Synthesis, antimicrobial evaluation, α-amylase inhibitory ability and molecular docking studies of 3-alkyl-1-(4-(aryl/heteroaryl)thiazol-2-yl)indeno[1,2-c]pyrazol-4(1H)-ones

In vivo antiviral activity and disassembly mechanism of novel 1-phenyl-5-amine-4-pyrazole thioether derivatives against Tobacco mosaic virus

(2021) Zhibing Wu et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Discovery and optimization of novel 3-benzyl-N-phenyl-1H-pyrazole-5-carboxamides as bifunctional antidiabetic agents stimulating both insulin secretion and glucose uptake

(2021) Jeyun Jo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anticancer activity and mechanism of action of new phthalimido-1,3-thiazole derivatives

(2021) Arsênio Rodrigues Oliveira et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes

(2020) Mohammed T.-E. Maghraby et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, modelling and molecular docking of new 5-arylazo-2-chloroacetamido thiazole derivatives as antioxidant agent

(2020) Aisha SM. Hossan   JOURNAL OF MOLECULAR STRUCTURE

Novel amine-functionalized benzimidazolium salts: Synthesis, characterization, bioactivity, and molecular docking studies

(2020) Murat Yiğit et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, synthesis, and biological evaluation of chalcone-linked thiazole-imidazopyridine derivatives as anticancer agents

(2020) Vellanki Ragha Suma et al.   MEDICINAL CHEMISTRY RESEARCH

Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization

(2020) Guangcheng Wang et al.   BIOORGANIC CHEMISTRY

Synthesis of Indenopyrazole Frameworks via Cascade C–H Functionalization/[3 + 2] Dipolar Cycloaddition/Aromatization Rearrangement Reactions

(2020) Min Wu et al.   ORGANIC LETTERS

Pyridine- and Thiazole-Based Hydrazides with Promising Anti-inflammatory and Antimicrobial Activities along with Their In Silico Studies

(2020) Vinuta Kamat et al.   ACS Omega

Antibacterial and anti-quorum sensing activities of a substituted thiazole derivative against methicillin-resistant Staphylococcus aureus and other multidrug-resistant bacteria

(2020) Yasser Musa Ibrahim et al.   MICROBIAL PATHOGENESIS

Microwave-assisted efficient synthesis of pyrazole-fibrate derivatives as stimulators of glucose uptake in skeletal muscle cells

(2020) Sampa Gupta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, structural investigations and antimicrobial activity of pyrazole nucleating copper and zinc complexes

(2020) Mohammad Azam et al.   POLYHEDRON

Structural Basis for DNA Gyrase Interaction with Coumermycin A1

(2019) Arnaud P. Vanden Broeck et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel indenopyrazole derivatives

(2019) Hayreddin Gezegen et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Anti‐diabetic properties of dietary phenolic compounds: Inhibition effects on α‐Amylase, Aldose Reductase and α‐Glycosidase

(2019) Yeliz Demir et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

New Series of Thiazole Derivatives: Synthesis, Structural Elucidation, Antimicrobial Activity, Molecular Modeling and MOE Docking

(2019) Ismail Althagafi et al.   MOLECULES

Pyrazole[3,4-d]pyridazine derivatives: Molecular docking and explore of acetylcholinesterase and carbonic anhydrase enzymes inhibitors as anticholinergics potentials

(2019) Parham Taslimi et al.   BIOORGANIC CHEMISTRY

New triazinoindole bearing thiazole/oxazole analogues: Synthesis, α-amylase inhibitory potential and molecular docking study

(2019) Fazal Rahim et al.   BIOORGANIC CHEMISTRY

Synthesis, Type II diabetes inhibitory activity, antimicrobial evaluation and docking studies of indeno[1,2-c]pyrazol-4(1H)-ones

(2019) Satbir Mor et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis of Thiazole Linked Imidazo[2,1-b]Thiazoles as Anticancer Agents

(2019) Huda K. Mahmoud et al.   POLYCYCLIC AROMATIC COMPOUNDS

Derivatives of pyridine and thiazole hybrid: Synthesis, DFT, biological evaluation via antimicrobial and DNA cleavage activity

(2019) Serpil Eryılmaz et al.   BIOORGANIC CHEMISTRY

Synthesis, molecular docking and QSAR study of thiazole clubbed pyrazole hybrid as α-amylase inhibitor

(2019) Meenakshi Duhan et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Novel carvacrol based new oxypropanolamine derivatives: Design, synthesis, characterization, biological evaluation, and molecular docking studies

(2019) Arlinda Bytyqi-Damoni et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis of novel β-amino carbonyl derivatives and their inhibition effects on some metabolic enzymes

(2019) Abdullah Biçer et al.   JOURNAL OF MOLECULAR STRUCTURE

Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line

(2019) Fatima Ezzahra Bennani et al.   BIOORGANIC CHEMISTRY

Synthesis, docking, in vitro and in vivo antidiabetic activity of pyrazole-based 2,4-thiazolidinedione derivatives as PPAR-γ modulators

(2018) Mohd. Javed Naim et al.   ARCHIV DER PHARMAZIE

Design, synthesis and biological evaluation of 1, 4-dihydro indeno[1,2- c ] pyrazole linked oxindole analogues as potential anticancer agents targeting tubulin and inducing p53 dependent apoptosis

(2018) Irfan Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anticancer Potential of Thiazole Derivatives: A Retrospective Review

(2018) Shweta Jain et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The effects of some antibiotics from cephalosporin groups on the acetylcholinesterase and butyrylcholinesterase enzymes activities in different tissues of rats

(2018) Fikret Türkan et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Some pyrazoles derivatives: Potent carbonic anhydrase, α-glycosidase, and cholinesterase enzymes inhibitors

(2018) Fikret Turkan et al.   ARCHIV DER PHARMAZIE

Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes

(2018) İlhami Gulçin et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Single-nucleotide-resolution mapping of DNA gyrase cleavage sites across the Escherichia coli genome

(2018) Dmitry Sutormin et al.   NUCLEIC ACIDS RESEARCH

Antidiabetic potential: in vitro inhibition effects of some natural phenolic compounds on α-glycosidase and α-amylase enzymes

(2017) Parham Taslimi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Synthesis, anti-inflammatory and neuroprotective activity of pyrazole and pyrazolo[3,4-d]pyridazine bearing 3,4,5-trimethoxyphenyl

(2017) Mashooq A. Bhat et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis of novel inhibitors of α-amylase based on the thiazolidine-4-one skeleton containing a pyrazole moiety and their configurational studies

(2017) Parvin Kumar et al.   MedChemComm

Synthesis and antimicrobial activity of pyrazole nucleus containing 2-thioxothiazolidin-4-one derivatives

(2017) H. B’Bhatt et al.   Arabian Journal of Chemistry

Green synthesis of pyrazole systems under solvent-free conditions

(2017) Zahra Soltanzadeh et al.   Green Chemistry Letters and Reviews

Synthesis of 2-phenylamino-thiazole derivatives as antimicrobial agents

(2017) Dominique Serge Ngono Bikobo et al.   Journal of Saudi Chemical Society

Synthesis of chalcone-imide derivatives and investigation of their anticancer and antimicrobial activities, carbonic anhydrase and acetylcholinesterase enzymes inhibition profiles

(2017) Umit Muhammet Kocyigit et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Synthesis and antimicrobial evaluation of novel ethyl 2-(2-(4-substituted)acetamido)-4-subtituted-thiazole-5-carboxylate derivatives

(2016) Chandrakant D. Pawar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dihydropyrano [2,3-c] pyrazole: Novel in vitro inhibitors of yeast α -glucosidase

(2016) Hamdy Kashtoh et al.   BIOORGANIC CHEMISTRY

Calcium carbide as the acetylide source: transition-metal-free synthesis of substituted pyrazoles via [1,5]-sigmatropic rearrangements

(2016) Yue Yu et al.   GREEN CHEMISTRY

Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase

(2016) Rita Meleddu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Convenient synthesis, anticancer evaluation and QSAR studies of some thiazole tethered indenopyrazoles

(2016) Satbir Mor et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis of Nitrogen Heterocycles via Photochemical Ring Opening of Pyridazine N-Oxides

(2016) Maribel Portillo et al.   ORGANIC LETTERS

Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity

(2015) Fang Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel 5-functionalized-pyrazoles: Synthesis, characterization and pharmacological screening

(2015) Shridevi D. Doddaramappa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bioactive thiazole and benzothiazole derivatives

(2015) Abdul Rouf et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anti-inflammatory and anti-ulcer evaluations of thiazole, thiophene, pyridine and pyran derivatives derived from androstenedione

(2015) Rafat M. Mohareb et al.   STEROIDS

Efficient and convenient synthesis, characterization, and antimicrobial evaluation of some new tetracyclic 1,4-benzothiazines

(2015) Satbir Mor et al.   SYNTHETIC COMMUNICATIONS

Synthesis and anticonvulsant activity of some new pyrazolo[3,4-b]pyrazines and related heterocycles

(2014) Abdel-Rahman Farghaly et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Copper(I)-Catalyzed Cycloaddition of 4-Bromosydnones and Alkynes for the Regioselective Synthesis of 1,4,5-Trisubstituted Pyrazoles

(2014) Elodie Decuypere et al.   ORGANIC LETTERS

When Aryldiazonium Salts Meet Vinyl Diazoacetates: A Cobalt-Catalyzed Regiospecific Synthesis of N-Arylpyrazoles

(2014) Haiheng Guo et al.   ORGANIC LETTERS

Regioselective Cycloaddition of Trifluorodiazoethane with Electron-Deficient Allenic Esters and Ketones: Access to CF3-Substituted Pyrazolines and Pyrazoles

(2014) Fa-Guang Zhang et al.   ORGANIC LETTERS

Dual Roles of Sulfonyl Hydrazides: A Three-Component Reaction To Construct Fully Substituted Pyrazoles Using TBAI/TBHP

(2014) Jie Zhang et al.   ORGANIC LETTERS

Highly Regioselective Organocatalyzed Synthesis of Pyrazoles from Diazoacetates and Carbonyl Compounds

(2013) Lei Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors

(2013) Hidemitsu Minegishi et al.   ACS Medicinal Chemistry Letters

Preparation and Chemistry of 3/5-Halogenopyrazoles

(2012) Yves L. Janin   CHEMICAL REVIEWS

Synthesis and antifungal activity of novel pyrazolecarboxamide derivatives containing a hydrazone moiety

(2012) Jian Wu et al.   Chemistry Central Journal

Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring

(2012) A.K. Mohammed Iqbal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New Aryl-1,3-thiazole-4-carbohydrazides, Their 1,3,4-Oxadiazole-2- thione, 1,2,4-Triazole, Isatin-3-ylidene and Carboxamide Derivatives. Synthesis and Anti-HIV Activity

(2012) Mehwash Zia et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES

Synthesis and Antioxidant and Antitumor Activity of Novel Pyridine, Chromene, Thiophene and Thiazole Derivatives

(2011) Ahmed A. Fadda et al.   ARCHIV DER PHARMAZIE

Discovery of novel antitubercular 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues

(2011) Mohamed Jawed Ahsan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles

(2011) Santos Fustero et al.   CHEMICAL REVIEWS

Thiazoles: having diverse biological activities

(2011) Shiv Jee Kashyap et al.   MEDICINAL CHEMISTRY RESEARCH

A facile 1,3-dipolar cycloaddition of azomethine ylides to 2-arylidene-1,3-indanediones: Synthesis of dispiro-oxindolylpyrrolothiazoles and their antimycobacterial evaluation

(2010) Shanmugavel Uma Maheswari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Triazole incorporated thiazoles as a new class of anticonvulsants: Design, synthesis and in vivo screening

(2010) Nadeem Siddiqui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antimicrobial activity of some new thiazole, thiophene and pyrazole derivatives containing benzothiazole moiety

(2010) Samir Bondock et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-breast cancer activity of some novel 1,2-dihydropyridine, thiophene and thiazole derivatives

(2010) Mansour S. Al-Said et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anti-microbial activity of some new fluorinated 1H-pyrazoles

(2010) Dun-Jia Wang et al.   JOURNAL OF FLUORINE CHEMISTRY

Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist

(2009) Atsushi Satoh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities

(2009) Mohamed Abdel-Aziz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Improved Regioselectivity in Pyrazole Formation through the Use of Fluorinated Alcohols as Solvents: Synthesis and Biological Activity of Fluorinated Tebufenpyrad Analogs

(2008) Santos Fustero et al.   JOURNAL OF ORGANIC CHEMISTRY

Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening

(2007) Taikou Usui et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS