Recent advances of quinones as a privileged structure in drug discovery

Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3

(2020) Rizhen Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of the First Human Arylsulfatase A Reversible Inhibitor Impairing Mouse Oocyte Fertilization

(2020) Silvia Caroselli et al.   ACS Chemical Biology

Synthesis and Biological Evaluation of Novel Isothiazoloquinoline Quinone Analogues

(2020) Ling Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of the First Vitamin K Analogue as a Potential Treatment of Pharmacoresistant Seizures

(2020) Xiaoyang Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel β‐carboline‐based indole‐4,7‐quinone derivatives as NAD(P)H: Quinone‐oxidoreductase‐1 inhibitor with potent antitumor activities by inducing reactive oxygen species, apoptosis, and DNA damage

(2020) Yibing Guo et al.   Chemical Biology & Drug Design

Turning donepezil in a multi‐target‐directed ligand through a rationale merging strategy

(2020) Rosaria Perone et al.   ChemMedChem

Bifunctional Naphtho[2,3-d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production

(2020) Zeping Zuo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antifungal activity of hypocrellin compounds and their synergistic effects with antimicrobial agents against Candida albicans

(2020) Shihao Song et al.   Microbial Biotechnology

Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy

(2020) Kai-Rui Feng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx

(2020) Sheng-Tao Cheng et al.   JOURNAL OF HEPATOLOGY

A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species

(2020) Shuai Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological properties, and acid dissociation constant of novel naphthoquinone–triazole hybrids

(2020) Yahya Nural et al.   BIOORGANIC CHEMISTRY

Antimalarial application of quinones: A recent update

(2020) Om P.S. Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel naphthoquinone-4-aminobenzensulfonamide/carboxamide derivatives as proteasome inhibitors

(2020) Sirin Uysal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer’s disease

(2020) Eva Mezeiova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fluorescent 1,4-Naphthoquinones To Visualize Diffuse and Dense-Core Amyloid Plaques in APP/PS1 Transgenic Mouse Brains

(2019) Naewoo Neo Shin et al.   ACS Chemical Neuroscience

Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase

(2019) Felipe A. Calil et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme

(2019) Monika Kadela-Tomanek et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effects of Acetylshikonin on the Infection and Replication of Coxsackievirus A16 in Vitro and in Vivo

(2019) Xia Liu et al.   JOURNAL OF NATURAL PRODUCTS

Discovery of Novel Simplified Sampangine Derivatives with Potent Antifungal Activities against Cryptococcal Meningitis

(2019) Zhuang Li et al.   ACS Infectious Diseases

Chemoproteomics of an Indole-Based Quinone Epoxide Identifies Druggable Vulnerabilities in Vancomycin-Resistant Staphylococcus aureus

(2019) Amogh Kulkarni et al.   JOURNAL OF MEDICINAL CHEMISTRY

The anti‐hepatitis B virus therapeutic potential of anthraquinones derived from Aloe vera

(2019) Mohammad K. Parvez et al.   PHYTOTHERAPY RESEARCH

Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase

(2019) Shixian Hua et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25

(2019) Igor A. Schepetkin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimalarial N1,N3-Dialkyldioxonaphthoimidazoliums: Synthesis, Biological Activity, and Structure–activity Relationships

(2019) Stephen Ahenkorah et al.   ACS Medicinal Chemistry Letters

Quinone-based fluorophores for imaging biological processes

(2018) Gleiston G. Dias et al.   CHEMICAL SOCIETY REVIEWS

Quinone-fused pyrazoles through regio-selective 1,3-dipolar cycloadditions: synthesis of tricyclic scaffolds and in vitro cytotoxic activity evaluation on glioblastoma cancer cells

(2018) Mauro Comes Franchini et al.   ChemMedChem

Design, synthesis and activity of BBI608 derivatives targeting on stem cells

(2018) Qifan Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimalarial naphthoquinones. Synthesis via click chemistry, in vitro activity , docking to Pf DHODH and SAR of lapachol-based compounds

(2018) Geraldo Célio Brandão et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

NAD(P)H:Quinone Oxidoreductase 1 (NQO1) as a Therapeutic and Diagnostic Target in Cancer

(2018) Kuojun Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of Novel Reactive Oxygen Species Inducers for the Treatment of Pancreatic Ductal Adenocarcinoma

(2018) Yuting Kuang et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Efficient Buchwald–Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration

(2018) Aaron T. Garrison et al.   JOURNAL OF MEDICINAL CHEMISTRY

Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells

(2018) Hauke Löcken et al.   JOURNAL OF NATURAL PRODUCTS

Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors

(2018) Liangkun Pan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A novel series of napabucasin derivatives as orally active inhibitors of signal transducer and activator of transcription 3 (STAT3)

(2018) Chungen Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Syntheses and antibacterial activity of soluble 9-bromo substituted indolizinoquinoline-5,12-dione derivatives

(2017) Hui Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

ROS in Cancer: The Burning Question

(2017) Iok In Christine Chio et al.   TRENDS IN MOLECULAR MEDICINE

Novel naphtho[2,1-d]oxazole-4,5-diones as NQO1 substrates with improved aqueous solubility: Design, synthesis, and in vivo antitumor evaluation

(2016) Xiang Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antimalarial activity of quinones and structurally-related oxirane derivatives

(2016) Paula F. Carneiro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids

(2016) K. Jones M. Swapnaja et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights

(2016) Eduardo H.G. da Cruz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in Vitro Screening of New Series of 2,6-Dipeptidyl-anthraquinones: Influence of Side Chain Length on HIV-1 Nucleocapsid Inhibitors

(2016) Francesco Frecentese et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antiviral activities of 15 dengue NS2B-NS3 protease inhibitors using a human cell-based viral quantification assay

(2015) Justin Jang Hann Chu et al.   ANTIVIRAL RESEARCH

Dihydrithieno[2,3-b]naphto-4,9-dione analogues as anticancer agents: Synthesis and in cell pharmacological studies

(2015) Alessia Bertamino et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel 1,4-naphthoquinone-based sulfonamides: Synthesis, QSAR, anticancer and antimalarial studies

(2015) Ratchanok Pingaew et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Privileged scaffolds in lead generation

(2015) Hongyu Zhao et al.   Expert Opinion on Drug Discovery

Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase

(2015) Atsushi Furuta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening

(2015) Jian-Sung Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tackling the Cytotoxic Effect of a Marine Polycyclic Quinone-Type Metabolite: Halenaquinone Induces Molt 4 Cells Apoptosis via Oxidative Stress Combined with the Inhibition of HDAC and Topoisomerase Activities

(2015) Shou-Ping Shih et al.   Marine Drugs

Sequential synthesis of amino-1,4-naphthoquinone-appended triazoles and triazole-chromene hybrids and their antimycobacterial evaluation

(2014) Balasubramanian Devi Bala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1)

(2014) Jinlei Bian et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

(2014) Elisabet Viayna et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects

(2014) Eugenie Nepovimova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and discovery of novel quinazolinedione-based redox modulators as therapies for pancreatic cancer

(2013) Divya Pathania et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones

(2011) David Siegel et al.   BIOCHEMICAL PHARMACOLOGY