Synthesis, anti-inflammatory activity, inverse molecular docking, and acid dissociation constants of new naphthoquinone-thiazole hybrids

Sustainable Synthesis, Antiproliferative and Acetylcholinesterase Inhibition of 1,4- and 1,2-Naphthoquinone Derivatives

(2023) Rafaela G. Cabral et al.   MOLECULES

Anti-inflammatory activity of bupropion through immunomodulation of the macrophages

(2023) Derya Yetkin et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Pharmacokinetics of some newly synthesized 1, 5- benzothiazepine scaffolds: A molecular docking and molecular dynamics simulation approach

(2023) Ahanthem Priyanca Devi et al.   JOURNAL OF KING SAUD UNIVERSITY SCIENCE

Computer-aided drug design

(2023) Abdulilah Ece   BMC Chemistry

Novel beta-lactam substituted benzenesulfonamides: in vitro enzyme inhibition, cytotoxic activity and in silico interactions

(2023) Özcan Güleç et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Escitalopram's inflammatory effect on the mammalian macrophages and its intracellular mechanism of action

(2023) Harika Topal Önal et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Biomedical applications of selective metal complexes of indole, benzimidazole, benzothiazole and benzoxazole: A review (From 2015 to 2022)

(2023) Ahmed Abdullah Al Awadh   SAUDI PHARMACEUTICAL JOURNAL

Design, synthesis, and biological evaluation of thiazole bioisosteres of goniofufurone through in vitro antiproliferative activity and in vivo toxicity

(2022) Miloš Svirčev et al.   BIOORGANIC CHEMISTRY

A Therapeutic Journey of Pyridine-Based Heterocyclic Compounds as Potent Anticancer Agents: A Review (From 2017 to 2021)

(2022) Munira Alrooqi et al.   Anti-Cancer Agents in Medicinal Chemistry

A review on the design, synthesis, and structure-activity relationships of benzothiazole derivatives against hypoxic tumors

(2022) Akif Hakan Kurt et al.   CURRENT ORGANIC SYNTHESIS

Inverse Molecular Docking Elucidating the Anticarcinogenic Potential of the Hop Natural Product Xanthohumol and Its Metabolites

(2022) Katarina Kores et al.   Foods

Exploration of naphthoquinone analogs in targeting the TCF-DNA interaction to inhibit the Wnt/β-catenin signaling pathway

(2022) Andrew Morris et al.   BIOORGANIC CHEMISTRY

The 1,2,3-triazole ‘all-in-one’ ring system in drug discovery: a good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool

(2022) Deniz Lengerli et al.   Expert Opinion on Drug Discovery

Novel urea-thiourea hybrids bearing 1,4-naphthoquinone moiety: Anti-inflammatory activity on mammalian macrophages by regulating intracellular PI3K pathway, and molecular docking study

(2022) Cagla Efeoglu et al.   JOURNAL OF MOLECULAR STRUCTURE

Thiazole derivatives in medicinal chemistry: Recent advancements in synthetic strategies, structure activity relationship and pharmacological outcomes

(2022) Atamjit Singh et al.   JOURNAL OF MOLECULAR STRUCTURE

Metabolic profiling of Lantana camara L. using UPLC-MS/MS and revealing its inflammation-related targets using network pharmacology-based and molecular docking analyses

(2022) Alaa A. El-Banna et al.   Scientific Reports

Conditioned media of mouse macrophages modulates neuronal dynamics in mouse hippocampal cells

(2022) Ayla Batu Öztürk et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A comprehensive review on synthesis, biological profile and photophysical studies of heterocyclic compounds derived from 2,3-diamino-1,4-naphthoquinone

(2022) Meena Devi et al.   JOURNAL OF MOLECULAR STRUCTURE

Effect of the dichloro-substitution on antiproliferative activity of phthalimide-thiazole derivatives. Rational design, synthesis, elastase, caspase 3/7, and EGFR tyrosine kinase activity and molecular modeling study

(2021) Beata Donarska et al.   BIOORGANIC CHEMISTRY

In Vivo Anti-inflammatory, Analgesic, and Sedative Studies of the Extract and Naphthoquinone Isolated from Diospyros kaki (Persimmon)

(2021) Saud Bawazeer et al.   ACS Omega

Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1,3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with cardiac safety profile

(2021) Salah A. Abdel-Aziz et al.   BIOORGANIC CHEMISTRY

Synthesis and comparison of in vitro dual anti-infective activities of novel naphthoquinone hybrids and atovaquone

(2021) Chané Erasmus et al.   BIOORGANIC CHEMISTRY

Synthesis, biological activity and docking calculations of bis-naphthoquinone derivatives from Lawsone

(2021) Muhammad Tariq Riaz et al.   BIOORGANIC CHEMISTRY

Design, synthesis, in vitro and in silico studies of some novel thiazole-dihydrofuran derivatives as aromatase inhibitors

(2021) Derya Osmaniye et al.   BIOORGANIC CHEMISTRY

Novel imidazo[2,1‐ b ]thiazole‐based anticancer agents as potential focal adhesion kinase inhibitors: Synthesis, in silico and in vitro evaluation

(2021) Faika Başoğlu et al.   Chemical Biology & Drug Design

OPLS4: Improving Force Field Accuracy on Challenging Regimes of Chemical Space

(2021) Chao Lu et al.   Journal of Chemical Theory and Computation

Synthesis, antimicrobial evaluation, α-amylase inhibitory ability and molecular docking studies of 3-alkyl-1-(4-(aryl/heteroaryl)thiazol-2-yl)indeno[1,2-c]pyrazol-4(1H)-ones

(2021) Satbir Mor et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti-inflammatory agents

(2021) Marina Modrić et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis, Biological Evaluation, Molecular Docking, and Acid Dissociation Constant of New Bis‐1,2,3‐triazole Compounds

(2021) Yahya Nural et al.   ChemistrySelect

1,4-Naphthoquinone Is a Potent Inhibitor of IRAK1 Kinases and the Production of Inflammatory Cytokines in THP-1 Differentiated Macrophages

(2021) Ismail Sami Mahmoud et al.   ACS Omega

New bis- and tetrakis-1,2,3-triazole derivatives: Synthesis, DNA cleavage, molecular docking, antimicrobial, antioxidant activity and acid dissociation constants

(2021) Yahya Nural et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In vivo screening and toxicity studies of indolinone incorporated thiosemicarbazone, thiazole and piperidinosulfonyl moieties as anticonvulsant agents

(2021) Eman A. Fayed et al.   BIOORGANIC CHEMISTRY

Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with molecular modelling study

(2021) Abdullah Y. Alzahrani et al.   BIOORGANIC CHEMISTRY

Synthesis of novel acylthioureas bearing naphthoquinone moiety as dual sensor for high-performance naked-eye colorimetric and fluorescence detection of CN− and F− ions and its application in water and food samples

(2021) Yahya Nural et al.   DYES AND PIGMENTS

Recent advances of quinones as a privileged structure in drug discovery

(2021) Li Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and SAR study of novel 4,5-dihydropyrazole-Thiazole derivatives with anti-inflammatory activities for the treatment of sepsis

(2021) Zhen Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Redox ticklers and beyond: Naphthoquinone repository in the spotlight against inflammation and associated maladies

(2021) Neha Kapoor et al.   PHARMACOLOGICAL RESEARCH

Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes

(2020) Mohammed T.-E. Maghraby et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and novel synthetic approach supported with molecular docking and biological evidence for naphthoquinone-hydrazinotriazolothiadiazine analogs as potential anticancer inhibiting topoisomerase-IIB

(2020) Samy Mohamady et al.   BIOORGANIC CHEMISTRY

1,4-Naphthoquinones: Some Biological Properties and Application

(2020) Dmitry Aminin et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Naphthoquinone Derivatives with Anti-Inflammatory Activity from Mangrove-Derived Endophytic Fungus Talaromyces sp. SK-S009

(2020) Hongju Liu et al.   MOLECULES

Synthesis of novel 2, 3, 5-tri-substituted thiazoles with anti-inflammatory and antibacterial effect causing clinical pathogens

(2020) Aejaz Ahmed et al.   Journal of Infection and Public Health

Bioactive indanes: insight into the bioactivity of indane dimers related to the lead anti‐inflammatory molecule PH46A

(2020) Kit Chan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Exploring the Nutraceutical Potential of Dried Pepper Capsicum annuum L. on Market from Altino in Abruzzo Region

(2020) Alice Della Valle et al.   Antioxidants

Identification and development of thiazole leads as COX-2/5-LOX inhibitors through in-vitro and in-vivo biological evaluation for anti-inflammatory activity

(2020) Jaismy Jacob P et al.   BIOORGANIC CHEMISTRY

Synthesis, biological properties, and acid dissociation constant of novel naphthoquinone–triazole hybrids

(2020) Yahya Nural et al.   BIOORGANIC CHEMISTRY

Synthesis of New Thiazole and Pyrazole Clubbed 1,2,3-Triazol Derivatives as Potential Antimycobacterial and Antibacterial Agents

(2020) Shivaji M. Jagadale et al.   POLYCYCLIC AROMATIC COMPOUNDS

Synthesis, anti-inflammatory and analgesic evaluation of thiazole/oxazole substituted benzothiazole derivatives

(2020) Gajendra Kumar et al.   BIOORGANIC CHEMISTRY

2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer’s disease

(2020) Eva Mezeiova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel highly functionalized 1,4-naphthoquinone 2-iminothiazole hybrids: Synthesis, photophysical properties, crystal structure, DFT studies, and anti(myco)bacterial/antifungal activity

(2019) Muge Gemili et al.   JOURNAL OF MOLECULAR STRUCTURE

Target ROS to induce apoptosis and cell cycle arrest by 5,7-dimethoxy-1,4-naphthoquinone derivative

(2018) Kun Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, crystal structure, DFT studies, acid dissociation constant, and antimicrobial activity of methyl 2-(4-chlorophenyl)-7a-((4-chlorophenyl)carbamothioyl)-1-oxo-5,5-diphenyl-3-thioxo-hexahydro-1H-pyrrolo[1,2-e]imidazole-6-carboxylate

(2018) Yahya Nural et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis, antimycobacterial activity, and acid dissociation constants of polyfunctionalized 3-[2-(pyrrolidin-1-yl)thiazole-5-carbonyl]-2H-chromen-2-one derivatives

(2018) Yahya Nural   MONATSHEFTE FUR CHEMIE

A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly

(2018) Supakanya Wongrakpanich et al.   Aging and Disease

A Naphthoquinone from Sinningia canescens Inhibits Inflammation and Fever in Mice

(2017) Luís A. Lomba et al.   INFLAMMATION

Quantitative structure activity relationships studies of non-steroidal anti-inflammatory drugs: A review

(2016) Sahaya Asirvatham et al.   Arabian Journal of Chemistry

Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity

(2015) Bing Liu et al.   Cancer Cell International

Protein kinase C in the immune system: from signalling to chromatin regulation

(2015) Pek Siew Lim et al.   IMMUNOLOGY

Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

(2014) Bradley Croy Doak et al.   CHEMISTRY & BIOLOGY

Spectroscopic Determination and Evaluation of Acidity Constants for Some Drug Precursor 2-Amino-4-(3- or 4-substituted phenyl) Thiazole Derivatives

(2010) Cemil Öğretir et al.   JOURNAL OF CHEMICAL AND ENGINEERING DATA

Regulation of JNK and p38 MAPK in the immune system: Signal integration, propagation and termination

(2009) Gonghua Huang et al.   CYTOKINE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE