Novel beta-lactam substituted benzenesulfonamides: in vitro enzyme inhibition, cytotoxic activity and in silico interactions

A novel series of thiosemicarbazone hybrid scaffolds: Design, Synthesis, DFT studies, metabolic enzyme inhibition properties, and molecular docking calculations

(2023) Hasan Yakan et al.   JOURNAL OF MOLECULAR STRUCTURE

Discovery of novel benzenesulfonamides incorporating 1,2,3-triazole scaffold as carbonic anhydrase I, II, IX, and XII inhibitors

(2023) Aida Buza et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Design, synthesis, and biological activity of novel dithiocarbamate‐methylsulfonyl hybrids as carbonic anhydrase inhibitors

(2022) Derya Osmaniye et al.   ARCHIV DER PHARMAZIE

A Decade of Tail-approach Based Design of Selective as well as Potent Tumor Associated Carbonic Anhydrase Inhibitors

(2022) Amit Kumar et al.   BIOORGANIC CHEMISTRY

Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach

(2022) Haytham O. Tawfik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A versatile study of novel A3B-type unsymmetric zinc(II) phthalocyanines containing thiazolidin-4-one: Their, carbonic anhydrase I, II isoenzymes, and xanthine oxidase inhibitors evaluation

(2022) Emel Karakılıç et al.   JOURNAL OF MOLECULAR STRUCTURE

Cytotoxic effect, enzyme inhibition, and in silico studies of some novel N-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif

(2022) Özcan Güleç et al.   MOLECULAR DIVERSITY

Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors

(2022) Mostafa M. Elbadawi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The solvent-controlled regioselective synthesis of 3-amino-5-aryl-rhodanines as novel inhibitors of human carbonic anhydrase enzymes

(2022) Ebru Bilen Ozer et al.   TETRAHEDRON

A safe alternative synthesis of primary carbamates from alcohols; in vitro and in silico assessments as an alternative acetylcholinesterase inhibitors

(2022) Ufuk Atmaca et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Synthesis of benzimidazole derivatives containing amide bond and biological evaluation as acetylcholinesterase, carbonic anhydrase I and II inhibitors

(2022) Zuhal Alım et al.   JOURNAL OF MOLECULAR STRUCTURE

Novel bis-ureido-substituted sulfaguanidines and sulfisoxazoles as carbonic anhydrase and acetylcholinesterase inhibitors

(2022) Nebih Lolak et al.   MOLECULAR DIVERSITY

Exploration of 1,2,3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase

(2022) Chnar Kakakhan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The synthesis, biological evaluation and in silico studies of asymmetric 3,5-diaryl-rhodanines as novel inhibitors of human carbonic anhydrase isoenzymes

(2022) Kemal Yararli et al.   JOURNAL OF MOLECULAR STRUCTURE

Identification of N-phenyl-2-(phenylsulfonyl)acetamides/propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities

(2021) Mostafa M. Elbadawi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel sulfonamides with anti‐Alzheimer and antioxidant capacities

(2021) Nihal Gök et al.   ARCHIV DER PHARMAZIE

Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations

(2021) Chandra Bhushan Mishra et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo[2,1-b][1,3,4]thiadiazoles as highly potent acetylcholinesterase and non-classical carbonic anhydrase inhibitors

(2021) Sercan Askin et al.   BIOORGANIC CHEMISTRY

Enzymes inhibition profiles and antibacterial activities of benzylidenemalononitrile derivatives

(2021) Pınar Güller et al.   JOURNAL OF MOLECULAR STRUCTURE

Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds

(2021) Belgin Sever et al.   ARCHIV DER PHARMAZIE

Biological effects of bis-hydrazone compounds bearing isovanillin moiety on the aldose reductase

(2021) Gönül Yapar et al.   BIOORGANIC CHEMISTRY

Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies

(2021) Assem H. Eldeeb et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel sulphonamide-bearing methoxyquinazolinone derivatives as anticancer and apoptosis inducers: synthesis, biological evaluation and in silico studies

(2021) Ali S. Alqahtani et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

β-Lactams with antiproliferative and antiapoptotic activity in breast and chemoresistant colon cancer cells

(2020) Azizah M. Malebari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Calcium Channel Blockers: Molecular Docking and Inhibition Studies on Carbonic Anhydrase I and II Isoenzymes

(2020) Cüneyt Türkeş et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Recent Advances in β-lactam Derivatives as Potential Anticancer Agents

(2020) Xinfen Zhang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action

(2020) Alessandro Bonardi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?

(2020) Chandra B. Mishra et al.   MEDICINAL RESEARCH REVIEWS

Towards more effective acetylcholinesterase inhibitors: a comprehensive modelling study based on human acetylcholinesterase protein–drug complex

(2019) Abdulilah Ece   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Synthesis and Biological Evaluation of Novel Genistein Amino Acid Ester Derivatives as Potential Anti‐Tumor Agents

(2019) Xiao‐kang Long et al.   ChemistrySelect

Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors

(2019) Cüneyt Türkeş et al.   BIOORGANIC CHEMISTRY

Advances in the structural annotation of human carbonic anhydrases and impact on future drug discovery

(2019) Alessio Nocentini et al.   Expert Opinion on Drug Discovery

Inhibition profiles of Voriconazole against acetylcholinesterase, α‐glycosidase, and human carbonic anhydrase I and II isoenzymes

(2019) Fevzi Topal   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

C4-Phenylthio β-lactams: Effect of the chirality of the β-lactam ring on antimicrobial activity

(2019) Rostislav Kuskovsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Heterocyclic lactam derivatives containing piperonyl moiety as potential antifungal agents

(2019) Shuangshuang Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyrazole[3,4-d]pyridazine derivatives: Molecular docking and explore of acetylcholinesterase and carbonic anhydrase enzymes inhibitors as anticholinergics potentials

(2019) Parham Taslimi et al.   BIOORGANIC CHEMISTRY

Fast Microsecond Dynamics of the Protein–Water Network in the Active Site of Human Carbonic Anhydrase II Studied by Solid-State NMR Spectroscopy

(2019) Himanshu Singh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel sulfamate derivatives of menthol: Synthesis, characterization, and cholinesterases and carbonic anhydrase enzymes inhibition properties

(2018) Shahla Daryadel et al.   ARCHIV DER PHARMAZIE

Applications of carbonic anhydrases inhibitors in renal and central nervous system diseases

(2018) Claudiu T. Supuran   EXPERT OPINION ON THERAPEUTIC PATENTS

Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment

(2017) Chandra Bhushan Mishra et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antimicrobial/antimalarial activities of novel naphthalimido trans-β-lactam derivatives

(2017) Javad Ameri Rad et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and evaluation of sulfonamide-bearing thiazole as carbonic anhydrase isoforms hCA I and hCA II

(2016) Soner Kılıcaslan et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Syntheses and studies of new forms of N-sulfonyloxy β-lactams as potential antibacterial agents and β-lactamase inhibitors

(2015) Serena Carosso et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antibiosis interaction of Staphylococccus aureus on Aspergillus fumigatus assessed in vitro by mixed biofilm formation

(2015) Adrián Ramírez Granillo et al.   BMC MICROBIOLOGY

Efficient Expression and Crystallization System of Cancer-Associated Carbonic Anhydrase Isoform IX

(2015) Janis Leitans et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis and Biological Evaluation of Some 2-Azetidinone Derivatives as Potential Antihyperlipidemic Agents

(2013) Nikhilesh Arya et al.   ARCHIV DER PHARMAZIE

Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: Solution and X-ray crystallographic studies

(2013) Murat Bozdag et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Synthesis and in vitro anti-tubercular evaluation of 1,2,3-triazole tethered β-lactam–ferrocene and β-lactam–ferrocenylchalcone chimeric scaffolds

(2012) Kewal Kumar et al.   DALTON TRANSACTIONS

Structural annotation of human carbonic anhydrases

(2012) Mayank Aggarwal et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo

(2012) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Original Michaelis Constant: Translation of the 1913 Michaelis–Menten Paper

(2011) Kenneth A. Johnson et al.   BIOCHEMISTRY

2-Azetidinone – A new profile of various pharmacological activities

(2010) Parul D. Mehta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors

(2010) Seppo Parkkila et al.   MODERN PATHOLOGY

High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design

(2009) Katherine H. Sippel et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Identifying and Characterizing Binding Sites and Assessing Druggability

(2009) Thomas A. Halgren   Journal of Chemical Information and Modeling

Novel Syntheses of Azetidines and Azetidinones

(2008) Alberto Brandi et al.   CHEMICAL REVIEWS