Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1,3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with cardiac safety profile

Mechanisms involved in the antinociceptive and anti-inflammatory effects of a new triazole derivative: 5-[1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl]-1H-tetrazole (LQFM-096)

(2020) Carina S. Cardoso et al.   INFLAMMOPHARMACOLOGY

A review on progression of epidermal growth factor receptor (EGFR) inhibitors as an efficient approach in cancer targeted therapy

(2020) Adileh Ayati et al.   BIOORGANIC CHEMISTRY

Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: Anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies

(2020) Abdallah M. Alfayomy et al.   BIOORGANIC CHEMISTRY

Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies

(2019) Bahaa G.M. Youssif et al.   BIOORGANIC CHEMISTRY

5-Chlorobenzofuran-2-carboxamides: From allosteric CB1 modulators to potential apoptotic antitumor agents

(2019) Bahaa G.M. Youssif et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New pyrazole derivatives: Synthesis, anti-inflammatory activity, cycloxygenase inhibition assay and evaluation of mPGES

(2019) Ghaneya S. Hassan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel xanthine derivatives as potential apoptotic antitumor agents

(2019) Mohamed Hisham et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium

(2018) A Kalinowski et al.   Mucosal Immunology

Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity

(2017) Mostafa H. Abdelrahman et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Combined effect of tris(2-chloroethyl)phosphate and benzo (a) pyrene on the release of IL-6 and IL-8 from HepG2 cells via the EGFR-ERK1/2 signaling pathway

(2017) Youjian Zhang et al.   RSC Advances

Selective EGFR (Epidermal Growth Factor Receptor) Deletion in Myeloid Cells Limits Atherosclerosis—Brief Report

(2017) Lynda Zeboudj et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of epidermal growth factor receptor attenuates atherosclerosis via decreasing inflammation and oxidative stress

(2017) Lintao Wang et al.   Scientific Reports

EGFR is a pivotal regulator of thrombin-mediated inflammation in primary human nucleus pulposus culture

(2017) Bor-Ren Huang et al.   Scientific Reports

EGFR regulates macrophage activation and function in bacterial infection

(2016) Dana M. Hardbower et al.   JOURNAL OF CLINICAL INVESTIGATION

Review on EGFR Inhibitors: Critical Updates

(2016) Davinder Singh et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Crystal structure of rofecoxib bound to human cyclooxygenase-2

(2016) Benjamin J. Orlando et al.   Acta Crystallographica Section F-Structural Biology Communications

EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice

(2016) Weixin Li et al.   Scientific Reports

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

One-pot synthesis and in vivo biological evaluation of new pyrimidine privileged scaffolds as potent anti-inflammatory agents

(2015) Santosh S. Undare et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Modulation of the pharmacological properties of meloxicam by octreotide in rats

(2015) Sally Abdul Wanees El-Awdan et al.   Journal of Saudi Chemical Society

Epidermal growth factor receptor targeting in cancer: A review of trends and strategies

(2013) Chetan Yewale et al.   BIOMATERIALS

Substituted thiazoles VII. Synthesis and antitumor activity of certain 2-(substituted amino)-4-phenyl-1,3-thiazole analogs

(2012) Ghada S. Hassan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New quinazolinone–pyrimidine hybrids: Synthesis, anti-inflammatory, and ulcerogenicity studies

(2012) Safinaz E. Abbas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury

(2012) Wen-sheng Qu et al.   Journal of Neuroinflammation

Comparative Computational Studies of 3,4-Dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile Derivatives as Potential Antinociceptive Agents

(2012) Janaína V. dos Anjos et al.   MOLECULES

Novel dihydropyrimidines and its pyrazole derivatives: Synthesis and pharmacological screening

(2011) B. Ramesh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Activation of Epidermal Growth Factor Receptor Is Required for NTHi-Induced NF-κB-Dependent Inflammation

(2011) Xiangbin Xu et al.   PLoS One

Voreloxin, a First-in-Class Anticancer Quinolone Derivative, in Relapsed/Refractory Solid Tumors: A Report on Two Dosing Schedules

(2010) R. H. Advani et al.   CLINICAL CANCER RESEARCH

Dasatinib, a Multikinase Inhibitor: Therapy, Safety, and Appropriate Management of Adverse Events

(2010) Sepideh Shayani   THERAPEUTIC DRUG MONITORING

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME SUBSTITUTED AMINO THIAZOLE DERIVATIVES

(2010) A. K PRAJAPATI et al.   JOURNAL OF THE CHILEAN CHEMICAL SOCIETY

Synthesis and Anticancer Activities of Some Thiazole Derivatives

(2009) Ismail Kayagil et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Inhibition of inducible nitric oxide production and iNOS protein expression in lipopolysaccharide-stimulated rat aorta and Raw 264.7 macrophages by ethanol extract of a Chinese herbal medicine formula (RCM-101) for allergic rhinitis

(2008) George Binh Lenon et al.   JOURNAL OF ETHNOPHARMACOLOGY

Quantitative structure-activity relationships (QSAR) of 4-amino-2,6-diarylpyrimidine-5-carbonitriles with anti-inflammatory activity

(2008) João Bosco P. da Silva et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY