Protein kinase C in the immune system: from signalling to chromatin regulation

The nuclear translocation of ERK1/2 as an anticancer target

(2015) Alexander Plotnikov et al.   Nature Communications

Selective protein kinase Cθ (PKCθ) inhibitors for the treatment of autoimmune diseases

(2014) Adam Curnock et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Protein kinase C inhibitors for immune disorders

(2014) Amnon Altman et al.   DRUG DISCOVERY TODAY

A238L Inhibits NF-ATc2, NF- B, and c-Jun Activation through a Novel Mechanism Involving Protein Kinase C- -Mediated Up-Regulation of the Amino-Terminal Transactivation Domain of p300

(2014) A. G. Granja et al.   JOURNAL OF IMMUNOLOGY

Chromatinized Protein Kinase C-θ Directly Regulates Inducible Genes in Epithelial to Mesenchymal Transition and Breast Cancer Stem Cells

(2014) Anjum Zafar et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein kinase C-η controls CTLA-4–mediated regulatory T cell function

(2014) Kok-Fai Kong et al.   NATURE IMMUNOLOGY

Protein Kinase C θ Regulates the Phenotype of Murine CD4+ Th17 Cells

(2014) Katarzyna Wachowicz et al.   PLoS One

B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C  

(2013) E. Salzer et al.   BLOOD

Loss-of-function of the protein kinase C   (PKC ) causes a B-cell lymphoproliferative syndrome in humans

(2013) H. S. Kuehn et al.   BLOOD

PKC-θ exists in an oxidized inactive form in naive human T cells

(2013) Marina Rode von Essen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation

(2013) C E Teh et al.   GENES AND IMMUNITY

Epigenetic regulation of inducible gene expression in the immune system

(2013) Pek Siew Lim et al.   IMMUNOLOGY

Interleukin (IL)-32β-mediated CCAAT/Enhancer-binding Protein α (C/EBPα) Phosphorylation by Protein Kinase Cδ (PKCδ) Abrogates the Inhibitory Effect of C/EBPα on IL-10 Production

(2013) Jeong-Woo Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting PKC in Human T Cells Using Sotrastaurin (AEB071) Preserves Regulatory T Cells and Prevents IL-17 Production

(2013) Xuehui He et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Design and Optimization of Selective Protein Kinase C θ (PKCθ) Inhibitors for the Treatment of Autoimmune Diseases

(2013) Juan-Miguel Jimenez et al.   JOURNAL OF MEDICINAL CHEMISTRY

In and out of the bull's eye: protein kinase Cs in the immunological synapse

(2013) Kok-Fai Kong et al.   TRENDS IN IMMUNOLOGY

TGF-β1 Downregulates AT1 Receptor Expression via PKC-δ-Mediated Sp1 Dissociation From KLF4 and Smad-Mediated PPAR-γ Association With KLF4

(2012) Xin-hua Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protein Kinase C-  Promotes Th17 Differentiation via Upregulation of Stat3

(2012) M.-J. Kwon et al.   JOURNAL OF IMMUNOLOGY

Protein Kinase C-  Inhibits Inducible Regulatory T Cell Differentiation via an AKT-Foxo1/3a-Dependent Pathway

(2012) J. Ma et al.   JOURNAL OF IMMUNOLOGY

Estrogen receptor-α, RBCK1, and protein kinase C β 1 cooperate to regulate estrogen receptor-α gene expression

(2012) Nina Gustafsson Sheppard et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events

(2012) Stamatios Liokatis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Apoptotic Phosphorylation of Histone H3 on Ser-10 by Protein Kinase Cδ

(2012) Choon-Ho Park et al.   PLoS One

Functional comparison of protein domains within aPKCs involved in nucleocytoplasmic shuttling

(2012) S. Seidl et al.   Biology Open

Chromatinized Protein Kinase C-θ: Can It Escape the Clutches of NF-κB?

(2012) Elissa L. Sutcliffe et al.   Frontiers in Immunology

Sotrastaurin, a Novel Small Molecule Inhibiting Protein-Kinase C: Randomized Phase II Study in Renal Transplant Recipients

(2011) S. Friman et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Structural Biology of the Toll-Like Receptor Family

(2011) Jin Young Kang et al.   Annual Review of Biochemistry

In Sjögren's syndrome, B lymphocytes induce epithelial cells of salivary glands into apoptosis through protein kinase C delta activation

(2011) Marie-Michèle Varin et al.   AUTOIMMUNITY REVIEWS

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Regulated Binding of Importin-α to Protein Kinase Cδ in Response to Apoptotic Signals Facilitates Nuclear Import

(2011) Tariq S. Adwan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

When Signaling Kinases Meet Histones and Histone Modifiers in the Nucleus

(2011) Sung Hee Baek   MOLECULAR CELL

Chromatin-Associated Protein Kinase C-θ Regulates an Inducible Gene Expression Program and MicroRNAs in Human T Lymphocytes

(2011) Elissa L. Sutcliffe et al.   MOLECULAR CELL

A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28

(2011) Kok-Fai Kong et al.   NATURE IMMUNOLOGY

M-CSF Induces Monocyte Survival by Activating NF-κB p65 Phosphorylation at Ser276 via Protein Kinase C

(2011) Yijie Wang et al.   PLoS One

Protein Kinase C   Is Required for T Cell Activation and Homeostatic Proliferation

(2011) G. Fu et al.   Science Signaling

Two Faces of Protein Kinase Cδ: The Contrasting Roles of PKCδ in Cell Survival and Cell Death

(2011) Alakananda Basu et al.   TheScientificWorldJOURNAL

Sotrastaurin, a Novel Small Molecule Inhibiting Protein Kinase C: First Clinical Results in Renal-Transplant Recipients

(2010) K. Budde et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Early Events in B Cell Activation

(2010) Naomi E. Harwood et al.   Annual Review of Immunology

Stat1 mediates an auto-regulation of hsp90β gene in heat shock response

(2010) Mo-bin Cheng et al.   CELLULAR SIGNALLING

RORα Attenuates Wnt/β-Catenin Signaling by PKCα-Dependent Phosphorylation in Colon Cancer

(2010) Ji Min Lee et al.   MOLECULAR CELL

Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4

(2010) Eric Metzger et al.   NATURE

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

(2010) Dan Levy et al.   NATURE IMMUNOLOGY

Protein Kinase C-  Mediates Negative Feedback on Regulatory T Cell Function

(2010) A. Zanin-Zhorov et al.   SCIENCE

Epigenetic control of inducible gene expression in the immune system

(2010) Pek Siew Lim et al.   Epigenomics

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Functional Anatomy of T Cell Activation and Synapse Formation

(2009) David R. Fooksman et al.   Annual Review of Immunology

AEB071 - a promising immunosuppressive agent

(2009) Claudia Sommerer et al.   CLINICAL TRANSPLANTATION

Nuclear localization signals and human disease

(2009) Laura M. McLane et al.   IUBMB LIFE

Phosphorylation of Histone H3 Thr-45 Is Linked to Apoptosis

(2009) Paul J. Hurd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different T Cell Receptor Signals Determine CD8+ Memory Versus Effector Development

(2009) E. Teixeiro et al.   SCIENCE

New Insights into the Early Molecular Events Underlying B Cell Activation

(2008) Naomi E. Harwood et al.   IMMUNITY

Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation

(2008) Tadashi Yokosuka et al.   IMMUNITY

The Scaffold MyD88 Acts to Couple Protein Kinase Cϵ to Toll-like Receptors

(2008) Amir Faisal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PKC inhibitor AEB071 may be a therapeutic option for psoriasis

(2008) Hans Skvara et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification and Characterization of a General Nuclear Translocation Signal in Signaling Proteins

(2008) Dana Chuderland et al.   MOLECULAR CELL

Differential requirement of PKC-θ in the development and function of natural regulatory T cells

(2008) Sonal Gupta et al.   MOLECULAR IMMUNOLOGY

T-cell fate and function: PKC-θ and beyond

(2008) Benjamin J. Marsland et al.   TRENDS IN IMMUNOLOGY