei Shao et al.   NATURE

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex

(2012) A. S. Thrane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

(2012) H.-H. Tsai et al.   SCIENCE

Fusion Pore Diameter Regulation by Cations Modulating Local Membrane Anisotropy

(2012) Doron Kabaso et al.   TheScientificWorldJOURNAL

Expression of Monoamine Transporters, Nitric Oxide Synthase 3, and Neurotrophin Genes in Antidepressant-Stimulated Astrocytes

(2012) Sarah Kittel-Schneider et al.   Frontiers in Psychiatry

1H-[13C]-Nuclear Magnetic Resonance Spectroscopy Measures of Ketamine's Effect on Amino Acid Neurotransmitter Metabolism

(2011) Golam M.I. Chowdhury et al.   BIOLOGICAL PSYCHIATRY

Neuroglia, der lebende Nervenkitt

(2011) H. Kettenmann et al.   FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE

Low gene expression of bone morphogenetic protein 7 in brainstem astrocytes in major depression

(2011) Gregory A. Ordway et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A morphometric study of glia and neurons in the anterior cingulate cortex in mood disorder

(2011) Rebecca A. Gittins et al.   JOURNAL OF AFFECTIVE DISORDERS

Calcium signalling in astroglia

(2011) Alexei Verkhratsky et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells

(2011) Sebastian Börner et al.   Nature Protocols

Towards a glutamate hypothesis of depression

(2011) Gerard Sanacora et al.   NEUROPHARMACOLOGY

Gap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats

(2011) Jian-Dong Sun et al.   NEUROPSYCHOPHARMACOLOGY

Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes

(2011) Igor Allaman et al.   PSYCHOPHARMACOLOGY

Taming the Ketamine Tiger

(2010) Edward F. Domino   ANESTHESIOLOGY

Astrocyte heterogeneity: an underappreciated topic in neurobiology

(2010) Ye Zhang et al.   CURRENT OPINION IN NEUROBIOLOGY

Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice

(2010) Yongjie Yang et al.   GLIA

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Hippocampal astrocytes are necessary for antidepressant treatment of learned helplessness rats

(2010) Masaaki Iwata et al.   HIPPOCAMPUS

Glial and glutamatergic markers in depression, alcoholism, and their comorbidity

(2010) José Javier Miguel-Hidalgo et al.   JOURNAL OF AFFECTIVE DISORDERS

Antidepressants act on glial cells: SSRIs and serotonin elicit astrocyte calcium signaling in the mouse prefrontal cortex

(2010) Carola G. Schipke et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Altered expression of glutamate signaling, growth factor and glia genes in the locus coeruleus of patients with major depression

(2010) R Bernard et al.   MOLECULAR PSYCHIATRY

Astroglial networks: a step further in neuroglial and gliovascular interactions

(2010) Christian Giaume et al.   NATURE REVIEWS NEUROSCIENCE

5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional ‘serotonin-specific reuptake inhibitors’

(2010) Shiquen Zhang et al.   Neuron Glia Biology

Blockade of Astrocytic Glutamate Uptake in Rats Induces Signs of Anhedonia and Impaired Spatial Memory

(2010) Anita J Bechtholt-Gompf et al.   NEUROPSYCHOPHARMACOLOGY

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Role of glial cells in the formation and maintenance of synapses

(2009) Frank W. Pfrieger   BRAIN RESEARCH REVIEWS

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

(2009) Frederico A.C. Azevedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Astrocytes going live: advances and challenges

(2009) Axel Nimmerjahn   JOURNAL OF PHYSIOLOGY-LONDON

Mutational and In Silico Analyses for Antidepressant Block of Astroglial Inward-Rectifier Kir4.1 Channel

(2009) K. Furutani et al.   MOLECULAR PHARMACOLOGY

Plasma membrane expansion: a neuron's Herculean task

(2009) Karl H. Pfenninger   NATURE REVIEWS NEUROSCIENCE

Juvenile separation stress induces rapid region- and layer-specific changes in S100ß- and glial fibrillary acidic protein–immunoreactivity in astrocytes of the rodent medial prefrontal cortex

(2009) K. Braun et al.   NEUROSCIENCE

Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression

(2009) Adolfo Sequeira et al.   PLoS One

Subcortical oligodendrocyte- and astrocyte-associated gene expression in subjects with schizophrenia, major depression and bipolar disorder

(2009) Kevin Barley et al.   SCHIZOPHRENIA RESEARCH

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

Sorting Out Astrocyte Physiology from Pharmacology

(2008) Todd A. Fiacco et al.   Annual Review of Pharmacology and Toxicology

Modulation of TRPC5 cation channels by halothane, chloroform and propofol

(2008) Y M Bahnasi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of Positionally Distinct Astrocyte Subtypes whose Identities Are Specified by a Homeodomain Code

(2008) Christian Hochstim et al.   CELL

Ca2+ entry through TRPC1 channels contributes to intracellular Ca2+ dynamics and consequent glutamate release from rat astrocytes

(2008) Erik B. Malarkey et al.   GLIA

Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes

(2008) Matteo Bergami et al.   JOURNAL OF CELL BIOLOGY

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Synaptic modulation by astrocytes via Ca2+-dependent glutamate release

(2008) M. Santello et al.   NEUROSCIENCE

Activity-Dependent Structural and Functional Plasticity of Astrocyte-Neuron Interactions

(2008) Dionysia T. Theodosis et al.   PHYSIOLOGICAL REVIEWS

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY