In vivo screening and toxicity studies of indolinone incorporated thiosemicarbazone, thiazole and piperidinosulfonyl moieties as anticonvulsant agents

Sulfaguanidine Hybrid with Some New Pyridine-2-One Derivatives: Design, Synthesis, and Antimicrobial Activity against Multidrug-Resistant Bacteria as Dual DNA Gyrase and DHFR Inhibitors

(2021) Ahmed Ragab et al.   Antibiotics-Basel

In vivo and in vitro anti-inflammatory, antipyretic and ulcerogenic activities of pyridone and chromenopyridone derivatives, physicochemical and pharmacokinetic studies

(2021) Eman A. Fayed et al.   BIOORGANIC CHEMISTRY

In vitro antimicrobial evaluation and in silico studies of coumarin derivatives tagged with pyrano-pyridine and pyrano-pyrimidine moieties as DNA gyrase inhibitors

(2021) Eman A. Fayed et al.   MOLECULAR DIVERSITY

Design, synthesis, antiproliferative evaluation, and molecular docking study of new quinoxaline derivatives as apoptotic inducers and EGFR inhibitors

(2021) Eman A. Fayed et al.   JOURNAL OF MOLECULAR STRUCTURE

Isatin-Schiff's base and chalcone hybrids as chemically apoptotic inducers and EGFR inhibitors; design, synthesis, anti-proliferative activities and in silico evaluation

(2021) Eman A. Fayed et al.   JOURNAL OF MOLECULAR STRUCTURE

Carboxamide appended quinoline moieties as potential anti-proliferative agents, apoptotic inducers and Pim-1 kinase inhibitors

(2021) Yousry A. Ammar et al.   MEDICINAL CHEMISTRY RESEARCH

Design, synthesis, in vitro antimicrobial evaluation and molecular docking studies of indol-2-one tagged with morpholinosulfonyl moiety as DNA gyrase inhibitors

(2020) Mohamed A. Salem et al.   BIOORGANIC CHEMISTRY

Design, synthesis, biological evaluation and molecular modeling of new coumarin derivatives as potent anticancer agents

(2019) Eman A. Fayed et al.   MEDICINAL CHEMISTRY RESEARCH

One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor

(2019) Mohamed A. Salem et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quinoline derivatives bearing pyrazole moiety: Synthesis and biological evaluation as possible antibacterial and antifungal agents

(2018) Mohamed F. El Shehry et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, antiproliferative activity, molecular docking and cell cycle analysis of some novel (morpholinosulfonyl) isatins with potential EGFR inhibitory activity

(2018) Yousry A. Ammar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase

(2018) Shweta Sinha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, cytotoxicity and molecular modeling studies of some novel fluorinated pyrazole-based heterocycles as anticancer and apoptosis-inducing agents

(2018) Eman A. Fayed et al.   MOLECULAR DIVERSITY

Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action

(2017) Eman Yahia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New chalcones bearing isatin scaffold: synthesis, molecular modeling and biological evaluation as anticancer agents

(2017) Yousry A. Ammar et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Naproxen derivatives: Synthesis, reactions, and biological applications

(2017) Y. A. Ammar et al.   SYNTHETIC COMMUNICATIONS

Synthesis, characterization and biological behavior of some Schiff's and Mannich base derivatives of Lamotrigine

(2017) A.A. Kulkarni et al.   Arabian Journal of Chemistry

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Synthesis and evaluation of antitumour activities of novel fused tri- and tetracyclic uracil derivatives

(2016) Samar ElKalyoubi et al.   JOURNAL OF CHEMICAL RESEARCH

Synthesis, potential anticonvulsant and antidepressant effects of 2-(5-methyl-2,3-dioxoindolin-1-yl)acetamide derivatives

(2015) Xinghua Zhen et al.   Acta Pharmaceutica Sinica B

Synthesis and Anxiolytic Activity of Some Novel 5-oxo-1, 4-oxazepine Derivatives

(2012) Bothiana A. AbdelFattah et al.   Letters in Drug Design & Discovery

Practical synthesis, anticonvulsant, and antimicrobial activity of N -allyl and N -propargyl di(indolyl)indolin-2-ones

(2011) Chandrasekaran Praveen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1-[(2-Arylthiazol-4-yl)methyl]azoles as a New Class of Anticonvulsants: Design, Synthesis, In vivo Screening, and In silico Drug-like Properties

(2011) Nematollah Ahangar et al.   Chemical Biology & Drug Design

Design, synthesis and antiepileptic properties of novel 1-(substituted benzylidene)-3-(1-(morpholino/piperidino methyl)-2,3-dioxoindolin-5-yl)urea derivatives

(2011) Chinnasamy Rajaram Prakash et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pharmacogenetics and Antiepileptic Drugs

(2010) Brian B. Spear   EPILEPSIA

Design & synthesis of N′-[substituted] pyridine-4-carbohydrazides as potential anticonvulsant agents

(2010) Laxmi Tripathi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY